基本介紹
- 中文名：毛應啟梁
- 畢業院校：復旦大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：緩解神經痛、炎症痛、癌痛的神經生物學機制研究
- 就職院校：復旦大學基礎醫學院中西醫結合學系
研究方向,主要貢獻,人物經歷,學術成果,
研究方向
1.針刺緩解神經痛、炎症痛、癌痛的神經生物學機制研究
2.針刺緩解化療引起感覺異常的作用機制研究
主要貢獻
建立了Walker 256大鼠乳腺癌致脛骨癌痛模型並通過比較骨癌痛與神經痛、炎症痛，觀察了Toll樣受體介導的脊髓神經炎症在骨癌痛中的作用以及Toll樣受體在針刺緩解慢性痛中的作用。目前主要從脊髓小膠質細胞活化調控的角度研究針刺緩解不同慢性痛的作用機制，以及針刺緩解化療引起的外周感覺異常（疼痛與感覺遲鈍）行為的作用機制。先後承擔國家自然科學基金青年項目1項和面上項目2項、上海市衛生局科研課題1項。已在BBI、Molecular Brain等雜誌發表第一作者或通訊作者學術論文十餘篇。
人物經歷
2014.12 -至今 ，任復旦大學基礎醫學院中西醫結合學系副教授
2012.8 - 2013.11，MD Anderson Cancer Center症狀研究系博士後
2011.11 - 2012.8，University of Illinois at Urbana-Champaign動物科學系博士後
2007.7留校，先後任復旦大學基礎醫學院中西醫結合學系助教、講師（2007.10 - 2014.12）
1997.9 - 2002.7，復旦大學上海醫學院（原上海醫科大學）基礎醫學專業本科
學術成果
論文
1.Hu LY, Mi WL, Wu GC, Wang YQ,Mao-Ying QL*. Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms. Curr Neuropharmacol. 2019,17(2):184-196. （Review）
2.Hu LY, Yang-Zhou, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ,Mao-Ying QL*. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain Behav Immun. 2018, 68: 132-145.
3.Liu H, Liu SB, Li Q, Wang H, Wang YQ,Mao-Ying QL*. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med. 2015:848603.
4.Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014, 23;9(6):e100701
5.Li X, Wang XW, Feng XM, Zhou WJ, Wang YQ,Mao-Ying QL*, Stage-dependent anti-allodynic effects of intrathecal Toll-like receptor 4 antagonists in a rat model of cancer induced bone pain. J Physiol Sci. 2013, 63(3):203-9.
6.Mao-Ying QL, Wang XW, Yang CJ, Li X, Mi WL, Wu GC, Wang YQ. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Mol Brain. 2012, 5:16.
7.Yang CJ, Li Q, Wu GC, Wang YQ,Mao-Ying QL*. A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats. Neurosci Lett. 2012, 513(2):198-203.
8.Yang CJ, Wang XW, Li X, Wu GC, Wang YQ,Mao-Ying QL*. A rat model of bone inflammation-induced pain by intra-tibial complete Freund's adjuvant injection. Neurosci.Lett. 2011, 490(3):175-9.
9.Qi-Liang Mao-Ying, Jun Zhao, Zhi-Qiang Dong, Jun Wang, Jin Yu, Min-Fen Yan, Yu-Qiu Zhang, Gen-Cheng Wu, Yan-Qing Wang. A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. Biochemical and Biophysical Research Communication. 2006, 345: 1292-1298.
10.Qi-Liang Mao-Ying, Ke-Mi Cui, Qiong Liu, Zhi-Qiang Dong, Wei Wang, Jun Wang, Hong Sha, Gen-Cheng Wu, Yan-Qing Wang. Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain. European Journal of Pain. 2006, 10(8): 689-94.
11.Shan Sun,Qi-Liang Mao-Ying, Hong Cao, Tingting Li, Mei Han, Haili Pan, Yan-Qing Wang, Zhi-Qi Zhao and Yu-Qiu Zhang. Is functional state of spinal microglia involved in the anit-allodynic and anti-hyperalgesic effects of electroacupuncture in rat model of monoarthritis? Neurobiology of Disease. 2007, 26(3): 558-68.
12.Qi-Liang Mao-Ying, Dian-Huan Ren, Wen-Li Mi, Qiong Liu, Yan-Qing Wang. Analgesic effects of electroacupuncture combined with Celebrex on rats with tibial cancer pain. Journal of Chinese Integrative Medicine. 2008, 6(8): 830-835. (article in Chinese with English abstract)
13.Qi-Liang Mao-Ying, Wen-Li Mi. Acupuncture Analgesia in Clinical Practice. 針刺治療神經生物學研究，Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng主編.2009, 162-193.（英文專著）
