基本介紹
人物經歷,研究方向,主要成就,承擔項目,代表性論文,
人物經歷
2002/09-2006/07,四川師範大學,化學與材料科學學院,理學學士
2006/09-2009/07,四川師範大學,化學與材料科學學院,工學碩士
2017/09-2020/08,四川大學,生物治療國家重點實驗室,理學博士
2021/02-2023/11,浙江大學藥學院-西南醫科大學醫學電生理學教育部重點實驗室博士後研究
2009/07-至今,西南醫科大學,基礎醫學院化學教研室,講師,副教授
2020/12-至今,西南醫科大學,基礎醫學院學科建設辦公室,副主任,主任
研究方向
基於人工智慧的藥物設計、活性機制研究、生物活性標誌物發現
主要成就
近5年來,在中科院2區及以上期刊等上發表研究論文20餘篇,IF累計超過30;主持獲批省部級項目1項,廳局級項目4項,縱向科研經費超過60萬元。編寫教材2部,授權專利1項,軟著1項,申請發明專利3項。
承擔項目
近三年承擔的項目主要有:
(1)四川省科技廳,縱向,23NSFSC5132,基於人工智慧驅動的JAK2激動劑設計及抗心肌缺血再灌注損傷活性研究,2023-01至2024-12,10萬元,主持
(2)四川省科技廳聯合創新項目子課題,縱向,基於AI的靶向JAK2小分子激動劑設計、最佳化及改善心肌缺血再灌注損傷的活性機制研究,2022-01至2024-12,40萬元,主持
(3)瀘州市科技局,縱向,基於人工智慧構建藥物誘導靶器官毒性預測共享平台(面上),2022-06至2025-6,5萬元,主持
(4)醫學電生理學教育部重點實驗室,縱向,人工智慧驅動的小分子設計及其在血小板減少症中的作用機制研究,2024-01至2027-12,5萬元,主持
代表性論文
近五年發表的代表性論文有:
(1) Yiwei Wang; Lei Huang; Siwen Jiang; Kan Li; Jun Zou; Shengyong Yang; CapsCarcino: A novel sparse data deep learning tool for predicting carcinogens, Food and Chemical Toxicology,2020, 135: 110921-110932 (中科院2區)
(2) Yiwei Wang; Lei Huang; Siwen Jiang; Yifei Wang; Jun Zou; Hongguang Fu; Shengyong Yang; Capsule Networks Showed Excellent Performance in the Classification of hERG Blockers/Nonblockers, Frontiers in Pharmacology, 2020, 10: 1-12 (中科院2區)
(3) Yiwei Wang; Binyou Wang; Jie Jiang; Jianmin Guo; Jia Lai; Xiaoyuan Lian; Jianming Wu; Multitask CapsNet: An Imbalanced Data Deep Learning Method for Predicting Toxicants, ACS Omega,2021, 6: 26542-26555 (中科院3區)
(4) Binyou Wang; Xiaoqiu Tan; Jianmin Guo; Ting Xiao; Yan Jiao; Junlin Zhao; Jianming Wu; Yiwei Wang*; Drug-Induced Immune Thrombocytopenia Toxicity Prediction Based on Machine Learning, Pharmaceutics, 2022, 14(5): 943(中科院2區)
(5) Binyou Wang; Jianmin Guo; Xiaofeng Liu; Yang Yu; Jianming Wu; Yiwei Wang*; Prediction of the effects of small molecules on the gut microbiome using machine learning method integrating with optimal molecular features, BMC Bioinformatics, 2023, 24(338) (中科院3區)
(6) Xiaofeng Liu; Binyou Wang; Yuan Liu; Yang Yu; Ying Wan; Jianming Wu; Yiwei Wang*; JAK2 inhibitors for the treatment of Philadelphia-negative myeloproliferative neoplasms: current status and future directions. Molecular Diversity, 2023, 1-12.(中科院2區)
(7) Ling Zhou, Chengyang Ni, Ruixue Liao, Xiaoqin Tang, Taian Yi, Mei Ran, Miao Huang, Rui Liao, Xiaogang Zhou, Dalian Qin, Long Wang, Feihong Huang, Xiang Xie, Ying Wan, Jiesi Luo*, Yiwei Wang*, Jianming Wu*Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia. eLife, 2024;13:RP94765.(中科院1區)
(8) Binyou Wang, Jianmin Guo, Bo Chen, Yan Jiao, Ying Wan, Jianming Wu*, Yiwei Wang*. Combination of ligand‑based and structure‑based virtual screening for the discovery of novel Janus kinase 2 inhibitors against philadelphia-negative myeloproliferative neoplasms. Molecular Diversity, 2024, 1-11. (中科院2區)
(9) 楊勝勇; 王譯偉; 鄒俊; 黃磊; 姜斯文; 基於膠囊網路的藥物分子藥代動力學性質和毒性預測方法, 2021-6-22,中國, ZL201910216282.1 (發明專利)