牛國清，博士副研究員，西南大學碩士，2010年回國後發表的論文多篇，現供職於中國科學院微生物研究所。
牛國清 博士副研究員。
教育經歷
2006年 中國科學院微生物研究所，博士
2002年西南大學（原西南農業大學），碩士
1998年西南大學（原西南農業大學），學士
工作經歷
2010年至今 副研究員 中國科學院微生物研究所，微生物資源前期開發國家重點實驗室，研究方向為微生物次級代謝產物的生物合成與分子調控。
2006年-2010年博士後 美國俄克拉荷馬大學健康科學中心，微生物學與免疫學系，研究方向為生物膜中變形鏈球菌的遺傳與生化研究。
2010年回國後發表的論文
1. Niu G, Tan H*. (2015) Nucleoside antibiotics: Biosynthesis, regulation and biotechnology.Trends in Microbiology23(2): 110-119.
2.Jiang L, Wang L, Zhang J, Liu H, Hong B, Tan H*,Niu G. (2015) Identification of novel mureidomycin analogues via rational activation of a cryptic gene cluster inStreptomyces roseosporusNRRL 15998.Scientific ReportsIn press.
3.Du D, Wang L, Tian Y, Liu H, Tan H,Niu G. (2015) Genome engineering and direct cloning of antibiotic gene clusters via phagefBT1 integrase-mediated site-specific recombination inStreptomyces.Scientific Reports5:8740.
4.Liu N,Niu G, Xie Z, Chen Z, Itzek A, Kreth J, Gillaspy A, Zeng L, Burne R, Qi F, Merritt J*. (2015) TheStreptococcus mutansirvAgene encodes a trans-acting riboregulatory mRNA.Molecular Cell57(1):179-190.
5.王璐，杜德堯，李金娥，田宇清，劉浩*，牛國清*，譚華榮。（2015）尼可黴素生物合成基因簇的改造及其異源表達。微生物學報55(6) :707 -718。
6.Zou Z, Du D, Zhang Y, Zhang J,Niu G*, Tan H*. (2014) A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis.Molecular Microbiology94(3):490-505.
7.Wei J, Tian Y,Niu G*, Tan H*. (2014) GouR, a TetR-family transcriptional regulator, coordinates the biosynthesis and export of gougerotin inStreptomyces graminearus.Applied and Environmental Microbiology80(2): 714-722.
8.Feng C, Ling H, Du D, Zhang J,Niu G*, Tan H*. (2014) Novel nikkomycin analogues generated by mutasynthesis inStreptomyces ansochromogenes.Microbial Cell Factories13(1): 59.
9. Niu G, Li L, Wei J, Tan H*. (2013) Cloning, heterologous expression, and characterization of the gene cluster required for gougerotin biosynthesis.Chemistry & Biology20(1):34-44.
10.Du D, Zhu Y, Wei J, Tian Y,Niu G*, Tan H*. (2013) Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters.Applied Microbiology and Biotechnology97(14): 6383-6396.
11.Jiang L, Wei J, Li L,Niu G*, Tan H*. (2013) Combined gene cluster engineering and precursor feeding to improve gougerotin production inStreptomyces graminearus.Applied Microbiology and Biotechnology97(24): 10469–10477.
12. Niu G, Tan H*. (2013) Biosynthesis and regulation of secondary metabolites in microorganisms.Science China Life Sciences56(7): 581-583.
13.Liu G, Chater KF, Chandra G,Niu G, Tan H*. (2013) Molecular regulation of antibiotic biosynthesis inStreptomyces.Microbiology and Molecular Biology Reviews77(1): 112-143.
14.Zhang Y, Zou Z,Niu G, Tan H*. (2013)jadR*andjadR2act synergistically to repress jadomycin biosynthesis.Science China Life Sciences56(7): 584-590.
15.Zhong X, Tian Y,Niu G, Tan H*. (2013) Assembly and features of secondary metabolite biosynthetic gene clusters inStreptomyces ansochromogenes.Science China Life Sciences56(7): 609-618.
16.Li J, Li L, Tian Y,Niu G, Tan H*. (2011) Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties.Metabolic Engineering13(3): 336-344.
2010年之前發表的論文
1. Niu G,Okinaga T, Qi F, Merritt J*. (2010) TheStreptococcus mutansIrvR repressor is a CI-like regulator that functions through autocleavage and Clp-dependent proteolysis.Journal of Bacteriology192(6): 1586-1595.
2.Xie Z, Okinaga T,Niu G, Qi F, Merritt J*. (2010) Identification of a novel bacteriocin regulatory system inStreptococcus mutans.Molecular Microbiology78(6): 1431-1447.
3.Okinaga T,Niu G,Xie Z, Qi F, Merritt J*. (2010) ThehdrRMoperon ofStreptococcus mutansencodes a novel regulatory system for coordinated competence development and bacteriocin production.Journal of Bacteriology192(7):1844-1852.
4.Okinaga T, Xie Z,Niu G,Qi F, Merritt J*. (2010) Examination of the hdrRM regulon yields insight into the competence system ofStreptococcus mutans.Molecular Oral Microbiology25(3):165-177.
5.Merritt J*,Niu G,Okinaga T, Qi F. (2009) Autoaggregation response ofFusobacterium nucleatum.Applied and Environmental Microbiology75(24):7725-7733.
6. Niu G, Okinaga T, Zhu L, Banas J, Qi F, Merritt J*. (2008) Characterization ofirvR, a novel regulator of theirvA-dependent pathway required for genetic competence and dextran-dependent aggregation inStreptococcus mutans.Journal of Bacteriology190(21): 7268-7274.
7.He X, Wu C, Yarbrough D, Sim L,Niu G, Merritt J, Shi W, Qi F*. (2008) Theciaoperon ofStreptococcus mutansencodes a unique component required for calcium-mediated autoregulation.Molecular Microbiology70(1):112-126.
8.Xie Z,Niu G, Li R, Liu G, Tan H*. (2007) Identification and characterization ofsanHandsanIinvolved in the hydroxylation of pyridyl residue during nikkomycin biosynthesis inStreptomyces ansochromogenes.Current Microbiology55(6):537-542.
9.Niu G, Liu G, Tian Y, and Tan H*. (2006) SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis inStreptomyces ansochromogenes.Metabolic Engineering8(3):183-195.
