基本介紹
人物經歷,任免信息,研究方向,主要貢獻,獲獎記錄,
人物經歷
1982畢業於山西醫科大學獲醫學學士學位，
1985畢業於山東省醫學科學院獲免疫學碩士學位，
1989畢業於白求恩醫科大學獲免疫學博士學位。
1993年開始多次赴美國國立衛生研究院癌症研究所進行合作研究。
2000年以來通訊作者在PNAS (2篇)、Hepatology(6篇)、J Heptol (3篇)、J Immunol (6篇)等發表SCI論文100餘篇; 中文論文200餘篇。國際會議或機構作學術報告或主持20餘次。所帶畢業博士碩士生共53名
中華人民共和國國務院學位委員會學科評議組成員，國家自然科學基金生命科學部專家評審組專家，國家名詞（免疫學）評審委員會專家，中國免疫學會副理事長，中國免疫學會腫瘤免疫與生物治療分會會長，中國抗癌協會生物治療專業委員會副主任委員。
中國免疫學會英文會刊<Cellular & Molecular Immunology>執行主編，《中國免疫學雜誌》副主編，《中國腫瘤生物治療雜誌》副主編。
曾任山東省醫學科學院學術委員會副主任、基礎醫學研究所所長、山東腫瘤生物治療研究中心主任、山東省腫瘤免疫與基因工程重點實驗室主任。
任免信息
2017年11月，當選中國工程學院醫藥衛生學部院士。
研究方向
主要貢獻
發表論文250餘篇，英文刊物發表論文23篇，17篇收入SCI。
在國內最先（1989年）綜合系統地引入腫瘤生物治療學。
1989年創建國內第一家腫瘤生物治療研究機構（山東腫瘤生物治療中心）並發起創建"中國免疫學會腫瘤生物治療分會"並任副主任委員。建成國家衛生部批准的首批"細胞治療實驗室"，探索出三套腫瘤生物治療方案並套用於臨床。先後研製四類10餘種單抗和PCR試劑盒。
自1990年起開展基因工程藥物研究，先後研製了IL-2、IL-6、IL-10、IL-12、IL-15、IL-18、SCF、leptin等重組產品，部分轉讓中試工藝。
生命科學學院和醫學中心田志剛教授課題組與美國華盛頓大學醫學院Wayne Yokoyama院士合作，發現一群肝臟特有的自然殺傷（Natural Killer, NK）細胞並闡明該NK細胞具備其它常規NK細胞不具備的免疫記憶功能。該研究成果由我校博士後彭慧、博士生薑曉君和陳永琳歷時6年完成，為共同第一作者，發表於2013年4月出版的《臨床研究雜誌》（The Journal of Clinical Investigation）。
研究論文：
1.Yan Y, Jiang W, Liu L, Wang X, Ding C,Tian Z*, Zhou R*. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome.Cell. 2015 Jan 15;160(1-2):62-73.
2.Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*,Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice.J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.
3.Li S, Sun R, Chen Y, Wei H,Tian Z*. TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression.Cancer Res. 2015 Jan 19.[Epub ahead of print]
4.Wang J, Li F, Wei H, Lian ZX, Sun R,Tian Z*. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation.J Exp Med. 2014 Nov 17;211(12):2397-410.
5.Tian Z. Outflanking HCV.Nat Immunol. 2014 Jan; 15(1):6-8.
6. Xu L, Yin W, Sun R, Wei H,Tian Z*. Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice.Hepatology. 2014 Feb; 59(2):443-52.
7. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G,Tian Z*, Tschopp J, Zhou R*. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.Immunity. 2013 Jun 27;38(6):1154-63.
8. Peng H, Jiang X, Chen Y, Sojka D, Gao X, Sun R, Wei H, Yokoyama W,Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.J Clin Invest2013, 123(4):1444-1456.
9. Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R,Tian Z*. Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice.Gastroenterology. 2013, 144:392-401.
10. Xu L, Yin WW, Wei HM, Sun R,Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice.PNAS USA2013; 110:16993-8.
11. Wang J, Li F, Sun R, Gao X, Wei H, Li L,Tian Z*. Airway bacteria dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages.Nat Commun2013; 4:2106.
12. Lan PX, Zhang C*, Han QJ, Zhang J,Tian ZG*. Reversal of HBV-induced systemic adaptive immunotolerance by recovering hepatocyte-intrinsic immunity.Hepatology2013, 58:73-85.
13.Wang X, Sun R*, Wei H,Tian Z*. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced lethal hepatitis: Interaction of γδ T cells with macrophages.Hepatology. 2013; 57:373-84.
14. Huang M, Sun R*, Wei H,Tian Z*. Simultaneous knockdown of multiple ligands of NKG2D high efficiently prevents NK cell-mediated fulminant hepatitis.Hepatology. 2013; 57:277-88.
2.Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*,Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice.J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.
3.Li S, Sun R, Chen Y, Wei H,Tian Z*. TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression.Cancer Res. 2015 Jan 19.[Epub ahead of print]
4.Wang J, Li F, Wei H, Lian ZX, Sun R,Tian Z*. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation.J Exp Med. 2014 Nov 17;211(12):2397-410.
5.Tian Z. Outflanking HCV.Nat Immunol. 2014 Jan; 15(1):6-8.
6. Xu L, Yin W, Sun R, Wei H,Tian Z*. Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice.Hepatology. 2014 Feb; 59(2):443-52.
7. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G,Tian Z*, Tschopp J, Zhou R*. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.Immunity. 2013 Jun 27;38(6):1154-63.
8. Peng H, Jiang X, Chen Y, Sojka D, Gao X, Sun R, Wei H, Yokoyama W,Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.J Clin Invest2013, 123(4):1444-1456.
9. Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R,Tian Z*. Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice.Gastroenterology. 2013, 144:392-401.
10. Xu L, Yin WW, Wei HM, Sun R,Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice.PNAS USA2013; 110:16993-8.
11. Wang J, Li F, Sun R, Gao X, Wei H, Li L,Tian Z*. Airway bacteria dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages.Nat Commun2013; 4:2106.
12. Lan PX, Zhang C*, Han QJ, Zhang J,Tian ZG*. Reversal of HBV-induced systemic adaptive immunotolerance by recovering hepatocyte-intrinsic immunity.Hepatology2013, 58:73-85.
13.Wang X, Sun R*, Wei H,Tian Z*. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced lethal hepatitis: Interaction of γδ T cells with macrophages.Hepatology. 2013; 57:373-84.
14. Huang M, Sun R*, Wei H,Tian Z*. Simultaneous knockdown of multiple ligands of NKG2D high efficiently prevents NK cell-mediated fulminant hepatitis.Hepatology. 2013; 57:277-88.
15. Jin Z, Sun R, Wei H, Gao Y, Chen Y,Tian Z. Natural killer T cells aggravate liver fibrosis of HBV transgenic mice via activating hepatic stellate cells.Hepatology2010; accepted.
16. Jiang W, Sun R, Wei H, Zhou R,Tian Z. Toll-like receptor 9 activation aggravates Con A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells.J Immunol2009; 182:3768-74
17. Hou X, Zhou R, Wei H, Sun R,Tian Z. NKG2D-Rea 1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis..Hepatology2009; 49:940-9
18.Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX,Tian Z. CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice.J Immunol. 2008;181:7221- 9
19.Chen QF, Wei HM, Sun R, Zhang J,Tian Z. Therapeutic RNA silencing of CX3CL1 gene prevents mice from adenovirus vector-induced acute liver injury.Hepatology2008; 47:648-58
20. Chen Y, Wei H, Sun R, Dong Z, Zhang J,Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells.Hepatology2007; 46(3):706-15.
21. Zhou R, Wei H, Sun R, Tian ZG. NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice. Proc Natl Acad Sci USA. 2007; 104:7512-5.
22. Dong Z, Zhang J, Sun S, Wei H,Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice.Hepatology2007; 45:1400-12.
23. Li B, Sun R, Wei H, Gao B,Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism.Hepatology2006; 43:1211-9.
24. Jiang W, Sun R, Wei HM,Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages.Proc Natl Acad Sci USA2005; 102: 17077-17082.
獲獎記錄
先後獲省部級科技進步二等獎3項、三等獎8項。
1996國家"百千萬人才工程"一、二層次專家。
2001中國科學院“百人計畫”獲得者。
2001國家傑出青年科學基金獲得者。
2004國家衛生部“突出貢獻中青年專家”。
2007國家教育部和國家基金委“天然免疫”創新研究群體學術帶頭人。
2008年獲國家自然科學獎二等獎，項目名稱”介導肝臟損傷與再生的天然免疫識別及其調控機制“。
2011年獲國家科技進步二等獎（第二位）。
2016年獲安徽省自然科學獎一等獎。
