王春光(同濟大學生命科學與技術學院教授)

王春光，中科院生物物理所博士，同濟大學生命科學與技術學院教授，研究員、博士生導師、蛋白質研究所副所長。

基本介紹

  • 中文名：王春光
  • 畢業院校：中科院生物物理所
  • 學位/學歷：博士
  • 專業方向： 微管作為一種重要的細胞骨架，參與細胞形狀和極性維持
  • 職務：同濟大學生命科學與技術學院蛋白質研究所副所長
研究方向,人物經歷,獲獎,代表論文,

研究方向

1.微管作為一種重要的細胞骨架，參與細胞形狀和極性維持、胞內物質運輸和細胞分裂等重要的生理活動。微管的動態組裝和穩定性維持受到很多因素的調節，微管狀態紊亂與癌症、神經退行性疾病等密切相關。我們主要研究各種調控微管組裝的蛋白質和小分子化合物的作用機理，以理解微管的調控過程及相關疾病的發生原因和藥物治療機理。
2.動物多肽神經毒素是自然界中產毒動物經過億萬年的進化而形成的具有高活性和高選擇性的神經毒素，可以作為神經生物學研究的有力工具和神經系統疾病的治療藥物。芋螺毒素因為其結構和功能的高度多樣性而倍受關注，也是我們目前的主要研究對象。

人物經歷

1991年9月－1995年7月，吉林大學生物化學與分子生物學系，獲學士學位；
1995年9月－2000年7月，中科院生物物理所，獲生物化學與分子生物學博士學位；
2000年9月－2003年3月，中科院上海生化所，博士後；
2003年4月－2006年3月，法國國家科研中心結構酶學和結構生物化學實驗室（Laboratoired'EnzymologieetBiochimieStructurales,CNRS），博士後；
2006年5月至今，同濟大學，研究員、博士生導師、蛋白質研究所副所長。

獲獎

2005年獲上海市科技進步一等獎；
2006年入選上海市“曙光學者”；
2007年獲上海市“浦江人才”資助；
2008年入選同濟大學優秀青年教師；
2009年入選教育部“新世紀優秀人才”；
2011年獲同濟大學十大“我心目中的好導師”稱號。

代表論文

  1. Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang*, Benoit Gigant*. Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin. Nat. Commun.2017, 8(1): 70.
  2. Longjin Yang, Han-Shen Tae, Zhou Fan, Xiaoxia Shao, Shaoqiong Xu, Suwen Zhao, David J. Adams*, Chunguang Wang*. A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αD-conotoxin GeXXA. Mar. Drugs. 2017, 15(6). 164.
  3. Shantong Jiang, Han-Shen Tae, Shaoqiong Xu, Xiaoxia Shao, David J. Adams*, Chunguang Wang*. Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor. Mar. Drugs. 2017, 15(6). 170.
  4. Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun, Xuejiao Hong, Ying Cao, Chunguang Wang*. Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein. Cell Cycle. 2016, 15(17): 2367-2375.
  5. Shaoqiong Xu, Tianlong Zhang, Shiva N. Kompella, Mengdi Yan, Aiping Lu, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, David J. Adams*, Jianping Ding*, Chunguang Wang*. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci. Rep.2015, 5: 14261.
  6. Weiyi Wang, Ting Shen, Raphael Guerois, Fuming Zhang, Hureshitanmu Kuerban, Yuncong Lv, Benoît Gigant*, Marcel Knossow*, and Chunguang Wang*. New insights into the coupling between microtubule depolymerization and ATP hydrolysis by kinesin-13 protein Kif2C. J. Biol. Chem. 2015, 290 (30): 18721-18731.
  7. Weiyi Wang, Luyan Cao, Chunguang Wang, Benoit Gigant, Marcel Knossow*. Kinesin, 30 years later: Recent insights from structural studies. Protein Sci.2015, 24(7): 1047-1056.
  8. Luyan Cao, Weiyi Wang, Qiyang Jiang, Chunguang Wang*, Marcel Knossow*, Benoit Gigant*. The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement. Nat. Commun.2014, 5: 5364.
  9. Aiping Lu, Longjin Yang, Shaoqiong Xu, and Chunguang Wang*. Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics, 2014, 13(1): 105-118.
  10. Wentao Peng, Zhijie Lin, Weirong Li, Jing Lu, Yueyuan Shen*, Chunguang Wang*. Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegansfidgetin-like 1 (FIGL-1) protein. J. Biol. Chem. 2013, 288: 29305-29312.
  11. Benoît Gigant, Weiyi Wang, Birgit Dreier, Qiyang Jiang, Ludovic Pecqueur, Andreas Plückthun, Chunguang Wang*, Marcel Knossow*. Structure of a kinesin–tubulin complex and implications for kinesin motility. Nat. Struct. Mol. Biol.2013, 20(8): 1001-1007.
  12. Maorong Wen, Chunguang Wang*. The nucleotide cycle of spastin correlates with its microtubule-binding properties. FEBS J.2013, 280: 3868-3877.
  13. Shaoqiong Xu, Hua Li, Xiaoxia Shao, Chongxu Fan, Bryan Ericksen, Jinsong Liu, Chengwu Chi*, Chunguang Wang*. Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue Virus NS2B-NS3 protease. J. Med. Chem.2012, 55(15): 6881-6887.
  14. Ludovic Pecqueur, Christian Duellberg, Birgit Dreier, Qiyang Jiang, Chunguang Wang, Andreas Pluckthun, Thomas Surrey, Benoit Gigant, Marcel Knossow*. A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A2012, 109(30): 12011-12016.
  15. Weiyi Wang, Qiyang Jiang, Manuela Argentini, David Cornu, Benoît Gigant, Marcel Knossow*, Chunguang Wang*. Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J. Biol. Chem.2012, 287(18): 15143-15153.
  16. Mingyu Ye, Keith K. Khoo, Shaoqiong Xu, Mi Zhou, Nonlawat Boonyalai, Matthew A. Perugini, Xiaoxia Shao, Chengwu Chi, Charles A. Galea, Chunguang Wang*, and Raymond S. Norton*. A helical conotoxin from Conus imperialishas a novel cysteine framework and defines a new superfamily. J. Biol. Chem.2012, 287(18): 14973-14983.
  17. Anthony Cormier, Marcel Knossow, Chunguang Wangand Benoit Gigant. The binding of vinca domain agents to tubulin: structural and biochemical studies. Methods in Cell Biology. 2010, 95: 369-386.
  18. Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du and Chunguang Wang*. Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J.2008, 275: 1976-1987.
  19. Chuanguang Wang, Anthony Cormier, Benoit Gigant, Marcel Knossow. Insight into the GTPase activity of tubulin from complexes with stathmin-like domains. Biochemistry, 2007, 46: 10595-10602.
  20. Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel, Marcel Knossow. Structural basis for the regulation of tubulin by vinblastine. Nature2005, 435(7041): 519-522.
  21. Chunguang Wang, Nicolas Gilles, Alain Hamon, Frédéric Le Gall, Maria Stankiewicz, Marcel Pelhate, Yumei Xiong, Dacheng Wang, Chengwu Chi. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry2003, 42(16): 4699-4708.

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