牛雪梅，1972年6月出生於廣西桂林，研究員，雲南大學學術學科帶頭人。專業從事次生代謝產物的研究，任雲南大學生物資源保護與利用重點實驗室, 研究員。
1989年9月-1996年7月, 廣西師範大學化學系, 學士/碩士，1996年8月-1999年2月, 廣西師範大學化學化工系, 講師, 有機化學，1999年3月-2001年12月, 中國科學院昆明植物研究所, 獲理學博士, 植物化學，2002年1月-2004年2月, 中國科學院昆明植物研究所, 助理研究員/副研究員, 植物化學, 天然產物化學，2004年3月- 2004年9月, 香港中文大學中醫學院, 博士後, 高等真菌次生代謝產物，2004年10月-2006年3月, 德國萊布尼茲天然產物及感染生物學研究所生物有機化學系, DAAD-Leibniz博士後, 微生物次生代謝產物，2006年4月-2007年7月, 德國馬普化學生態研究所生物化學系, 博士後, 化學生態學，2007年11月--, 雲南大學生物資源保護與利用重點實驗室, 研究員, 次生代謝產物及功能。
基本介紹
- 中文名：牛雪梅
- 國籍：中國
- 出生地：廣西桂林
- 出生日期：1972年6月
基本信息,人物經歷,研究方向,參研項目,
基本信息
Laboratory for Conservation and Utilization of Bio-resources
Yunnan University
Kunming 650091
Yunnan, China
人物經歷
1989年9月-1993年7月, 廣西師範大學化學系, 獲理學學士
1993年9月-1996年7月, 廣西師範大學化學系, 獲理學碩士, 有機化學(藥物合成)
1996年8月-1999年2月, 廣西師範大學化學化工系, 講師, 有機化學
1999年3月-2001年12月, 中國科學院昆明植物研究所, 獲理學博士, 植物化學
2002年1月-2003年6月, 中國科學院昆明植物研究所, 助理研究員, 植物化學, 天然產物化學
2003年7月-2004年2月, 中國科學院昆明植物研究所, 副研究員, 植物化學, 天然產物化學
2004年3月- 2004年9月, 香港中文大學中醫學院, 博士後, 高等真菌的次生代謝產物
2004年10月-2006年3月, 德國萊布尼茲天然產物及感染生物學研究所生物有機化學系, DAAD-Leibniz博士後, 微生物次生代謝產物
2006年4月-2007年7月, 德國馬普化學生態研究所生物化學系, 博士後, 化學生態學
2007年11月--, 雲南大學生物資源保護與利用重點實驗室, 研究員, 次生代謝產物及功能
EDUCATION AND EXPERIENCE:
09/1989-07/1996, Studies of Chemistry at Department of Chemistry, Guangxi Normal University, China:
Master’s thesis on 'synthesis of allantoin’
07/1996-03/1999, Lecturer at Department of Chemistry, Guangxi Normal University, Guilin, China
03/1999-12/2001, PhD thesis at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences
01/2002-06/2003, Assistant Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences
07/2003-12/2007, Associate Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences
03/2004-09/2004, Postdoctoral Fellow at School of Chinese Medicine, The Chinese University of Hongkong,
10/2004-03/2006, Postdoctoral Fellow at Leibniz Institute for Natural Product Research and Infection Biology Hans-Kn?ll-Institute (HKI),Jena, Germany
04/2006-07/2007, Postdoctoral Fellow at Department of Biochemistry, & Research Group Biosynthesis/NMR, Max Planck for Chemical Ecology, Jena, Germany
11/2007-present, Professor at Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China
AWARD：
2004.10-2006.3, Postdocoral fellowship by German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD)-Leibniz
研究方向
微生物和植物中的天然產物的分離和結構鑑定
捕食線蟲真菌的化學防禦機制
套用酶和微生物的生物轉化
植物與相關微生物之間的化學相互作用
RESEARCH INTERESTS：
Isolation and structure elucidation of natural products from microorganisms and plants in Yunnan
Use of enzymes and microorganisms for biotransformations
Chemical defense mechanism of nematode-trapping fungi
Chemical interaction between plants and the associated microorganisms
參研項目
目前承擔或參與國家自然科學基金委、雲南省科技廳等在研項目。
PUBLICATIONS (2002-):
1. Wu DK, Zhang CP, Zhu CY, Wang YL, Guo LL, Zhang KQ, and Niu XM*. Metabolites from Carnivorous Fungus Arthrobotrys entomopaga and Their Functional Roles in Fungal Predatory Ability,J. Agric. Food Chem.2013, 61, 4108−4113. (*corresponding author)
2. Luo SH, Hua J, Niu XM, Liu Y, Li CH, Zhou YY, Jing SX, Zhao X, Li SH, Defense sesterterpenoid lactones from Leucosceptrum canum, Phytochemistry, 2013, 86, 29 - 35.
3. Tan JL, Niu XM, Yang GY, Wang L, Duan YX, Han Y, Zhang KQ, Zhang CM. Quantitative Determination of Phytosterols in Tobacco Leaves by UPLC-MS/MS.J Liq Chromatogr R T, 2013, 36, 591-599.
4. Guo JP, Zhu CY, Zhang CP, Chu YS, Wang YL, Zhang JX, Wu DK, Zhang KQ, NiuXM*. Thermolides, Potent Nematocidal PKS-NRPS Hybrid Metabolites from Thermophilic Fungus Talaromyces thermophilus, J Am Chem Soc, 2012, 134(50), 20306-20309. (*corresponding author)
5. Zhang HX, Tan JL, Wei LX, Wang YL, Zhan CP, Wu DK, Zhu CY, Zhang Y, Zhang KQ, Niu XM*. Morphology Regulatory Metabolites from Arthrobotrys oligospora. J Nat Prod, 2012, 75(7), 1419-1423. (*corresponding author)
6. Wu HY, Wang YL, Tan JL, Zhu CY, Li DX, Huang R, Zhang KQ, Niu XM *. Regulation of the Growth of Cotton Bollworms by Metabolites from an Entomopathogenic Fungus Paecilomyces cateniobliquus. J Agric Food Chem,2012, 60(22), 5604-5608. (*corresponding author)
7. Luo SH, Liu Y, Hua J, Niu XM, Jing SX, Zhao X, Schneider B, Gershenzon J, Li SH, Unique Proline-Benzoquinone Pigment from the Colored Nectar of "Bird's Coca Cola Tree" Functions in Bird Attractions. Organic Lett,2012, 14(16), 4146-4149.
8. Li SH, Nagy NE, Hammerbacher A, Krokene P, Niu XM, Gershenzon J, Schneider B. Localization of Phenolics in Phloem Parenchyma Cells of Norway Spruce (Picea abies), ChemBioChem, 2012, 13, 2707 - 2713.
9. Guo JP, Tan JL, Wang YL, Wu HY, Zhang CP,Niu XM*, Pan WZ, Huang XW, Zhang KQ. Isolation of Talathermophilins from a Thermophilic Fungus Talaromyces thermophilus YM3-4. J Nat Prod, 2011, 74(10), 2278-2281. (*corresponding author)
10. Wei LX, Zhang HX, Tan JL, Chu YS, Li N, Xue HX, Wang YL, Niu XM *, Zhang Y, Zhang KQ. Arthrobotrisins A-C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora. J Nat Prod, 2011, 74(6), 1526-1530. (*corresponding author)
11. Niu XM, Zhang KQ. Arthrobotrys oligospora: a Model Organism for Understanding the Interaction between Fungi and Nematodes. Mycology, 2011, 2(2), 59-78.
12. Niu QH, Tian YX, Zhang L, Xu XE, Niu XM, Zhang KQ, Huang XW. Overexpression of the Key Virulence Proteases Bace16 and Bae16 in Bacillus nematocida B16 to Improve its Nematocidal Activity.J Mol Microb Biotech, 2011, 21, 130-137.
13. Yang JK, Wang L, Ji XL, Feng Y, Li XM, Zou CG, Xu JP, Ren Y, Mi QL, Wu JL, Liu SQ, Liu Y, Huang XW, Wang HY, Niu XM, Li J, Liang LM, Luo YL, Ji KF, Zhou W, Yu ZF, Li GH, Liu YJ, Li L, Qiao M, Feng L, Zhang KQ. Genomic and Proteomic Analyses of the FungusArthrobotrys oligospora Provide Insights into Nematode-Trap Formation. Plos Pathog, 2011, 7, e1002179.
14. Yang JK, Zhao XN, Liang LM, Xia ZY, Lei LP, Niu XM, Zou CG, Zhang KQ. Overexpression of a Cuticle-Degrading Protease Ver112 Increases the Nematicidal Activity of Paecilomyces lilacinus. Appl Microbiol Biot, 2011, 89, 1895-1903.
15. Li GH, Yang ZS, Zhao PJ, Zheng X, Luo SL, Sun R, Niu XM, Zhang KQ. Three New Acorane Sesquiterpenes from Trichoderma sp. YMF1.02647. Phytochemistry Lett, 2011, 4, 86-88.
16. Chu YS, Niu XM *, Wang YL, Guo JP, Pan WZ, Huang XW, Zhang KQ. Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus. Organic Lett, 2010, 12(19), 4356-4359. (*corresponding author)
17. Niu XM, Wang YL, Chu YS, Xue HX, Li N, Wei LX, Mo MH, Zhang KQ. Nematodetoxic Aurovertin-Type Metabolites from a Root-Knot Nematode Parasitic Fungus Pochonia chlamydosporia. J Agric Food Chem,2010,58(2), 828-834.
18. Li CH, Niu XM, Luo Q, Xie MJ, Luo SH, Zhou YY, SH Li. Novel Polyesterified 3,4-seco-Grayanane Diterpenoids as Antifeedants from Pieris formosa.Organic Lett, 2010, 12 (10), 2426-2429.
19. Luo SH, Luo Q, Niu XM, Xie MJ, Zhao X, Schneider B, Gershenzon J, Li SH. Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids. Angew Chem Int Edit, 2010, 49, 4471-4475.
20. Niu QH, Huang XW, Zhang L, Xu JP, Yang DM, Wei KB, Niu XM, An ZQ, Bennett JW, Zou CG, Yang JK, Zhang KQ. A Trojan Horse Mechanism of Bacterial Pathogenesis against Nematodes. Proc Natl Acad SciUSA, 2010, 107 (38), 16631-16636.
21. Yang ZS, Li GH, Zhao PJ, Zheng X, Luo SL, Li L, Niu XM, Zhang KQ. Nematicidal activity of Trichoderma spp. and Isolation of an Active compound. World J Microb Biot. 2010, 26, 2297-2302.
22. Mi QL, Yang JK, Ye FP, Gan ZW, Wu CW, Niu XM, Zou CG, Zhang KQ. Cloning and Over expression of Pochonia chlamydosporia Chitinase Gene Pcchi44, a Potential Virulence Factor in Infection against Nematodes. Process Biochem,2010, 45(5), 810-814.
23. Zhao X, Zheng GW, Niu XM, Li WQ, Wang FS, Li SH,Terpenes from Eupatorium adenophorum and their Allelopathic Effects on Arabidopsis Seeds Germination.JAgric Food Chem, 2009,57, 478-482.
24. Niu XM, Dahse HM, Menzel KD, Lozach O, Walther G, Meijer L, Grabley S, Sattler I. Butyrolactone I Derivatives from Aspergillus terreus Carrying an Unusual Sulfate Moiety, J Nat Prod, 2008,71, 689-692.
25. Huang XS, He J, Niu XM, Menzel KD, Dahse HM, Grabley S, Fiedler HP, Sattler I, Hertweck C. Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with a Benzo[a]pyrene-Type Carbocyclic Ring System.Angew Chem Int Edit, 2008,47, 1-5.
26. Li SH, Niu XM, Zahn S, Gershenzon J, Weston J, Schneider B.Diastereomeric Stilbene Glucoside Dimers from the Bark of Norway Spruce (Picea abies). Phytochemistry, 2008, 69, 772-782.
27. Niu XM,Li SH,Görls H, Schollmeyer D, Hilliger M, Grabley S, Sattler I. Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces species. Organic Lett, 2007, 9(13), 2437-2440.
28. Niu XM, Li SH, Sun HD, Che CT.Two new Lanostanoids from Ganoderma resinaceum.J Asian Nat Prod Res, 2007, 9(7), 659-664.
29. Zhao Y, Niu XM, Qian LP, Liu ZY, Zhao QS, Sun HD. Synthesis and Cytotoxicity of Some New Eriocalyxin B Derivatives. Euro J Med Chem, 2007, 42(4), 494-502.
30. Niu XM, Li SH, Sun HD, Che CT. Prenylated Phenolics from Ganoderma fornicatum. J Nat Prod, 2006, 69(9), 1364-1365.
