狄翠霞,女,中國科學院大學專任教師。
基本介紹
- 中文名:狄翠霞
- 國籍:中國
- 畢業院校:甘肅農業大學
- 學位/學歷:博士
人物經歷,教育背景,工作經歷,研究方向,科研成果,出版信息,科研項目,參與會議,
人物經歷
教育背景
2014-07--2014-08 日本的國立放射醫學綜合研究所 合作研究學者
2008-09--2010-08 德國癌症研究中心(DKFZ) 博士後
2003-09--2008-05 蘭州大學生命科學學院 理學博士
1999-09--2003-06 甘肅農業大學生命科學學院 理學學士
工作經歷
★2012年11月~至今 | 中國科學院近代物理研究所 | 副研究員 碩士生導師 |
★2010年10月~2012年10月 | 中國科學院近代物理研究所 | 助理研究員 |
★2008年9月~2010年10月 | 德國癌症研究中心(DKFZ) | 博士後 |
2012-10~ 中國科學院近代物理研究所, 副研究員
2010-10~2012-10,中國科學院近代物理研究所, 助理研究員
研究方向
研究方向:腫瘤、DNA損傷修復、選擇性剪接、DNA甲基化、凋亡、新藥篩選
科研成果
出版信息
1. Cuixia Di,Lu Han, Hong Zhang, Shuai Xu, Aihong MAO, et al. Dially disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway. Scientific reports. 2015. DOI:10.1038/srep16020. (IF: 5.58)
2. Cuixia Di,Chao Sun, Hongyan Li, Jing Si, Hong Zhang et al. Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73. Cell Cycle. 2015. 14(23):3725-33.(IF: 4.57)
3. Cuixia Di, Lina Yang, Hong Zhang, Xiaofei Ma, Xin Zhang,et al. Mechanisms, function and clinical applications of DNp73. Cell Cycle. 2013,12(12):1861-67.(IF: 4.57)
4. Cuixia Di, Lina Yang, Hong Zhang, Lizhe An, Xin Zhang, Xiaofei Ma et al. Anti-Apoptotic ΔNp73 Degraded by Ionizing Irradiation of Different LET in Hela Cells. GENE. 2013,515(1):208-13.(IF: 2.341)
5. Cuixia Di, Hong Zhang, Zhenglong Sun, Honglei Jia, Lina Yang,et al. Spatial Distribution of Polygalacturonase-Inhibiting proteins in Arabidopsis and Their Expression Induced by Stemphylium solani infection. GENE. 2013,515(1):208-13.(IF: 2.341)
6. Cuixia Di, Ming Li, Feng Long, Muqun Bai, Yajie liu, et al. Molecular cloning, functional analysis and localization of a novel gene encoding PGIPin Chorispora bungeana. Planta.2009,23(1):169-178.(IF: :3.26)
7. Cuixia Di, Manxiao Zhang, Shijian Xu, Tuo Cheng, Lizhe An. Role of Poly-galacturonase Inhibiting Protein in Plant Defense. Critical Reviews in Microbiology. 2006, 32(2):91-100.(IF: 6.02)
8. Hongyan Li, Hong Zhang, Cuixia Di, et al. Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes. Reproductive Toxicology.2015, 58:45-53. (IF: 3.23)
9. Aihong Mao, Yang Liu, Hong Zhang, Cuixia Di, et al. MicroRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation. DNA and Cell Biology. 2014, 33(10).· (IF: 2.06)
10. Mao A, Liu Y, Wang Y, Zhao Q, Zhou X, Sun C, Di Cuixia, Si J, Gan L, Zhang H. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells. Tumour Biol. 2015, 33(10): 667-679
11. Zhou xin, Yupei Wang, Jing Si, Rong Zhou, Lu Gan. Cuixia Di. Laser controlled singlet oxygen generation in mitochondria to promote mitochondrial DNA replication in vitro. Scitific reports .2015,18;5:16925.(IF: 5.58)
12. Sun C, Wang ZH, Liu Y, Liu YY, Li HY, Cuixia Di, et al. Carbon Ion Beams Induce Hepatoma Cell Death by NADPH Oxidase-mediated Mitochondrial Damage. Journal of Cellular Physiology. 2014, 229(1): 100-107
13. Yuanyuan Liu, Yang liu, Hong Zhang, Chao Sun , Queyue Zhao, Cuixia Di, et al. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells. Cell Biology International. 2014, 38(11): 1304-1310
14. Li HY, Xie Y, Zhang H, Liu Y, Sun C, Liu YY, Di CuiXia, Miao GY, Zhang X,Zhou X, Ma XF, Xu S, Gan L. Simulated microgravity conditions and carbonion irradiation-induced spermatogenic cells apoptosis and sperm DNA damage. Biomedical and Environmental Sciences. 2013, 26(9): 726-734
15. Li HY, Zhang H, Xie Y, He YX, Miao GY, Yang LN, Di Cuixia, He Y. Proteomicanalysis for testis of mice exposed to carbon ion radiation. Mutat Res. 2013, 755:148-155
16. Si Jing, Zhang Hong, Wang Zhenhua, Wu Zhenhua, Lu Jiang, Di Cuixia, Zhou Xin. Effects of 12C6+ ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression. Mutant research. 2013.745-746.(IF: 2.85)
17. Wu Z, Wang X, Yang R, Liu Y, Zhao W, Si J, Ma X, Sun C, Liu Y, Tan Y, Liu W, Zhang X, Di Cuixia, Wang Z, Zhang H, Zhang Z. Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice. Exp Ther Med. 2013. 5(3):771-776. (IF: 0.85)
Yang Liu, Luwei Zhang, Yuanyuan Liu, Chao sun,· Hong Zhang, Guoying Miao, Cui Xiao Di. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. Journal of cellular physiology.2014, 230(5):1094-103.
18. Yajie Liu · Zhiguang Zhao · Jing Si · Cuixia Di .Brassinosteroids alleviate chilling-induced oxidative damage by enhancing antioxidant defense system in suspension cultured cells of Chorispora bungeana.Plant Growth Regulation. 2009. 59(3):207-214
19. Yong Zhang. Tong-Wen Yang. Li-Jing Zhang. Teng-Guo Zhang. Cuixia Di. Isolation and Expression Analysis of Two Cold‐Inducible Genes Encoding Putative CBF Transcription Factors from Chinese Cabbage. Journal of Integrative Plant Biology. 2006. 48(7):848 - 856.
20. 繆國英, 張紅, 盧啟明, 李鴻岩,狄翠霞,郭逸瀟. 重離子對人胃癌細胞DNA錯配修復基因MSH2表達的影響. 2015, 32(1):110-4.
21. 韓璐,狄翠霞,毛愛紅,顏家瑋,張紅. 離子通道TRPV1阻滯劑capsazepine 誘導人肝癌HepG2細胞凋亡機制研究.中華腫瘤防治雜誌,22(10), pp103, 2015.
22. 韓璐,張紅,狄翠霞,謝漪,劉圓圓.離子通道與腫瘤關係研究現狀.生理科學進展,2014,45(3):225-229.
23. 趙邱越 ,王振華 ,謝漪 ,許帥, 狄翠霞,張紅. 薑黃素對重離子輻射損傷小鼠睪丸組織的防護作用研究.原子核物理評論. 2014, 31(1):101-5.
24. 許帥,張紅,劉陽,趙邱越,狄翠霞等. 二烯丙基二硫對荷S180肉瘤小鼠的輻射增敏效應. 雷射生物學報. 2013,22(02): 119-124
25. 楊立娜, 張紅, 狄翠霞, 張秋寧,王小虎. 集簇性DNA損傷在輻射研究中的進展.原子核物理評論,29(2), pp196,2012
26. 無細胞蛋白質晶片的製備及其套用. 中國生物化學與分子生物學報.2012
27. 狄翠霞, 張紅, 王振華. p73變異體研究現狀及其在腫瘤放療中的套用前景. 原子核物理評論, 29(1) , pp103, 2012
28. 狄翠霞, 張紅,楊立娜,王小虎. 無細胞蛋白質晶片的製備及其套用. 中國生物化學與分子生物學報. 28(1), pp28, 2012
科研項目
( 1 ) 輻射誘導的p73 變異體對腫瘤細胞凋亡的調控作用, 主持, 國家級, 2013-01--2015-12
( 2 ) 胃癌新標誌物的篩選和套用, 主持, 國家級, 2012-01--2014-12
( 3 ) 胃癌新標誌物的篩選及套用, 主持, 省級, 2012-01--2014-12
( 4 ) 線粒體:放射性腦損傷的受害者還是施害者?, 參與, 國家級, 2012-01--2014-12
( 5 ) 胃癌新標誌物的篩選和套用, 主持, 國家級, 2015-08--2018-07
參與會議
(1)基因的選擇性剪接和輻射腫瘤生物學 第十四次中國暨國際生物物理大會 狄翠霞,張紅 2015-11-16
(2)Anti-apoptotic DeltaNp73 degraded by ionizing radiation of diferent LET in human cervical carcinoma HeLa cells 國際質子治療協作委員會(PTCOG)第51屆年會 狄翠霞,張紅 2013-05-17
(3)Analysis of protein isoforms that are relevant to diagnostics and Cuixia Di, Mohamed Saiel Saeed Alhamdani, Christoph Schr?der and J?rg D. Hoheisel 2010-11-25
(4)Transgenic Technologies and society Cuixia Di 2009-11-06