王湘如

王湘如，男，湖北宜昌人。華中農業大學教授、博士生導師，生豬健康養殖協同創新中心骨幹研究人員。

基本介紹

• 中文名：王湘如
• 學位/學歷：博士
• 職業：教師
• 專業方向：人獸共患細菌性傳染病流行病學等
• 任職院校：華中農業大學動物科學技術學院動物醫學院

個人經歷

教育經歷

2004.09 - 2009.06， 華中農業大學，動物醫學專業畢業，農學學士

2009.09 - 2014.06， 華中農業大學，預防獸醫學專業畢業，農學博士

工作經歷

2012.02-2012.08，上海國家人類基因組南方研究中心合作研究

2012.10-2014.04，美國約翰斯·霍普金斯大學醫學院聯合研究

研究方向

人獸共患細菌性傳染病流行病學、致病機制；豬群重要細菌性疾病的新型疫苗與分子診斷製劑開發

學術成果

A著作類

B論文類

1.Xiangru Wang, Xiaojuan Xu, Shu Zhang, Fengjuan Guo, Xuwang Cai, Huanchun Chen. Identification and analysis of potential virulence-associated genes in Haemophilus parasuis based on genomic subtraction. Microb Pathog, 2011, 51: 291–296. (IF=2.0)

2.Xiangru Wang, Xiaojuan Xu, Yucong Wu, Lanying Li, Ruijuan Cao, Xuwang Cai, Huanchun Chen. Polysaccharide biosynthesis protein CapD is a novel pathogenicity-associated determinant of Haemophilus parasuis involved in serum-resistance ability. Vet Microbiol, 2013, 164: 184-189. (IF=3.327)

3.Xiangru Wang, Haihong Hao, Zhuofei Xu, Huajun Zheng, Canying Liu, Liuya Wei, Ruixuan Zhang, Dingren Bi, Huanchun Chen, Chen Tan. Plasmid-mediated multidrug resistance and virulence in an avian pathogenic Escherichia coli strain isolated in China. J Global Antimicrob Resist, 2014, 2: 57-58. (IF=1.086)

4.Liping Chen, Xuwang Cai, Xiangru Wang, Xueli Zhou, Dongfang Wu, Xiaojuan Xu, Huanchun Chen. Characterization of plasmid-mediated lincosamide resistance in a field isolate of Haemophilus parasuis. J Antimicrob Chemother, 2010, 65: 2256-8. (IF=5.068)

5.陳西, 王湘如, 徐曉娟, 郭鳳娟, 陳煥春, 蔡旭旺. 副豬嗜血桿菌細胞致死膨脹毒素的細胞毒性研究, 畜牧獸醫學報, 2011, 42 (12): 1750-1755.

6.Canying Liu, Huajun Zheng, Minjun Yang, Zhuofei Xu, Xiangru Wang, Liuya Wei, Biao Tang, Feng Liu, Yanyan Zhang, Yi Ding, Xibiao Tang, Bin Wu, Timothy J. Johnson, Huanchun Chen, Chen Tan. Genome analysis and in vivo virulence of porcine extraintestinal pathogenic Escherichia coli strain PCN033. BMC Genomics, 2015, 16(1): 717. (IF=3.986)

7.Yi Ding, Dongmei Zhu, Jianmin Zhang, Longsheng Yang, Xiangru Wang, Huanchun Chen, Chen Tan. Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China. Emerg Microbes Infec, (2015) 4, e69 (IF=4.012)

8.Jing Chen, Lijie Su, Xiangru Wang, Tao Zhang, Feng Liu, Huanchun Chen, Chen Tan. Polyphosphate Kinase Mediates Antibiotic Tolerance in Extraintestinal Pathogenic Escherichia coli PCN033. Front Microbiol, 2016, 19(7): 724. doi: 10.3389/fmicb.2016.00724. (IF=4.165)

9.Yan Zhang, Dandan Ding, Manli Liu, Xiaopei Yang, Bingbing Zong, Xiangru Wang, Huanchun Chen, Weicheng Bei, Chen Tan. Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiol Res. 2016, 185: 45-54. (IF=2.723)

10.Ying Peng, Xiangru Wang, Jin Shou, Bingbing Zong, Yan Zhang, Jia Tan, Jing Chen, Linlin Hu, Yongwei Zhu, Huanchun Chen, Chen Tan. Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system. Sci Rep. 2016, 27(6): 26816. (IF=5.228)

11.Jiachen Huang1, Xiangru Wang1, Qi Cao, Fenfen Feng, Xiaojuan Xu, Xuwang Cai. ClpP participates in stress tolerance and negatively regulates biofilm formation in Haemophilus parasuis. Vet Microbiol, 2016, 182: 141-9. (Co-first, IF=2.511)

12Xiangru Wang, Liuya Wei, Bin Wang, Ruixuan Zhang, Canying Liu, Dingren Bi, Huanchun Chen, Chen Tan. Complete genome sequence and characterization of avian pathogenic Escherichia coli field isolate ACN001. Stand. Genomic Sci., 2016, 11:13. (IF=1.594)

13Ruicheng Yang, Wentong Liu, Ling Miao, Xiaopei Yang, Jiyang Fu, Beibei Dou, Aoling Cai, Xin Zong, Chen Tan, Huanchun Chen, Xiangru Wang#. Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier. Oncotarget, 2016, 7(39): 63839-63855. doi: 10.18632/oncotarget.11696. (Corresponding author, IF=5.008, 5 year IF=5.415)

14.Xiangru Wang, Ravi Maruvada, Andrew J Morris, Jun O Liu, Michael J. Wolfgang, Dong Jae Baek, Robert Bittman and Kwang Sik Kim. Sphingosine 1-Phosphate Activation of EGFR as a Novel Target for Meningitic Escherichia coli Penetration of the Blood–Brain Barrier. PLoS Pathog, 2016, 12(10): e1005926. doi:10.1371/journal.ppat.1005926 (IF=7.003, 5 year IF=7.758)

15. Xiaopei Yang, Jiyang Fu, Ruicheng Yang, Wentong Liu, Tao Zhang, Bo Yang, Ling Miao, Beibei Dou, Chen Tan, Huanchun Chen, Xiangru Wang#. EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis. J Neuroinflamm, 2016, 13: 274. doi: 10.1186/s12974-016-0734-0 (IF=4.667, 5 year IF=5.366)

16.Ruicheng Yang, Fei Huang, Jiyang Fu, Beibei Dou, Bojie Xu, Ling Miao, Wentong Liu, Xiaopei Yang, Chen Tan, Huanchun Chen, Xiangru Wang#. Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli. Sci Rep. 2016, 6:38903 (IF=5.228, 5 year IF=5.525)

17.Feng Liu, Jiyang Fu, Canying Liu, Jing Chen, Minhua Sun, Huanchun Chen, Chen Tan, Xiangru Wang#. Characterization and distinction of two flagellar systems in extraintestinal pathogenic Escherichia coli PCN033. Microbiol Res. 2017, 196: 69-79. (IF=2.723, 5 year IF=2.695)

18.Pei Li, Rui Wang, Wenqi Dong, Linlin Hu, Bingbing Zong, Yanyan Zhang, Xiangru Wang, Aizhen Guo, Anding Zhang, Yaozu Xiang, Huanchun Chen, Chen Tan. Comparative proteomics analysis of human macrophages infected with virulent Mycobacterium bovis. Front Cell Infect Microbiol. 2017, 7: 65. (IF=5.218)

19.Bingbing Zong, Liuya Wei, Yan Zhang, Xiangru Wang, Huanchun Chen, Chen Tan. Effect of kpsM on the virulence of porcine extraintextinal pathogenic Escherichia coli. FEMS Microbiol Lett. 2016, Oct 12. pii: fnw232. (IF=1.858)

20.Qi Cao, Fenfen Feng, Huan Wang, Xiaojuan Xu, Huanchun Chen, Xuwang Cai, Xiangru Wang#. Haemophilus parasuis CpxRA two-component system confers bacterial tolerance to environmental stresses and macrolide resistance. Microbiol Res. 2018, 206: 177-185. (IF=3.04)

科研項目

1. 華中農業大學校自主科技創新基金“致腦膜炎大腸桿菌突破血腦屏障的新型分子靶標鑑定及信號通路研究”, 2014-2017

2. 國家自然科學基金青年基金“EGFR在腸外致病性大腸桿菌突破宿主血腦屏障中的作用及其機制研究”, 31502062, 2016-2018

3. 國家自然科學基金面上項目“LncRSPH9-4調控致腦膜炎大腸桿菌破壞血腦屏障的作用機制研究”, 31772736, 2018-2021

4. 國家重點研發計畫“病原入侵中樞神經系統的機制研究”, 2016YFD0500406, 2016.07-2020.12

榮譽獎項

1. 湖北省畜牧獸醫學會2014-2016年度優秀學術論文一等獎、二等獎、三等獎各1項

2. 華中農業大學2017年本科生創新論文（設計）指導獎。