汪源，男，四川大學華西生物治療國家重點實驗室教授，博士生導師。
基本介紹
人物簡介,研究方向,代表論文,
人物簡介
汪源，四川大學華西生物治療國家重點實驗室研究員、博士生導師。清華大學學士（2001-2005），密西根大學博士（2005-2011）、博士後（2011-2013），美國國家兒童醫學中心博士後（2013-2016）。
課題組通過構建創新腫瘤模型，結合單細胞和空間多組學分析，研究惡性腦瘤、淋巴瘤、卵巢癌等實體腫瘤的發生髮展機制，探索腫瘤早期診斷和預防的新策略。先後以通訊或第一作者在Cell, Nature Cancer, Cancer Cell, Cell Research, Nature Communications, Science Advances等學術期刊發表論文，榮獲美國兒童腫瘤基金會“Young Investigator Award”、美國國防部“NF研究項目年度突破”，受邀在中國細胞生物學學會年會、中國神經科學學會年會、美國神經學會年會、美國兒童腫瘤基金會年會等國際國內重要學術會議上做大會報作和分組報告。
現任中國神經科學學會神經幹細胞和組織工程分會委員、神經腫瘤分會委員、中國細胞生物學會青年委員會委員、四川省細胞生物學會理事。擔任學術期刊National Science Review編輯工作組成員、Cancer Letters編委。主持國家重點研發計畫青年項目、自然科學基金面上項目和四川省傑出青年科技基金等課題。
研究方向
1、腫瘤發生髮展的細胞、分子機制
2、癌前細胞的早期標記、診斷和干預
3、單細胞和空間轉錄組技術開發和套用
4、神經幹細胞命運決定機制
代表論文
- Yao, Pengle; Xiao, Peng; Huang, Zongyao; Tang, Min; Tang, Xiwen; Yang, Gaoxia;Zhang, Qi; Li, Xinpei; Yang, Zhengnan; Xie, Chuanxing; Gong, Hui; Wang, Guihua;Liu, Yutong; Wang, Xiuxuan; Li, Huifang; Jia, Da; Dai, Lunzhi; Chen, Lu; Chen, Chong;Liu, Yu; Xiao, Hengyi; Zhang, Yan; Wang, Yuan; Protein-level mutantp53 reporters identify druggable rare precancerous clones in noncancerous tissues, Nature Cancer, 2023
- Ren, Yanming; Huang, Zongyao; Zhou, Lingling; Xiao, Peng; Song, Junwei; He, Ping; Xie, Chuanxing; Zhou, Ran; Li, Menghan; Dong, Xiangqun; Mao, Qing; You, Chao; Xu, Jianguo; Liu, Yanhui; Lan, Zhigang; Zhang, Tiejun; Gan, Qi; Yang, Yuan; Chen, Tengyun; Huang, Bowen; Yang, Xiang; Xiao, Anqi; Ou, Yun; Su, Zhengzheng; Chen, Lu; Zhang, Yan; Ju, Yan; Zhang, Yuekang; Wang, Yuan; Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas, Nature Communications, 2023, 14
- Duan, Jie; Wang, Yuan; Modeling nervous system tumors with human stem cells and organoids, Cell Regeneration, 2023, 12
- Niu, Xiaodong; Yang, Yuan; Ren, Yanming; Shengtao, Zhou; Mao, Qing; Wang, Yuan; Crosstalk between m6Aregulators and mRNA during cancer progression, Oncogene, 2022, 41: 4407-4419
- Ding, Chaoqiong; Yan, Xiang; Xu, Mengying; Zhou, Ran; Zhao, Yuanchun; Zhang, Dan; Huang, Zongyao; Pan, Zhenzhong; Xiao, Peng; Li, Huifang; Chen, Lu; Wang, Yuan; Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages, Scientific Data, 2022, 9(69)
- Wang, Xiaofei; Zhou, Ran; Xiong, Yanzhen; Zhou, Lingling; Yan, Xiang; Wang, Manli; Li, Fan; Xie, Chuanxing; Zhang, Yiming; Huang, Zongyao; Ding, Chaoqiong; Shi, Kaidou; Li, Weida; Liu, Yu; Cao, Zhongwei; Zhang, Zhen-Ning; Zhou, Shengtao; Chen, Chong; Zhang, Yan; Chen, Lu; Wang, Yuan; Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma, Cell Research, 2021, 31(6): 684-702
- Yang, Zhengnan; Wang, Wei; Zhao, Linjie; Wang, Xin; Gimple, Ran C.; Xu, Lian; Wang, Yuan; Rich, Jeremy N.; Zhou, Shengtao; Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs, Science Advances, 2021, 7(9) (共同通訊)
- Fan, Xiaolin; Xiong, Yanzhen; Wang, Yuan; A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications, Frontiers of Medicine, 2019, 13(5): 531-539
- Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan; Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1, eLife, 2014, 3 (共同一作)
- Wang, Yuan; Kim, Edward; Wang, Xiaojing; Novitch, Bennett G;Yoshikawa, Kazuaki; Chang, Long-Sheng; Zhu, Yuan; ERK inhibition rescues defectsin fate specification of Nf1-deficient neural progenitors and brain abnormalities, Cell, 2012, 150(4): 816-830
- Wang, Yuan; Yang, Jiong; Zheng, Huarui; Tomasek, Gerald J;Zhang, Peng; McKeever, Paul E; Lee, Eva Y-H P; Zhu, Yuan; Expression of mutantp53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model, Cancer Cell, 2009,15(6): 514-526
