王娟(西北農林科技大學副教授)

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王娟,女,1983年10月生,山東德州人,博士,西北農林科技大學副教授。

基本介紹

  • 中文名:王娟 
  • 出生日期:1983年10月 
  • 職業:教師
  • 畢業院校:愛爾蘭都柏林大學
  • 學位/學歷:博士
  • 專業方向:微生物與免疫
  • 任職院校:西北農林科技大學
  • 籍貫:山東德州
人物經歷,學術成果,論著論文,科研項目,

人物經歷

2008年6月畢業於濱州醫學院,臨床醫學專業,獲學士學位
2011年6月畢業於西安交通大學,醫學院,微生物與免疫專業,獲碩士學位
2015年6月畢業於愛爾蘭都柏林大學,公共衛生與人口健康學院,食品安全實驗室,獲博士學位
2014年9月至2015年9月,愛爾蘭都柏林大學,食品安全中心實驗室,博士後
2015年10月2017年12月,西北農林科技大學,動物醫學院預防獸醫系,講師
2018年1月至今,西北農林科技大學,動物醫學院預防獸醫系,副教授

學術成果

於2011年9月~2015年6月在愛爾蘭都柏林大學食品安全中心重點實驗室攻讀博士學位,主要從事細菌耐藥方面的研究,博士論文題目為《產超廣譜β內醯胺酶類大腸埃希菌內耐藥性質粒DNA基因序列的研究》,積累了細菌耐藥機理和傳播機制,分子生物學和信息生物學等研究方面的經驗,並取得了一定的成果。其中通過對16條分離自瑞士健康人群和農場食源性動物中的產超廣譜β內醯胺酶(ESBLs)類大腸桿菌的耐藥質粒DNA全基因序列的比對研究發現,來自健康人體和農場食源性動物的耐藥性質粒具有相似的基因序列,所攜帶的抗生素耐藥基因擁有相似的基因環境。另外通過分子生物和信息生物學的方法發現,質粒不相容群分型為IncI1,IncN,IncF和IncB/O的質粒類別,可以介導產超廣譜β內醯胺酶類基因 blaCTX-M-1和 blaTEM-52在健康人群和農場食源性動物之間的傳播。基因插入序列IS Ecp1 和IS 26 ,作為重要的遺傳元件,可以增強 blaCTX-M-1基因的表達和介導其在不同質粒間的克隆傳播和水平傳播。另外,研究還首次報導了來自健康人體和食源性動物的耐藥質粒攜帶有相近的毒素-抗毒素系統。博士期間的研究結果首次報導了分離自瑞士健康人體和農場動物的大腸桿菌的質粒DNA序列,對瑞士人畜共患病和臨床常用抗生素的耐藥基因的傳播途徑提供了有力證據,對減少畜牧業抗生素的使用提供了有力支持。
於2014年9月~2015年9月在都柏林大學食品安全中心重點實驗室做了為期一年的博士後研究,在博士後研究期間,以重要參與人身份參與了多項科研項目,其中包括愛爾蘭地區豬源性耐甲氧西林金黃色葡萄球菌(MRSA)的遺傳特性和耐藥特徵分析,嬰兒奶粉中阪崎腸桿菌的檢測和分析,奶源性腸球菌的基因分型和檢測等。在參與的愛爾蘭地區豬源性MRSA的遺傳特性和耐藥特徵分析的研究項目中,通過對愛爾蘭地區來自不同養殖場和不同成熟段豬體內分離的MRSA的基因分型和耐藥性的檢測,表明愛爾蘭地區MRSA具有多重耐藥的特點,研究結果為加強愛爾蘭地區生豬養殖重點地區豬源MRSA的檢測和流行傳播機制的研究奠定了基礎。
截止目前已發表中英文文章25篇,其中SCI 23篇,累計影響因子超過70分,其中第一作者署名文章共10篇(累計影響因子34.78分)。

論著論文

(1) Juan Wang, Min Yuan, Hai Chen, Xia Chen, Yuanchun Jia, Xiong Zhu, Li Bai, Xue Bai, Séamus Fanning, Jinxing Lu, Juan Li*. First Report of Klebsiella Oxytoca Strain Simultaneously Producing NDM-1, IMP-4 and KPC-2 Carbapenemases. Antimicrobial Agents and Chemotherapy. 2017; 61(9): e00877-17. (影響因子:4.398,SCI二區,Top期刊)
(2) Juan Wang, Xianglei Li, Juan Li, Daniel Hurley, Xue Bai, Zhongyi Yu, Yu Cao, Ellen Wall, Séamus Fanning*, Li Bai*. Complete Genetic Analysis of A Salmonella Enterica Serovar Indiana Isolate Accompanying Four Plasmids Carrying mcr-1, ESBL and Other Resistance Genes in China. Veterinary Microbiology. 2017; 210:142-146. (影響因子:2.568,SCI二區,Top期刊)
(3) Li Bai#, Juan Wang#, Daniel Hurley, Zhongyi Yu, Lili Wang, Qian Chen, Juan Li, Fengqin Li and Séamus Fanning*. A novel disrupted mcr-1 gene and a lysogenized phage P-1 like sequence, cultured from a human atypical enteropathogenic Eschrichia coli (aEPEC) recovered in China. Journal of Antimicrobial Chemotherapy. 2017; 14-Jan:dkw564. (影響因子:5.101,SCI二區,Top期刊)
(4) Juan Wang, James Gibbons, Kathleen McGrath, Li Bai, Fengqin Li, Finola C. Leonard, Roger Stephan and Séamus Fanning*. Molecular characterization of blaESBL-producing Escherichia coli cultured from pig farms in Ireland. Journal of Antimicrobial Chemotherapy. 2016; 71: 3062-5. (影響因子:5.101,SCI二區,Top期刊)
(5) Juan Wang, Daniel Hurley, Kathleen McGrath, Li Bai, Herbert Hachler, Roger Stephan and Séamus Fanning*. Draft genome sequence of Escherichia coli 26R 793, a plasmid-free recipient strain commonly used in conjugation assays. Genome Announcement. 2016; 4(5): e00707-16. (線上開放期刊)
(6) Juan Wang, Roger Stephan, Katrin Zurfluh, Herbert Hächler and Séamus Fanning*. Characterization of the genetic environment of blaESBL genes, integrons and toxin-antitoxin systems identified on large transferrable plasmids in multi-drug resistant Escherichia coli. Frontiers in Microbiology. 2014; 6, 5:716. (影響因子:4.077,SCI二區)
(7) Juan Wang, Roger Stephan, Karen Power, Qiongqiong Yan, Herbert Hächler and Séamus Fanning*. Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans. Journal of Antimicrobial Chemotherapy. 2014; 69(10):2658-68. (影響因子:5.101,SCI二區,Top期刊)
(8) Karen Power#, Juan Wang#, Maria Karczmarczyk, Brenden Crowley, Meaghan Cotter, Pippa Haughton, Maureen Lynch, Kirsten Schaffer and Séamus Fanning*. Molecular analysis of OXA-48-carrying conjugative IncL/M-like plasmids in clinical isolates of Klebsiella pneumoniae in Ireland. Microbial Drug Resistance. 2014; 20(4):270-4. (影響因子:2.442,SCI三區)
(9) Maria Karczmarczyk#, Juan Wang#, Nola Leonard and Séamus Fanning*. Complete nucleotide sequence of a conjugative IncF plasmid from an Escherichia coli isolate of equine origin containing blaCMY-2 within a novel genetic context. FEMS Microbiology Letters. 2014; 352(1):123-7. (影響因子:1.915,SCI四區)
(10) Juan Wang, Roger Stephan, Maria Karczmarczyk, Qiongqiong Yan, Herbert Hächler and Séamus Fanning*. Molecular characterization of blaESBL-harboring conjugative plasmids identified in multi-drug resistant Escherichia coli isolated from food-producing animals and healthy humans. Frontiers in Microbiology. 2013; 11,4:188. (影響因子:4.077,SCI二區)
(11) Li Bai, Lili Wang, Xiaorong Yang, Juan Wang, Xin Gan, Wei Wang, Jin Xu, Qian Chen, Ruiting Lan, Séamus Fanning and Fengqin Li*. Prevalence and molecular characteristics of extended-spectrum β-lactamase genes in Escherichia coli isolated from diarrheic patients in China. Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy. 2017. 00144. (影響因子:4.077,SCI二區)
(12) Evan Brennan, Marta Martins, Matthew P. McCusker, Juan Wang, Bruno Martins Alves, Daniel Hurley, Farid El Garch, Frederique Woehrle, Christin Miossec, Leisha McGrath, Shabarinath Srikumar, Patrick Wall and Séamus Fanning*. Multidrug-resistant Escherichia coli in bovine animals, Europe. Emerging Infectious Diseases. 2016; 22(9): eid2209.160140. (影響因子:7.322,SCI一區,Top期刊)
(13) Li Bai, Daniel Hurley, Juan Li, Qiong Meng, Juan Wang, Séamus Fanning and Yanwen Xiong*. Characterisation of multidrug-resistant Shiga toxin-producing Escherichia coli cultured from pigs in China: co-occurrence of extended-spectrum β-lactamase- and mcr-1-encoding genes on plasmids. International Journal of Antimicrobial Agents. 2016;48(4):445-8. (影響因子:4.233,SCI二區)
(14) Li Bai, Jiayong Zhao, Xin Gan, Xiuli Zhang, Shenghui Cui, Shengli Xia, Yujie Hu, Shaofei Yan, Jiahui Wang, Juan Wang, Xiuli Zhang, Shenghui Cui, Shengli Xia, Yujie Hu, Shaofei Yan, Jiahui Wang, Fengqin Li, Séamus Fanning and Jin Xu*. Emergence and diversity of Salmonella enterica serovar Indiana isolates with concurrent resistance to ciprofloxacin and cefotaxime from patients and food-producing animals in China. Antimicrobial Agents and Chemotherapy. 2016; 60(6): 3365-71. (影響因子:4.398,SCI二區,Top期刊)
(15) Qiongqiong Yan, Juan Wang, Jayanthi Gangiredla, Yu Cao, Marta Martins, Gopal Gopinath, Roger Stephan, Keith Lampel, Ben Tall and Séamus Fanning*. Comparative genotypic and phenotypic analysis of Cronobacter species cultured from four powdered infant formula production facilities: indication of pathoadaptation along the food chain. Applied and Environmental Microbiology. 2015; 81(13):4388-402. (影響因子:3.766,SCI二區,Top期刊)
(16) Darren Carroll, Juan Wang, Séamus Fanning and Barry McMahon*. Antimicrobial resistance in wildlife: implications for public health. Zoonoses and Public Health. 2015; 62(7):534-42. (影響因子:2.422,SCI三區,Top期刊)
(17) Muhammad Nawaz, Chaofeng Ma, MAR Basra, Juan Wang, Jiru Xu*. Amelioration of ovalbumin induced allergic symptoms in Balb/c mice by potentially probiotic strains of lactobacilli. Beneficial Microbes. 2015; 6(5):669-78. (影響因子:2.946,SCI三區)
(18) Katrin Zurfluh, Karen Power, Jochen Klumpp, Juan Wang, Séamus Fanning and Roger Stephan*. A novel Tn3-like composite transposon harbouring blaVIM-1 in Klebsiella pneumonia spp. pneumonia isolated from river water. Microbial Drug Resistance. 2015; 21(1):43-9. (影響因子:2.442,SCI三區)
(19) Katrin Zurfluh, Juan Wang, Jochen Klumpp, Magdalena Nuesch-Inderbinen, Séamus Fanning and Roger Stephan*. Vertical transmission of highly similar blaCTX-M-1-harbouring IncI1 plasmids in Escherichia coli with different MLST types in the poultry production pyramid. Frontiers in Microbiology. 2014; 5:519. (影響因子:4.077,SCI二區)
(20) Ash Burns, Bryan Markey, Anna Shore, Marie Galligan, Julia Sabirova, James Gibbons, David Coleman, Malhotra Surbhi, John Egan, Séamus Fanning, Juan Wang and Nola Leonard*. A longitudinal study of Staphylococcus aureus colonization in pigs in Ireland. Veterinary Microbiology. 2014; 5;174(3-4):504-13. (影響因子:2.568,SCI二區,Top期刊)

科研項目

(1)國家自然科學基金青年基金項目: nik 基因影響 mcr-1 基因表達和傳播的作用及機制研究,26萬元,2018/01-2020/12
(2)陝西省博士後特別資助:多粘菌素耐藥基因播散機制的研究,15萬元,2017/02-2018/11
(3)中國博士後科學基金第十一批特別資助:鬆弛酶基因影響 mcr-1 基因表達和傳播的機制研究,15萬元,2018/04-2019/10
(4)中國博士後科學基金第六十一批面上項目:質粒編碼ESBLs類基因傳播分子機制及其適應性代價研究,5萬元,2017/02-2018/11
(5)中央高校基本科研業務費:9萬元,2017/05-2020/04
(6)陝西省引進博士資助經費:20萬元,2018/04-2021/03
(7)西北農林科技大學博士科研啟動經費:豬源性多重耐藥質粒的產生及跨種屬傳播機制,20萬元,2016/01-2018/12

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