安徽醫科大學基礎醫學院教授,博士,博士生導師。安徽省“生物醫藥工程”產、學、研基地負責人。安徽省精品課程《生物化學》與《分子生物學》主持人。從事一線教學近30年,講授研究生課程:《分子生物學》、《蛋白質結構與功能》;講授本科生課程:《生物化學與分子生物學》、《生物化學》、《蛋白質工程》等。主持參加多項國家級課題。發表科研和教學論文100多篇,其中SCI論文30多篇,主編規劃教材3部,副主編和參編教材多部。現任安徽醫科大學基礎醫學院副院長。
1981.9-1985.6:安徽師範大學生命科學學院生物學專業學習獲學士學位
1985.9-1987.6:南京農業大學動物醫學院動物生理、生物化學專業碩士研究生
1997.9-2000.7:南京農業大學動物醫學院動物生物化學專業學習獲博士學位
1987.7-1997.8:合肥師範學院生命科學學院教師,先後任助教、講師。
2000.7.11-:安徽醫科大學基礎醫學院生物化學教研室副教授(2000.7-2004.7)、教授(2004.8-),其間在2005年和2008年分別到韓國高麗大學和加拿大多倫多大學做訪問學者;教研室副主任(2002.4-2005.9)、教研室主任(2005.10-2018.6),基礎醫學院副院長(2012.6-)。
1. 國家自然科學基金(面上項目):乳源六肽結合EEF1D逆轉卵巢癌細胞耐藥性及其分子機制(81472448),2015.01-2018.12,主持,72萬;
2. 國家自然科學基金(面上項目):乳源免疫六肽抗卵巢癌及其機制的研究(30872992),2009.01-2011.12,主持,30萬;
3. 國家自然科學基金(青年基金):選擇性自噬受體在阿茲海默氏病中的功能及機制研究(81601107),2017.01-2019.12,參與,17萬;
4. 國家自然科學基金(面上項目):KLF14在非酒精性脂肪肝發病過程中的作用研究(31371193),2014.01-2014.12,參與,15萬;
5. 安徽省自然科學基金(面上項目):乳源六肽結合EEF1D逆轉卵巢癌細胞耐藥性及其分子機制(1508085MH196),2015.07-2017.06,主持,12萬;
6. 安徽省自然科學基金(面上項目):乳蛋白生物活性肽—免疫調節肽的套用基礎研究(03043802),2003.01-2005.12,主持,5萬;
7. 安徽省教育廳自然科學基金項目(面上項目):β-酪啡肽-7的製備、鑑定和抗乳腺癌研究(2005KJ257),2005.01-2007.12,主持,4萬;
8. 安徽省高等學校省級質量工程項目:生物化學與分子生物學虛擬仿真實驗教學中心(2016xnzx020),2017.01-2019.12,主持,20萬。
1. Qia Xu, Hao Xi, Xi Chen, Yin Xu, Peng Wang, Jingwen Li, Wenmei Wei, Fang Gu*, Yide Qin*(通訊). Milk derived hexapeptide PGPIPN prevents [and] attenuates acute alcoholic liver injury in mice by reducing endoplasmic reticulum stress. Int J Mol Med. 2020, 46(3):1107-1117.
2. Ruowen Guo, Yide Qin*(通訊). LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p/TP53 Axis. Onco Targets Ther. 2020, 13:7387-7398.
3. Liwei Liu, Mingya Yang, Qia Xu, Min Zhou, Yan Cheng, Heming Xu, Yide Qin*(通訊), Bo Liu*. Killing efficiency affected by mutually modulated PD-1 [and] PD-L1 expression via NKT-hepatoma cell interactions. Immunotherapy. 2020, doi: 10.2217/imt-2020-0062.
4. Wen-Mei Wei, Feng-Qi Dong, Ren-Hui Zheng*, Yan-Ying Liu, Ting-Ting Zhao, Wei-Jun Fang, Yi-De Qin*(通訊). Theoretical study of the mechanism of palladium-catalyzed hydroaminocarbonylation of styrene with ammonium chloride. Computational [and] Theoretical Chemistry. 2020, 1191:113040.
5. Wen-Mei Wei, Feng-Qi Dong, Ren-Hui Zheng*, Xue Yang, Wei-Jun Fang, Yi-De Qin*(通訊). Theoretical study of the mechanism of Pd(II)-catalyzed nucleophilic addition initiated by aminopalladation. Computational [and] Theoretical Chemistry. 2019, 1170:112638.
6. Wen‑mei Wei, Shi Hong, Wei‑jun Fang, Ren‑hui Zheng*, Yi‑de Qin*(通訊). Formation of OH radicals from the simplest Criegee intermediate CH2OO [and] water. Theoretical Chemistry Accounts. 2019, 138:13.
7. Wen-Mei Wei*, Qia Xu, Ren-Hui Zheng*, Yi-De Qin*(通訊). Computational studies on the self-reaction mechanism of the simplest criegee intermediate CH2OO. Rev Roum Chim. 2018, 63(4):321-336.
8. Juan Zhou, Xue Yang, Wenxiao Zhang, Jing Wang, Cai Wei, Fang Gu, Ting Lei, Yide Qin*(通訊). Construction of an Anticancer Fusion Peptide (ACFP) Derived from Milk Proteins [and] an Assay of Anti-ovarian Cancer Cells in vitro. Anti-Cancer Agents in Medicinal Chemistry. 2017, 17(4): 635~643.
9. Nan Qi, Chen Liu, Haoran Yang, Wanrong Shi, Shenyi Wang, Yan Zhou, Cai Wei, Fang Gu, Yide Qin*(通訊). Therapeutic hexapeptide (PGPIPN) prevents [and] cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism [and] oxidative stress. Oncotarget. 2017, 8(50):88079-88093.
10. Juan Zhou, Mengjing Zhao, Yigui Tang, Jing Wang, Cai Wei, Fang Gu, Ting Lei, Zhiwu Chen, Yide Qin*(通訊). The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression [and] signaling pathways. BMC Cancer. 2016, 16:246.
11. Mengjing Zhao, Cai Wei, Xue Yang, Juan Zhou, Jing Wang, Fang Gu, Ting Lei, Yide Qin*(通訊). The milk-derived hexapeptide PGPIPN inhibits the invasion [and] migration of human ovarian cancer cells by regulating the expression of MTA1 [and] NM23H1 genes. Int J Oncol. 2016, 48(4): 1721-1729.
12. Hongwu Li, Fuquan Jin, Keguo Jiang, Shuang Ji, Li Wang, Zhaofei Ni, Xianguo Chen, Zhongdong Hu, Hongbing Zhang, Yehai Liu*, Yide Qin*(通訊), Xiaojun Zha*. mTORC1-mediated downregulation of COX2 restrains tum[or] growth caused by TSC2 deficiency. Oncotarget. 2016, 7(19): 28435-28447.
13. Sheng-Yong Luo, Shuo Chen, Yi-De Qin*(通訊), Zhi-Wu Chen*. Urotensin-ⅡRecept[or] Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway. PLoS One. 2016, 11(1):e0146094.
14. Y. Qin*(通訊), N. Qi, Y. Tang, J. He, X. Li, F. Gu, S. Zou *. Isolation [and] identification of a high molecular weight protein in sow milk. Animal. 2015, 9(5): 847-854.
15. Wen-mei Wei*, Xue Yang, Ren-hui Zheng*, Yi-de Qin*(通訊), Yun-kai Wu, Fan Yang. Theoretical studies on the reactions of the simplest Criegee intermediate CH2OO with CH3CHO. Computational [and] Theoretical Chemistry. 2015, 1074:142–149.
16. Wei Wang, Fang Gu, Cai Wei, Yigui Tang, Xin Zheng, Mingqiang Ren, Yide Qin*(通訊). PGPIPN, a therapeutic hexapeptide, suppressed human ovarian cancer growth by targeting BCL2. PLoS One. 2013, 8(4):e60701.
17. Guangman Zhang, Genshen Zhong, Xiudong Wang, Lisheng Wang, Yide Qin*(通訊), Aiping Yu*. Optimization of fed-batch fermentation f[or] a staphylokinase-hirudin fusion protein in Escherichia coli BL21. Afr J Biotechnol. 2010, 9(32):5078-5083.
18. Guangchuang Yu, Fei Li, Yide Qin, Xiaochen Bo*, Yibo Wu, Shengqi Wang*. GOSemSim: an R package f[or] measuring semantic similarity among GO terms [and] gene products. Bioinformatics. 2010, 26(7): 976~978.
19. Xiudong Wang, Guangman Zhang, Lisheng Wang, Qinglin Zhang, Yide Qin, Chutse Wu, Aiping Yu*. A fusion protein with improved thrombolytic effect [and] low bleeding risk. Thromb Haemost. 2009, 102(6):1194-203.
20. Jipeng Li, Hanjiang Fu*, Chengwang Xu, Yi Tie, Ruiyun Xing, Jie Zhu, Yide Qin, Zhixian Sun, Xiaofei Zheng*. miR-183 inhibits TGF-beta1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells. BMC Cancer. 2010, 10:354.
21. Fei-qun Zheng, Yin Xu, Ren-jie Yang*, Bin Wu*, Xiao-hua Tan, Yi-de Qin, Qun-wei Zhang. Combination effect of oncolytic adenovirus therapy [and] herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models. Acta Pharmacol Sin. 2009, 30(5): 617–627.
22. Yin Xu,Fei-qun Zheng, Qun-wei Zhang,Yang Liu, Hai-feng Duan, Chun-ping Cui,Bin Wu*, Yi-de Qin*(通訊). Cross-talk between extracellular S1P/S1P2 [and] P42/44 MAPK in bcr/abl positive chronic myeloid leukemia cells. Chin J Cancer Res. 2009, 21(1): 20-27.
23. 秦宜德主編:醫學分子生物學(第2版)(規劃教材,ISBN:978-03-063016-2).科學出版社/北京,2020.
24. 秦宜德副主編:生物化學(第4版)(國家級規劃教材,ISBN:978-7-04-053468-9). 高等教育出版社/北京,2020.
25. 秦宜德主編:生物化學與分子生物學實驗(規劃教材,ISBN:978-7-312-04138-9). 中國科學技術大學出版社/合肥,2017.
26. 秦宜德副主編:生物化學(第3版)(國家級規劃教材,ISBN:978-7-04-044325-7). 高等教育出版社/北京,2016.
27. 秦宜德主編:醫學分子生物學(規劃教材,ISBN:978-7-03-037955-9).科學出版社/北京,2013.
28. 秦宜德副主編:醫學生物化學與分子生物學實驗技術(ISBN:978-7-302-26700-3),清華大學出版社/北京,2011.
29. 秦宜德副主編:醫學生物化學與分子生物學實驗教程(ISBN:978-7-03-025128-2),科學出版社/北京,2009.
1. 2003年、2006-2007年度、2017-2018年度安徽醫科大學優秀教師;
2. 2010年度、2017年度安徽醫科大學優秀研究生指導教師;
3. 2010-2011年度安徽醫科大學模範教師;
4. 2017年獲得安徽醫科大學教學名師稱號。