基本介紹
- 中文名：湯日寧
- 學位/學歷：博士
- 職業：醫生 ，教師
- 專業方向：慢性腎臟病礦物質和骨代謝異常（CKD-MBD）發病機制的研究
- 任職院校：東南大學醫學院
個人經歷,研究方向,榮譽獎項,學術成果,
個人經歷
湯日寧 博士，主任醫師、博士生導師、科副主任。東南大學附屬中大醫院腎科規培生教學負責人，溧水人民醫院副院長。中華醫學會腎臟病分會青年委員，中國醫師協會整合醫學腎臟病學分會委員，江蘇省醫學會腎臟病分會委員，中國非公立醫療機構協會腎臟病透析專業委員會青年分委會副主任。國家自然科學基金評審專家，教育部學位論文-學位中心評審專家。
研究方向
1.慢性腎臟病礦物質和骨代謝異常（CKD-MBD）發病機制的研究
2.糖尿病腎病發病機制的研究
榮譽獎項
先後獲得教育部自然科學一等獎、江蘇省科技進步二等獎、南京市科技進步二等獎等政府成果獎勵3項，獲得江蘇省衛生廳醫學新技術引進獎一等獎1項。主持國家自然科學基金面上項目3項，江蘇省自然科學基金1項，江蘇省科教強衛醫學重點人才，江蘇省第三層次“333工程”培養對象，江蘇省高層次人才“六個一工程”拔尖人才項目。獲得江蘇省優秀碩士學位論文、江蘇省優秀博士學位論文和東南大學優秀博士學位論文各1項，發表SCI論文26篇。
學術成果
近五年發表代表性論著如下：（Published representative works in the past five years）
1.Ni LH,Tang RN(共同第一作者), Lv LL, Wu M, Wang B, Wang FM, Ni HF, Song KY, Wang LT, Meng-Zuo, Chen Q, Liu BC.A rat model of SHPT with bone abnormalities in CKD induced by adenine and a high phosphorus diet.Biochem Biophys Res Commun.2018;498(3):654-659
2.Tang RN，Wu P，An L，NADPH oxidase p22phox C242T polymorphism is associated with macroalbuminuria in diabetic patients: A meta-analysis，Journal of Diabetes and Its Complications，2017.3.10，31(7)：1207-1211
3.Zhu DD,Tang RN(共同第一作者),Lv LL,Wen Y,Liu H,Zhang XL,Ma KL,Liu BC.Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells.Cardiovasc Diabetol.2016;15:42.
4.Wu PP,Tang RN(共同第一作者), An L. A meta-analysis of MTRR A66G polymorphism and colorectal cancer susceptibility. J BUON. 2015; 20(3):918-922.5.Wu M,Tang RN(共同第一作者), Liu H, Pan MM, Lv LL, Zhang JD, Crowley SD, Liu BC. Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition. Int J Cardiol, 2014;171(3):e65-69.
6.Wu M.Tang RN(共同第一作者),Liu H. Ma KL. Lv LL. Liu BC. Nucleartranslocationof β-Cateninmediates theparathyroidhormone-inducedendothelial-to-mesenchymaltransition inhumanrenalglomerularendothelialcells.J Cell Biochem,2014;115(10):1692-1701.
7.Tang RN,Lv LL, Zhang JD,Dai HY,Li Q,Zheng M,Ni J,Ma KL,Liu BC. Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats.Int J Cardiol, 2013; 162(2): 92-99.
8.Wu M,Tang RN,Liu H,Xu M,Pan MM,Liu BC.Cinacalcet attenuates the renal endothelial-to-mesenchymal transition in ratswith adenine-induced renal failure.Am J Physiol Renal Physiol,2014;306(1):F138-146.
9.Jiang H,Tang RN(共同第一作者), Wang J.Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials.Eur J Clin Microbiol Infect Dis. 2013;32(9):1121-1128.
10.Liu BC,Tang RN,Liu ZH.Current clinicalresearch of acute kidney injury in China.Chin Med J (Engl).2015;128(9):1268-1271.
11.Han YC, Tu Y, Liu H, Pan MM,Tang RN, Liu BC. Hospital-acquired acute kidney injury: an analysis of baseline estimated glomerular filtration rate and in-hospital mortality.J Nephrol. 2015 [Epub ahead of print]
12.Ding LH, Liu D, Xu M, Wu M, Liu H,Tang RN, Ma KL, Chen PS, Liu BC.TLR2-MyD88-NF-κB pathway is involved in tubulointerstitial inflammation caused by proteinuria.Int J Biochem Cell Biol. 2015;69:114-120.
13.Liu D, Wen Y, Tang TT, Lv LL,Tang RN, Liu H, Ma KL, Crowley SD, Liu BC.Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.J Biol Chem. 2015;290(29):18018-18028.
14.Wang J, Wen Y, Lv LL, Liu H,Tang RN, Ma KL, Liu BC.Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro.Acta Pharmacol Sin. 2015;36(7):821-830.
15.Liu J, Ma KL, Zhang Y, Wu Y, Hu ZB, Lv LL,Tang RN, Liu H, Ruan XZ, Liu BC.Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease.Int J Biochem Cell Biol. 2015;61:8-619.
16.Xu M, Liu D, Ding LH, Ma KL, Wu M, Lv LL, Wen Y, Liu H,Tang RN, Liu BC.FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway.Acta Pharmacol Sin. 2014;35(12):1537-1545.
17.Ding LH, Liu D, Xu M, Liu H, Wu M,Tang RN, Lv LL, Ma KL, Liu BC.Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats.Acta Pharmacol Sin. 2014;35(10):1293-1301.
18.Chen JF, Liu H, Ni HF, Lv LL, Zhang MH, Zhang AH,Tang RN, Chen PS, Liu BC.Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats.PLoS One. 2013;8(12):e83593.
19.Lv LL, Cao Y, Liu D, Xu M, Liu H,Tang RN, Ma KL, Liu BC.Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery.Int J Biol Sci. 2013;9(10):1021-31.
20.Lv LL, Cao YH, Pan MM, Liu H,Tang RN, Ma KL, Chen PS, Liu BC.CD2AP mRNA in urinary exosome as biomarker of kidney disease.Clin Chim Acta. 2014;428:26-31.
21.Ni HF, Chen JF, Zhang MH, Pan MM, Zhang JD, Liu H,Tang RN, Ma KL, Liu BC.FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats.Ren Fail. 2013;35(7):996-1004.
30.湯日寧，伍敏，劉宏，高民，張曉良，劉必成.高糖誘導人主動脈內皮細胞-軟骨轉分化.中華腎臟病雜誌，2013,29(3):183-188.
參編書目：
1.劉必成，湯日寧，等。腎臟纖維化-基礎與臨床。北京，科學出版社。2016.1
