汪海(中國農業大學農學院教授)

汪海，男，博士，中國農業大學作物基因組與生物信息學系教授。

基本介紹

• 中文名：汪海
• 畢業院校：復旦大學
• 學位/學歷：博士
• 專業方向：植物分子生物學
• 任職院校：中國農業大學

人物經歷

教育經歷

2006/09-2012/07 復旦大學，保送碩博連讀，植物分子生物學專業

2011/03-2012/07 Hong Kong Baptist University，交流學習

2008/08-2011/03 Donald Danforth Plant Science Center，交流學習

2002/09-2006/07 復旦大學，本科，生物科學專業

工作經歷

2019/10至今 中國農業大學農學院，教授

2017/11-2019/10 入選“唐氏 康奈爾-中國學者項目”，在康奈爾大學Edward Buckler實驗室開展人工智慧技術開發

2016/01-2019/10 中國農科院生物技術研究所，副研究員

2012/07-2015/12 中國農科院生物技術研究所，助理研究員

研究方向

實驗室總體目標：機器學習輔助玉米遺傳改良 。具體包括以下兩點：

（1）建立從基因組變異預測表型變異的機器學習模型

以玉米為模式植物，綜合利用機器學習技術以及分子生物學、遺傳學手段，針對“基因型—> 分子表型 —> 田間表型”軸線中的信息流動，建立機器學習模型；進而利用上述模型，在自然群體中準確預測基因組變異的分子表型效應和田間表型效應。

（2）表型預測模型在玉米重要農藝性狀改良中的套用

通過對表型預測模型的解析，在玉米自然群體中發掘遺傳變異控制表型變異的分子機制和遺傳機制；並在機制解析的基礎上，利用合成生物學技術改良玉米的重要農藝性狀。

學術成果

課題項目

主持國家自然科學基金、基礎研究引導計畫優青引導項目、協同創新項目各1項，參加國家自然科學基金重點項目、國家重點研發計畫“七大農作物育種”專項、隆平高科-中國農科院生物所科企合作項目各1項。

論文著作

(1) Wang H, Yan SJ, Xin HJ, Huang WJ, Zhang H, Teng SZ, Yu YC, Fernie AR, Lu XD, Li PC, Li SY, Zhang CY, Ruan YL, Chen LQ*, Lang ZH* (2019). A subsidiary cell-localized glucose transporter promotes stomatal conductance and photosynthesis. Plant Cell

(2) Washburn JDMejia-Guerra MK, Ramstein G, Kremling KA, Valluru R, Buckler ES*, Wang H* (2019). Evolutionarily informed deep learning methods for predicting relative transcript abundance from DNA sequence. PNAS,116:5542–5549

(3) Wang H, Wu GX, Zhao BB, Wang BB, Lang ZH, Zhang CY, Wang HY (2016) Regulatory modules controlling early shade avoidance response in maize seedlings. BMC Genomics 17: 269

(4) Li SY Wang HLi FQ, Chen ZL, Li XY, Zhu L, Wang G, Yu J, Huang DF, Lang ZH (2015) The maize transcription factor EREB58 mediates the jasmonate-induced production of sesquiterpene volatiles. Plant Journal 84: 296–308

(5) Wang H, Wang HY (2015) Phytochrome signaling: time to tighten up the loose ends. Molecular Plant 8: 540–551

(6) Wang H, Wang HY (2015) Multifaceted roles of FHY3 and FAR1 in light signaling and beyond. Trends in Plant Science 20: 453–461

(7) Wang H, Wang HY (2015) The miR156/SPL Module, a Regulatory Hub and Versatile Toolbox, Gears up Crops for Enhanced Agronomic Traits. Molecular Plant 8: 677–688

(8) Wang H, Li SY#, Teng SZ, Liang HS, Xin HJ, Gao H, Huang DF, and Lang ZH (2017). Transcriptome profiling revealed novel transcriptional regulators in maize responses to Ostrinia furnacalis and jasmonic acid. PLoS One 12: e0177739.

(9) Wang H, Lu YQ, Jiang TT, Berg H, Li C, Xia YJ (2013) The Arabidopsis U-box/ARM repeat E3 ligase AtPUB4 influences growth and degeneration of tapetal cells, and its mutation leads to conditional male sterility. Plant Journal 74: 511–523

(10) Wang H, Lu YQ, Liu P, Wen W, Zhang JH, Ge XC, Xia YJ (2013) The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Plant Journal 73: 262–275

(11) Wang H, Wang SB, Lu YQ, Alvarez S, Hicks LM, Ge XC, Xia YJ (2012) Proteomic analysis of early-responsive redox-sensitive proteins in Arabidopsis. Journal of Proteome Research 11: 412–424

(12) Wang H, Wang SB, Xia YJ (2012) Identification and Verification of Redox-Sensitive Proteins in Arabidopsis thaliana. In Z-Y Wang, Z Yang, eds, Plant Signalling Networks: Methods and Protocols. Humana Press, Totowa, NJ, pp 83–94 (Book chapter)

(13) Wang H, Liang Q, Cao KM, Ge XC (2011) Endogenous protein mono-ADP-ribosylation in Arabidopsis thaliana. Planta 233: 1287–1292

(14) Li SY, Wang Z, Zhou Y, Li C, Wang G, Wang H, Zhang J, Liang G, Lang ZH (2018) Expression of cry2Ah1 and two domain II mutants in transgenic tobacco confers high resistance to susceptible and Cry1Ac-resistant cotton bollworm. Scientific Report 8: 508

(15) Xie YR, Liu Y, Wang H, Ma XJ, Wang BB, Wu GX, Wang HY (2017) Phytochrome-interacting factors directly suppress MIR156 expression to enhance shade-avoidance syndrome in Arabidopsis. Nature Communication 8: 348

(16) Liu Y, Xie YR, Wang H, Ma XJ, Yao W, Wang HY (2017) Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation ofPHOSPHATE STARVATION RESPONSE1. Plant Cell 29:2269–2284

(17) Sun H, Zhou N, Wang H, Huang DF, Lang ZH (2017) Processing and targeting of proteins derived from polyprotein with 2A and LP4/2A as peptide linkers in a maize expression system. PLoS One 12: e0174804

(18) Pan YY, Chen R, Zhu L, Wang H, Huang DF, Lang ZH (2016) Utilizing modified ubi1 introns to enhance exogenous gene expression in maize (Zea mays L.) and rice (Oryza sativa L.). Journal of Integrative Agriculture 15: 1716–1726

(19) Liu P, Zhang H, Wang H, Xia YJ (2014) Identification of redox-sensitive cysteines in the Arabidopsis proteome using OxiTRAQ, a quantitative redox proteomics method. Proteomics 14: 750–762

(20) Lu YQ, Li C, Wang H, Chen H, Berg H, Xia YJ (2011) AtPPR2, an Arabidopsis pentatricopeptide repeat protein, binds to plastid 23S rRNA and plays an important role in the first mitotic division during gametogenesis and in cell proliferation during embryogenesis. Plant Journal 67: 13–25

(21) Wang XF, Wang H, Li YL, Cao KM, Ge XC (2009) A rice lipid transfer protein binds to plasma membrane proteinaceous sites. Molecular Biology Reports 36: 745–750

(22) Ge XC, Wang H, Cao KM (2008) Transformation by T-DNA integration causes highly sterile phenotype independent of transgenes in Arabidopsis thaliana. Plant Cell Reports 27: 1341–1348