毛志勇(同濟大學生命科學與技術學院教授)

個人簡介

毛志勇，教授，博士生導師。2002年畢業船白酷於姜市希蒸南京大學，獲生物科學學士學位；2004年畢業於南京大學植物學專業，獲得植物學碩士學位；2010年畢業於美國羅徹斯特大學，獲博晚幾蒸連士學位，主要從事DNA雙鏈斷裂修復的分子生物學機制的研究。2010年-2012年於羅徹斯特大學生物系從事博士後研究，主要研究方向是衰老以及腫瘤與DNA修復之間的關係。2012年9月於同濟大學建立課題組開展衰老相關基因組穩定性的機制研究。

毛淋提晚志勇教授已在Nature、Nucleic Acids Res、Cell Death Differ、Cell Reports、Oncogene等重要學術期刊發表通訊作者論文十餘篇，在Science、PNAS等學術期刊發表第一作者論文七篇。

毛志勇教授於2013年擔任科技部“973”計畫青年項目首席科學家定挨芝，2013年獲上海市“浦江人才”項目資助，2016年獲國家自然科學基嚷享金委優秀青年項目資助，2019年獲上海市“優秀學術帶頭人”項目資助。

研究方向

1、衰老及相關疾病發生髮展過程中DNA修復變化和調控機制

2、慨尋燥幹細胞基因組穩定性維持和調控機制

3、延緩衰老及預防、治療衰老相關疾病的新方法的開發和轉化

代表性論文

1.Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z, Ge B. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature.2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. * Corresponding authors.

2.Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y, Gorbunova V,Mao Z. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res.2019 Jul 10. pii: gkz592. doi: 10.1093/nar/gkz592.* Corresponding author.

3.Tang H, Geng A, Zhang T, Wang C, Jiang Y,Mao Z.Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion. Protein & Cell.2019 May;10(5):370-375. doi: 10.1007/s13238-018-0591-y.* Corresponding author.

4. Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y,Mao Z.Use of the XRCC2 promoter for in vivocancer diagnosis and therapy. Cell Death & Disease.2018 Mar 16;9(4):420. doi: 10.1038/s41419-018-0453-9.* Corresponding authors.

5. Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Li Lan,Mao Z. POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY). 2017 Dec 8;9(12):2529-2543. * Corresponding authors.

6. Zhang F, Tang H, Jiang Y,Mao Z. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene.2017 Sep 7;36(36):5168-5176. doi: 10.1038/onc.2017.127. * Corresponding authors.

7.Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z*, Kang J*. Sirt6 promotes DNA end joining in iPS cells derived from old mice. Cell Reports.2017 March 21: 18: 2880–2892. * Corresponding authors.

8. Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL,Mao Z. Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Cell Death Differ.2016 Nov 1;23(11):1765-1777. doi: 10.1038/cdd.2016.65.Corresponding author.

9.Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol.2015 Jan 15;35(2):406-16. * Corresponding authors.

10. Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z.SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle.2015;14(2):269-76. doi: 10.4161/15384101.2014.980641. * Corresponding author.

11.Xu Y, Ohms SJ, Li Z, Wang Q, Gong G, Hu Y, Mao Z, Shannon MF, Fan JY. Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance. PLoS One.2013 Nov 26;8(11):e82062. * Corresponding authors.

12.Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G, Zhang J.Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol. 2018 Dec;14(12):1118-1126. doi: 10.1038/s41589-018-0150-0.11.

13. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J, Tang F, Liu GH. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res.2016 Feb;26(2):190-205. doi: 10.1038/cr.2016.4.

14.Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V. Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet.2014 Jul 17;10(7):e1004511.

15. Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V. Regulation of Rad51 promoter. Cell Cycle. 2014 Jul 1;13(13):2038-45.

16.Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature.2013 Jul 18;499(7458):346-9.

17.Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A.Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.Proc Natl Acad Sci U S A.2012 Jul 17;109(29):11800-5.

18.Mao Z, Ke Z, Gorbunova V, Seluanov A.Replicatively senescent cells are arrested in G1 and G2 phases.Aging (Albany NY).Jun;4(6):431-5.

19.Van Meter M, Mao Z, Gorbunova V and Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY).2011 Sep;3(9):829-35.

20.Van Meter M, Mao Z, Gorbunova V and Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.Cell Cycle.2011 Sep. 15; 15:18.

21. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1.Science.17 June 2011: 1443-1446.

22.Seluanov A, Mao Z, Gorbunova V. Analysis of DNA Double-Strand Break (DSB) Repair in Mammalian Cells. J Vis Exp.2010 Sep 8;(43).

23. Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. Naked mole-rat cells are hypersensitive to contact inhibition – a clue to extraordinary cancer resistance. Proc Natl Acad Sci U S A.2009 Nov 17; 106(46): 19352-7.

24. Mao Z, Jiang Y, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia.2009 Jul; 11(7):683-691. * These authors contributed equally to this work.

25. Mao Z, Bozzella M, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle.2008 Sep 15; 7:18, 1-5. * These authors contributed equally to this work.

26. Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst).2008 Oct 1;7(10):1765-71.

27.Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic Acids Res.2007;35(22):7466-74.

28. Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A.2007 Aug 7;104(32):13068-73.

29. Li PF, Mao ZY, Rao XJ, Wang XM, Min MZ, Qiu LW and Liu ZL. Biosorption of uranium by lake-harvested biomass from a cyanobacterium bloom. Bioresour Technol.2004 Sep;94(2):193-5.

30. Wang X, Zhao X, Mao ZY, Wang XM and Liu ZL. Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. Neuroreport.2003 Dec 19;14(18):2457-61.

毛志勇(同濟大學生命科學與技術學院教授)

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個人簡介

研究方向

代表性論文

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