熊 偉,教授,博士生導師。國家中組部“青年千人計畫”獲得者。
人物簡介
研究方向
研究課題
(2) 配體門控型離子通道受體與藥物鎮痛、耐受和成癮的關係
(3) 突觸前離子通道受體的發育與調節機制
代表論文
Also see NEWS AND VIEWS: Receptors: Cannabis medicine without a high. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011)
Research Highlight: Nature Reviews Neuroscience 12: 306 (2011)
Commented and rated as ‘Must Read” by Faculty of 1000 (2011)
2.Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
3.Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
4.Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)
5.Wei Xiong, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37 (2011)
6.Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. Behavioural Brain Research (IF≈3.5), 173:116-121 (2006).
7.Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by μ-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)
8.Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology, 17(4):765-71. (2012)
9.Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)