個人經歷
中國藥大學博士蒸全後(1997);
南京師範大學教授、博導(1999);
美國德克薩斯大學訪問教授(2000);
《遺傳陵膠辨嫌》,《動物學研究》編委。
研究方向
文昌魚是現存生物中與脊椎動物最相似的
無脊椎動物,因此是研究脊椎動物起源及其
胚胎髮育機制的理想模型。我們課題組主要運用基因敲除、轉基因、顯微注射、原位雜交、
掃描電鏡等試驗手段,研究文昌魚早期胚胎髮育機制,特別是體軸建立機制,以期對立良察脊椎動物器官起源與發育機制有更深入的拜只凳理解
學術成果
代表性論文(Selected Publications)
1. Li G, Liu X, Xing CF, Zhang HY, Shimeld SM, Wang YQ*. (2017) Cerberus-Nodal-Lefty-Pitx signaling cascade controls left-right asymmetry in amphioxus.PNAS, 14(114): 3684–3689
2.Li G, Wang J, Yuan L, Wang H,Wang YQ*. (2015) A simple method for selecting spawning-ready individuals out from laboratorial cultured amphioxus population.Journal of experimental zoology, 324(7):629-635.
3.Feng J, Li G, Liu X, Wang J,Wang YQ*. (2014) Functional analysis of the promoter region of amphioxus beta-actin gene: a useful tool for driving gene expression in vivo.Mol Biol Rep. 41:6817–6826
4.Li G, Feng J, Lei Y, Wang J, Wang H, Shang LK, Liü DT, Zhao H, Zhu YandWang YQ*.(2014) Mutagenesis at specific genomic loci of amphioxus Branchiostoma belcheriusing TALEN method.Journal of Genetics and Genomics. 41(4):215-219
5. Liü X, Li G, Feng J, Yang X,Wang YQ*. (2013) An efficient microinjection method for unfertilized eggs of Asian amphioxus Branchiostoma belcheri.Dev Genes Evol.223:269-278
6.Li WY, Zhong J,Wang YQ*. 2013. Genetic diversity and population structure of two lancelets along the coast of China.Zoological Science. 30(2):83-91
7.Qian GH, Li G, Chen X,Wang YQ*. (2013) Characterization and embryonic expression of four amphioxus Frizzledgenes with important functions during early embryogenesis.Gene Expr Patterns.13(8):445-453
8.Li G, Shu ZH andWang YQ*. (2013) Year-round reproduction and induced spawning of Chinese amphioxus, Branchiostoma Belcheri, in laboratory.PLoS ONE.8(9): e75461
9.Xu QH, Li G, Cao LX, Wang ZJ, Ye H, Chen XY, Yang X,Wang YQ*and Chen LB. (2012) Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri.BMC Evolutionary Biology.12:239
10.Li G, Yang X, Shu ZH, Chen XY andWang YQ*. (2012) Consecutive spawnings of Chinese amphioxus, Branchiostoma belcheri, in captivity.PLoS ONE. 7(12): e50838
11.Li DL, Li G, Wang KR, Liu X, Li W, Chen XY,Wang YQ*. (2012) Isolation and functional analysis of the promoter of the amphioxus Hsp70a gene.Gene. 510(1):39-46
12.Sun Y, Zhang QJ, Zhong J,Wang YQ*. (2010) Characterization and expression of AmphiBMP3/3b gene in amphioxus Branchiostoma japonicum. Develop.Growth Differ., 52:157-167
13.Li G, Zhang J, Sun Y, Wang H,Wang YQ*. (2009) The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates.Mol Biol Evol.26 (7):1619-1630.
14.Li G, Zhang QJ, Zhong J,Wang YQ*. (2009) Evolutionary and functional diversity of green fluorescent proteins in cephalochordates.Gene. 446(1):41-49.
15.Li G, Shi P andWang YQ*. (2007) Evolutionary dynamics of the ABCA-chr17q24 cluster genes in vertebrates.Genomics. 89 (3) 385–391.
16.Wang W, Zhong J, Su B, Zhou Y,Wang YQ*. (2007) Comparison of Pax1/9 locus reveals 500-Million-Year-Old syntenic block and evolutionary conserved non-coding regions.Mol Biol Evol. 24: 784-791
17.Li G, Zhang QJ, Ji ZL,Wang YQ*. (2007) Origin and evolution of vertebrate ABCA genes: A story from Amphioxus.Gene. 405 (1-2):88-95.
18.Zhang QJ, Li G, Sun Y,Wang YQ*. (2009) Chromosome Preparation and Preliminary Observation of Two Amphioxus Species in Xiamen.Zoological Research.30(2): 131−136
5. Liü X, Li G, Feng J, Yang X,Wang YQ*. (2013) An efficient microinjection method for unfertilized eggs of Asian amphioxus Branchiostoma belcheri.Dev Genes Evol.223:269-278
6.Li WY, Zhong J,Wang YQ*. 2013. Genetic diversity and population structure of two lancelets along the coast of China.Zoological Science. 30(2):83-91
7.Qian GH, Li G, Chen X,Wang YQ*. (2013) Characterization and embryonic expression of four amphioxus Frizzledgenes with important functions during early embryogenesis.Gene Expr Patterns.13(8):445-453
8.Li G, Shu ZH andWang YQ*. (2013) Year-round reproduction and induced spawning of Chinese amphioxus, Branchiostoma Belcheri, in laboratory.PLoS ONE.8(9): e75461
9.Xu QH, Li G, Cao LX, Wang ZJ, Ye H, Chen XY, Yang X,Wang YQ*and Chen LB. (2012) Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri.BMC Evolutionary Biology.12:239
10.Li G, Yang X, Shu ZH, Chen XY andWang YQ*. (2012) Consecutive spawnings of Chinese amphioxus, Branchiostoma belcheri, in captivity.PLoS ONE. 7(12): e50838
11.Li DL, Li G, Wang KR, Liu X, Li W, Chen XY,Wang YQ*. (2012) Isolation and functional analysis of the promoter of the amphioxus Hsp70a gene.Gene. 510(1):39-46
12.Sun Y, Zhang QJ, Zhong J,Wang YQ*. (2010) Characterization and expression of AmphiBMP3/3b gene in amphioxus Branchiostoma japonicum. Develop.Growth Differ., 52:157-167
13.Li G, Zhang J, Sun Y, Wang H,Wang YQ*. (2009) The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates.Mol Biol Evol.26 (7):1619-1630.
14.Li G, Zhang QJ, Zhong J,Wang YQ*. (2009) Evolutionary and functional diversity of green fluorescent proteins in cephalochordates.Gene. 446(1):41-49.
15.Li G, Shi P andWang YQ*. (2007) Evolutionary dynamics of the ABCA-chr17q24 cluster genes in vertebrates.Genomics. 89 (3) 385–391.
16.Wang W, Zhong J, Su B, Zhou Y,Wang YQ*. (2007) Comparison of Pax1/9 locus reveals 500-Million-Year-Old syntenic block and evolutionary conserved non-coding regions.Mol Biol Evol. 24: 784-791
17.Li G, Zhang QJ, Ji ZL,Wang YQ*. (2007) Origin and evolution of vertebrate ABCA genes: A story from Amphioxus.Gene. 405 (1-2):88-95.
18.Zhang QJ, Li G, Sun Y,Wang YQ*. (2009) Chromosome Preparation and Preliminary Observation of Two Amphioxus Species in Xiamen.Zoological Research.30(2): 131−136