程劍松

程劍松 男 博士南開大學藥學院講師.2000年畢業於南開大學生命科學學院，獲生化與分子生物學學士學位。

基本介紹

• 中文名：程劍松
• 國籍：中國
• 民族：漢
• 性別：男

簡介

2006年獲南開大學微生物學博士學位。隨後赴美國加州大學戴維斯分校(University of California, Davis)化學系進行博士後訓練, 專業為糖生物化學。主要研究糖基轉移酶（包括唾液酸轉移酶和岩藻糖轉移酶等）的催化機制及其在碳水化合物生化合成（Chemoenzymatic synthesis）方面的套用以及蛋白的糖基化修飾。於2009年底回國，並於2010年7月加入南開大學藥學院。目前，已發表SCI論文20篇。

SCI論文

1. Han W, Cai L, Wua B, Lic L, Xiao Z, Cheng J*, Wang PG*. The wciN gene encodes an α-1,3-galactosyl transferase involved in the biosynthesis of the capsule repeating unit of Streptococcus pneumoniae serotype 6B. Biochemistry (ACS). 2012. 51(29):5804-10.

2. Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A.Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays.J Biol Chem. 2012 PMID: 22549775.

3. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. Nat Biotechnol. 2011, 29(5):428-35. PMID:21478876.

4. Zhang, L.; Lau, K.; Cheng, J.; Yu, H.; Li, Y.; Sugiarto, G.; Huang, S.; Huang, R.; Thon, V.; Wang, P.G.; Chen, X. Helicobacter hepaticus Hh0072 gene encodes a novel {alpha}1-3-fucosyltransferase belonging to CAZy GT11 family. 2010. Glycobiology. PMID: 20466652.

5. Cheng, J.; Huang, S.; Yu, H.; Li, Y.; Lau, K.; Chen, X*. Trans-sialidase activity of Photobacterium damsela 2,6-sialyltransferase and its application in the synthesis of sialosides. Glycobiology. 2010 Feb. 20(2):260-8. PMID: 20024109.

6. Yu, H.; Cheng, J.; Ding, L.; Khedri, Z.; Chen, Y.; Chin, S.; Lau, K.; Tiwari, V.; Chen, X*. Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J Am Chem Soc. 2009 Dec 30. 131(51):18467-77. PMID: 19947630.

7. Cao, H.; Li, Y.; Lau, K. ; Muthana, S. ; Yu, H.; Cheng, J.; Chokhawala, H. A.; Sugiarto, G.; Zhang, L.; Chen, X*. Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org. Biomol. Chem., 2009 Dec 21;7(24):5137-45. PMID: 20024109.

8. Cao, H.; Muthana, S.; Li, Y.; Cheng, J.; Chen, X. * Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. Bioorg. Med. Chem. Lett. 2009, 19(20):5869-71. PMID: 19740656.

9. Muthana, S.; Yu, H.; Cao, H.; Cheng, J.; Chen, X*. Chemoenzymatic synthesis of macrocyclic carbohydrates of different sizes. J. Org. Chem. 2009, Featured article. 74(8):2928-36. PMID: 19296596.

10. Feng, L.; Reeves, P.R.; Lan, R.; Ren, Y.; Gao, C.; Zhou, Z.; Ren, Y.; Cheng, J.; Wang, W.; Wang, J.; Qian, W.; Li, D.; Wang, L*. A recalibrated molecular clock and independent origins for the cholera pandemic clones. PLoS. ONE. 2008, 3, e4053. PMID: 19115014.

11. Ren, Y.; Liu, B.; Cheng, J.; Liu, F.; Feng, L.; Wang, L*. Characterization of Escherichia coli O3 and O21 O antigen gene clusters and development of serogroup-specific PCR assays. J Microbiol Methods. 2008, 75, 329-334. PMID: 18700154.

12. Cao, H.; Huang, S.; Cheng, J.; Li, Y.; Muthana, S.; Son, B.; Chen, X*. Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block. Carbohydr. Res. 2008, 343, 2863-2869. PMID: 18639240.

13. Chokhawala, H. A.; Huang, S.; Lau, K.; Yu, H.; Cheng, J.; Thon, V.; Hurtado-Ziola, N.; Guerrero, J. A.; Varki, A.; Chen, X*. Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. ACS Chemical Biology. 2008, 3, 567-576. PMID: 18729452. PMC2588434.

14. Cheng, J.; Yu, H.; Lau, K.; Huang, S.; Chokhawala, H. A.; Li, Y.; Tiwari, V. K.; Chen, X*. Multifunctionality of Campylobacter jejuni sialyltransferase CstII: Characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities. Glycobiology. 2008, 18, 686-697. PMID: 18509108. PMC2588429.

15. Wang, Z.; Gilbert, M.; Eguchi, H.; Yu, H.; Cheng, J.; Muthana, S.; Zhou, L.; Wang, P. G.; Chen, X.; Huang, X*. Chemoenzymatic syntheses of tumor-associated carbohydrate antigen Globo-H and stage-specific embryonic antigen 4. Adv. Synth. Catal. 2008, 350, 1717-1728.

16. Cheng, J.; Liu, B.; Bastin, D.A.; Han, W.; Wang, L. and Feng, L*. Genetic Characterization of the Escherichia coli O66 Antigen and Functional Identification of its wzy Gene. J. Microbiol. 2007, 45, 69-74. PMID: 17342059.

17. Feng, L.; Wang, W.; Cheng, J.; Ren, Y.; Zhao, G.; Gao, X.; Tang, Y.; Liu, X.; Han, W.; Peng, X.; Liu, R. and Wang, L*. Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir. Proc. Natl. Acad. Sci. USA. 2007, 104, 5602-5607. PMID: 17372208.

18. Cheng, J.; Wang, Q.; Wang, W.; Wang, Y.; Wang, L and Feng, L*. Characterization of E. coli O24 and O56 O antigen gene clusters reveals a complex evolutionary history of the O24 gene cluster. Curr. Microbiol. 2006, 53, 470-476. PMID: 17072668.

19. Wang, W.; Peng, X.; Wang, Q.; Cheng, J.; Wang, L*. Sequence of Escherichia coli O11 O-antigen gene cluster and identification of molecular markers specific to O11. Acta Microbiologica Sinica. 2006, 46, 341-346. PMID: 16933598.

20. Cheng, J.; Wang, W.; Wang, Q.; Gao, X.; Peng, X. and Wang, L. Molecular characterization of O-antigen gene cluster of Escherichia coli O23 reference strain and identification of UDP-N-acetylglucosamine 4-epimerase. Acta Microbiologica Sinica. 2006, 46, 702-708. PMID: 17172013

21. Senchenkova, S.N.; Feng, L.; Yang, J.; Shashkov, A.S.; Cheng, J.; Liu, D.; Knirel, Y.A.; Reeves, P.R.; Jin, Q.; Ye, Q. and Wang, L*. Structural and Genetic Characterization of the Shigella boydii Type 10 and Type 6 O Antigens. J. Bacteriol. 2005, 187, 2551-2554. PMID: 15774901.

22. Guo, H.; Kong, Q.; Cheng, J.; Wang, L. and Feng, L*. Characterization of the Escherichia coli O59 and O155 O-antigen gene clusters: the atypical wzx genes are evolutionary related. FEMS. Microbiol. Lett. 2005, 248,153-161. PMID: 15990253.

23. Feng, L.; Senchenkova, S.N.; Yang, J.; Shashkov, A.S.; Tao, J.; Guo, H.; Cheng, J.; Ren, Y.; Knirel, Y.A.; Reeves, P.R. and Wang, L*. Synthesis of the Heteropolysaccharide O antigen of Escherichia coli O52 Requires an ABC Transporter: Structural and Genetic Evidence. J. Bacteriol. 2004, 186, 4510-4519. PMID: 15231783.

24. Kong, Q.; Cheng, J.; Wang, L*. Sequence of Escherichia coli O141 O-antigen gene cluster and analysis of its evolutionary history. Acta Genetica Sinica. 2004, 31, 1448-1454. PMID: 15633653.

25. Kong, Q.; Cheng, J.; Wang, L*. Sequence of Escherichia coli O138 O-antigen gene cluster and Gne identification by bioinformatics. Acta Microbiologica Sinica. 2004, 44, 756-760. PMID: 16110955.