竇同意，男，博士，大連理工大學生命與醫藥學院講師。
基本介紹
- 中文名：竇同意
- 畢業院校：中科院大連化物所
- 學位/學歷：博士
- 職業：教師
- 專業方向：新功能蛋白的分離、鑑定與結構功能關係研究等
- 任職院校：大連理工大學生命與醫藥學院
個人經歷,研究方向,學術成果,
個人經歷
2005.09 — 2009.07 天津大學 製藥工程 工學學士
2009.09 — 2016.01 中科院大連化物所 生物化工 工學博士
2015.03 — 2015.06 芬蘭赫爾辛基大學 分子藥理 博士交流生
2015.03 — 2015.06 大連理工大學 生命與醫藥學院 講師
研究方向
新功能蛋白的分離、鑑定與結構功能關係研究；臨床代謝組學、宏基因組學、轉錄組學數據的分析與數據挖掘。
學術成果
承擔項目
1.大連理工大學基本科研業務費，Xyl_S酶的催化機理及其關鍵催化結構域的鑑定
2.國家自然科學基金-青年基金24萬，一種新型去糖基酶的催化機理及其關鍵催化結構域的鑑定
代表性論文
[1]Tongyi Dou, Hongwei Luan, Guangbo Ge, Mingming Dong, Hanfa Zou, Yuqi He, Pan Cui, Jiayue Wang, Dacheng Hao, Shilin Yang, Ling Yang*. "Functional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel."Scientific Reports
[2]Tongyi Dou, Hongwei Luan, XingbaoLiu, Shiyang Li, Xunfu Du and Ling Yang*. "Enzymatic hydrolysis of 7-xylosyltaxanes by an extracellular xylosidase fromCellulosimicrobium cellulans."Biotechnology Letters, 2015
[3] Ziru Dai, Guangbo Ge, Lei Feng, Jing Ning, Lianghai Hu, Qiang Jin, Dandan Wang, Xia Lv,Tongyi Dou, JingnanCui, Ling Yang*. "A highly selective ratiometric two-photon fluorescent probe for human cytochrome P450 1A."Journal of the American Chemical Society, 2015
[4] Xing-Kai Qian, Ping Wang, Yang-Liu Xia,Tongyi Dou, Qiang Jin, Dan-Dan Wang, Da-Cheng Hao, Xiao-Lin Bi, Guang-Bo Ge, Ling Yang, A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B: Chemical, 2016
[5] 錢星凱，夏楊柳，竇同意，侯潔，馬紅，葛廣波，秘曉林，楊凌*.兒茶酚-氧位-甲基轉移酶與疾病的關係,《藥學學報》，2016
[6] Pan Cui,Tongyi Dou, Guangbo Ge. Efficient enzymatic preparation of Esculentoside B following condition optimization by response surface methodology. Journal of Molecular Catalysis B: Enzymatic
[7] Pan Cui,Tongyi Dou, Guangbo Ge. Highly selective and efficient biotransformation of linarin to produce tilianin by naringinase. Biotechnology Letters, 2016
[8] Yangliu Xia, Xia Lv, Guiyuan He,Tongyi Dou, Guang-Bo Ge, Ling Yang. In vitro characterization of the glucuronidation pathways of D-luciferin mediated by human UDP-glucuronosyltransferases. Drug Metabolism and Pharmacokinetics, 2017
[9] Wei Lei, Dan-Dan Wang,Tongyi Dou, Jie Hou, Liang Feng, Heng Yin, Qun Luo, Jie Sun, Guang-Bo Ge, Ling Yang. Assessment of the inhibitory effects of pyrethroids against human carboxylesterases. Toxicology and Applied Pharmacology, 2017
[10] Zi-Miao Weng, Ping Wang, Guang-Bo Ge, Zi-Ru Dai, Da-Chang Wu, Li-Wei Zou,Tongyi Dou, Jie Hou, Tong-Yan Zhang, Ling Yang. Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase. Food and Chemical Toxicology, Available online 24 March 2017
[11] Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y. Hong,Tongyi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge, and Ling Yang. A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5, J. Med. Chem., 2017
[12] Ping Wang, Yang-Liu Xia, Li-Wei Zou, Xing-Kai Qian,Tongyi Dou, Qiang Jin, Shi-Yang Li, Yang Yu, Dan-Dan Wang, Qun Luo, Guangbo Ge, Ling Yang. An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase. Accepted manuscript online: 16 May 2017
[13] Li-Wei Zou, Tong-Yi Dou, Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge, Ling Yang, Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1, Frontiers in Pharmacology, 2017, Accepted.
