《溫度敏感的TRPV2離子通道鈣離子分電流(Pf)的測定研究》是鄭良宏為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：溫度敏感的TRPV2離子通道鈣離子分電流(Pf)的測定研究
- 項目類別 ：青年科學基金項目
- 依託單位 ：北京大學
- 項目負責人：鄭良宏
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Nicotine dynamically modulates dopamine clearance in rat striatum in vivo | 期刊論文 | W. Yao|S. R. Wang|J. Zhu|D. Huang|P. L. Zuo|X. J. Kang|C. L. Fu|Z. Zhou|B. Zhang| |
2 | Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo | 期刊論文 | S. T. Kuo|Q. Li|S. R. Wang|H. Q. Dou|H. D. Xu|C. X. Zhang|X. J. Kang|Z. Zhou|B. Zhang| |
3 | Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus | 期刊論文 | H. P. Huang|F. P. Zhu|X. W. Chen|Z. Q. Xu|C. X. Zhang|Z. Zhou| |
4 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Dopamine release from transplanted neural stem cells in Parkinsonian rat&nb | 期刊論文 | Kang X, Xu H, Teng S, Zhang X, Deng Z|Zhou L, Zuo P, Liu B, Liu B, Wu Q|Wang L, Hu M, Dou H, Liu W, Zhu F|Li Q, Guo S, Gu J, Lei Q, Lü J|Mu Y, Jin M, Wang S, Jiang W|Liu K, Wang C, Li W, Zhang K, Zhou Z| |
5 | Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine | 期刊論文 | Zhou, Li|Jiao, Ruiying|Dou, Haiqiang|Zuo, Panli|Zhang, Xiaoyu|Zheng, Lianghong|Wang, Shirong|Wang, Changhe|Zhou, Zhuan| |
6 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Nicotine dynamically modulates dopamine clearance in rat striatum in&a | 期刊論文 | Guo N, Yao W, Wang SR, Zhu J, Huang D|Zuo PL, Kang XJ, Fu CL|Zhou Z, Zhang B| |
7 | Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta-cells | 期刊論文 | Y. F. Xu|J. P. Sun|S. Shang|S. Guo|L. H. Zheng|C. C. Chen|I. C. Bruce|X. Yu|Z. Zhou| |
8 | Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices | 期刊論文 | Q. H. Wu|J. Lu|Y. Xiu|L. N. Liu|H. P. Huang|S. Guo|H. Zheng|C. X. Zhang|Z. Zhou| |
9 | Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons | 期刊論文 | M. L. Li|L. Zhou|R. Y. Jiao|C. H. Wang|S. R. Wang|H. Yang|B. Zhang|Z. Zhou|Z. Q. Xu| |
10 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Temporal components of cholinergic terminal to dopaminergic terminal t | 期刊論文 | Wang L, Zhang X, Xu H, Zhou L, Jiao R|Liu W, Zhu F, Kang X, Liu B|Teng S, Wu Q, Li M, Dou H, Zuo P|Wang C, Wang S, Zhou Z| |
11 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucle | 期刊論文 | Zhang B, Zhang XY, Luo PF, Huang W|Zhu FP, Liu T, Du YR, Wu QH|Lü J, Xiu Y, Liu LN, Huang HP|Guo S, Zheng H, Zhang CX, Zhou Z| |
12 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Extracellular Ca2？per se inhibits quantal size of catecholamine releas | 期刊論文 | Shang S, Wang C, Liu B, Wu Q, Zhang Q|Liu W, Zheng L, Xu H, Kang X|Zhang X, Wang Y, Zheng H, Wang S|Xiong W, Liu T, Zhou Z| |
13 | <span style="font-family:'Calibri','sans-serif';color:black;font-size:14pt;">Calcium influx activates adenylyl cyclase 8 for sustained insulin& | 期刊論文 | Dou H, Wang C, Wu X, Yao L, Zhang X|Xu H, Liu B, Wu Q, Zhang Q|Hu M, Wang Y, Wang L, Wu Y, Shang S|Kang X, Zheng L, Zhang J, Raoux M|Lang J, Li Q, Su J, Yu X, Chen L, Zhou Z| |
14 | Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells | 期刊論文 | Q. H. Wu|M. Q. Hu|Z. Y. Chai|X. Wu|H. Zheng|C. Zhang|L. C. Wang|W. Xiong|Z. Zhou| |
15 | Gain-of-function mutations in SCN11A cause familial episodic pain | 期刊論文 | J. Luo|S. Feng|X. Ma|H. Ma|Z. Chai|Z. Zhou|J. Yao|X. Zhang|J. Y. Liu| |
項目摘要
Transient receptor potential (TRP) channels是一個非選擇性陽離子通道家族，它們是人和動物的分子感覺器，分別感受溫度、痛覺、機械、味覺等基本環境因子和傷害性刺激。當TRP被激活時， 鈣離子便流入TRP離子通道，並通過鈣離子依賴性（激酶，分泌，收縮）產生細胞功能。因此TRP鈣離子通透性是一個重要問題。本項目研究的重點是使用周專-Neher發明的測量陽離子通道鈣離子分電流的方法(Pf，例如NMDAR通道Pf=10%)，研究TRPV1特性並測定迄今未知的溫度敏感TRPV2離子通道的Pf，從而為研究它們的生理功能研究提供重要基礎。申請人曾參與周專實驗室測定HCN通道的Pf, 並掌握了Pf方法（Yu et al, PNAS，2004；Am J Physiol, 2007）。我們的預實驗結果已經初步檢測了TRPV1的鈣離子Pf=5.4%。
