段成國，男，中國科學院大學專任教師。
基本介紹
- 中文名：段成國
- 國籍：中國
- 民族：漢
- 畢業院校：山東農業大學
- 學位/學歷：博士
人物經歷,教育背景,工作經歷,研究方向,科研成果,發表論文,發表著作,參與會議,科研項目,
人物經歷
教育背景
2004-09--2008-07 中國科學院微生物研究所 博士學位
2001-09--2004-07 山東農業大學 碩士學位
1997-09--2001-07 山東農業大學 學士學位
工作經歷
2018 入選第十四批國家“****”青年人才
2016.11-至今： 研究員，博士生導師，中國科習拘備學院分子植物科學卓越創新中心，上海煮朽辯充植物逆境滲射婆生物學研究中心
2011.10-2016.10：艱埋循鑽博士後，美國普渡大學
2008.07-2011.10：助理研究員，中國科學院微生物研究所，植物基因組學國家重點實驗室
研究方向
1. 植物兆她籃表觀遺傳信息（DNA甲想紙基化、組蛋白修飾）的催化、識別與作用機制；
2. 非編碼RNA及RNA修飾汽屑危在植物-病原微生物互作中的作用；
3. 植物病原真菌致病機制及抗病策略開發
科研成果
發表論文
（1）Xie SS#, Zhang YZ#, Peng L, Yu DT, Zhu G, ZhaoQZ, Wang CH, Xie Q, Duan CG*. JMJ28 guides sequence-specific targetingof ATX1/2-containing COMPASS-like complex in Arabidopsis. Cell Rep. 2023, 42(3): 112163.
（2）Zhang J#, Yuan J#, Lin J#,Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylationcatalyzed by SUVH6 in plants. Proc Natl Acad Sci U S A. 2023, 120 (1): e2208525120.
（3）Liu T, Xu LG, Duan CG*.The trans-kingdom communication of noncoding RNAs in plant-environmentinteractions. Plant Genome, 2022: e20289.
（4）Chang YN#, Wang ZJ#, RenZ, Wang CH, Wang P, Zhu JK, Li X*, Duan CG*.NUCLEAR PORE ANCHOR and EARLY IN SHORT DAYS 4 negatively regulate abscisic acidsignaling by inhibiting Snf1-related protein kinase2 activity and stability inArabidopsis. J Integr Plant Biol. 2022, 64 (11): 2060-2074.
（5）Zhu C#, Liu JH#, Zhao JH, Liu T, Chen YY, WangCH, Zhang ZH, Guo HS, Duan CG*. A fungal effector suppresses the nuclear exportof AGO1-miRNA complex to promote infection in plants. Proc Natl Acad Sci U S A.2022, 119(12): e2114583119.
（6）You LY#, Lin J#, Xu HW#,Chen CX, Chen JY, Zhang J, Zhang J, Li YX, Ye C, Zhang H, Jiang J, Zhu JK, LiQQ*, DuanCG*. Intragenic heterochromatin-mediated alternativepolyadenylation modulates miRNA and pollen development in rice. New Phytol.2021, 232 (2): 835-852.
（7）Zhang YZ#, Lin J#, Ren Z#, Chen CX#, Miki D#,Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ*, Zhu JK*, Duan CG*. Genome-widedistribution and functions of the AAE complex in epigenetic regulation inArabidopsis. J Integr Plant Biol. 2021, 63 (4): 707-722.
（8）Zhang YZ#, Yuan JL#, Zhang L#, Chen CX, Wang Y,Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Duan J*, Duan CG*. Coupling ofH3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2complex in Arabidopsis. Nat Commun. 2020 11 (1): 6212.
（9）Zhang J, Zhang YZ, Jiang J, Duan CG*. Thecrosstalk between epigenetic mechanisms and alternative RNA processingregulation. Front Genet. 2020, 11: 998.
（10）Chang YN, Zhu C, Jiang J,Zhang H, Zhu JK, Duan CG*. Epigenetic regulation in plant abiotic stressresponses. J Integr Plant Biol. 2020, 62 (5): 563-580.
（11）Cui C#, Wang JJ#, ZhaoJH#, Fang YY, He XF, Guo HS, Duan CG*. ABrassica miRNA Regulates Plant Growth and Immunity through Distinct Modes ofAction. Mol Plant. 2020, 13 (2): 231-245.
（12）Zhu C, Liu T, Chang YN, Duan CG*. Small RNAFunctions as a Trafficking Effector in Plant Immunity. Int J Mol Sci. 2019, 20 (11):2816.
（13） Zhu G, Chang Y, Xu X, TangK, Chen C, Lei M, Zhu JK, Duan CG*.EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulatingnucleo-cytoplasmic partitioning of HDA6. J Integr Plant Biol. 2019, 61 (12): 1243-1254.
（14）Duan CG*, Zhu JK*, Cao X*. Retrospective andperspective of plant epigenetics in China. J Genet Genomics. 2018, 45 (11): 621-638.
（15）Duan CG#*, Wang X#, Zhang L, Xiong X, Zhang Z,Tang K, Pan L, Hsu CC, Xu H, Tao WA, Zhang H, Zhu JK*. A protein complexregulates RNA processing of intronic heterochromatin-containing genesin Arabidopsis. Proc Natl Acad Sci U S A. 2017,114 (35): e7377-E7384.
（16） Duan CG*, ZhuJK. Dissecting the Subnuclear Localization Patterns of Argonaute Proteins andOther Components of the RNA-Directed DNA Methylation Pathway in Plants. MethodsMol Biol. 2017, 1640: 129-135.
（17）Duan CG#,Wang X#, Xie S, Pan L, Miki D, Tang K, Hsu CC, Lei M, Zhong Y, Hou YJ, Wang Z,Zhang Z, Mangrauthia SK, Xu H, Zhang H, Dilkes B, Tao WA, Zhu JK. A pair oftransposon-derived proteins function in a histone acetyltransferase complex foractive DNA demethylation. Cell Res. 2017, 27 (2): 226-240.
（18）Fang YY, Zhao JH, Liu SW,Wang S, DuanCG*, Guo HS*. CMV2b-AGO Interaction Is Required for theSuppression of RDR-Dependent Antiviral Silencing in Arabidopsis. FrontMicrobiol. 2016, 24 (7): 1329.
（19）Duan CG#, Wang X#, Tang K, Zhang H, MangrauthiaSK, Lei M, Hsu CC, Hou YJ, Wang C, Li Y, Tao WA, Zhu JK*. MET18 Connects theCytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation inArabidopsis. PLoS Genet. 2015, 11 (10): e1005559.
（20）Li Y#, DuanCG#, Zhu X, Qian W, Zhu JK*. A DNA ligase required for activeDNA demethylation and genomic imprinting in Arabidopsis. Cell Res. 2015, 25 (6):757-60.
（21）Duan CG#,Zhang H#, Tang K#, Zhu X, Qian W, Hou YJ, Wang B, Lang Z, Zhao Y, Wang X, WangP, Zhou J, Liang G, Liu N, Wang C, Zhu JK*. Specific but interdependentfunctions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBOJ. 2015, 34 (5): 581-92.
（22）Wang X#, DuanCG#, Tang K, Wang B, Zhang H, Lei M, Lu K, Mangrauthia SK,Wang P, Zhu G, Zhao Y, Zhu JK. RNA-binding protein regulates plant DNAmethylation by controlling mRNA processing at the intronicheterochromatin-containing gene BM1. Proc Natl Acad Sci U S A. 2013, 110 (38): 15467-72.
（23）Feng L#, DuanCG#, Guo HS*. Inhibition of in vivo slicer activity ofArgonaute protein 1 by the viral 2b protein independent of its dsRNA-bindingfunction. Mol Plant Pathol. 2013, 14 (6): 617-22.
（24）Duan CG, WangCH, Guo HS*. Application of RNA silencing to plant disease resistance. Silence.2012 May 31;3(1):5.
（25）Duan CG#,Fang YY#, Zhou BJ, Zhao JH, Hou WN, Zhu H, Ding SW, Guo HS*. Suppression ofArabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, andDNA methylation by distinct domains of the Cucumber mosaic virus 2b protein.Plant Cell. 2012,24(1):259-74.
（26）Hou WN#, Duan CG#, Fang RX, Zhou XY, Guo HS*.Satellite RNA reduces expression of the 2b suppressor protein resulting in theattenuation of symptoms caused by Cucumber mosaic virus infection. Mol PlantPathol. 2011, 12 (6): 595-605.
（27）Duan CG, Wang CH, Fang RX,Guo HS*. Artificial MicroRNAs highly accessible to targets confer efficientvirus resistance in plants. J Virol. 2008, 82 (22): 11084-11095.
（28）Du QS#, Duan CG#, Zhang ZH#, Fang YY, Fang RX,Xie Q, Guo HS*. DCL4 targets Cucumber mosaic virus satellite RNA at novelsecondary structures. J Virol. 2007, 81 (17): 9142-9151
發表著作
（1） 小分子RNA介導的基因表達調控, Regulation of Gene Expression by Small RNAs, 科學出版社, 2012-01, 第 2 作者
參與會議
（1）The interplay between intragenic heterochromatin and RNA processing in Arabidopsis 第30屆國際擬南芥大會 2019-06-17
（2）Epigenetic silencing-mediated alternative polyadenylation (APA) regulates CHG methyaltion by promoting the proper expression of histone demethylase IBM1 第十九屆國際植物學大會 2017-07-21
科研項目
（1）2018 國家“****”項目資助；
（2）2017 國家自然科學基金面上項目《DNA甲基化調控植物與棉花黃萎病菌Verticillium dahliae互作的分子機制》，主持，2018.01-2021.12
（3）2016 中國科學院自主部署/引進人才經費資助
（4）2010 國家自然科學基金青年基金《病毒衛星RNA來源的siRNA對病毒致病性的影響研究》 , 主持, 2010.01-2012.12
（5）Zhu C#, Liu JH#, Zhao JH, Liu T, Chen YY, WangCH, Zhang ZH, Guo HS, Duan CG*. A fungal effector suppresses the nuclear exportof AGO1-miRNA complex to promote infection in plants. Proc Natl Acad Sci U S A.2022, 119(12): e2114583119.
（6）You LY#, Lin J#, Xu HW#,Chen CX, Chen JY, Zhang J, Zhang J, Li YX, Ye C, Zhang H, Jiang J, Zhu JK, LiQQ*, DuanCG*. Intragenic heterochromatin-mediated alternativepolyadenylation modulates miRNA and pollen development in rice. New Phytol.2021, 232 (2): 835-852.
（7）Zhang YZ#, Lin J#, Ren Z#, Chen CX#, Miki D#,Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ*, Zhu JK*, Duan CG*. Genome-widedistribution and functions of the AAE complex in epigenetic regulation inArabidopsis. J Integr Plant Biol. 2021, 63 (4): 707-722.
（8）Zhang YZ#, Yuan JL#, Zhang L#, Chen CX, Wang Y,Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Duan J*, Duan CG*. Coupling ofH3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2complex in Arabidopsis. Nat Commun. 2020 11 (1): 6212.
（9）Zhang J, Zhang YZ, Jiang J, Duan CG*. Thecrosstalk between epigenetic mechanisms and alternative RNA processingregulation. Front Genet. 2020, 11: 998.
（10）Chang YN, Zhu C, Jiang J,Zhang H, Zhu JK, Duan CG*. Epigenetic regulation in plant abiotic stressresponses. J Integr Plant Biol. 2020, 62 (5): 563-580.
（11）Cui C#, Wang JJ#, ZhaoJH#, Fang YY, He XF, Guo HS, Duan CG*. ABrassica miRNA Regulates Plant Growth and Immunity through Distinct Modes ofAction. Mol Plant. 2020, 13 (2): 231-245.
（12）Zhu C, Liu T, Chang YN, Duan CG*. Small RNAFunctions as a Trafficking Effector in Plant Immunity. Int J Mol Sci. 2019, 20 (11):2816.
（13） Zhu G, Chang Y, Xu X, TangK, Chen C, Lei M, Zhu JK, Duan CG*.EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulatingnucleo-cytoplasmic partitioning of HDA6. J Integr Plant Biol. 2019, 61 (12): 1243-1254.
（14）Duan CG*, Zhu JK*, Cao X*. Retrospective andperspective of plant epigenetics in China. J Genet Genomics. 2018, 45 (11): 621-638.
（15）Duan CG#*, Wang X#, Zhang L, Xiong X, Zhang Z,Tang K, Pan L, Hsu CC, Xu H, Tao WA, Zhang H, Zhu JK*. A protein complexregulates RNA processing of intronic heterochromatin-containing genesin Arabidopsis. Proc Natl Acad Sci U S A. 2017,114 (35): e7377-E7384.
（16） Duan CG*, ZhuJK. Dissecting the Subnuclear Localization Patterns of Argonaute Proteins andOther Components of the RNA-Directed DNA Methylation Pathway in Plants. MethodsMol Biol. 2017, 1640: 129-135.
（17）Duan CG#,Wang X#, Xie S, Pan L, Miki D, Tang K, Hsu CC, Lei M, Zhong Y, Hou YJ, Wang Z,Zhang Z, Mangrauthia SK, Xu H, Zhang H, Dilkes B, Tao WA, Zhu JK. A pair oftransposon-derived proteins function in a histone acetyltransferase complex foractive DNA demethylation. Cell Res. 2017, 27 (2): 226-240.
（18）Fang YY, Zhao JH, Liu SW,Wang S, DuanCG*, Guo HS*. CMV2b-AGO Interaction Is Required for theSuppression of RDR-Dependent Antiviral Silencing in Arabidopsis. FrontMicrobiol. 2016, 24 (7): 1329.
（19）Duan CG#, Wang X#, Tang K, Zhang H, MangrauthiaSK, Lei M, Hsu CC, Hou YJ, Wang C, Li Y, Tao WA, Zhu JK*. MET18 Connects theCytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation inArabidopsis. PLoS Genet. 2015, 11 (10): e1005559.
（20）Li Y#, DuanCG#, Zhu X, Qian W, Zhu JK*. A DNA ligase required for activeDNA demethylation and genomic imprinting in Arabidopsis. Cell Res. 2015, 25 (6):757-60.
（21）Duan CG#,Zhang H#, Tang K#, Zhu X, Qian W, Hou YJ, Wang B, Lang Z, Zhao Y, Wang X, WangP, Zhou J, Liang G, Liu N, Wang C, Zhu JK*. Specific but interdependentfunctions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBOJ. 2015, 34 (5): 581-92.
（22）Wang X#, DuanCG#, Tang K, Wang B, Zhang H, Lei M, Lu K, Mangrauthia SK,Wang P, Zhu G, Zhao Y, Zhu JK. RNA-binding protein regulates plant DNAmethylation by controlling mRNA processing at the intronicheterochromatin-containing gene BM1. Proc Natl Acad Sci U S A. 2013, 110 (38): 15467-72.
（23）Feng L#, DuanCG#, Guo HS*. Inhibition of in vivo slicer activity ofArgonaute protein 1 by the viral 2b protein independent of its dsRNA-bindingfunction. Mol Plant Pathol. 2013, 14 (6): 617-22.
（24）Duan CG, WangCH, Guo HS*. Application of RNA silencing to plant disease resistance. Silence.2012 May 31;3(1):5.
（25）Duan CG#,Fang YY#, Zhou BJ, Zhao JH, Hou WN, Zhu H, Ding SW, Guo HS*. Suppression ofArabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, andDNA methylation by distinct domains of the Cucumber mosaic virus 2b protein.Plant Cell. 2012,24(1):259-74.
（26）Hou WN#, Duan CG#, Fang RX, Zhou XY, Guo HS*.Satellite RNA reduces expression of the 2b suppressor protein resulting in theattenuation of symptoms caused by Cucumber mosaic virus infection. Mol PlantPathol. 2011, 12 (6): 595-605.
（27）Duan CG, Wang CH, Fang RX,Guo HS*. Artificial MicroRNAs highly accessible to targets confer efficientvirus resistance in plants. J Virol. 2008, 82 (22): 11084-11095.
（28）Du QS#, Duan CG#, Zhang ZH#, Fang YY, Fang RX,Xie Q, Guo HS*. DCL4 targets Cucumber mosaic virus satellite RNA at novelsecondary structures. J Virol. 2007, 81 (17): 9142-9151
發表著作
（1） 小分子RNA介導的基因表達調控, Regulation of Gene Expression by Small RNAs, 科學出版社, 2012-01, 第 2 作者
參與會議
（1）The interplay between intragenic heterochromatin and RNA processing in Arabidopsis 第30屆國際擬南芥大會 2019-06-17
（2）Epigenetic silencing-mediated alternative polyadenylation (APA) regulates CHG methyaltion by promoting the proper expression of histone demethylase IBM1 第十九屆國際植物學大會 2017-07-21
科研項目
（1）2018 國家“****”項目資助；
（2）2017 國家自然科學基金面上項目《DNA甲基化調控植物與棉花黃萎病菌Verticillium dahliae互作的分子機制》，主持，2018.01-2021.12
（3）2016 中國科學院自主部署/引進人才經費資助
（4）2010 國家自然科學基金青年基金《病毒衛星RNA來源的siRNA對病毒致病性的影響研究》 , 主持, 2010.01-2012.12
