程廷才

主要研究基因組生物信息學，家蠶分子免疫學與分子生物學。

基本介紹

  • 中文名：程廷才
  • 國籍：中國
  • 民族：漢族
  • 出生地：中國
  • 畢業院校：西南大學
  • 學位/學歷：博士
  • 專業方向：蠶學與系統生物學
  • 職務：講師
個人履歷,科學成就,代表性論文,

個人履歷

1997年-2001年，西南農業大學，蠶桑絲綢學院，本科/學士
2002年-2004年，西南農業大學，蠶學與系統生物學研究所，碩士研究生
2005年-2008年，西南大學，蠶學與系統生物學研究所，博士研究生/博士，
2008年-2009年，重慶大學，農學及生命科學研究院，講師
2010年-2011年，重慶大學，農學及生命科學研究院，副教授
2012年-至今，西南大學，家蠶基因組生物學國家重點實驗室，副教授

科學成就


以家蠶基因組和基因晶片為基礎，全基因組水平鑑定了家蠶免疫相關基因和相關信號傳導途徑；對家蠶先天免疫系統的關鍵基因家族，如抗菌肽家族、免疫球蛋白家族和Toll受體基因家族等，進行進化分析和功能鑑定；利用家蠶全基因組晶片，對家蠶病原微生物的免疫應答進行全面的表達譜比較分析，鑑定了家蠶針對特異病原微生物免疫應答的關鍵基因及其生物學功能，初步提出了家蠶免疫應答機理的網路調控分子機理。近年來已在國內外高水平期刊發表論文20多篇。

代表性論文

  1. Yang W*, Cheng T*, Ye Mg, Deng X, Yi H, Huang Y, Tan X, Han D, Wang B, Xiang Z, Cao Y, Xia Q. Functional Divergence among Silkworm Antimicrobial Peptide Paralogs by the Activities of Recombinant Proteins and the Induced Expression Profiles. PLoS ONE, 2011, 6(3) (equal contribution)
  2. Cheng T, Xia Q, Zhang Y, Xu P, Tan X, Fang T, Xiang Z. Identification and comparative analysis of immune-related genes and pathways in the silkworm, Bombyx mori. Acta Entomologica Sinica. 2009, 52 (3): 235-245
  3. Cheng T, Zhang Y, Liu C, Xu P, Gao Z, Xia Q, Xiang Z. Identification and analysis of Toll-related genes in the domesticated silkworm, Bombyx mori. Dev. Comp. Immunol. 2008, 32, 464-475
  4. Cheng T, Zhao P, Liu C, Xu P, Gao Z, Xia Q, Xiang Z. Structures, regulatory regions and inductive expression patterns of antimicrobial peptide genes in the silkworm, Bombyx mori. Genomics. 2006, 87 (3): 56-65
  5. Cheng T, Xia Q, Qian J, Liu C, Lin Y, Zha X, Xiang Z. Mining single nucleotide polymorphisms from EST data of silkworm, Bombyx mori, inbred strain Dazao.Insect Biochem Mol Biol. 2004, 34(6): 523-530
  6. Cheng T, Xia Q, Liu C, Zhao P, Zha X, Xu H, Xiang Z, Three Bombyx mori genes, chi, glue and frua, encode proteins homologous to microorganism and primary analysis of horizontal gene transfer. Acta Genetica Sinica (in Chinese with English abstract). 2004, 31 (10): 1082-1088.
  7. Liu C, Yamamoto K, Cheng T, Kadono-Okuda K, Narukawa J, Liu S, Han Y, Futahashi R, Kidokoro K, Noda H, Kobayashi I, Tamura T, Ohnuma A, Banno Y, Dai F, Xiang Z, Goldsmith M, Mita K, Xia Q. Repression of tyrosine hydroxylase is responsible for the sex-linked chocolate mutation of the silkworm, Bombyx mori. PNAS, 107(29), pp 12980-12985
  8. Huang L, Cheng T, Xu P, Duan J, Fang T, Xia Q. A genome-wide Survey for host response of silkworm, Bombyx mori during pathogenbacillus bombyseptieus infection. Plos ONE. 2009. 12(4): e8098
  9. Huang L, Cheng T, Xu P, Duan J, Fang T, Xia Q. Immunoglobulin superfamily is conserved but evolved rapidly and active in the silkworm, Bombyx mori.Insect Mol Biol. 2009, 18(4): 517-530 (equal contribution)
  10. Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, Cheng T, et al.. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science. 2009, 326(5951): 433-436
  11. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha XF, Cheng T, Chai C, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004, 306 (5703):1937-1940
  12. International Silkworm Genome Consortium. The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem Mol Biol. 2008, 38(12): 1036-1045
  13. Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, He N, Zhang L, Xiang Z. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol. 2007, 8 (8): R162
  14. Duan J, Li R, Cheng D, Fan W, Zha X, Cheng T, Wu Y, Wang J, Mita K, Xiang Z, Xia Q. SilkDB v2.0: a platform for silkworm (Bombyx mori) genome biology. Nucleic Acids Res. 2010, 38: D453-456.
  15. Wang Y, Cheng T, Subrahmanyam R, Zou Z, Xia Q, Xiang Z, Jiang H. Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects.Dev. Comp. Immunol. 2007, 31 (10): 1002-1012.
  16. Liu S, Xia Q, Zhao P, Cheng T, Hong K, Xiang Z. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori). BMC Dev. Biol. 2007, 7: 88.
  17. Xu H, Xia Q, Liu C, Cheng T, Zhao P, Duan J, Zha X, Liu S. Identification and characterization of piggyBac-like elements in the genome of domesticated silkworm, Bombyx mori. Mol. Genet. Genomics. 2006, 276 (1): 31-40
  18. Liu C, Zhao P, Cheng T, Zha X, Xia Q, Xiang Z. Analysis of a novel transcription mode of Fhx/P25 gene in Bombyx mori. Prog. Biochem. Biophys. 2005, 32(8):740-746
  19. Wen H, Lan X, Cheng T, He N, Shiomi K, Kajiura Z, Zhou Z, Xia Q, Xiang Z, Nakagaki M. Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori). Mol. Biol. Rep. 2009, 36(4): 711-716.
  20. Liu C, Shuai X, Cheng T, Xu H, Li C, Dai F, Xia Q, Xiang Z. Study on The RNA Interference of Bombyx mori Embryo. Prog. Biochem. Biophys. (in Chinese with English abstract). 2004, 31 (4):322-327.
  21. 胡文波, 朱曉南, 劉春, 程廷才, 黃小鳳, 蔣禮, 夏菊, 張潔, 夏慶友. 家蠶Osiris基因家族成員的系統進化與組織表達晶片分析. 蠶業科學, 37(1), 2011
  22. 許平震, 張美蓉, 程廷才, 夏慶友. 家蠶模式識別受體βGRP4的序列分析及誘導表達. 蠶業科學, 37(4), 2011
  23. 許平震, 張美蓉, 程廷才, 黃璐琳, 譚祥, 夏慶友. 家蠶模式識別受體PGRP、βGRP編碼基因的克隆鑑定及表達譜分析. 蠶業科學, 36(3), 2010
  24. 程廷才, 王根洪, 李娟, 夏慶友. 昆蟲抗菌肽基因表達調控機理. 蠶學通訊. 2004, 24(3): 20-26.
  25. 張雨麗, 程廷才, 許平震, 黃璐琳, 夏慶友. 家蠶先天免疫基因Bmimd的克隆、表達及序列分析. 昆蟲學報. 2008, 51(5): 459-465.

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