基本介紹
- 中文名：牟曉東
- 外文名：Xiaodong Mu
- 國籍：中國
- 民族：漢
- 出生地：山東省煙臺市
- 畢業院校：美國馬里蘭大學醫學院 博士 、北京大學生命科學學院 碩士 、山東大學生物系 本科
- 職稱：研究員
研究方向,主要成就,
研究方向
1、幹細胞及外泌體的特性和疾病治療的套用研究：應於遺傳疾病，組織修復再生，延緩衰老，減輕癌症惡病體質等;
2、細胞衰老的機制以及抗衰老新藥物的研究：細胞骨架及機械性能在調控細胞天然免疫和細胞衰老進程中的作用和調控機制，抗衰老藥物的開發和作用機制等。
主要成就
Zhang L, Zhao J, MuX, McGowan SJ, Angelini L, O'Kelly RD, Yousefzadeh MJ, Sakamoto A, AversaZ, LeBrasseur NK, Suh Y, Huard J, Kamenecka TM, Niedernhofer LJ, Robbins PD. Novel smallmolecule inhibition of IKK/NF-κB activation reduces markers of senescence andimproves healthspan in mouse models of aging. Aging Cell. 2021 Dec.
MuX*, Tseng C, Hambright W, Matre P, Lin CY, Chanda P, ChenW, Gu J, Ravuri S, Cui Y, Zhong L, Cooke JP, Niederhofer LJ, Robins PD, andHuard J*. Cytoskeleton stiffness regulates cellular senescence and innateimmune response in Hutchinson-Guilford Progeria Syndrome. Aging Cell. 2020July.
Mu X*, Lin CY, Hambright WS, Tang Y, Ravuri S, Lu A, Matre P, Chen W, Gao X,Cui Y, Zhong L, Wang B, Huard J*. Aberrant RhoA activation in macrophagesincreases senescence-associated secretory phenotypes and ectopic calcificationin muscular dystrophic mice. Aging (Albany NY). 2020 Dec 23
Matre P, Mu X, Wu J, Danila D, Hall M, KoloninM, Darabi R, Huard J. CRISPR/Cas9-based Dystrophin Restoration Reveals a NovelRole for Dystrophin in Bioenergetics and Stress Resistance of MuscleProgenitors. Stem Cells. 2019 October.
Kawakami Y, Hambright WS,Takayama K, Mu X, Lu A, Cummins JH,Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, NiedernhoferLJ, Huard J.Rapamycin Rescues Age-Related Changes in Muscle-DerivedStem/Progenitor Cells from Progeroid Mice. Mol Ther MethodsClin Dev. 2019 May.
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, CorboL, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J,Niedernhofer LJ, Kamenecka TM, Robbins PD. Development of novel NEMO-bindingdomain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun.
Mu X*, Tang Y, Takayama K, Chen W, Lu A, Wang B,Weiss K, Huard J*. RhoA/Rock Inhibition Improves the Beneficial Effects ofGlucocorticoid Treatment in Dystrophic Muscle: Implications for Stem Cell Depletion. Hum Mol Genet. 2017 May.
HuardJ, Lu A, Mu X, Guo P, Li Y. MuscleInjuries and Repair: What's New on the Horizon! Cells Tissues Organs. 2016 Nov. Review.
Mu X, Patel S, Mektepbayeva D, Mahjoub A, Huard J,Weiss K. Retinal Targets ALDH Positive Cancer Stem Cell and Alters thePhenotype of Highly Metastatic Osteosarcoma Cell. Sarcoma.2015.
MuX, Tang Y, Lu A, Takayama K, Usas A, Wang B, Weiss K,Huard J. The role of Notch signaling in muscle progenitor cell depletion andthe rapid onset of histopathology in muscular dystrophy. HumMol Genet. 2015 Feb 12.
