生物醫用材料導論(清華大學出版社出版圖書)

內容簡介

本書重點講述生物材料和生物學的基本概念和目前的進展，並提供了生物材料和生物技術領域最新的信息。全書共分三部分。第一部分主要講述生物陶瓷材料。闡述了生物材料的定義、概念和生物陶瓷的結構、性質、化學成分以及常規的製備方法。第二部分主要講述高分子生物材料及其在生物環境下的分解、腐蝕和化學變化。第三部分主要講述生物組織工程，包括生物結構、硬組織彌補、電腦模擬、新材料性能確定技術等內容。

本書各章節分別由幾位生物材料、生物組織工程和醫藥學領域的專家撰寫。第一、第二部分為生物材料的基礎部分，可作為材料科學系、生物工程系以及醫學相關領域的本科生生物材料課的教材。第三部分可以作為研究生和科研人員研究組織工程相關課題的參考書。

PartIBioactiveCeramicsandMetals
1IntroductiontoBioceramics3
1.1BioactiveMaterials3
1.1.1Definitions3
1.1.2CommonBiomaterials4
1.1.3BioactiveCeramics5
1.1.4BiologicalApatites5
1.1.5BasicRequirementsforBoneImplants6
1.1.6CoatingofHydroxyapatiteonPorousCeramics8
1.1.7BiomaterialsinTissueAttachment11
1.2References12
2BioactiveCeramics:Structure,Synthesis,andMechanicalProperties13
2.1StructureofHydroxyapatite14
2.1.1GeneralStructureandChemistryofHydroxyapatite14
2.1.2StructuralCharacteristicsofHydroxyapatite15
2.1.3SubstitutedApatite16
2.2SynthesisofHydroxyapatitePowder19
2.2.1DryChemicalMethods19
2.2.2WetChemicalMethods20
2.3MechanicalPropertiesofHydroxyapatite23
2.4OtherBioceramics25
2.4.1TricalciumPhosphate25
2.4.2BioactiveGlasses25
2.5References26
2.6Problems28
3BioceramicProcessing29
3.1FabricationandMechanicalPropertiesofPorousBioceramics30
3.1.1HighTemperatureRoutes30
3.1.2LowTemperatureRoutes32
3.1.3RapidPrototypingTechniques33
3.1.4MechanicalPropertiesofPorousBioceramics34
3.2CoatingofBioceramicThickFilmsonBio-InertPorousSubstrates34
3.2.1SlipCasting35
3.2.2ElectrophoreticDeposition35
3.2.3Bioceramic-GlassSlurryMethod36
3.2.4ThermalDeposition37
3.2.5Sol-GelSynthesis37
3.2.6BiomimeticGrowth39
3.3CoatingonDenseSubstrates39
3.3.1Enameling39
3.3.2Plasma-SprayedCoatings40
3.3.3Sputtering41
3.4HydroxyapatiteCoatingsforNon-HardTissueApplications42
3.5Composites43
3.5.1Bioceramic-PolymerComposite43
3.5.2ReinforcedHydroxyapatite44
3.5.3HydroxyapatiteandTricalciumPhosphateComposite44
3.6Summary45
3.7References45
3.8Problems46
4CoatingofHydroxyapatiteontoInnerPoreSurfacesoftheReticulatedAlumina47
4.1HydroxyapatiteCoatingMethodsandCharacterization47
4.1.1CoatingofHydroxyapatitebytheHydroxyapatite-GlassSlurryMethod47
4.1.2CoatingofHydroxyapatitebyaThermalDepositionMethod53
4.1.3CharacterizationofHydroxyapatiteFilm53
4.1.4CoatingofHydroxyapatiteUsingSol-GelSynthesis57
4.2AdhesionofHydroxyapatiteFilmonAluminaSubstrate58
4.3References59
4.4Problems60
5PropertiesandCharacterizationofBiomaterials61
5.1CharacterizationofCeramics61
5.2BioactivePropertiesandHardTissueProsthetics62
5.2.1BoneBiology62
5.2.2CriticalIssuesonInterfacesBetweentheHardTissueandBiomaterials63
5.2.3FactorsthatInfluenceBioreactivity64
5.2.4BoneImplant64
5.2.5BondingMechanisms65
5.2.6InvitroBehaviorofHydroxyapatite66
5.3MeasurementsofGrowthandDissolutionofHydroxyapatiteCeramics68
5.4InvitroTestConductedinThisReasearch68
5.5MechanicalProperties70
5.6References71
5.7Problems73
6BioactivityofHydroxyapatite74
6.1GeneralAspects74
6.2InvitroTestingMaterialsandPreparation74
6.3CharacterizationofImmersionSolution75
6.4MorphologyoftheReactedSurfaces79
6.5References84
6.6Problems84
7HydroxyapatiteDepositionMechanisms85
7.1MaterialSynthesisandHydroxyapatiteCoating85
7.1.1GeneralAspectsonChemistry,Structure,andThermalBehaviorofHydroxyapatite85
7.1.2MaterialSynthesisandHydroxyapatiteCoating86
7.1.3CoatingofHydroxyapatiteontoInnerSurfacesofPoresinReticulatedAlumina87
7.1.4Hydroxyapatite-GlassSlurryMethod87
7.1.5ThermalDepositionandSol-GelMethods90
7.2MechanismsofBioactivity92
7.2.1InvitroBiochemistryBehaviorofHydroxyapatite92
7.2.2Growth—DissolutionMechanism94
7.2.3KineticsModelsforCrystallizationandDissolution96
7.2.4ExperimentalDeterminationofReactionMechanisms99
7.2.5EffectofHeatTreatmentonHydroxyapatite100
7.2.6StructuralEffectonBioactivity102
7.2.7TemperatureEffectonBioactivity103
7.2.8FactorsContributingtoReactivityofHydroxyapatite105
7.3References108
7.4Problems108
8BiomedicalMetallicMaterials110
8.1MicrostructuresandProcessing110
8.2CorrosionResistanceofMetals115
8.3BiologicalToleranceofMetal117
8.4StainlessSteel118
8.5Cobalt-BasedAlloys123
8.6TitaniumandItsAlloys127
8.7TiNiShapeMemoryAlloy131
8.8Summary135
8.9References137
8.10Problems138
PartⅡPolymericBiomaterials
9PolymerBasics143
9.1ClassificationofPolymers143
9.1.1Source143
9.1.2PolymerChainStructure144
9.1.3PolymerThermalBehavior146
9.1.4PolymerStability146
9.2CharacteristicsofPolymer147
9.2.1DegreeofPolymerization147
9.2.2PolymerCrystals148
9.2.3TheGlassTransitionTemperatureandMeltingTemperature148
9.3SynthesisofPolymers149
9.3.1FreeRadicalPolymerization149
9.3.2CondensationPolymerization153
9.3.3OtherTypesofPolymerization154
9.4References156
9.5Problems157
10NaturallyOccurringPolymerBiomaterials158
10.1GeneralIntroductiontoProteins158
10.2Collagen159
10.2.1Cross-LinkingofCollagen162
10.3Alginate166
10.4ChitinandChitosan167
10.5References168
10.6Problems171
11SyntheticNonBiodegradablePolymers172
11.1Polyethylene172
11.1.1HighDensityPolyethylene173
11.1.2UltrahighMolecularWeightPolyethylene174
11.2Poly(methylmethacrylate)175
11.3Polyester177
11.4Polycarbonate178
11.5Polyamides179
11.6Polyurethane180
11.7Polysulfones184
11.8Poly(etheretherketone)184
11.9References185
11.10Problems186
12SyntheticBiodegradablePolymers187
12.1AliphaticPolyester187
12.1.1Poly(glycolide)189
12.1.2Poly(lactide)189
12.1.3Poly(lactide-co-glycolide)191
12.1.4Poly(ε-caprolactone)192
12.1.5Poly(para-dioxanone)192
12.2Poly(propylenefumarate)193
12.3PolyaminoAcid194
12.4References195
12.5Problems196
13PolymerMatrixCompositeBiomaterials197
13.1FiberReinforcedComposites198
13.2FillerReinforcedComposites199
13.3MethodstoImprovetheInterfacialBondingBetweenPhasesinComposites200
13.3.1SelfReinforcementofFiber/PolymerComposites200
13.3.2PlasmaTreatmentofFibers200
13.3.3CouplingAgent201
13.4References203
13.5Problems206PartⅢTissueEngineering:ANewEraofRegenerativeMedicine
14BiomaterialsforTissueEngineering211
14.1GeneralAspectsofBiomaterialsUsedforTissueEngineering211
14.2RepresentativeBiomaterialsUsedforTissueEngineering212
14.2.1Polymers212
14.2.2Bioceramics213
14.3BiomaterialConstructsforTissueEngineering:Scaffolds214
14.3.1DefinitionandRequirementsforScaffoldsUsedinTissueEngineering215
14.3.2PrinciplesofScaffoldDesign215
14.3.3ScaffoldFabricationTechnologies216
14.4References223
14.5Problems226
15CellsandBiomoleculesforTissueEngineering227
15.1CellsforTissueEngineering227
15.2GrowthFactorDeliveryinTissueEngineering230
15.3RegulatoryMatrixProteins232
15.4References234
15.5Problems237
16TransportandVascularizationinTissueEngineering238
16.1TransportinEngineeredTissue238
16.2Vascularization239
16.2.1NewBloodVesselFormation239
16.2.2VascularizationinTissueEngineering240
16.3References240
16.4Problems241
17HostResponsetoTissueEngineeredGrafts243
17.1TheForeignBodyResponsetoSyntheticComponents243
17.2ResponsetoBiologicalComponents244
17.3References246
17.4Problems247
18OtherImportantIssuesandFutureChallengesinTissueEngineering249
18.1OrganReplacementandRegeneration249
18.2OrganotypicandHistiotypicModels250
18.3Mechanotransduction251
18.4FutureChallenges252
18.5References253
18.6Problems253

生物醫用材料導論(清華大學出版社出版圖書)

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