童望宇

童望宇,男,博士,現為安徽大學生命科學學院教授、博士生導師。

基本介紹

  • 中文名:童望宇
  • 畢業院校:浙江大學
  • 學位/學歷:博士
  • 專業方向:生物化工、微生物與生化藥學
  • 職務:安徽大學生命科學學院博士生導師
  • 職稱:教授
人物經歷,研究方向,出版圖書,學術成果,著作,專利,論文,

人物經歷

1979/9~1983/8 天津科技大學 食品工程 工學學士
1983/9~1985/8 長春職業技術學院 食品工程 助教
1985/9~1988/4 天津科技大學 發酵工程 工學碩士
1988/5~1998/8 昆明理工大學 發酵工程 講師
1998/9~2001/8 浙江大學 生物化工 工學博士
2001/9~2002/8 Inha University Biological Postdoc
2002/9~2007/4 華東理工大學生物工程學院生物反應器工程國家重點實驗室 生物化工 副教授/教授
2006/7~2007/2 The Ohio State University USAFood Microbiology Visiting Assistant Professor
2007/2~2007/10 Cornell University Biomolecular Visiting Scientist
2008/5~ 安徽大學生命科學學院 生物工程 教授/博導

研究方向

集成化生物技術――生物上、中、下游集成化技術與機理研究,特別是具有自主智慧財產權的基因編輯技術的機理與套用研究。理論上,研究分子生物學原理(基因表達調控)與發酵調控原理(環境因子調控);套用上,通過理性設計結合現代生物技術等實驗手段解決微生物轉化與降解、蛋白(酶)設計與表達、及生物分離過程中的難題。主要涉及環境微生物轉化與降解、微生物製藥(甾體與蛋白藥物)、與生物分離(蛋白質分離與復性)等領域。

出版圖書

作者名稱:童望宇
作者類型:
作者時間:2006年01月01日
《製藥微生物技術:基礎與套用》是2006年化學工業出版社出版的圖書,作者是童望宇、章亭洲、傅向陽。

學術成果

著作

(1)Wang-Yu Tong(2013) Biotransformation of Terpenoids and Steroids (In: Handbook of Natural Products), Springer Berlin Heidelberg, Germany, ISBN: 978-3-642-22143-9, 3(88): 2733-2759.
(2)Wang-Yu Tong, Xue-Chang Zhang, Shan-Qun Jiang, Xiang Dong(2013)Integrated Biotechnology: Fundamentals and Applications, Studium Press LLC, P.O. Box 722 200, Houston, TX 77072, USA, ISBN: 1-933699-70-1/ 9781933699707.
(3)童望宇,沈亞領,張勰�譯,《蛋白質藥物――開發與生產,Development and Manufacture of Protein Pharmaceuticals》,化學工業出版社,ISBN號:7-5025-8359-9, 2006年5月第1版
(4)童望宇,章亭洲,傅向陽編著,《製藥微生物技術――基礎與套用》(現代生物技術製藥叢書),化學工業出版社,ISBN號: 7-5025-7386-0,2006年1月第1版

專利

(1)童望宇,許鑫,張雁,孫焰,曹素麗(20161207)一種維吉尼亞鏈黴菌IBL14 type I-B-sv14型CAS基因編輯系統,申請號:201611113137.3
(2)童望宇,邱彩花,楊興旺,王安靜(20161201)一種基於維吉尼亞鏈黴菌IBL14基因cas7-5-3的基因編輯方法,申請號:CN201611089333.1
(3)童望宇,李雪,雍德祥(20151225)一種維吉尼亞鏈黴菌IBL14產青黴素重組菌株的構建方法,申請號:CN 201510999333.4,公開(公告)號:CN105505976,公開(公告)日:20160420
(4)童望宇,雍德祥,李雪,邱彩花(20151225)一種維吉尼亞鏈黴菌IBL14中的CRISPR-Cas系統及套用其進行基因編輯的方法,申請號:CN 201511002817.3,公開(公告)號:CN105543266,公開(公告)日:20160504
(5)童望宇,于振海,謝球(20141124)一種高產丙氨酸的枯草桿菌工程菌的構建方法,申請號:201410680819.7,公開(公告)號:CN104593405A,公開(公告)日:20150506
(6)童望宇,謝球,于振海(20141124)一種改性大豆蛋白製備膠囊的製備方法,申請號:201410674900.4,公開(公告)號:CN104368008A,公開(公告)日:20150225
(7)童望宇,韓毛振,羅學才(20131223)一種具有高活菌數的益生菌微膠囊的製備方法,申請號:201310715323.4,公開(公告)號:CN103704719A,公開(公告)日:20140409,授權公告日:20160817
(8)童望宇,羅學才(20131223)一種貨架期內具有高活菌數的枯草桿菌微膠囊的製備方法,申請號:201310714772.7,公開(公告)號:CN103704718A,公開(公告)日:20140409,授權公告日:20160427
(9)童望宇,盧雲霞(20131221)一種發酵乳用高效發酵劑的製備方法,申請號:201310709580.7,公開(公告)號:CN103710283A,公開(公告)日:20140409
(10)童望宇,孔哲、盧雲霞(20130411)以豆粕和菊芋為原料生產的糖尿病患者系列保健食品,申請號:201310124140.5,申請日:20130411,主分類號:A23L 1/09,公開(公告)號:103250948A,公開(公告)日:20130821,授權公告日:20150624
(11)童望宇,宋俊蘭,陳昭元(20120813)一種大腸桿菌胞外生產外源蛋白的集成化方法,申請號:201210287000.5,申請日:20120813,主分類號:C12P 21/00,公開(公告)號:102827904A,公開(公告)日:20121219,授權公告日:20140604
(12)童望宇,陳昭元,謝麗(20120813)一種用於重組蛋白分泌型表達的雙基因突變大腸桿菌的構建方法,申請號:201210286769.5,申請日:20120813,主分類號:C12N 15/70,公開(公告)號:102827860A,公開(公告)日:20121219,授權公告日:20140604

論文

(1) Qing-Xi Wu, Xin Xu, Qiu Xie,Wang-Yu Tong*, Yan Chen (2016) Evaluation of chitosan hydrochloride-alginate as entericmicro-probiotic-carrier with dual protective barriers, International Journal of Biological Macromolecules, 93: 665-671(*: corresponding author, the same as below)
(2) Yan Zhang1, Mao-Zhen Han1, Shu-Liang Zhu, Man Li, Xiang Dong, Xue-Cai Luo, Zhe Kong,Yun-Xia Lu, Shu-Yan Wang,Wang-Yu Tong* (2105) Studies on the function and catalytic mechanism of O-methyltransferases SviOMT02, SviOMT03 and SviOMT06 fromStreptomyces virginiae IBL14, Enzyme and Microbial Technology, 73-74: 72-79.
(3) Zhao-Yuan Chen, Jie Cao, Li Xie, Xiao-Fei Li, Zhen-hai Yu andWang-Yu Tong* (2014) Construction of leaky strains and extracellular production of exogenous proteins in recombinant Escherichia coli, Microbial Biotechnology, 7(4): 360-370, doi: 10.1111/1751-7915.12127.
(4) Zhi-Zhen Li1, Xiao-Fei Li1, Wei Yang1, Xiang Dong1, Jie Yu2, Shu-Liang Zhu1, Man Li1, Li Xie1 andWang-Yu Tong1,* (2013) Identification and functional analysis of cytochrome P450 complement in Streptomyces virginiae IBL14, BMC Genomics, 14(1):130, doi: 10.1186/1471-2164-14-130.
(5) Feng-Qing Wang, Cheng-Gang Zhang, Bo Li, Dong-Zhi Wei,Wang-Yu Tong*,(2009) New Microbiological Transformations of Steroids by Streptomyces virginiae IBL-14, Environmental Science & Technology, 43(15): 5967-5974.
(6) Q. R. Guo,W. Y. Tong*, D. Z. Wei, and X. Y. Tao (2008) Expression and purification of Soluble B lymphocyte stimulator from recombinant Escherichia coli, Applied Biochemistry and Microbiology 44(2):187-192.
(7) Feng Zhou, Dong-Zhi Wei,Wang-Yu Tong*, Yi-Qi Zhu, Yun-Mei Jiang (2007) Some characteristics and purification of anti-human ovarian carcinoma × anti-human CD3 single chain bispecific antibody, Biotechnology and Applied Biochemistry, 47(1) 39-47.
(8) Yi-Qi Zhu,Wang-Yu Tong*, Dong-Zhi Wei*, Feng Zhou,Jing-Bo Zhao (2007) Environmental stimuli on the soluble expression of anti-human ovarian carcinoma × anti-human CD3 single-chain bispecific antibody in recombinant Escherichia coli, Biochemical Engineering Journal, 37 (2): 184-191.
(9) Kun Chen,Wang-Yu Tong*, Dong-Zhi Wei* , Wei Jiang (2007) The 11β-hydroxylation of 16,17α-epoxyprogesterone and the purification of the 11β-hydroxylase from Absidia coerulea IBL02, Enzyme and Microbial Technology, 41(1-2):71-79.
(10) Qi-Ran Guo, Dong-Zhi Wei*,Wang-Yu Tong* (2006) Partial Purification of Human Parathyroid Hormone 1-84 (PTH) as a Thioredoxin Fusion Form in Recombinant Escherichia coli by Thermoosmosis Shock, Protein Expression and Purification, 49 (1) 32-38.
(11)Wang-Yu Tong1,*,Shan-Jing Yao2,* and Zi-Qiang Zhu2 (2005) Partial purification properties of Human Epidermal Growth Factor from Recombinant Escherichia coli by Expanded Bed Adsorption, World Journal of Microbiology & Biotechnology, 21 (1): 51-57.
(12) Xiang-Yang Fu,Wang-Yu Tong*and Dong-Zhi Wei*, (2005) Extracellular Production of Human Parathyroid Hormone as a Thioredoxin Fusion Form in Escherichia coli by Chemical Permeabilization Combined with Heat Treatment,Biotechnology Progress, 21 (5), 1429 -1435.
(13)Wang-Yu Tonga,*, Xiang-Yang Fua, Sang-Mok Leeb, Jie Yuc, Jian-Wen Liua, Dong-Zhi Weia and Yoon-Mo Koob,*(2004)Purification of L -(+)-lactic acid from fermentation broth with paper sludge as a cellulosic feedstock using weak anion exchanger Amberlite IRA-92,Biochemical Engineering Journal, 18(2):89-96.
(14)Wang-Yu Tong, Shan-Jing Yao*, Zi-Qiang Zhu (2001) Separation characteristics of human epidermal growth factor in ion exchange chromatography with STREAMLINE DEAE resin, Chemical Engineering Science, 56(24): 6959-6965.
(15)W.-Y. Tong, S.-J. Yao*, Z.-Q. Zhu, J. Yu (2001) An improved procedure for production of human epidermal growth factor from recombinant E. coli, Applied Microbiology and Biotechnology, 57: 674-679.

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