程景勝 天津大學化工學院教授.研究工作集中於微生物製藥,針對"微生物細胞對環境的適應性及產物合成的高效性”問題,①運用系統生物學方法從蛋白和代謝物水平揭示工業酵母菌接種密度的依賴性和真空環境適應性回響機制,發現高密度接種導致細胞代謝途徑間轉換的特性;②採用工程策略調節多粘芽孢桿菌胞外氧化還原態勢,結合外源還原劑調節顯著提高2,3-丁二醇產量和產率。③建立了提高次生代謝物產量的新策略,為新型抗生素合成調節提供理論依據;有助於運用合成生物學和系統代謝工程策略構建robust的工業菌株。④研究輔因子對SMX降解和生物轉化的影響,探究SMX在微生物細胞內的代謝途徑,為人工建立以輔因子為基礎的混菌體系提供依據。已發表學術論文40餘篇,獲得授權專利5項,申請專利10項。
程景勝 天津大學化工學院教授.研究方向:生物製藥:抗菌活性物; 生物表面活性劑;綠色生物農藥
系統生物技術: 微生物與環境互作.
講授課程:
生物製藥工藝學(本科生)
細胞培養工程(研究生)
學術兼職:
1)擔任國家自然科學基金;美國自然科學基金會(NSF);新加坡(MOE Translational R&D and Innovation Fund),廣西自然科學基金,黑龍江省自然科學基金等通訊評審專家;
2)擔任國際刊物審稿人: Frontiers in Microbiology, Bioresource Technology,Journal of Chemical Technology & Biotechnology, International Journal of Biomedical Science, Proteomics Insights, Biotechnology and Applied Biochemistry, Frontiers of Chemical Engineering in China等的審稿人;
3)天津市細胞生物學會理事。
學術成就:
2011年,教育部新世紀優秀人才計畫獲得者;
2009年,獲國家留學基金委資助,作為天津大學青年骨幹教師(訪問學者)在美國麻省理工學院化工系 Gregory Stephanopoulos 院士Bioinformatics & Metabolic Engineering實驗室進行交流訪問一年;
科研項目:
(1) 主持國家自然科學基金(青年基金,1項),(面上項目,2項),(國際合作交流項目,1項);
(2) 主持973計畫子課題 2 項;
(3) 主持教育部新世紀優秀人才支持計畫 1項 ;
(4) 主持天津市自然科學基金(重點項目)1項;
(5) 主持科技部農業科技成果轉化項目 1項。
參加973計畫課題(1項);國家自然科學基金(重點項目) 1項。
論著專利:
- Yi-Bi Zhang, Jiao Zhou, Qiu-Man Xu,Jing-Sheng Cheng*, Yu-Lu Luo, Ying-Jin Yuan. Exogenous cofactors for the improvement of bioremoval and biotransformation of sulfamethoxazole byAlcaligenes faecalis. SCIENCE OF THE TOTAL ENVIRONMENT, 2016, 565: 547-556
- Xin Li, Qiu-Man Xu,Jing-Sheng Cheng*, Ying-Jin Yuan. Improving the bioremoval of sulfamethoxazole and alleviating cytotoxicity of its biotransformation by laccase producing system under coculture ofPycnoporus sanguineusandAlcaligenes faecalis. BIORESOURCE TECHNOLOGY, 2016, 220: 333-340.
- Qiu-Man Xu, Ya-Zhe Wang, Hui Liu,Jing-Sheng Cheng*. Physiological responses and chromosomal aberration in root tip cells ofAllium sativumL. to cerium treatments. PLANT AND SOIL, 2016, 409(1-2): 447-458.
- Jing-Sheng Cheng*, Yan Zhao, Bin Qiao, Hua Lu*, Yao Chen, Ying-Jin Yuan*. Comprehensive Profiling of Proteome Changes Provide Insights of IndustrialPenicillium chrysogenumDuring Pilot and Industrial Penicillin G Fermentation. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2016, 179(5): 788-804.
- Jun-Jun Dai,Jing-Sheng Cheng*, Ying-Quan Liang, Tong Jiang, Ying-Jin Yuan. Regulation of extracellular oxidoreduction potential enhanced (R, R)-2,3-butanediol production byPaenibacillus polymyxaCJX518. BIORESOURCE TECHNOLOGY, 2014, 167: 433-440.
- Jing-Sheng Cheng*, Shao-Fei, Cui, Ming-Zhu Ding, Ying-Jin Yuan*. Insights into the roles of exogenous glutamate and proline in improving streptolydigin production ofStreptomyces lydicuswith metabolomic analysis. J Ind Microbiol Biotechnol. 2013 Nov;40(11):1303-14.
- Jing-Sheng Cheng*, Ying-Quan, Liang, Ming-Zhu Ding, Shao-Fei, Cui, Xiao-Min Lv, and Ying-Jin Yuan*. Metabolic analysis reveals the amino acid responses ofStreptomyces lydicusto pitching ratios during improving streptolydigin production. Applied Microbiology and Biotechnology, 2013, 10.1007/s00253-013-4790-4 , 97(13):5943-54
- Jing-Sheng Cheng*, Yan-Hong Niu, Shu-Huan Lu and Ying-Jin Yuan*. Metabolome analysis reveals ethanolamine as potential marker for improving lipid accumulation of model photosynthetic organisms. Journal of Chemical Technology and Biotechnology, 2012, 87(10): 1409–1418
- Jing-Sheng Cheng, Xiao-Min Lv, and Ying-Jin Yuan*. Investigation of proteomic responses ofStreptomyces lydicusto pitching ratios for Improving streptolydigin production. Biotechnology and Bioprocess Engineering,2012, 17(5):997-1007
- Zhou H,Jing-Sheng Cheng, Wang B, Fink GR, Stephanopoulos G*. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production bySaccharomyces cerevisiae. Metabolic Engineering, 2012, 14(6):611-622
- Jing-Sheng Cheng*, Ming-Zhu Ding, Hong-Chi Tian, Ying-Jin Yuan*. Inoculation density-dependent responses and pathway shifts inSaccharomyces cerevisiae. Proteomics, 2009, 9(20):4704-4713
- Jing-Sheng Cheng, Xiao Zhou, Ming-Zhu Ding, Ying-Jin Yuan*, (2009) Proteomic insights into adaptive responses ofSaccharomyces cerevisiaeto the repeated vacuum fermentation. Applied Microbiology and Biotechnology, 83(5):909-923
- Jing-Sheng Cheng, Ying-Jin Yuan*. (2009) Release of proteins: insights into oxidative response ofTaxus cuspidatainduced by shear stress. Journal of Molecular Catalysis B: Enzymatic. 2009, 58:84-92
- Jing-Sheng Cheng. Bin Qiao. Ying-Jin Yuan*. (2008) Comparative proteome analysis of robustSaccharomyces cerevisiaeinsights into industrial continuous and batch fermentation. Applied Microbiology and Biotechnology, 81(2):327-338
- Jing-Sheng Cheng, Qiu-Man Xu, Jin-ChuanWu, Ying-Jin Yuan*. (2008) ERK-like MAPK signaling and cytochrome c response to oleic acid in two-liquid-phase suspension cultures ofTaxus cuspidata. Biochemical Engineering Journal, 41 (3): 274–279