基本介紹
- 中文名：羅雄劍
- 國籍：中國
- 畢業院校：武漢大學
- 職稱：研究員
基本信息,簡歷,研究方向,承擔科研項目,專家類別,代表論著,
基本信息
羅雄劍 研究員
職 務： 神經系統疾病課題組負責人
學 歷： 理學博士
通訊地址： 雲南省昆明市教場東路32號 中國科學院昆明動物研究所
簡歷
同年9月赴羅切斯特大學醫學中心（University of Rochester Medical Center）從事博士後研究工作，2014年9月通過中國科學院“百人計畫”引進回昆明動物研究所工作。現為神經系統疾病課題組負責人。長期從事於精神分裂症遺傳和神經發育機制研究,在精神分裂症遺傳機制研究方面取得顯著成績。首次發現和鑑別了一些新的精神分裂症易感基因如CAMKK2和ZNF323，探討了這些基因在精神分裂症發生中的可能機理。同時還揭示了Gata3和Lmo4基因在聽神經系統發育中的重要作用。已在Molecular Psychiatry、The American Journal of Psychiatry、Schizophrenia Bulletin、Human Molecular Genetics、The Journal of Neuroscience、Journal of Medical Genetics等雜誌發表論文二十餘篇。
2014.09-現在 中國科學院昆明動物所研究員
2010.09-2014.08 美國羅切斯特大學 博士後（Postdoctoral Research Associate，University of Rochester）
2005.09-2010.07 中國科學院昆明動物研究所 遺傳學博士
2001.09-2005.07 武漢大學生命科學學院 獲學士學位
研究方向
精神分裂症是一種影響患者思維、情感和行為的嚴重的神經系統疾病。作為人類最常見的疾病之一，精神分裂症影響了大約1%的人口。由於病因複雜，反覆發作以及大多在青壯年發病，精神分裂症嚴重影響患者生活，同時也給患者家屬和社會帶來了沉重的負擔。目前的研究表明遺傳因素和環境因素在精神分裂症的發生中都有作用，其中又以遺傳因素為主(精神分裂症遺傳力達到0.8左右)。
實驗室主要圍繞精神分裂症的遺傳機制和發病機理進行深入的系統研究。結合人類遺傳學、生物信息學以及神經生物學，從分子、細胞、模式動物和人等多個層次進行重要精神分裂症易感基因的功能及其機制研究，主要目標是闡明精神分裂症遺傳機制和致病機理，最終為預防和治療精神分裂症提供診斷及預後的分子標誌物以及治療靶標。目前研究興趣集中在探索和發現新的精神分裂症易感基因，並深入研究這些精神分裂症易感基因如何影響神經系統發育和功能，最終導致精神分裂症發生。目前研究方向主要集中在以下三個方面：
1.利用人類遺傳學和整合生物信息學研究精神分裂症的遺傳機制：
2.運用小鼠和靈長類動物模型研究精神分裂症的致病機理：
目前精神分裂症的病因仍不清楚，累積的研究表明精神分裂症是由神經系統發育異常導致的。 因此，了解精神分裂症易感基因如何影響神經系統發育對了解精神分裂症發生至關重要。本課題組利用基因敲除方法在小鼠和靈長類動物模型中深入研究精神分裂症易感基因在神經系統發育中的作用，探索精神分裂症易感基因的分子功能和致病機理。
3.探索精神分裂症的潛在治療靶標和開發抗精神疾病藥物：
依託昆明動物所豐富的靈長類資源，本課題組將嘗試建立精神分裂症靈長類動物模型，並利用靈長類動物模型探索精神分裂症的潛在治療靶標和開發抗精神疾病藥物。
承擔科研項目
中科院昆明動物所“百人計畫”啟動項目
專家類別
研究員，百人計畫
代表論著
1.Xiong-jian Luo# (Corresponding author), Ming Li, Liang Huang, Stacy Steinberg, Manuel Mattheisen, Gary Donohoe, Yongyong Shi, Chuansheng Chen, Weihua Yue, Anna Alkelai, Bernard Lerer, Zhiqiang Li, Qizhong Yi, Marcella Rietschel, Sven Cichon, David A. Collier, Sarah Tosato, Jaana Suvisaari, Dan Rujescu, Vera Golimbet, Teimuraz Silagadze, Naser Durmishi, Milica Pejovic Milovancevic, Hreinn Stefansson, Thomas G. Schulze, Markus M. N?then, Chunhui Chen, Ronan Lyne, Derek W. Morris, Michael Gill, Aiden Corvin, Dai Zhang, Qi Dong, Robert K. Moyzis, Engilbert Sigurdsson, Kari Stefansson, Fang Hu, MooDS SCZ Consortium&, Bing Su, and Lin Gan# (2013). Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene.
2.Ming Li*, Xiong-jian Luo*, Marcella Rietschel, Cathryn M. Lewis, Manuel Mattheisen, Bertram Müller-Myhsok, Stéphane Jamain, Marion Leboyer, Mikael Landén, Paul M. Thompson, Sven Cichon, Markus M. N?then, Thomas G. Schulze, Patrick F. Sullivan, Sarah E. Bergen, Gary Donohoe, Derek W. Morris, April Hargreaves, Michael Gill, Aiden Corvin, Christina Hultman, Arthur W. Toga, Lei Shi, Qiang Lin, Hong Shi, Lin Gan, Andreas Meyer-Lindenberg, Darina Czamara, Chantal Henry, Bruno Etain, Joshua C. Bis, M. Arfan Ikram, Myriam Fornage, Stephanie Debette, Lenore J. Launer, Sudha Seshadri, Susanne Erk, Henrik Walter, Andreas Heinz, Frank Bellivier, Jason L. Stein, Sarah E. Medland, Alejandro Arias Vasquez, Derrek P. Hibar, Barbara Franke, Nicholas G. Martin, Margaret J. Wright, MooDS Bipolar Consortium, The Swedish Bipolar Study Group, The Alzheimer’s Disease Neuroimaging Initiative, ENIGMA consortium, CHARGE consortium, Bing Su (2013). Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function and bipolar disorder susceptibility. Molecular Psychiatry
3.Xiong-jian Luo# (Corresponding author), Liang Huang, Peilin Jia, Ming Li, Bing Su, Zhongming Zhao, Lin Gan (2013), Protein-protein interaction and pathway analyses of top schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and enrichment of nucleosome (chromatin) assembly genes in schizophrenia susceptibility loci. Schizophrenia Bulletin.
4.Xiong-jian Luo# (Corresponding author), Liang Huang, Leng Han, Zhenwu Luo, Fang Hu, Roger Tieu, Lin Gan (2014). Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia reveal key schizophrenia susceptibility genes. Schizophrenia Bulletin. First published online March
5.Xiong-jian Luo, Min Deng, Xiaoling Xie, Liang Huang, Hui Wang, Lichun Jiang, Guoqing Liang, Fang Hu, Roger Tieu, Rui Chen, and Lin Gan (2013). GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Human Molecular genetics.
6.Min Deng*, Xiong-jian Luo*, Ling Pan, Hua Yang, Xiaoling Xie, Guoqing Liang, Liang Huang, Fang Hu, Amy Kiernan, and Lin Gan (2014). LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. The Journal of Neuroscience.
7.X-j Luo, H-b Diao, J-k Wang, H Zhang, Z-m Zhao and B Su (2008), Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese. Journal of Medical Genetics
8.Xiong-jian Luo#,* (Corresponding author), Liang Huang, Ming Li, Lin Gan# (2013), Protein-protein interaction analysis of schizophrenia susceptibility genes reveals common processes/pathways contributing to risk of schizophrenia. Schizophrenia Research. Volume
9.Xiong-jian Luo*, Ming Li*, Liang Huang, Kwangsik Nho, Min Deng, Qiang Chen, Daniel R. Weinberger, Alejandro Arias Vasquez, Mark Rijpkema, Venkata S. Mattay, Andrew J Saykin, Li Shen, Guillén Fernández, Barbara Franke, Jing-chun Chen, Xiang-ning Chen, Jin-kai Wang, Xiao Xiao, Xue-bin Qi, Kun Xiang, Ying-Mei Peng, Xiang-yu Cao, Yi Li, Xiao-dong Shi, for the Alzheimer’s Disease Neuroimaging Initiative, Lin Gan & Bing Su (2012), The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors. PLoS ONE.
10.Ming Li*, Xiong-jian Luo*, Xiao Xiao*, Lei Shi, Xing-yan Liu, Li-de Yin , Xiao-yuan Ma, Shun-ying Yang, Xing-fu Pu, Jin Yu, Hong-bo Diao, Hong Shi, Bing Su (2011), Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population. The World Journal of Biological Psychiatry.
11.Liang Huang, Fang Hu, Xiangyun Zeng, Lin Gan#, Xiong-jian Luo# (Corresponding author) (2013). Further evidence for the association between the LSM1 gene and schizophrenia.
12.Ming Li*,Yin Mo*, Xiong-jian Luo*, Xiao Xiao* Lei Shi, Ying-mei Peng, Xing-yan Liu, Li-de Yin, Hong-bo Diao, Bing Su (2011), Genetic association and identification of a functional SNP at GSK3β for schizophrenia susceptibility. Schizophrenia Research
13.Ming Li, Xiong-jian Luo, Xiao Xiao, Lei Shi, Xing-yan Liu, Li-de Yin, Hong-bo Diao, Bing Su (2011), Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia. The American Journal of Psychiatry
14.Ming Li, Xiong-jian Luo, Xu Zhang, Zhao-hui Yang, Kun Xiang, Xiao Xiao, Bing Su, Ya-li Zhao, Yan Shen, Qi Xu, Xiang-ning Chen, Jing-chun Chen, Xing-yan Liu, Li-de Yin, Xiao-yuan Ma, Shun-ying Yang, Jin Yu, Hong-bo Diao, Xiao-dong Shi (2011), A common variant of the cardiomyopathy associated 5 gene (CMYA5) is associated with schizophrenia in Chinese population. Schizophrenia Research.
15.Peng Y, Yang Z, Zhang H, Cui C, Qi X, Luo X, Tao X, Wu T, Ouzhuluobu, Basang, Ciwangsangbu, Danzengduojie, Chen H, Shi H, Su B (2011), Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Molecular Biology and Evolution
16.Ming Li*, Hui Zhang*, Xiong-jian Luo, Xue-bin Qi, Bing Su (2013). Meta-analysis indicates that the European GWAS-identified risk SNPwithin ZNF804A is not associated with schizophrenia in Han Chinese population. PLos ONE
17.Xiangning Chen, Cuie Sun, Qi Chen, F. Anthony O’Neill, Dermot Walsh, Ayman H. Fanous, Kodavali V. Chowdari, Vishwajit L. Nimgaonkar, Adrian Scott, Sibylle G. Schwab, Dieter B.Wildenauer, Ronglin Che, Wei Tang, Yongyong Shi, Lin He, Xiong-jian Luo, Bing Su, Todd L.Edwards, Zhongming Zhao, Kenneth S. Kendler (2009), Apoptotic Engulfment Pathway and Schizophrenia, PLoS ONE
18.Ming Li, Cui-juan Shi, Yong-yong Shi, Xiong-jian Luo, Xue-bin Zheng, Zhi-qiang Li, Jian-jun Liu, Siow-Ann Chong, Jimmy Lee, Yi Wang, Xing-yan Liu, Li-de Yin, Xing-fu Pu, Hong-bo Diao, Qi Xu, Bing Su (2012), ZNF804A and schizophrenia susceptibility in Asian populations. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
19.Ming Li, Yi Wang, Xue-bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong-jian Luo, Siow-Ann Chong, Jimmy Lee, Marcella Rietsche, Feng-yu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R. Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philp B. Mitchell, Peter R. Schofield, MooDS Consortium, Jian-jun Liu, Bing Su (2012), Meta-analysis and brain imaging data support the involvement of VRK2 in schizophrenia susceptibility. Schizophrenia Research
20.Liang Huang, Fang Hu, Liang Feng, Xiong-jian Luo, Guoqing Liang, Xiang-yun Zeng, Jing-lin Yi, Lin Gan (2014). Bhlhb5 is required for the subtype development of retinal amacrine and bipolar cells in mice. Developmental Dynamics
21.Jie-wei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue-bin Zheng, Xiong-jian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, TetsuroOhmori, Jin-xin Bei, Siow-Ann Chong, Jimmy Lee, Zhiqiang Li, Jian-jun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing Su (2013). An Evaluation of Association Between a Novel Hippocampal Biology Related SNPand Schizophrenia. PLoS ONE. 8(11): e80696. .
