《線粒體超氧炫分子機制和功能研究》是程和平為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：線粒體超氧炫分子機制和功能研究
- 項目類別 ：重點項目
- 依託單位 ：北京大學
- 項目負責人：程和平
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Identification of EFHD1 as a novel Ca2+ sensor for mitoflash activation | 期刊論文 | Hu, Keping|Wei, Liping|Cheng, Heping|Wang, Xianhua| |
2 | Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes | 期刊論文 | Wang, Yanru|Wang, Xianhua|Cheng, Heping|Zheng, Ming| |
3 | Superoxide Flashes Reveal Novel Properties of Mitochondrial Reactive Oxygen Species Excitability in Cardiomyocytes | 期刊論文 | Wang, Xianhua|Wang, Wang|Tan, Wenchang|Cheng, Heping| |
4 | Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle | 期刊論文 | Zhou, Jingsong|Wang, Xianhua|Zhang, Xiuqin|Cheng, Heping| |
5 | Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond | 期刊論文 | Hou, Tingting|Wang, Xianhua|Ma, Qi|Cheng, Heping| |
6 | Imaging ROS signaling in cells and animals | 期刊論文 | Shang, Wei|Hou, Tingting|Cheng, Aiwu|Cheng, Heping| |
7 | Synergistic Triggering of Superoxide Flashes by Mitochondrial Ca2+ Uniport and Basal Reactive Oxygen Species Elevation | 期刊論文 | Zheng, Ming|Gao, Feng|Wang, Xianhua|Cheng, Heping| |
8 | Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics | 期刊論文 | Qi, Wenfeng|Wang, Xianhua|Ma, Qi|Cheng, Heping| |
9 | Imaging Ca2+ Nanosparks in Heart With a New Targeted Biosensor | 期刊論文 | Wang, Xianhua|Cannell, Mark B.|Wang, Shi-Qiang|Cheng, Heping| |
10 | Subsarcolemmal mitochondrial flashes induced by hypochlorite stimulation in cardiac myocytes | 期刊論文 | Wang, X.|Yang, D.|Liu, J.|Cheng, H.| |
11 | Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity | 期刊論文 | Sheu, Shey-Shing|Cheng, Heping|Dirksen, Robert T.|Wang, Wang| |
12 | Calcium gradients underlying cell migration | 期刊論文 | Wei, Chaoliang|Wang, Xianhua|Zheng, Ming|Cheng, Heping| |
13 | Mitochondrial Superoxide Flashes: From Signaling to Disease | 學術專著 | Xianhua Wang|Qi Ma|Heping Cheng| |
14 | ROS regulation of microdomain Ca2+ signalling at the dyads | 期刊論文 | Wang, Xianhua|Yan, Yuan|Zheng, Ming|Cheng, Heping| |
15 | Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology | 期刊論文 | Wei-LaPierre, Lan|Cheng, Heping|Dirksen, Robert|Sheu, Shey-Shing| |
16 | Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart | 期刊論文 | Wang, Yuefan|Yang, Zhen|Zheng, Ming|Cheng, Heping| |
17 | Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations | 期刊論文 | Hou TingTing|Yin RongKang|Cheng HePing|Wang XianHua| |
18 | beta-Adrenergic-stimulated L-type channel Ca2+ entry mediates hypoxic Ca2+ overload in intact heart | 期刊論文 | Cao, Ji-Min|Ji, Guangju|Zhang, Rongli|Cheng, Heping| |
19 | 自由基生物醫學 | 學術專著 | 侯婷婷|王顯花|鄭銘|程和平| |
20 | Kissing and nanotunneling mediate intermitochondrial communication in the heart | 期刊論文 | Wang, Xianhua|Franzini-Armstrong, Clara|Zheng, Ming|Cheng, Heping| |
21 | Protons Trigger Mitochondrial Flashes | 期刊論文 | Zhao, Yan|Wang, Yanru|Gao, Feng|Cheng, Heping| |
22 | Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans | 期刊論文 | Wang, Xianhua|Shyr, Yu|Cheng, Heping|Dong, Meng-Qiu| |
23 | Superoxide constitutes a major signal of mitochondrial superoxide flash | 期刊論文 | Ye, Tao|Cheng, Heping|Gao, Feng|Wang, Xianhua| |
24 | Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease | 期刊論文 | Guo, Caixia|Sun, Qinmiao|Chen, Quan|Tang, Tie-Shan| |
項目摘要
活性氧（ROS）是一類化學性質非常活潑的含氧分子或自由基，在細胞信號轉導、能量代謝以及許多病理過程中都發揮至關重要的作用。線粒體是ROS生成、清除、平衡調控的一個主要細胞器。申請人最新研究發明了一種超氧陰離子螢光蛋白探針cpYFP，並發現了新的線粒體超氧生成事件超氧炫（Superoxide Flash）。但有關線粒體超氧炫的機理、功能及疾病相關性等方面的許多重要問題亟待解答，目前世界各地100多家實驗室正在進行跟蹤研究，共同催生一個嶄新的領域。基於前沿動態和核心優勢，本項目擬利用生物物理學、生物信息學、分子生物學以及生理和病理學等手段，研究超氧炫信號的產生與調控的分子機制，尋找超氧炫所激活的下游信號分子和信號通路，並試圖確定介導超氧炫發生的線粒體膜通透性孔道（mPTP）的分子實質。此外，通過發展ROS在體分子成像技術，探討超氧炫線上粒體能量代謝以及代謝相關重大疾病中的作用與意義。
