米雙利

米雙利，美國癌症研究協會（AACR）會員，美國血液學學會（ASH）會員，多次參加國際學術會議，如美國冷泉港藥物遺傳學大會、美國癌症研究學會國際年會、美國血液學國際年會等，並多次進行大會報告。

基本介紹

• 中文名：米雙利
• 職 稱： 研究員
• 職 務： 博士生導師
• 研究方向：腫瘤基因組學，藥物遺傳學

個人信息

職 稱: 研究員

職 務: 博士生導師

研究方向: 腫瘤基因組學，藥物遺傳學

教育及工作經歷

2009.8 - present Professor, Beijing Institute of Genomics, Chinese Academy of Sciences, China

2008.7 - 2009.8 Postdoctoral Scholar/Research Associate, Pharmacogenetics Anticancer Agents Research Group, University of Chicago, USA

2005.7 - 2008.7 Postdoctoral Fellow, Department of Medicine, Section of Hematology/Oncology,

University of Chicago, USA

1999 - 2005 Ph.D Degree, College of Life Sciences, Peking University, Beijing, China

主要研究領域

microRNA是近幾年成為研究熱點的一大類小分子RNA，由於它的普遍性、複雜性和重要性，使之成為目前各種生物體功能與發育研究的熱門對象，特別是 microRNA在癌症的發生、發展中起著極為關鍵的作用。我們的工作主要利用基因晶片、高通量測序等全基因組研究手段，闡明在不同白血病類型中的 microRNA的特異表達情況，以及它們與不同種類白血病的發病關係；通過分析基因調控區甲基化水平、基因拷貝數、組蛋白修飾情況等表觀遺傳學因素，研究microRNA差異表達的機理；同時利用造血幹細胞分化培養、RNAi技術、轉基因小鼠模型等，在體外和體內系統中分別研究microRNA及其靶基因對於白血病的發生髮展、血細胞種系的分化所起到的作用。

藥物遺傳學（Pharmacogenetics and Pharmacogenomics）是將遺傳學、基因組學、生物信息學、臨床醫學和藥學有機結合在一起的前沿學科，為實現個體化醫療奠定重要的基礎。我們的工作主要利用Genome-Wide Association Study，研究個體基因結構與表達差異（如SNP、mRNA、miRNA、CNV等）和多種抗癌藥物對個體回響或毒性差異的關聯性，為臨床醫療和藥物試驗提供依據。

科研項目

1. 國家自然科學基金重大國際合作研究項目：利用開放科學數據云促進高通量腫瘤基因組研究，在研，主持

2. 科技部973項目：DNA損傷回響重要蛋白維持基因組穩定性機制研究,在研，課題骨幹

3. 科技部973項目：在肺癌微環境中表觀遺傳修飾對肺癌發展轉移的作用機制，在研，課題骨幹；

4. 國家自然科學基金面上項目：白血病異常融合蛋白MLL-ENL對小鼠細胞全基因組microRNA的表達調控研,結題，主持；

5. 教育部留學回國人員啟動基金，主持

代表論著

1.Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi SL*. Exosomal MicroRNA: Trafficking, sorting and function

2. Mi S, Zhang J, Zhang W, Huang RS. Circulating microRNAs as biomarkers for inflammatory diseases

3. Wang QF, Wu G, Mi S, He F, Wu J, et al. MLL Fusion Proteins Preferentially Regulate a Subset of Wild Type MLL Target Genes in the Leukemic Genome

4. Wen Y, Gamazon ER, Bleibel WK, Wing C, Mi S, et al. An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers

5. Tao Y, Ruan J, Yeh SH, Lu X, Wang Y, et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

6. Mi S, Li Z, Chen P, He C, Cao D, et al. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia

7. Huang RS, Johnatty SE, Gamazon ER, Im HK, Ziliak D, et al. Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients

8. Stark AL, Zhang W, Mi S, Duan S, O'Donnell PH, et al. Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines

9. Huang RS, Mi S. Candidate genes pharmacogenetics of anti-cancer agents

10. Hartford C, Duan S, Delaney S, Mi S, Kistner E, et al. Population Specific Genetic Variants Important in Susceptibility to Cytarabine Arabinoside Cytotoxicity

11. Duan S, Huang RS, Zhang W, Mi S, Bleibel WK, et al. Expression and Alternative Splicing of Folate Pathway Genes in HapMap Lymphoblastoid Cell Lines

12. Duan S *, Mi S *, Zhang W, Dolan M.E. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes

13. Li Z, Luo RT, Mi S, Sun M, Chen P, et al. Consistent deregulation of gene expression between human and murine MLL-rearrangement leukemias. Cancer Res

14. Li Z *, Lu J*, Sun M*, Mi S*, Zhang H, et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. P Natl Acad Sci USA

15. Mi S, Lu J, Sun M, Li Z, Zhang H,et al. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

16. Wang M, Xie H, Mi S, Chen J. Recent patents on the identification and clinical application of microRNAs and target genes

17. Zhang XY, Wu Y, Yan JY, Gao Y, Wang Y, et al. Y55 and D78 are crucial amino acid residues of a new IgE epitope on trichosanthin

18. Mi SL, An CC, Wang Y, Chen JY, Che NY, et al. Trichomislin, a novel ribosome-inactivating protein, induces apoptosis that involves mitochondria and caspase-3

19. Wang Y, Mi SL, Lou M, Gao Y, Chen ZL, et al. Enhanced Green Fluorescence protein tracks Trichosanthin in human choriocarcinoma cells as a feasible and stable reporter

20. Yan Y, An C, Li L, Gu J, Wang L, et al. The sense and antisense expression of gibberellin 20-oxidase gene (rga5) in rice and its effects on GA1 level and agronomic traits

發表專利

1. 天花粉蛋白突變體及其編碼基因

2. Mutants of Trichosanthin With Anti-Tumor Activity and Lowered Side-Effects