田仕凱，現任中國科學技術大學化學系，有機化學，教授。2005年“百人計畫”入選者。主要研究設計與發展新型多組分反應、以設計綠色催化劑為研究重點等方向。
基本介紹
- 中文名：田仕凱
- 國籍：中國
- 民族：漢族
- 職業：教授
- 畢業院校：中國科學技術大學
- 性別：男
個人簡歷,主要研究方向,文章及專著,
個人簡歷
1989.09 - 1993.07，蘭州大學化學系，有機化學，理學學士
1993.09 - 1996.07，中國科學院上海有機化學研究所，有機合成化學，理學碩士
1996.09 - 1998.12，中國科學院上海有機化學研究所，有機合成化學，理學博士
1999.02 - 2002.04，美國Brandeis大學化學系，不對稱催化，博士後
2002.04 - 2005.08，美國Vertex製藥公司，藥物化學，研究員
2005.09 - 現在，中國科學技術大學化學系，有機化學，教授（2005年“百人計畫”入選者）
主要研究方向
新反應的發現及套用：1）設計與發展新型多組分反應，從而可快速有效地構築複雜有機化合物，以便進行藥物、有機催化劑、金屬配體和其他功能分子的活性篩選和結構最佳化。2）以設計綠色催化劑為研究重點，發展具有廣泛合成套用價值和對環境友好的催化反應。3）以套用和發展新型有機合成反應為出發點，高效率地合成生物活性天然產物。
新藥的設計與合成：藉助高效有機合成反應和高通量活性篩選技術，發現藥物先導化合物，進行結構最佳化來提高其各方面的藥物性質。
獲獎及榮譽
文章及專著
1. “Asymmetric Organic Catalysis with Modified Cinchona Alkaloids” Shi-Kai Tian, Yonggang Chen, Jianfeng Hang, Liang Tang, Paul MaDaid, and Li Deng, Acc. Chem. Res. 2004, 37, 621-631.
2. “Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base” Shi-Kai Tian, Ran Hong and Li Deng, J. Am. Chem. Soc. 2003, 125, 9900-9901.
3. “Asymmetric Synthesis of a-Amino Acids via Cinchona Alkaloid-Catalyzed Kinetic Resolution of Urethane-Protected a-Amino Acid N-Carboxyanhydrides” Jianfeng Hang, Shi-Kai Tian, Liang Tang, and Li Deng, J. Am. Chem. Soc. 2001, 123, 12696-12697.
4. “A Highly Enantioseletive Chiral Lewis Base-Catalyzed Asymmetric Cyanation of Ketones” Shi-Kai Tian and Li Deng, J. Am. Chem. Soc. 2001, 123, 6195-6196.
5. “A Formal Catalytic Asymmetric Synthesis of (+)-Biotin with Modified Cinchona Alkaloids” Chulho Choi, Shi-Kai Tian, and Li Deng, Synthesis 2001, 1737-1741.
6. “A Highly Enantioseletive Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids” Yonggang Chen, Shi-Kai Tian, and Li Deng, J. Am. Chem. Soc. 2000, 122, 9542-9543.
7. “A Facile Route to Bulladecin-Type Acetogenins?Total Synthesis of Asimilobin and Correction of the Configuration of Its Tetrahydrofuran Segment” Zhi-Min Wang, Shi-Kai Tian, and Min Shi, Eur. J. Org. Chem. 2000, 349-356.
8. “Total Synthsis of Gigantetrocin A” Zhi-Min Wang, Shi-Kai Tian, and Min Shi, Chirality 2000, 12, 581-589.
9. “Diaminotriazoles Useful as Inhibitors of Protein Kinases” Albert C. Pierce, Michael Arnost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Mark Ledeboer, Shi-Kai Tian, Jingwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, 2004, WO 2004/046120 A2
10. “Catalytic Asymmetric Cyanosilylation of Ketones, Aldehydes, Thioketones, Imines and Hydrazones” Li Deng and Shi-Kai Tian, 2003, WO 03/68714.
11. “Highly Enantioseletive Catalytic Desymmetrization of Cyclic meso Anhydrides with Modified Cinchona Alkaloids” Li Deng, Yonggang Chen, and Shikai Tian, 2001, WO 01/74741.
12 Catalytic Regioselective Synthesis of Structurally Diverse Indene Derivatives from N-Benzylic Sulfonamides and Disubstituted Alkynes - Org. Lett. - 2010 -
2) Catalytic Coupling of N-Benzylic Sulfonamides with Silylated Nucleophiles at Room Temperature - Chem. Commun. - 2010 -
13) A Highly Tunable Stereoselective Olefination of Semistabilized Triphenylphosphonium Ylides with N-Sulfonyl Imines - J. Am. Chem. Soc. - 2010 -
14) Byproduct-Catalyzed Four-Component Reactions of Aldehydes with Hexamethyldisilazane, Chloroformates, and Nucleophiles in Acetonitrile Leading to Protected Primary Amines, α-Amino Esters, and β-Amino Ketones - Chem. Eur. J. - 2010 -
15) An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides - J. Org. Chem. - 2009 -
16) Controllable Stereoselective Synthesis of Trisubstituted Alkenes by a Catalytic Three-Component Reaction of Terminal Alkynes, Benzylic Alcohols, and Simple Arenes - Org. Biomol. Chem. - 2009 -
17) Catalyst-Free Alkylation of Sulfinic Acids with Sulfonamides via sp3 C-N Bond Cleavage at Room Temperature - Org. Lett. - 2009 -
18) Stereoselective Synthesis of Polysubstituted Alkenes through a Phosphine-Mediated Three-Component System of Aldehydes, α-Halo Carbonyl Compounds, and Terminal Alkenes - Chem. Eur. J. - 2009 -
19) Selective Benzylic and Allylic Alkylation of Protic Nucleophiles with Sulfonamides through Double Lewis Acid Catalyzed Cleavage of sp3 Carbon-Nitrogen Bonds - Chem. Eur. J. - 2009 -
