中山大學腫瘤醫院於2023年6月13日在歐洲《細胞腫瘤學》雜誌發表研究成果，結論：APT在鑑別早期肺癌（原位癌和 I 期癌，占比81%）和肺結節及健康人群中，AUROC=0.9132
相關臨床研究
相關臨床研究
文獻索引：Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Xie, Chuanbo et al. Cell Oncol. (Dordrecht) 10.1007/s13402-023-00838-1. 2023.
文獻索引：Blood-test based targeted visualization enables early detection of premalignant and malignant tumors in asymptomatic individuals. Burg S, et al. J Clin Med Images (2022) 6(9).
3.其他已發表國際臨床研究文獻
序號
文獻名稱
1
Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Xie, Chuanbo et al. Cell Oncol. (Dordrecht) 10.1007/s13402-023-00838-1. 2023.
2
Blood-test based targeted visualization enables early detection of premalignant and malignant tumors in asymptomatic individuals. Burg S, et al. J Clin Med Images (2022) 6(9).
3
Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a ew diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma, S. Saman Cancer Biomarkers 27 (2020) 129–137
4
APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression, Yang Li et al. Nat Commun. 2017, 10, 2502
5
EDIM-TKTL1/Apo10 Blood Test: An InnAP-Te Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer Johannes F. Coy Int. J. Mol. Sci. 2017, 18, 878
6
Analysis of circulating CD14D/CD16Dmonocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma Martin Grimm et al. ORAL AND MAXILLOFACIAL PATH. 2016,03
7
A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells Martin Grimm et al. BMC Cancer 2013, 13:569
8
Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis Natalie Jansen, Johannes F. Coy Future Oncol. (2013) 9(4), 605–609
9
EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies Oliver Feyen et al. Future Oncol. (2012) 8(10), 1349–1359
10
Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis Susanne Bentz et al. Am J Physiol Gastrointest Liver Physiol 300: G598–G607, 2011
11
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells Xiaojun Xu et al. Int. J. Cancer: 124, 1330–1337, 2009
12
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted S. Langbein et al. British Journal of Cancer 94, 578 – 585, 2006
