王書敏，女，博士，中國農業大學動物科學技術學院講師。
基本介紹
- 中文名：王書敏
- 學位/學歷：博士
- 職業：教師
- 專業方向：CRISPR/Cas系統介導家畜基因編輯以及胎盤發育機理研究
- 任職院校：中國農業大學動物科學技術學院
人物經歷,研究方向,主講課程,學術成果,
人物經歷
2004.09-2010.06河北師範大學生理學專業 博士學位
2010.08-2014.05中國科學院動物研究所生殖生物學國家重點實驗室 博士後
2014.05- 中國農業大學 動物科技學院 動物遺傳育種與繁殖專業 講師
研究方向
CRISPR/Cas系統介導家畜基因編輯店鑽背想以及胎盤發育姜應茅機理研究。
主講課程
參與了動物遺傳育種與繁殖專業的《家畜繁殖學》本科教學，以及《動物轎定簽繁殖與胚胎工程技術實晚挨驗踐》、《外文科技文獻研讀》研究生教學。
學術成果
主要科研工作：
1.國家青年科學基金：Notch信號通路在低氧誘導小鼠胎盤sFlt1表達中的作用機制祝戰（已結題）
2.博士後科學基金：Notch信號通路在小鼠胎盤發育中的作用（已結題）
3.中央高校基本科研業務費專項禁拳棕您資金項目：煉戶習 CRISPR/Cas9高效介導FUT1基因優勢SNP引入豬基因組的研究(在研)
科研成果：
Fu Z*, Wang B*,Wang S*, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice.Biol Reprod.2014 Mar 13;90(3):52. (IF 4.009) *：共同一作。
S.-M. Wang, L.-J. Fu, X.-L. Duan, D. R. Crooks, P. Yu, Z.-M. Qian, X.-J. Di, J. Li, T. A. Rouault and Y.-Z. Chang. Role of hepcidin in murine brain iron metabolism.Cell. Mol. Life Sci.2010, 67:123-133. (IF 5.808)
Xu X,Wang S,Liu J, Dou D, Liu L, Chen Z, Ye L, Liu H, He Q, Raj JU, Gao Y. Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p.J Cell Sci.2012 Oct 4. (IF 6.111)
Zhang S, Lin HY, Kong SB,Wang SM, Wang HM, HB Wang, Armant DR. Physiological and molecular determinants of embryo implantation.Mol Aspects Med.2013 Oct;34(5):939-80.(IF 9.97)
Lu JH, Zhang S, Nakano H,Wang SM, Simmons DG, Wang Q, Shen LJ, Wang WX, Wang BY, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC, Wang HB. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.PLoS Biol.2013;11(4):e1001536.(IF 11.452)
Sui L, An L, Tan K, Wang Z,Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J.Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas.Biol Reprod.2014 Dec;91(6):155.(IF 4.009)
Lu W, Tu Z,Wang S, Lu J, Wang Q, Wang W, Wang B, Wang H, Ni H, Guo Y. Spatiotemporal expression of Wnt signaling pathway components during bovine placental development.Theriogenology.2013 Nov;80(8):893-902.(IF 2.082)
Wang Q, Lu JH, Zhang S,Wang SM, Wang WX, Wang BY, Wang FC, Chen Q, Duan EK, Leitges M, Kispert A, and Wang HB. Wnt6 is essential for stromal cell proliferation during decidualization.Biol Reprod.2013 Jan 3;88(1):5.(IF 4.009)
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y,Wang S,Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H.Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Res. 2014 Aug;24(8):925-42.(IF12.413)
Fu Z, Chen Y, Wu W,Wang S, Wang W, Wang B, Wang H.Molecular and cellular aspects of blastocyst dormancy and reactivation for implantation.J Stem Cells.2013;8(2):59-77.
Kun Tan, Lei An,Shumin Wang, Xiaodong Wang, Zhenni Zhang, Kai Miao, Linlin Sui, Wei Xia, Shuzhi He, Jingzhou Nie, Zhonghong Wu, Jianhui Tian. Melatonin modulates cytoskeletal organization in pre-implantation embryos: Implications for the beneficial effect onin vitroembryonic development.Plos one(accepted)
Zhang S, Lin HY, Kong SB,Wang SM, Wang HM, HB Wang, Armant DR. Physiological and molecular determinants of embryo implantation.Mol Aspects Med.2013 Oct;34(5):939-80.(IF 9.97)
Lu JH, Zhang S, Nakano H,Wang SM, Simmons DG, Wang Q, Shen LJ, Wang WX, Wang BY, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC, Wang HB. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.PLoS Biol.2013;11(4):e1001536.(IF 11.452)
Sui L, An L, Tan K, Wang Z,Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J.Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas.Biol Reprod.2014 Dec;91(6):155.(IF 4.009)
Lu W, Tu Z,Wang S, Lu J, Wang Q, Wang W, Wang B, Wang H, Ni H, Guo Y. Spatiotemporal expression of Wnt signaling pathway components during bovine placental development.Theriogenology.2013 Nov;80(8):893-902.(IF 2.082)
Wang Q, Lu JH, Zhang S,Wang SM, Wang WX, Wang BY, Wang FC, Chen Q, Duan EK, Leitges M, Kispert A, and Wang HB. Wnt6 is essential for stromal cell proliferation during decidualization.Biol Reprod.2013 Jan 3;88(1):5.(IF 4.009)
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y,Wang S,Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H.Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Res. 2014 Aug;24(8):925-42.(IF12.413)
Fu Z, Chen Y, Wu W,Wang S, Wang W, Wang B, Wang H.Molecular and cellular aspects of blastocyst dormancy and reactivation for implantation.J Stem Cells.2013;8(2):59-77.
Kun Tan, Lei An,Shumin Wang, Xiaodong Wang, Zhenni Zhang, Kai Miao, Linlin Sui, Wei Xia, Shuzhi He, Jingzhou Nie, Zhonghong Wu, Jianhui Tian. Melatonin modulates cytoskeletal organization in pre-implantation embryos: Implications for the beneficial effect onin vitroembryonic development.Plos one(accepted)
