王萬河

個人經歷

工作經歷 Work Experience

2019/12-至今西北工業大學醫學研究院副教授

2014/10-2015/11 香港浸會大學科研助理

教育經歷 Education Experience

2015/12-2019/09 香港浸會大學化學哲煉拳潤學博士

2017/08-2017/08 Monash University（澳大利亞）海外交流計畫

2011/09-2014/06 吉林大學藥牛定講物化學醫學碩背厚束士

2007/09-2011/07 昆明理工大學製藥去套工程工程學士

學術成果

代表性成果：

[1] G.-J. Yang, W. Wang (co-first author), W.-F. S. Mok, C. Wu, Y.-K. B. Law, X.-M. Miao, K.-J. Wu, H.-J. Zhong, C.-Y. Wong, K.-W. V. Wong*, D.-L. Ma*, C.-H. Leung*. "Selective inhibition of lysine-specific demethylase 5A (KDM5A) using a rhodium(III) complex for triple-negative breast cancer therapy". Angew. Chem. Int. Ed., 2018, 57, 13091. (Impact factor: 12.257, Inside back cover, 化學一區)

[2] W. Wang, K. Vellaisamy, G. Li, C. Wu, C.-N. Ko, C.-H. Leung*, D.-L. Ma*. "Development of a long-lived luminescence probe for visualizing β-galactosidase in ovarian carcinoma cells". Anal. Chem., 2017, 89, 11679. (Impact factor: 6.350, 化學一區)

[3] W. Wang, Z. Mao, M. Wang, L.-J. Liu, D. W. J. Kwong, C.-H. Leung, D.-L. Ma*. “A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al ions” Chem. Commun., 2016, 52, 3611. (Impact factor: 6.164, Inside front cover, 化學一區，高宙懂匪被引文章)

[4] L.-J. Liu, W. Wang (co-first author), S.-Y. Huang, Y. Hong, G. Li, S. Lin, J. Tian, Z. Cai, H.-M. D. Wang, D.-L. Ma*, C.-H. Leung. “Inhibition of the ras/raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound” Chem. Sci., 2017, 8, 4756. (Impact factor: 9.556, Inside back cover, 化學一區)

[5] K. Vellaisamy, G. Li, W. Wang (co-first author), C.-H. Leung,* D.-L. Ma*. “A long-lived peptide-conjugated iridium(III) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2” Chem. Sci., 2018, 9, 8171. (Impact factor: 9.556, Front cover, 化學一煉墓影凝棕嫌盛恥區)

[6] W. Wang, C. Yang, S. Lin, K. Vellaisamy, G. Li, W. Tan, C.-H. Leung, D.-L. Ma*. “First synthesis of an oridonin-conjugated iridium(III) complex for the intracellular tracking of NF-κB in living cells” Chem. Eur. J., 2017, 23, 4929. (Impact factor: 5.160, 化學二區)

[7] W. Wang, C. Yang, G. Li, Y.-C. Tse, C.-H. Leung, D.-L. Ma*. “An iridium(III) complex-based chemosensor for the detection of thiourea in living cells” Sens. Actuator B-Chem., 2017, 251, 374. (Impact factor: 6.393, 分析化學一區)

[8] W. Wang, C. Wu, C. Yang, G. Li, Q.-B. Han, S. Li, M.-Y. Lee, C.-H. Leung, D.-L. Ma*. "A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells". Sens. Actuator B-Chem., 2018, 255, 1953. (Impact factor: 6.393, 分析化學一區)

[9] W. Wang, L. Lu, C. K.-J. Wu, J. Liu, C.-H. Leung, C.-Y. Wong, D.-L. Ma*. "Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells". Sens. Actuator B-Chem., 2019, 288, 392. (Impact factor: 6.393, 分析化學一區)

[10] C. Yang, W. Wang (co-first author), J. Liang, G. Li, K. Vellaisamy, C.-Y. Wong, D.-L. Ma*, C.-H. Leung. “A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells” J. Med. Chem., 2017, 60, 2597. (Impact factor: 6.054, 藥物化學一區)

代表性專利：

[1] 喹唑啉類化合物、其中間體、製備方法、藥物組合物和套用, 柏旭, 余建鑫, 王萬河, 張永, 鄭連友, 夏廣新, 張春玲, 王余吉, 周倩, 張大鵬（CN106316965A）, 2017/01/11.

[2] Quinazoline compound, intermediate, preparation method, pharmaceutical composition and uses thereof, 柏旭, 余建鑫, 王萬河, 張永, 鄭連友, 夏廣新, 張春玲, 王余吉, 周倩, 張大鵬（WO2017005137A1）, 2017/01/12.

學術活動 Professional Activities

2017 香港浸會大學研究生核心課程-科研技能專題討論會特邀嘉賓

2017 5 MacroTrend Conference on Applied Science: Paris 2017會議口頭報告"Iridium complex-based probe for visualizing β-galactosidase in ovarian carcinoma cells", 法國巴黎

榮譽獎項

2017 中國分析測試協會科學技術三等獎（中國分析測試協會，國家級）排名9/9

2017 亞坤內地研究生獎學金計畫（香港浸會大學）

王萬河

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個人經歷

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榮譽獎項

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