殷黎晨

殷黎晨，蘇州大學功能納米與軟物質研究院教授， 博士生導師。

基本介紹

  • 中文名：殷黎晨
  • 職業：教師
人物經歷,招生方向,招聘信息,研究方向,代表論文,

人物經歷

2005年7月獲復旦大學生物科學專業學士學位；2010年7月獲復旦大學生物化學與分子生物學專業博士學位。2010年11月至2014年1月在美國伊利諾伊大學香檳分校（UIUC）材料科學與工程系從事博士後研究工作。2014年1月加盟蘇州大學功能納米與軟物質研究院，被聘為特聘教授、博士生導師。
國家傑出青年科學基金、優秀青年科學基金獲得者，入選江蘇省特聘教授（重點資助）、江蘇省雙創人才、江蘇省六大人才高峰。圍繞生物醫用高分子材料、生物大分子藥物遞送系統開展研究，發表SCI論文150餘篇，其中以通訊作者在Nature Chemical Biology、Nature Communications、Science Advances、PNAS、JACS、Angewandte Chemie、Advanced Materials等知名期刊發表論文80餘篇。論文他引9000餘次，H因子50。獲中國發明專利19項，美國專利2項。為歐美權威教材《Biomaterials Science》、工具書《Encyclopedia of Nanomaterials》等撰寫章節。主持國家重點研發計畫課題1項、國家自然科學基金7項、江蘇省重點研發計畫1項。擔任美國化學會年會（2019）分會主席、Biomaterial Science期刊副主編、Journal of Controlled Release期刊助理編輯、Advanced Drug Delivery Reviews期刊客座編輯以及多個學術期刊編委/青年編委，任中國抗癌協會醫工整合專委會常務委員。

招生方向

本課題組熱忱歡迎有志從事科研工作的本科生、碩士研究生和博士研究生加盟。本課題組的研究為交叉學科，招生方向包括“化學”、“生物學”以及“材料學”，歡迎具有化學、材料或生物背景的同學報考。

招聘信息

博士後：擬招收3-5名從事高分子生物材料合成、納米藥物設計、基因藥物遞送研究的博士後研究人員，要求能夠獨立開展研究工作，具有良好的英文寫作與交流能力；易於溝通，可以協助指導研究生。具有高分子化學、有機化學、生物材料或藥劑學背景的申請者優先考慮。待遇優厚，且有機會到國外交流訪學。
講師/副教授：擬招聘1-2名課題組講師/副教授，要求獲得（或即將獲得）博士學位，具有高分子化學、生物材料或藥劑學背景，在主流期刊上發表過SCI論文，能夠獨立開展研究並指導研究生。

研究方向

（1）聚胺基酸生物材料：研究可用於藥物載體、基因載體、免疫調節劑的聚胺基酸的合成與功能化修飾，探討聚胺基酸的二級結構效應和調控方式。
（2）智慧型化藥物遞送系統：研究可改善蛋白質、多肽、核酸、小分子化學藥物、氣體分子等功效的新型給藥載體的加工、改性、組裝、體內外作用機理及其給藥系統的設計。
（3）抗炎治療與抗腫瘤治療：根據疾病的發病機制及病灶部位的生理特點，設計新型納米藥物調控腫瘤、炎症等免疫微環境，用於腫瘤、炎症（如肝炎、胰腺炎、心肌梗死、急性肺損傷、腦卒中、骨性關節炎等）、自身免疫性疾病（如潰瘍性結腸炎、類風濕性關節炎、系統性紅斑狼瘡等）的治療。
主持國家重點研發計畫課題1項、國家自然科學基金7項、江蘇省重點研發計畫1項。擔任美國化學會年會（2019）分會主席、Biomaterial Science期刊副主編、Journal of Controlled Release期刊助理編輯、Advanced Drug Delivery Reviews期刊客座編輯以及多個學術期刊編委/青年編委，任中國抗癌協會醫工整合專委會常務委員。

代表論文

  1. Xun Liu, Ziyin Zhao, Wei Li, Ningyu Liu, Qiang Yang, Lichen Yin*. Engineering nucleotidoproteins for base pairing-assisted cytosolic delivery and genome editing. Angew Chem Int Ed, 2023, in press.
  2. Chenglong Ge, Junliang Zhu, Huan Ye, Yuansong Wei, Yuheng Lei, Renxiang Zhou, Ziyuan Song, Lichen Yin*. Rational Construction of Protein-mimetic Nano-switch System Based on Secondary Structure Transition of Synthetic Polypeptide. J Am Chem Soc, 2023, 145, 11206-11214.
  3. Yang Zhou, Qiujun Liang, Xuejie Wu, Shanzhou Duan, Chenglong Ge, Huan Ye, Jianhui Lu, Rongying Zhu, Yongbing Chen, Fenghua Meng, Lichen Yin*. siRNA delivery against myocardial ischemia reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes. Adv Mater, 2023, 35, 2210691.
  4. Yuansong Wei, Xudong Li, Juanhui Lin, Yang Zhou, Jiandong Yang, Mengying Hou, Fan Wu, Jing Yan, Chenglong Ge, Duanmin Hu, Lichen Yin*. Oral delivery of siRNA using fluorinated, small-sized nanocapsules toward anti-inflammation treatment. Adv Mater, 2023, 35, 2206821.
  5. Ziyin Zhao, Xun Liu, Mengying Hou, Renxiang Zhou, Fan Wu, Jing Yan, Wei Li, Yujia Zheng, Qinmeng Zhong, Lichen Yin*. Endocytosis-independent and Cancer-selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate. Adv Mater, 2022, 34, 2110560.
  6. Xun Liu, Ziyin Zhao, Fan Wu, Yongbing Chen, Lichen Yin*. Tailoring Hyperbranched Poly(β-amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery. Adv Mater, 2022, 34, 2108116.
  7. Mengying Hou, Yuansong Wei, Ziyin Zhao, Wenqing Han, Renxiang Zhou, Yang Zhou, Yiran Zheng, Lichen Yin*. Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases. Adv Mater, 2022, 34, 2108817.
  8. Jing Yan, Xun Liu, Chenglong Ge, Fan Wu, Huan Ye, Xingye Chen, Yuansong Wei, Renxiang Zhou, Shanzhou Duan, Rongying Zhu, Yiran Zheng, Lichen Yin*. Platelet pharmacytes for the hierarchical amplification of anti-tumor immunity in response to self-generated immune signals. Adv Mater, 2022, 34, 2109517.
  9. Yang Zhou, Yekun Deng, Zhongmin Liu, Mengyuan Yin, Mengyin Hou, Ziyin Zhao, Xiaozhong Zhou, Lichen Yin*. Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis. Sci Adv, 2021, 7, eabl6432.
  10. Yekun Deng, Yang Zhou, Qiujun Liang, Chenglong Ge, Jiandong Yang, Bingchen Shan, Yong Liu, Xiaozhong Zhou*, Lichen Yin*. Inflammation-Instructed Hierarchical Delivery of IL-4/miR-21 Orchestrates Osteoimmune Microenvironment Toward the Treatment of Rheumatoid Arthritis. Adv Funct Mater, 2021, 31, 2101033.
  11. Jiandong Yang, Shanzhou Duan, Huan Ye, Chenglong Ge, Chunxian Piao, Yongbing Chen, Minhyung Lee, Lichen Yin*. Pro-peptide-reinforced, mucus-penetrating pulmonary siRNA delivery mitigates cytokine storm in pneumonia. Adv Funct Mater, 2021, 31, 2008960.
  12. Yong Liu, Lichen Yin*.α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery. Adv Drug Deliver Rev, 2021, 171, 139-163.
  13. Xudong Li, Yuansong Wei, Yuchen Wu, Lichen Yin*. Hypoxia-instructed pro-protein therapy assisted with self-catalyzed nanozymogen. Angew Chem Int Ed, 2020, 59, 22544-22553.
  14. Shixian Lv, Hojun Kim, Ziyuan Song, Feng Lin, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J. Dillon, Cecilia Leal, Lichen Yin*, Jianjun Cheng*. Unimolecular polypeptide micelles via ultra-fast polymerization of N-carboxyanhydrides. J Am Chem Soc, 2020, 142, 8570-8574.
  15. Chenglong Ge, Jiandong Yang, Shanzhou Duan, Yong Liu, Fenghua Meng, Lichen Yin*. Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury. Nano Lett, 2020, 20, 1738−1746.
  16. Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*, Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters. Biomaterials, 2020, 255, 120166.
  17. Yongjuan Li, Juanjuan Dang, Qiujun Liang, Lichen Yin*. Thermal-responsive carbon monoxide (CO) delivery expedites metabolic exhaustion of cancer cells toward reversal of chemotherapy resistance.ACS Cent Sci, 2019, 5, 1044−1058.
  18. Yongjuan Li, Juanjuan Dang, Qiujun Liang, Lichen Yin*. Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction. Biomaterials, 2019, 209, 138-151.
  19. Juanjuan Dang, Huan Ye, Yongjuan Li, Qiujun Liang, Xudong Li, Lichen Yin*. Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism. Biomaterials, 2019, 223, 119463.
  20. Jinhui Wang, Hua He, Xin Xu, Xiao Wang, Yongbing Chen, Lichen Yin*. Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy. Biomaterials, 2018, 171, 72-82.
  21. Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li,Min Lan, Xuesi Chen, Jianjun Cheng,Lichen Yin*. High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor−Receptor Coordination Interactions. J Am Chem Soc, 2018, 140, 1235−1238.
  22. Hong-Xia Wang, Ziyuan Song, Yeh-Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Mingqiang Li, Dangtong Huang, Lichen Yin*, Jianjun Cheng*, Kam W. Leong*. Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide. Proc Natl Acad Sci USA, 2018, 115, 4903-4908.
  23. Hua He, Yongbing Chen, Yongjuan Li, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng*,Lichen Yin*. Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering. Adv Funct Mater, 2018, 28, 1706710.
  24. Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*, Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat Chem Biol, 2017, 13, 415-424.
  25. Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*, Lichen Yin*, Jianjun Cheng*. Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands. Nat Commun, 2017, 8:92.
  26. Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek, Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*. Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides. Proc Natl Acad Sci USA, 2017, 114, 12675-12680.
  27. Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying, Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition. Angew Chem Int Ed, 2017, 56, 10826-10829.

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