蘇州大學副教授，主要從事電離輻射損傷代謝、放射生物劑量估計和電離輻射防護藥物方面的研究。和他人合作在國內外學術期刊發表多篇方向性論文。
基本介紹
- 中文名：王暢
- 國籍：中國
- 民族：漢族
- 性別：女
- 技術職稱：副教授
- 學科專業名稱：放射醫學
人物經歷,研究方向,主要貢獻,
人物經歷
1995年考入陝西師範大學化學系，1999年畢業獲得理學學士學位。同年九月考入該校化學系，從事化學發光和微流控晶片的研究，於2002年獲得理學碩士學位。同年九月開始在中科院大連化學物理研究所攻讀博士學位，在導師許國旺研究員的指導下從事代謝組學研究——電噴霧質譜和液相色譜-質譜聯用技術的磷脂分析方法研究及其在磷脂代謝中的套用。於2006年3月於中國科學院大連化學物理研究所獲得理學博士學位。2006年4月起至今於蘇州大學工作，從事電離輻射損傷代謝、放射生物劑量估計和電離輻射防護藥物的研究。
研究方向
電離輻射損傷代謝研究、放射生物劑量估計研究、電離輻射防護藥物研究
主要貢獻
已在國內外期刊和會議上發表文章如下：
1 Chang Wang, Sigang Xie, Jun Yang, Qing Yang, Guowang Xu. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap Mass Spectrometry. Anal. Chim.Acta, 2004, 525（1）：1-10
2 Chang Wang, Hongwei Kong, Yufeng Guan, Jun Yang, Jianren Gu, Shengli Yang, Guowang Xu. Plasma Phospholipid Metabolic Profiling and Biomarkers of Type 2 Diabetes Mellitus Based on High Performance Liquid Chromatography/Electrospray Mass Spectrometry and Multivariate Statistical Analysis. Anal. Chem., 2005，77：4108-4116
3 Chang Wang, Jun Yang, Peng Gao, Xin Lu，Guowang Xu. Identification of phospholipid structures in human blood by direct-injection quadrupole-linear ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19: 2443–2453
4 Chang Wang, Yun Yang, Jihua Nie. Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–mass spectrometry technique. J. Biomed.Chromatogr，2009, 23: 1079-1085.
5 Lewen Jia, Chang Wang, Hongwei Kong, Jun Yang, Fanglou Li, Shen Lv, Guowang Xu. Effect of PA-MSHA Vaccine on Plasma Phospholipids Metabolic Profiling and the Ratio of Th2/Th1 Cells within Immune Organ of Mouse IgA Nephropathy, J. Pharm. Bioanal., 2007，4: 646-654
1 Chang Wang, Sigang Xie, Jun Yang, Qing Yang, Guowang Xu. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap Mass Spectrometry. Anal. Chim.Acta, 2004, 525（1）：1-10
2 Chang Wang, Hongwei Kong, Yufeng Guan, Jun Yang, Jianren Gu, Shengli Yang, Guowang Xu. Plasma Phospholipid Metabolic Profiling and Biomarkers of Type 2 Diabetes Mellitus Based on High Performance Liquid Chromatography/Electrospray Mass Spectrometry and Multivariate Statistical Analysis. Anal. Chem., 2005，77：4108-4116
3 Chang Wang, Jun Yang, Peng Gao, Xin Lu，Guowang Xu. Identification of phospholipid structures in human blood by direct-injection quadrupole-linear ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19: 2443–2453
4 Chang Wang, Yun Yang, Jihua Nie. Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–mass spectrometry technique. J. Biomed.Chromatogr，2009, 23: 1079-1085.
5 Lewen Jia, Chang Wang, Hongwei Kong, Jun Yang, Fanglou Li, Shen Lv, Guowang Xu. Effect of PA-MSHA Vaccine on Plasma Phospholipids Metabolic Profiling and the Ratio of Th2/Th1 Cells within Immune Organ of Mouse IgA Nephropathy, J. Pharm. Bioanal., 2007，4: 646-654
6 Lewen Jia, Chang Wang, Sumin Zhao, Xin Lu, Guowang Xu. Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry. J. Chromatogr. B, 2007, 860 (1) : 134-140
7 Lewen Jia, Chang Wang, Hongwei Kong , Zongwei Cai, Guowang Xu. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy，Metabolomics, 2006, 2（2），95-104
8 Qiurong Li, Li Tan, Chang Wang, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts. Eur. J. Nutrition, 2006, 45(3):144-151
9 Qiurong Li, Meng Wang, Li Tan, Chang Wang, Qian Shi, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. J. Lipid Res. 2005, 46: 1904-1913.
10 Jun Yang, Xinjie Zhao, Xiaoli Liu, Chang Wang, Peng Gao, Jiangshan Wang, Lanjuan Li, Jianren Gu, Shengli Yang, Guowang Xu. High Performance Liquid Chromatography-Mass Spectrometry for Metabnomics: Potential Biomarkers for Acute Determination in Liver Function of Chronic Hepatitis B. J.Proteome Res., 2006, 5:554-561.
11 王暢，謝四剛，楊軍，楊青，許國旺. 液相色譜-線性離子阱質譜法鑑定人血中磷脂醯乙醇胺類分子組成．色譜，2004，22（4）：316-320.
12 王暢，鄭育芳，熊建輝，翁前鋒. Ca2 + 與乳清蛋白結合的親和毛細管電泳研究. 化學學報, 2004,62(3):279-282.
13 王暢，呂家根，章竹君. 微透析採樣螢光法研究6-硫鳥嘌呤與蛋白結合作用.化學學報, 2002，60(9):1672-1676
7 Lewen Jia, Chang Wang, Hongwei Kong , Zongwei Cai, Guowang Xu. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy，Metabolomics, 2006, 2（2），95-104
8 Qiurong Li, Li Tan, Chang Wang, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts. Eur. J. Nutrition, 2006, 45(3):144-151
9 Qiurong Li, Meng Wang, Li Tan, Chang Wang, Qian Shi, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. J. Lipid Res. 2005, 46: 1904-1913.
10 Jun Yang, Xinjie Zhao, Xiaoli Liu, Chang Wang, Peng Gao, Jiangshan Wang, Lanjuan Li, Jianren Gu, Shengli Yang, Guowang Xu. High Performance Liquid Chromatography-Mass Spectrometry for Metabnomics: Potential Biomarkers for Acute Determination in Liver Function of Chronic Hepatitis B. J.Proteome Res., 2006, 5:554-561.
11 王暢，謝四剛，楊軍，楊青，許國旺. 液相色譜-線性離子阱質譜法鑑定人血中磷脂醯乙醇胺類分子組成．色譜，2004，22（4）：316-320.
12 王暢，鄭育芳，熊建輝，翁前鋒. Ca2 + 與乳清蛋白結合的親和毛細管電泳研究. 化學學報, 2004,62(3):279-282.
13 王暢，呂家根，章竹君. 微透析採樣螢光法研究6-硫鳥嘌呤與蛋白結合作用.化學學報, 2002，60(9):1672-1676
14 Guowang Xu，Chang Wang. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap Mass Spectrometry. The third Sino-Japanese Joint Seminar on Separation Sciences. 2004, 20-22.
15 Guowang Xu, Jun Yang, Chang Wang, Hongwei Kong, Xinjie Zhao, Kailong Yuan, Jiangshan Wang, Xin Lu，Metabonomics applications in disease biomarker discovery and safety and efficacy assessments of traditional chinese medicines based on GCXGC-TOF MS and UPLC-Q-TOFMSn ，Ninth International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-9), York (United Kingdom), February 8th-10th, 2006．
16 Guowang Xu, Chang Wang, Jun Yang, Xinjie Zhao, Jiangshan Wang, Hongwei Kong, Kailong Yuan, Yuan Wang, Chenfei Ma, Xin Lu, Applications of GCxGC-TOF MS and UPLC/Q-TOF MSn in Metabonomics: Disease Biomarker Discovery and Safety Assessment and Quality Control of Traditional Chinese Medicines, 16th Annual Conference on Chromatography of Japan, Gifu, 2005.11
15 Guowang Xu, Jun Yang, Chang Wang, Hongwei Kong, Xinjie Zhao, Kailong Yuan, Jiangshan Wang, Xin Lu，Metabonomics applications in disease biomarker discovery and safety and efficacy assessments of traditional chinese medicines based on GCXGC-TOF MS and UPLC-Q-TOFMSn ，Ninth International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-9), York (United Kingdom), February 8th-10th, 2006．
16 Guowang Xu, Chang Wang, Jun Yang, Xinjie Zhao, Jiangshan Wang, Hongwei Kong, Kailong Yuan, Yuan Wang, Chenfei Ma, Xin Lu, Applications of GCxGC-TOF MS and UPLC/Q-TOF MSn in Metabonomics: Disease Biomarker Discovery and Safety Assessment and Quality Control of Traditional Chinese Medicines, 16th Annual Conference on Chromatography of Japan, Gifu, 2005.11
17 著作：參與撰寫《代謝組學——方法與套用》，科學出版社(ISBN: 978-7-03-021528-4), 2008年，第8章：類脂和類脂組學（pp161-194）
科研項目：
脂類組學方法篩選急性輻射損傷生物劑量估計指標（批准號：31000385），國家自然科學基金，項目負責人。
胺基酸靶標分析用於急性輻射損傷生物劑量估計的研究，江蘇省高校自然科學研究項目（批准號：10KJB310012）
胺基酸靶標分析用於急性輻射損傷生物劑量估計的研究，江蘇省高校自然科學研究項目（批准號：10KJB310012）
