王修啟，男，1968年3月生，華南農業大學研究員，博士生導師。美國動物科學學會會員、美國家禽學會會員。中國動物營養分會理事，中國動物生理生化分會理事。研究方向：① 成體幹細胞（腸道幹細胞和骨骼肌衛星細胞）；② 蛋白質代謝（胺基酸轉運、感應和蛋白質合成）；③ 功能性飼料添加劑。目前主持國家基金面上項目1項，十三五重點研發計畫項目子課題2項、廣州市國際合作項目1項、廣東省家禽產業技術體系營養崗位專家；先後完成國家基金重點項目， NSFC-廣東聯合基金重點項目、國家基金面上項目、973項目子課題2項、廣東省國際合作項目、廣東省重大科技專項，948重點項目課題、動物福利行業專項課題、廣東省科技計畫項目、教育廳重點項目、廣州市科學研究項目等科研課題。2011年以來發表SCI論文近50篇，已授權發明專利5項，在審發明專利9項。建立分子營養實驗室，共建“廣東省肉鴿產業科技創新中心”和“華農-快大豬營養研究中心”。圍繞嘔吐毒素、大腸桿菌耐熱腸毒素和溫熱應激等損傷豬腸道幹細胞發育的機制及其營養干預，取得突破性進展，居於國際領先水平。
基本介紹
- 中文名：王修啟
- 國籍：中國
- 民族：漢族
- 出生地：河南新鄉
- 出生日期：1968年3月
- 職業：華南農業大學研究員
學習工作簡歷,科研課題,學術成果,一、發表論文,二、科研成果,三、專利,四、學術兼職,五、國際交流合作,
學習工作簡歷
1990年本科畢業於河南農業大學（農學學士）；1994年碩士畢業於河南農業大學（理學碩士）；2003年獲得南京農業大學農學博士學位；2004-2006年，華南農業大學畜牧學博士後；2012年Texas A & M University訪問學者。1991年在河南省新鄉縣小冀鎮政府工作；1994-2004年，在河南省農業科學院畜牧獸醫研究所工作；2006年以來，供職於華南農業大學動物科學學院。
科研課題
(1) 2019.1-2022.12 國家自然科學基金面上項目——嘔吐毒素損傷豬腸道幹細胞發育的機制及營養干預(31872389)
(2) 2018.1-2020.12 十三五重點研發計畫——“日糧組成與飼養體制對畜禽健康優質肉形成調控及機制”子課題“肌纖維類型的形成規律與營養對其組成的調控”（2018YFD0500403）
(3) 2018.4-2020.3 廣州市國際合作項目——EAAT3介導谷氨酸轉運促進仔豬腸上皮發育的機制（201807010001）
(2) 2018.1-2020.12 十三五重點研發計畫——“日糧組成與飼養體制對畜禽健康優質肉形成調控及機制”子課題“肌纖維類型的形成規律與營養對其組成的調控”（2018YFD0500403）
(3) 2018.4-2020.3 廣州市國際合作項目——EAAT3介導谷氨酸轉運促進仔豬腸上皮發育的機制（201807010001）
(4) 2016.7-2020.12 十三五重點研發計畫——“環境影響畜禽生長免疫的生理機制”子課題“溫熱環境對豬腸道結構和功能的影響及機制(2016YFD0500501)”
(5) 2016.9-2020.12廣東省家禽產業技術體系創新團隊家禽營養崗位科學家（2016LM1116）
(6) 2016.1-2017.12 廣東省國際合作項目——豬骨骼肌衛星細胞遷移的分子機制及其調控（2016A050502045）
(7) 2015.1-2016.12 廣州市科學研究項目——mTOR信號通路調控豬骨骼肌衛星細胞增殖、生長和分化的分子機制（201510010020）
(8) 2014.1-2018.12 國家自然科學基金重點項目（共同PI）——“仔豬小腸上皮隱窩絨毛軸更新與蛋白質代謝的分子機制”(31330075)
(9) 2013.1-2017.12 973項目——“豬利用氮營養素的機制及營養調控”子課題“腸道黏膜胺基酸感應-轉運機制研究”（2013CB127302）
(10) 2013.1-2014.12 廣東省教育廳科技創新重點項目——“斷奶仔豬安全生產關鍵技術研究與示範”（2012CXZD0015）
(11) 2013.1-2015.12 廣東省科技廳項目——“斷奶仔豬高效生產關鍵技術研究”(2012B020305006)
(12) 2012.1-2016.12 973項目——“豬肌纖維發育與肌內脂肪沉積的機制及營養調控”子課題“豬骨骼肌mTOR信號通路網路解析”（2012CB124704）
(13) 2012.7-2015.6 廣東省星火計畫項目——“全進全出”制肉鴿養殖新模式關鍵技術集成與示範（2012A020603012）
(14) 2011.1-2015.12 948重點項目課題——“豬應激相關基因功能評價研究”（2011-G35）
(15) 2010.1-2014.12公益性行業(農業)科研專項——“畜禽福利養殖關鍵技術體系研究與示範”課題“豬雞福利養殖營養調控關鍵技術研究”（201003011）
(16) 2010.1-2013.12 NSFC-廣東省人民政府聯合基金項目——“廣東優質黃羽肉雞蛋白質代謝的分子機理及其調控”（U0931004）
(17) 2009.7-2012.6 廣東省重大科技專項——“粵東地區規模化豬場零排放關鍵技術集成研究與示範”(2009A080303009
學術成果
一、發表論文
1、2011年以來的SCI論文（* 通訊作者）：
(1) Zhou J. Y., Zhang S. W., Lin H. L., Gao C. Q., Yan H. C., Wang X. Q.*. Hydrolyzed Wheat Gluten Alleviates Deoxynivalenol-Induced Intestinal Injury by Promoting Intestinal Stem Cell Proliferation and Differentiation via Upregulation of Wnt/β-catenin Signaling in Mice. Food and Chemical Toxicology, 2019, Accepted. IF:3.977
(2) Xie W. Y., Fu Z., Pan N. X., Yan H. C., Wang X. Q.*, Gao C. Q.*. Leucine promotes the growth of squabs by increasing crop milk protein synthesis through the TOR signaling pathway in the domestic pigeon (Columba livia). 2019, Poultry Science, Accepted. IF: 2.216
(3) Liang S. J., Li X. G., Wang X. Q.*. Notch signaling in mammalian intestinal stem cells: maintaining homeostasis and determining cell fate. Current Stem Cell Research & Therapy. 2019, Accepted. IF：2.168
(4) Zhou J. Y., Huang D. G., Qin Y. C., Li X. G., Gao C. Q., Yan H. C., Wang X. Q.*. mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation. 2019, Journal of Cellular Physiology, 2019, DOI: 10.1002/jcp.28542. IF: 3.923
(5) Liang S. J., Chen M. X., Gao C. Q., Yan H. C., Zhang G. L., Wang X. Q.*. Sex identification of pigeons using polymerase chain reaction analysis with simple DNA extraction. Avian Biology Research. 2019, 12(2) ：45–48. IF：0.938
(6) Li X. G., Zhu M., Chen M. X., Fan H. B., Fu H. L., Zhou J. Y., Zhai Z. Y., Gao C. Q., Yan H. C., Wang X. Q.*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway.Toxicology Letters. 2019, 305:19-31. IF：3.166
(7) Jin C. L., Zhang Z. M., Ye J. L., Gao C. Q., Yan H. C., Li H. C., Yang J. Z., Wang X. Q.*. Lysine-induced swine satellite cell migration is mediated by the FAK pathway.Food& Function, 2019, 10, 583 - 591. IF: 3.289
(8) Jin C. L., Gao C. Q., Wang Q., Zhang Z. M., Xu Y. L., Li H. C., Yan H. C.*, Wang X. Q.*. Effects of pioglitazone hydrochloride and vitamin E on meat quality, antioxidant status and fatty acid profiles in finishing pigs. Meat Science. 2018，145：340-346. IF: 3.126
(9) Jin C. L., Wang, Q., Zhang, Z. M., Xu Y. L., Yan H. C., Li H. C., Gao C. Q., Wang X. Q.*. Dietary supplementation with pioglitazone hydrochloride and chromium-methionine improves growth performance, meat quality and antioxidant ability in finishing pigs. Journal of Agricultural and Food Chemistry. 2018, 66: 4345-4351. IF：3.154
(10) Li X. G., Wang Z., Chen R. Q., Fu H. L., Gao C. Q., Yan H. C., Xing G. X., Wang X. Q.*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/β-catenin signaling. International Journal of Molecular Sciences, 2018, 19(4), 1036 IF:3.226
(11) Gao C. Q., Xu Y. L., Jin C. L., Hu X. C., Li H. C., Yan H. C., Wang X. Q.*. Comparison of the differentiation capacity of skeletal muscle satellite cells in Lantang and Landrace piglets. Oncotarget, 2017, 8:43192-43200. IF：5.168
(12) Gupta P., Xie M. N., Narayanan S., Wang Y. J., Wang X. Q., Yuan T., Wang Z. Y., Yang D. H.,Chen Z.S.. GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-mediated Multidrug Resistance. Journal of Cellular Biochemistry, 2017, DOI 10.1002/jcb.25975 IF：3.368
(13) Zhang X. Y., Zhang Y. K., Wang Y. J., Gupta P., Zeng L. L., Xu M. G., Wang X. Q., Yang D. H., Chen Z. S.. Osimertinib (AZD9291), a mutant-selective EGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Molecules 21(9):1236 IF: 2.465
(14) Hu X. C., Gao C. Q., Wang X. H., Yan H. C., Wang X. Q.*. Crop milk protein is synthesized following activation of the Akt/mTOR signaling pathway in the domestic pigeon (Columba livia). British Poultry Science, 2016, 57(6): 855-862. IF：0.933
(15) Ye J. L., Gao C. Q., Li X. G., Jin C. L., Wang D., Wang W. C., Shu G., Kong X. F., Yao K., Yan H. C. , Wang X. Q.*. EAAT3 promotes amino acid transport and proliferation in porcine intestinal epithelial cells. Oncotarget, 2016, 7(25): 38681-38692. IF：6.359
(16) Wang D., Gao C. Q., Chen R. Q., Jin C. L., Li H. C., Yan H. C., Wang X. Q.*. Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells. Oncotarget, 2016, 7(21)：30845-30854. IF：6.359
(17) Li X. G., Xu G. F., Zhai Z. Y., Gao C. Q., Li . H. C., Yan H.C., Xi Q. Y., Guan W. T., Wang S. B., Wang X. Q.*. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget, 2016,7(21)：30597-30609. IF：6.359
(18) Li X. G., Sui W. G., Gao C. Q., Yan H. C., Yin Y. L ., Li H. C., Wang X. Q.*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science, 2016, 94(4):1541–1549. IF: 2.108
(19) Chen M. X.， Li X. G., Yan H. C., Wang X. Q.*, Gao C. Q.. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Colum ba livia). Poultry Science, 2016, 95(6):1425-1432. IF：1.672
(20) Gao C. Q., Yang J. X., Chen M. X., Yan H. C., Wang X. Q.*. Growth curves and age-related changes in carcass characteristics, organs, serum parameters, and intestinal transporter gene expression in domestic pigeon (Columba livia). Poultry Science, 2016, 95:867–877. IF：1.672
(21) Gao C. Q., Zhang H. J., Yan H. C., Yuan L., Dahanayaka S., Li H. C., Wang X. Q.*.Satellite cells isolated from skeletal muscle with proliferate faster in wens yellow feather chicks. Animal Science Journal,2016, 87: 126–133 IF：1.044
(22) Chen M. X.,Li X. G., , Yang J.X., Gao C. Q.,Wang X. Q.*, Yan H. C.. The growth of embryo and gene expression of nutrient transporters in the small intestine of domestic pigeon (Columba livia). Journal of Zhejiang University-SCIENCE B, 2015, 16(6):511-523. IF: 1.293
(23) Gao C. Q., Zhao Y. L., Li H. C., Sui W. G., Yan H. C., Wang X. Q.*. Heat stress inhibits proliferation, promotes growth and induces apoptosis in cultured lantang swine skeletal muscle satellite cells. Journal of Zhejiang University-SCIENCE B 2015, 16(6):549-559.IF: 1.293
(24) Gao C. Q., Zhi R., Yang Z., Li H. C., Yan H. C., Wang X. Q.*. Low dose of IGF-I increases cell size of skeletal muscle satellite cells via Akt/S6K signaling pathway. Journal of Cellular Biochemistry, 2015, 116:2637–2648IF：3.368
(25) Lv Y. F.,Tang C. H., Wang X. Q., Zhao Q. Y., Zhang J. M.. Effects of dietary supplementation with palygorskite on nutrientutilization in weaned piglets. Livestock Science, 2015, 174: 82–86. IF: 1.100
(26) Wang L. N., Chen X. L., Li X. G., Shu G., Yan H. C., Wang X. Q.*. Evaluation of adrenocorticotropin regulated glucocorticoid synthesis pathway in adrenal of different breeds of pigs. Livestock Science, 2014, 169:185-191. IF: 1.100
(27) Li C. M., Yan H.C., Fu H. L., Xu G. F., Wang X. Q.*.Molecular cloning, sequence analysis and function of the intestinal epithelial stem cell marker bmi1 in pig intestinal epithelial cells.Journal of Animal Science. 2014, 92(1): 85-94. IF: 1.920
(28) Tang C. H.#, Wang X. Q.#, Zhang J. M.. Effects of supplemental palygorskite instead of zinc oxide on growth performance, apparent nutrition digestibiliyt and fecal zinc excretion in weaned piglets. Animal Science Journal. 2014, 85(4): 435-439. IF: 1.044
(29) Li X. G., Sui W. G., Yan H.C., Jiang Q. Y., Wang X. Q.*. The in ovo administration of L-trans pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) selectively regulates small intestinal growth in chicks. Animal, 2014, 8(10): 1677–1683. IF: 1.784
(30) Wu D.,Zhang J. M., Wang X. Q. , Deng L. Q. , Li L. J.. Effect of phytase transgenic corn on growth performance and calcium and phosphorus utilization in broilers. The Journal of Poultry Science, 2014, 51(1): 29-34. IF:0.787
(31) Chen X., Wang X. Q.*, Feng, Y., Yang W. J., Shu G., Jiang, Q. Y., Yuan L. Effects of dietary thiazolidinedione supplementation on growth performance, intramuscular fat and related genes expression in the longissimusdorsi muscle of finishing pigs. Asian-Australasian Journal of Animal Sciences，2013, 26(7):1012-1020.IF: 0.563
(32) Zeng P. L., Yan H. C., Wang X. Q.*, Zhang C. M., Zhu C., Shu G., Jiang Q. Y.. Effects of dietary lysine levels on apparent nutrient digestibility and serum amino acid absorption mode in growing pigs. Asian-Australasian Journal of Animal Sciences，2013, 26(7):1003-1011.IF: 0.563
(33) Wang S., Zhang J. M., Wang X. Q.*. The effect of dietary supplementation with phytase transgenic corn and different levels of non-phytate phosphorus on the performance of laying hens. British Poultry Science, 2013, (54)4: 466–470. IF：0.782
(34) WangX. Q., Jiang W., Tan H. Z., Zhang D. X., Zhang H. J., Wei S., Yan H. C..Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of TOR signaling pathway of female broiler chickens. Journal of Animal Physiology and Animal Nutrition, 2013, 97(4):797-806.IF：1.317
(35) Chen X., Jiang W., Tan H. Z., Xu G. F., Zhang X. B., Wei S., Wang X. Q. *. Effects of outdoor access on growth performance and meat characteristics of broiler chickens. Poultry Science, 2013，92（2）：435-443. IF：1.544
(36) Li X. G., Chen X. L.Wang X. Q.*. Changes in relative organ weights and intestinal transporter gene expression in embryos from white Plymouth rock and Wens yellow feather chickens. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2013，164（2）：368-375. IF：2.371
(37) Wang X. Q., Chen X., Tan H. Z.,Zhang D. X.,Zhang H. J., Wei S.,Yan H. C.. Nutrient density and slaughter age have differential effects on carcase performance, muscle and meat quality in fast and slow growing broiler genotypes. British Poultry Science, 2013，54（1）：50-61. IF：0.782
(38) Zhang J. M., Lv Y. F., Tang C. H., Wang X. Q.. Effects of dietary supplementation with palygorskite on intestinal integrity in weaned piglets. Applied Clay Science, 2013, (86) 185–189. IF: 2.703
(39) Wang X. Q., Yang W. J., Yang Z, Shu G., Wang S. B., Jiang Q. Y., Yuan L., Wu T. S. .The differential proliferative ability of satellite cells in Lantang and Landrace pigs. PLoS ONE. 2012, 7(3): e32537. IF: 3.534
(40) WangX. Q., Zeng P. L., Feng Y., Zhang C. M., Yang J. P., Shu G., Jiang Q. Y. Effects of dietary lysine levels on apparent nutrient digestibility and cationic amino acid transporter mRNA abundance in the small intestine of finishing pigs, Susscrofa. Animal Science Journal. 2012，83: 148-155. IF：1.044
(41) Yang L. H., Lin H. D., Xi Q. Y., Ding J. H., Liu X. L., Shu G., Jiang Q. Y., Wang X. Q.*, Zhang Y. L.. Polyantibody against β2-adrenergic receptor extracellular domain act as an agonist to this receptor in porcine model. Livestock Science. 2012,150 (1-3) 248-255. IF:1.100
(42) Shu G., Liao W. Y., Feng J. Y., Yu K. F., Zhai Y. F., Wang S. B., Khondowe P., Wang X. Q.*, JiangQ. Y.. Active immunization of fatty acid translocase specifically decreased visceral fat deposition in male broilers. Poultry Science, 2011，90（11）：2557-2564.IF：1.544
(43) Zeng P. L., Li X. G., Wang X. Q.*, Zhang D. X., Shu G., Luo Q. B.. The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration. Poultry Science, 2011， 90（11）：2548-2556.IF：1.544
(44) Wang X. Q., Feng Y., Shu G., Jiang Q. Y., Yang J. P., Zhang Z. F. Effect of dietary supplementation with hydrolyzed wheat gluten on growth performance, cell immunity and serum biochemical indices of weaned piglets (Susscrofa). Agricultural Sciences in China, 2011,10(6):938-945.IF：0.625
(45) Wang X. Q., Wang S., Zhang J. M., Yang J. P. The effect of dietary supplementation with phytase transgenic corn on growth performance, phosphorus utilization and excretion in growing pigs (Susscrofa). Agricultural Sciences in China,2011,10(5): 769-776.IF：0.625
(1) Zhou J. Y., Zhang S. W., Lin H. L., Gao C. Q., Yan H. C., Wang X. Q.*. Hydrolyzed Wheat Gluten Alleviates Deoxynivalenol-Induced Intestinal Injury by Promoting Intestinal Stem Cell Proliferation and Differentiation via Upregulation of Wnt/β-catenin Signaling in Mice. Food and Chemical Toxicology, 2019, Accepted. IF:3.977
(2) Xie W. Y., Fu Z., Pan N. X., Yan H. C., Wang X. Q.*, Gao C. Q.*. Leucine promotes the growth of squabs by increasing crop milk protein synthesis through the TOR signaling pathway in the domestic pigeon (Columba livia). 2019, Poultry Science, Accepted. IF: 2.216
(3) Liang S. J., Li X. G., Wang X. Q.*. Notch signaling in mammalian intestinal stem cells: maintaining homeostasis and determining cell fate. Current Stem Cell Research & Therapy. 2019, Accepted. IF：2.168
(4) Zhou J. Y., Huang D. G., Qin Y. C., Li X. G., Gao C. Q., Yan H. C., Wang X. Q.*. mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation. 2019, Journal of Cellular Physiology, 2019, DOI: 10.1002/jcp.28542. IF: 3.923
(5) Liang S. J., Chen M. X., Gao C. Q., Yan H. C., Zhang G. L., Wang X. Q.*. Sex identification of pigeons using polymerase chain reaction analysis with simple DNA extraction. Avian Biology Research. 2019, 12(2) ：45–48. IF：0.938
(6) Li X. G., Zhu M., Chen M. X., Fan H. B., Fu H. L., Zhou J. Y., Zhai Z. Y., Gao C. Q., Yan H. C., Wang X. Q.*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway.Toxicology Letters. 2019, 305:19-31. IF：3.166
(7) Jin C. L., Zhang Z. M., Ye J. L., Gao C. Q., Yan H. C., Li H. C., Yang J. Z., Wang X. Q.*. Lysine-induced swine satellite cell migration is mediated by the FAK pathway.Food& Function, 2019, 10, 583 - 591. IF: 3.289
(8) Jin C. L., Gao C. Q., Wang Q., Zhang Z. M., Xu Y. L., Li H. C., Yan H. C.*, Wang X. Q.*. Effects of pioglitazone hydrochloride and vitamin E on meat quality, antioxidant status and fatty acid profiles in finishing pigs. Meat Science. 2018，145：340-346. IF: 3.126
(9) Jin C. L., Wang, Q., Zhang, Z. M., Xu Y. L., Yan H. C., Li H. C., Gao C. Q., Wang X. Q.*. Dietary supplementation with pioglitazone hydrochloride and chromium-methionine improves growth performance, meat quality and antioxidant ability in finishing pigs. Journal of Agricultural and Food Chemistry. 2018, 66: 4345-4351. IF：3.154
(10) Li X. G., Wang Z., Chen R. Q., Fu H. L., Gao C. Q., Yan H. C., Xing G. X., Wang X. Q.*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/β-catenin signaling. International Journal of Molecular Sciences, 2018, 19(4), 1036 IF:3.226
(11) Gao C. Q., Xu Y. L., Jin C. L., Hu X. C., Li H. C., Yan H. C., Wang X. Q.*. Comparison of the differentiation capacity of skeletal muscle satellite cells in Lantang and Landrace piglets. Oncotarget, 2017, 8:43192-43200. IF：5.168
(12) Gupta P., Xie M. N., Narayanan S., Wang Y. J., Wang X. Q., Yuan T., Wang Z. Y., Yang D. H.,Chen Z.S.. GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-mediated Multidrug Resistance. Journal of Cellular Biochemistry, 2017, DOI 10.1002/jcb.25975 IF：3.368
(13) Zhang X. Y., Zhang Y. K., Wang Y. J., Gupta P., Zeng L. L., Xu M. G., Wang X. Q., Yang D. H., Chen Z. S.. Osimertinib (AZD9291), a mutant-selective EGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Molecules 21(9):1236 IF: 2.465
(14) Hu X. C., Gao C. Q., Wang X. H., Yan H. C., Wang X. Q.*. Crop milk protein is synthesized following activation of the Akt/mTOR signaling pathway in the domestic pigeon (Columba livia). British Poultry Science, 2016, 57(6): 855-862. IF：0.933
(15) Ye J. L., Gao C. Q., Li X. G., Jin C. L., Wang D., Wang W. C., Shu G., Kong X. F., Yao K., Yan H. C. , Wang X. Q.*. EAAT3 promotes amino acid transport and proliferation in porcine intestinal epithelial cells. Oncotarget, 2016, 7(25): 38681-38692. IF：6.359
(16) Wang D., Gao C. Q., Chen R. Q., Jin C. L., Li H. C., Yan H. C., Wang X. Q.*. Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells. Oncotarget, 2016, 7(21)：30845-30854. IF：6.359
(17) Li X. G., Xu G. F., Zhai Z. Y., Gao C. Q., Li . H. C., Yan H.C., Xi Q. Y., Guan W. T., Wang S. B., Wang X. Q.*. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget, 2016,7(21)：30597-30609. IF：6.359
(18) Li X. G., Sui W. G., Gao C. Q., Yan H. C., Yin Y. L ., Li H. C., Wang X. Q.*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science, 2016, 94(4):1541–1549. IF: 2.108
(19) Chen M. X.， Li X. G., Yan H. C., Wang X. Q.*, Gao C. Q.. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Colum ba livia). Poultry Science, 2016, 95(6):1425-1432. IF：1.672
(20) Gao C. Q., Yang J. X., Chen M. X., Yan H. C., Wang X. Q.*. Growth curves and age-related changes in carcass characteristics, organs, serum parameters, and intestinal transporter gene expression in domestic pigeon (Columba livia). Poultry Science, 2016, 95:867–877. IF：1.672
(21) Gao C. Q., Zhang H. J., Yan H. C., Yuan L., Dahanayaka S., Li H. C., Wang X. Q.*.Satellite cells isolated from skeletal muscle with proliferate faster in wens yellow feather chicks. Animal Science Journal,2016, 87: 126–133 IF：1.044
(22) Chen M. X.,Li X. G., , Yang J.X., Gao C. Q.,Wang X. Q.*, Yan H. C.. The growth of embryo and gene expression of nutrient transporters in the small intestine of domestic pigeon (Columba livia). Journal of Zhejiang University-SCIENCE B, 2015, 16(6):511-523. IF: 1.293
(23) Gao C. Q., Zhao Y. L., Li H. C., Sui W. G., Yan H. C., Wang X. Q.*. Heat stress inhibits proliferation, promotes growth and induces apoptosis in cultured lantang swine skeletal muscle satellite cells. Journal of Zhejiang University-SCIENCE B 2015, 16(6):549-559.IF: 1.293
(24) Gao C. Q., Zhi R., Yang Z., Li H. C., Yan H. C., Wang X. Q.*. Low dose of IGF-I increases cell size of skeletal muscle satellite cells via Akt/S6K signaling pathway. Journal of Cellular Biochemistry, 2015, 116:2637–2648IF：3.368
(25) Lv Y. F.,Tang C. H., Wang X. Q., Zhao Q. Y., Zhang J. M.. Effects of dietary supplementation with palygorskite on nutrientutilization in weaned piglets. Livestock Science, 2015, 174: 82–86. IF: 1.100
(26) Wang L. N., Chen X. L., Li X. G., Shu G., Yan H. C., Wang X. Q.*. Evaluation of adrenocorticotropin regulated glucocorticoid synthesis pathway in adrenal of different breeds of pigs. Livestock Science, 2014, 169:185-191. IF: 1.100
(27) Li C. M., Yan H.C., Fu H. L., Xu G. F., Wang X. Q.*.Molecular cloning, sequence analysis and function of the intestinal epithelial stem cell marker bmi1 in pig intestinal epithelial cells.Journal of Animal Science. 2014, 92(1): 85-94. IF: 1.920
(28) Tang C. H.#, Wang X. Q.#, Zhang J. M.. Effects of supplemental palygorskite instead of zinc oxide on growth performance, apparent nutrition digestibiliyt and fecal zinc excretion in weaned piglets. Animal Science Journal. 2014, 85(4): 435-439. IF: 1.044
(29) Li X. G., Sui W. G., Yan H.C., Jiang Q. Y., Wang X. Q.*. The in ovo administration of L-trans pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) selectively regulates small intestinal growth in chicks. Animal, 2014, 8(10): 1677–1683. IF: 1.784
(30) Wu D.,Zhang J. M., Wang X. Q. , Deng L. Q. , Li L. J.. Effect of phytase transgenic corn on growth performance and calcium and phosphorus utilization in broilers. The Journal of Poultry Science, 2014, 51(1): 29-34. IF:0.787
(31) Chen X., Wang X. Q.*, Feng, Y., Yang W. J., Shu G., Jiang, Q. Y., Yuan L. Effects of dietary thiazolidinedione supplementation on growth performance, intramuscular fat and related genes expression in the longissimusdorsi muscle of finishing pigs. Asian-Australasian Journal of Animal Sciences，2013, 26(7):1012-1020.IF: 0.563
(32) Zeng P. L., Yan H. C., Wang X. Q.*, Zhang C. M., Zhu C., Shu G., Jiang Q. Y.. Effects of dietary lysine levels on apparent nutrient digestibility and serum amino acid absorption mode in growing pigs. Asian-Australasian Journal of Animal Sciences，2013, 26(7):1003-1011.IF: 0.563
(33) Wang S., Zhang J. M., Wang X. Q.*. The effect of dietary supplementation with phytase transgenic corn and different levels of non-phytate phosphorus on the performance of laying hens. British Poultry Science, 2013, (54)4: 466–470. IF：0.782
(34) WangX. Q., Jiang W., Tan H. Z., Zhang D. X., Zhang H. J., Wei S., Yan H. C..Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of TOR signaling pathway of female broiler chickens. Journal of Animal Physiology and Animal Nutrition, 2013, 97(4):797-806.IF：1.317
(35) Chen X., Jiang W., Tan H. Z., Xu G. F., Zhang X. B., Wei S., Wang X. Q. *. Effects of outdoor access on growth performance and meat characteristics of broiler chickens. Poultry Science, 2013，92（2）：435-443. IF：1.544
(36) Li X. G., Chen X. L.Wang X. Q.*. Changes in relative organ weights and intestinal transporter gene expression in embryos from white Plymouth rock and Wens yellow feather chickens. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2013，164（2）：368-375. IF：2.371
(37) Wang X. Q., Chen X., Tan H. Z.,Zhang D. X.,Zhang H. J., Wei S.,Yan H. C.. Nutrient density and slaughter age have differential effects on carcase performance, muscle and meat quality in fast and slow growing broiler genotypes. British Poultry Science, 2013，54（1）：50-61. IF：0.782
(38) Zhang J. M., Lv Y. F., Tang C. H., Wang X. Q.. Effects of dietary supplementation with palygorskite on intestinal integrity in weaned piglets. Applied Clay Science, 2013, (86) 185–189. IF: 2.703
(39) Wang X. Q., Yang W. J., Yang Z, Shu G., Wang S. B., Jiang Q. Y., Yuan L., Wu T. S. .The differential proliferative ability of satellite cells in Lantang and Landrace pigs. PLoS ONE. 2012, 7(3): e32537. IF: 3.534
(40) WangX. Q., Zeng P. L., Feng Y., Zhang C. M., Yang J. P., Shu G., Jiang Q. Y. Effects of dietary lysine levels on apparent nutrient digestibility and cationic amino acid transporter mRNA abundance in the small intestine of finishing pigs, Susscrofa. Animal Science Journal. 2012，83: 148-155. IF：1.044
(41) Yang L. H., Lin H. D., Xi Q. Y., Ding J. H., Liu X. L., Shu G., Jiang Q. Y., Wang X. Q.*, Zhang Y. L.. Polyantibody against β2-adrenergic receptor extracellular domain act as an agonist to this receptor in porcine model. Livestock Science. 2012,150 (1-3) 248-255. IF:1.100
(42) Shu G., Liao W. Y., Feng J. Y., Yu K. F., Zhai Y. F., Wang S. B., Khondowe P., Wang X. Q.*, JiangQ. Y.. Active immunization of fatty acid translocase specifically decreased visceral fat deposition in male broilers. Poultry Science, 2011，90（11）：2557-2564.IF：1.544
(43) Zeng P. L., Li X. G., Wang X. Q.*, Zhang D. X., Shu G., Luo Q. B.. The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration. Poultry Science, 2011， 90（11）：2548-2556.IF：1.544
(44) Wang X. Q., Feng Y., Shu G., Jiang Q. Y., Yang J. P., Zhang Z. F. Effect of dietary supplementation with hydrolyzed wheat gluten on growth performance, cell immunity and serum biochemical indices of weaned piglets (Susscrofa). Agricultural Sciences in China, 2011,10(6):938-945.IF：0.625
(45) Wang X. Q., Wang S., Zhang J. M., Yang J. P. The effect of dietary supplementation with phytase transgenic corn on growth performance, phosphorus utilization and excretion in growing pigs (Susscrofa). Agricultural Sciences in China,2011,10(5): 769-776.IF：0.625
2、國際會議論文
(1) Jin C. L., Gao C. Q., Zhang Z. M., Yan H. C., Wang X. Q.*. Lysineinduced stimulation of proliferation, differentiation and migration in swine satellite cells is mediated by the mTORC1 and FAK pathways. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(2) Jin C. L., Gao C. Q., Wang Q., Yan H. C., Wang X. Q.*. Pioglitazone hydrochloride combined with vitamin e or chromiummethionine improves meat quality and muscle antioxidant ability in finishing pigs. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(3) Zhou J. Y., Li X. G., Gao C. Q., Yan H. C., Wang X. Q.*. Heat exposure inhibits the proliferation and expansion of porcine intestinal epithelial cells and stem cells by down-regulating the Wnt/β-catenin pathway. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(4) Li X. G., Zhu M., Chen M. X., Zhou J. Y., Gao C. Q., Yan H. C., Wang X. Q.*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity and Wnt/β-catenin pathway. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(5) Gao C. Q., Jin C. L., Yan H. C., Wang X. Q.*. FAK-mTOR pathway mediated different proliferation, migration and differentiation abilities of satellite cells in Lantang and Landrace piglets. 2017 ASAS-CSAS Annual Meeting & Trade Show. 2017, July 8-12, Baltimore, Maryland, USA.
(6) Li X. G., Chen R. Q., Gao C.Q., Chen M. X., Yan H. C., Wang X. Q.*. Bmi1 or Lgr5 promote proliferation of porcine intestinal epithelial cells by activating Wnt/β-catenin signaling pathway. 5th Symposium on Gut Health in Production of Food Animals, 2016.11
(7) Zhu M., Ye J. L., Gao C.Q., Li X. G., Sui W. G., Yan H. C., Wang X. Q.*. EAAT3 regulates proliferation of porcine intestinal epithelial cells through the mammalian target of rapamycin pathway. 5th Symposium on Gut Health in Production of Food Animals, 2016.11
(8) Li X. G. ，Sui W. G.，Fan H. B.，Gao C. Q.，Yan H. C.，Wang X. Q.*. Glutamate availability regulates IPEC-1 cell proliferation and crude protein digestibility in piglets，14th International Congress on Amino Acids, Peptides and Proteins，617-617，2015.8.3-2015.8.7
(9) Gao C. Q. ，Chen M. X.，Yang J. X.，Li X. G.，Yan H. C.，Wang X. Q.*. The relationship between gene expression of intestinal nutrient transporters and growth of pigeon (Columba livia) during pre- and posthatch development，14th International Congress on Amino Acids, Peptides and Proteins，617-618，2015.8.3-2015.8.7
(10) Gao C. Q., Xu G. F.，Yan H. C.，Wang X. Q.*.Molecular cloning and functional characterization of the caudal type homeobox transcription factor 2 (CDX2) in pig intestinal epithelial cells，14th International Congress on Amino Acids, Peptides and Proteins，617-617，2015.8.3-2015.8.7
(11) Li X.G.，Wang X. Q.*. The relationship between excitatory amino acid transporter 3 and the growth of small intestine in chick embryos，13th International Congress on Amino Acids, Peptides and Proteins，612-612，2013.10.5-2013.10.7
(1) Jin C. L., Gao C. Q., Zhang Z. M., Yan H. C., Wang X. Q.*. Lysineinduced stimulation of proliferation, differentiation and migration in swine satellite cells is mediated by the mTORC1 and FAK pathways. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(2) Jin C. L., Gao C. Q., Wang Q., Yan H. C., Wang X. Q.*. Pioglitazone hydrochloride combined with vitamin e or chromiummethionine improves meat quality and muscle antioxidant ability in finishing pigs. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(3) Zhou J. Y., Li X. G., Gao C. Q., Yan H. C., Wang X. Q.*. Heat exposure inhibits the proliferation and expansion of porcine intestinal epithelial cells and stem cells by down-regulating the Wnt/β-catenin pathway. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(4) Li X. G., Zhu M., Chen M. X., Zhou J. Y., Gao C. Q., Yan H. C., Wang X. Q.*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity and Wnt/β-catenin pathway. 2018 ASAS-CSAS Annual Meeting & Trade Show. 2018, July 8-12, Vancouver, British Columbia, Canada.
(5) Gao C. Q., Jin C. L., Yan H. C., Wang X. Q.*. FAK-mTOR pathway mediated different proliferation, migration and differentiation abilities of satellite cells in Lantang and Landrace piglets. 2017 ASAS-CSAS Annual Meeting & Trade Show. 2017, July 8-12, Baltimore, Maryland, USA.
(6) Li X. G., Chen R. Q., Gao C.Q., Chen M. X., Yan H. C., Wang X. Q.*. Bmi1 or Lgr5 promote proliferation of porcine intestinal epithelial cells by activating Wnt/β-catenin signaling pathway. 5th Symposium on Gut Health in Production of Food Animals, 2016.11
(7) Zhu M., Ye J. L., Gao C.Q., Li X. G., Sui W. G., Yan H. C., Wang X. Q.*. EAAT3 regulates proliferation of porcine intestinal epithelial cells through the mammalian target of rapamycin pathway. 5th Symposium on Gut Health in Production of Food Animals, 2016.11
(8) Li X. G. ，Sui W. G.，Fan H. B.，Gao C. Q.，Yan H. C.，Wang X. Q.*. Glutamate availability regulates IPEC-1 cell proliferation and crude protein digestibility in piglets，14th International Congress on Amino Acids, Peptides and Proteins，617-617，2015.8.3-2015.8.7
(9) Gao C. Q. ，Chen M. X.，Yang J. X.，Li X. G.，Yan H. C.，Wang X. Q.*. The relationship between gene expression of intestinal nutrient transporters and growth of pigeon (Columba livia) during pre- and posthatch development，14th International Congress on Amino Acids, Peptides and Proteins，617-618，2015.8.3-2015.8.7
(10) Gao C. Q., Xu G. F.，Yan H. C.，Wang X. Q.*.Molecular cloning and functional characterization of the caudal type homeobox transcription factor 2 (CDX2) in pig intestinal epithelial cells，14th International Congress on Amino Acids, Peptides and Proteins，617-617，2015.8.3-2015.8.7
(11) Li X.G.，Wang X. Q.*. The relationship between excitatory amino acid transporter 3 and the growth of small intestine in chick embryos，13th International Congress on Amino Acids, Peptides and Proteins，612-612，2013.10.5-2013.10.7
二、科研成果
1.“肉鴿產業化新模式關鍵技術研究與示範”（第1完成人）， 2011年完成廣東省成果登記：粵科成登字20110055
2.肉鴿養殖“2+4”生產模式創新體系研究與示範（第1完成人），2010年度廣東省農業技術推廣獎3等獎
3.“小麥抗營養因子降解技術及小麥配合飼料研究與產業化開發”， 2003年河南省科技進步2等獎（第3完成人）
三、專利
1、授權發明專利:
(1) 王修啟，嚴會超，高春起，陳榮強，李長茂. 一種豬Lgr5基因及其套用. 專利號：ZL 2015100826586.
(2) 黎相廣，王喆，王修啟，高春起，嚴會超，傅厚龍，翟振亞，陳明霞. 一種豬腸道幹細胞的分離培養方法. 專利號：ZL 2015100829669
(3) 王喆，王修啟，黎相廣，高春起，嚴會超，傅厚龍，陳明霞，翟振亞，范宏博. 一種豬腸道隱窩的分離液及其分離方法. 專利號：ZL 201510080396X.
(4) 王修啟，嚴會超. 一種環保減排的斷奶仔豬飼料及其製備方法和套用. 專利號：ZL 201410405570.9
(5) 王修啟，束剛，江青艷，馮幼，陳鑫. 鹽酸吡格列酮在禽畜飼料添加劑中的套用. 專利號：ZL200910214549X
(1) 王修啟，嚴會超，高春起，陳榮強，李長茂. 一種豬Lgr5基因及其套用. 專利號：ZL 2015100826586.
(2) 黎相廣，王喆，王修啟，高春起，嚴會超，傅厚龍，翟振亞，陳明霞. 一種豬腸道幹細胞的分離培養方法. 專利號：ZL 2015100829669
(3) 王喆，王修啟，黎相廣，高春起，嚴會超，傅厚龍，陳明霞，翟振亞，范宏博. 一種豬腸道隱窩的分離液及其分離方法. 專利號：ZL 201510080396X.
(4) 王修啟，嚴會超. 一種環保減排的斷奶仔豬飼料及其製備方法和套用. 專利號：ZL 201410405570.9
(5) 王修啟，束剛，江青艷，馮幼，陳鑫. 鹽酸吡格列酮在禽畜飼料添加劑中的套用. 專利號：ZL200910214549X
2、申請發明專利
(1) 王修啟，周加義，高春起，嚴會超，張賽武，林華林. 谷氨酸結合肽在製備緩解動物嘔吐毒素誘導的腸道損傷的製劑中的套用. 申請號：201910173215.6
(2) 王修啟，周加義，高春起，嚴會超，黃登桂，秦穎超，張賽武. L-天冬氨酸鋅在製備促進動物腸道發育和緩解腸道損傷製劑中的套用. 申請號：201810615137.6
(3) 周加義，王喆，李昊恩，黃登桂，高春起，嚴會超，王修啟. 一種緩解動物嘔吐毒素腸道損傷的保護劑. 申請號：201810162551.6
(4) 王修啟，高春起，嚴會超，金成龍，王強，譚會澤，張祥斌，王連想.鹽酸吡格列酮和維生素E在肥育豬飼料添加劑方面的套用. 申請號：201710404098.0
(5) 王修啟，嚴會超，高春起，金成龍，王強，譚會澤，張祥斌，王連想.鹽酸吡格列酮和蛋氨酸鉻在肥育豬飼料添加劑方面的套用. 申請號：201710404095.7
(6) 金成龍，王修啟，高春起，嚴會超，王紅. 鹽酸吡格列酮和賴氨酸在肥育豬飼料添加劑方面的套用. 申請號：201710158015.4
(7) 高春起，王修啟，金成龍，嚴會超. 亮氨酸在促進種鴿鴿乳分泌和乳鴿生長方面的套用. 申請號：201710181223.6
(8) 王修啟，梁少傑，陳明霞，高春起，嚴會超. 一種用於鑑定鴿子性別的引物，試劑盒及其鑑別方法. 申請號：2016103207489.
(9) 黎相廣，王修啟，高春起，嚴會超，朱敏，周加義. 一種促進豬腸道隱窩細胞體外擴增的培養基及其培養方法. 申請號：201610826211.X
(1) 王修啟，周加義，高春起，嚴會超，張賽武，林華林. 谷氨酸結合肽在製備緩解動物嘔吐毒素誘導的腸道損傷的製劑中的套用. 申請號：201910173215.6
(2) 王修啟，周加義，高春起，嚴會超，黃登桂，秦穎超，張賽武. L-天冬氨酸鋅在製備促進動物腸道發育和緩解腸道損傷製劑中的套用. 申請號：201810615137.6
(3) 周加義，王喆，李昊恩，黃登桂，高春起，嚴會超，王修啟. 一種緩解動物嘔吐毒素腸道損傷的保護劑. 申請號：201810162551.6
(4) 王修啟，高春起，嚴會超，金成龍，王強，譚會澤，張祥斌，王連想.鹽酸吡格列酮和維生素E在肥育豬飼料添加劑方面的套用. 申請號：201710404098.0
(5) 王修啟，嚴會超，高春起，金成龍，王強，譚會澤，張祥斌，王連想.鹽酸吡格列酮和蛋氨酸鉻在肥育豬飼料添加劑方面的套用. 申請號：201710404095.7
(6) 金成龍，王修啟，高春起，嚴會超，王紅. 鹽酸吡格列酮和賴氨酸在肥育豬飼料添加劑方面的套用. 申請號：201710158015.4
(7) 高春起，王修啟，金成龍，嚴會超. 亮氨酸在促進種鴿鴿乳分泌和乳鴿生長方面的套用. 申請號：201710181223.6
(8) 王修啟，梁少傑，陳明霞，高春起，嚴會超. 一種用於鑑定鴿子性別的引物，試劑盒及其鑑別方法. 申請號：2016103207489.
(9) 黎相廣，王修啟，高春起，嚴會超，朱敏，周加義. 一種促進豬腸道隱窩細胞體外擴增的培養基及其培養方法. 申請號：201610826211.X
四、學術兼職
國家生豬產業技術創新戰略聯盟副理事長；中國畜牧獸醫學會動物營養學分會理事、動物生理生化分會理事；美國動物科學和家禽科學學會會員；中國畜牧業協會鴿業分會常務理事；廣東省博士後聯誼會理事。SciTz Stem Cells Research & Therapy, Journal of Biochemistry and Molecular Biology Research, The Open Nutrition Journal等國際期刊編委；Animal,British Journal of Nutrition, Journal of Animal Science, Amino Acids, Genes and Nutrition, Cell Proliferation, The Journal of Animal Physiology and Animal Nutrition, Poultry Science, British Poultry Science, The Journal of Poultry Science, Annals of Animal Science, Journal of Integrative Agriculture, Molecular and Cellular Biochemistry, Oncotarget, Food&Function，Asian-Australasian Journal of Animal Sciences, Czech Journal of Animal Science, CyTA - Journal of Food，Animal Production Science等國際期刊審稿專家。
五、國際交流合作
參加2017年美國動物科學學會會議（巴爾的摩）、2016年美國密蘇里州聖路易斯5th食用動物腸道健康論壇、2013年在Texas舉辦的13th ICAPP學術會議，2010AAAP（台灣屏東）、2008AAAP（越南河內）、2006AAAP（韓國釜山）國際學術會議。2016年邀請Oklahoma State University張國龍教授訪問華南農大；2016年和2015年邀請St. John's University 陳哲生教授到校交流；2015年邀請休斯頓醫學中心劉平華博士到校交流；2014年邀請The Ohio State University 李海昌博士到校交流；2013年邀請Washington State University 姜志華教授到校交流；2013年訪問美國休斯敦醫學中心Yong Xv博士實驗室；2012年訪問美國 Texas A & M University 和 University of Medicine/Dentistry of New Jersey；2011年邀請比利時 K.U.Leuven 大學的 EDDY 教授到華南農業大學進行專題講座與交流。
