步文博，男，1973年10月生，山東人，博士，研究員，博士生導師，國家重點實驗室副主任。
基本介紹
- 中文名：步文博
- 出生地：山東
- 出生日期：1973年10月
- 職業：博士，研究員
- 性別：男
個人簡介,取得成績,
個人簡介
步文博，男，1973年10月生，山東人，博士，研究員，博士生導師，高性能陶瓷和超微結構國家重點實驗室副主任。曾先後入選“上海市青年科技啟明星計畫及跟蹤計畫”、“The University of Queensland, Australia高級研究學者”及“上海市人才發展資金計畫”。
取得成績
目前，主要從事新型無機生物醫用材料及其多模式腫瘤影像診斷與治療的套用基礎研究，研究方向：1. 用於腫瘤高效診斷與治療的新型多功能納米診療劑研究；2. 基於稀土功能材料的納米探針及其生物醫學套用基礎研究；3. 無機納米材料的生物學效應與生物安全性研究。
近年來，在國家自然科學基金委和上海市科委的資助下，作為項目負責人，先後主持承擔了包括五項國家自然科學基金（專項、面上、青年）在內的多項國家級科研項目；作為學術骨幹，參與承擔了包括973計畫、863計畫、國家自然基金重點項目等多項國家級科研項目。作為第一作者/通訊作者，在“J. Am. Chem. Soc.”、“Angew. Chem. Int. Ed.”、“Adv. Mater.”等國際核心SCI學術期刊上發表研究論文30餘篇，其中一篇學術論文獲“2012年中國百篇最具影響國際學術論文”（Biomaterials, 2012, 33, 1079-1089.）；獲授權中國發明專利3項；參與撰寫兩部英文學術專著的部分章節。
曾榮獲：上海市青年科技啟明星跟蹤計畫（2012）、上海市人才發展資金（2012）、中國科學院上海分院第三屆傑出青年科技創新人才提名獎（2012）、上海市長寧區第七輪專業技術拔尖人才獎（2010）、第五屆柳大綱優秀青年科技獎（2008）、上海市青年科技啟明星計畫（2007）、國防科學技術二等獎（2004）等多項榮譽與學術獎勵。
主要承擔的科研項目（項目負責人）：
國家自然科學基金類（五項）：
1. 國家自然科學基金（面上），項目編號：51372260，期限：2014-2017， 80萬元（在研）
2. 國家自然科學基金（專項），項目編號：50823007，期限：2009-2012，140萬元（結題）
3. 國家自然科學基金（面上），項目編號：50972154，期限：2010-2012， 36萬元（結題）
4. 國家自然科學基金（面上），項目編號：50672115，期限：2007-2009， 29萬元（結題）
5. 國家自然科學基金（青年），項目編號：50502037，期限：2006-2006， 9萬元（結題）
人才計畫基金類（三項）：
1. 上海市人才發展資金資助計畫，項目編號：2012035，期限：2012-2014（在研）
2. 上海市青年科技啟明星計畫（跟蹤），項目編號：12QH1402500，期限：2012-2014（在研）
3. 上海市青年科技啟明星計畫（A類），項目編號：07QA14061，期限：2007-2009（結題）
其它基金類（兩項）：
1. 納米技術專項（重點），項目編號：11nm0505000，期限：2011-2014，50萬元（在研）
2. 納米技術專項（重點），項目編號：0852nm03900，期限：2008-2010，40萬元（結題）
部分代表性學術論文列表（第一作者/通訊作者）：
1.Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua and Jianlin Shi*.
Ultrasmall NaGdF4 nanodots for efficient MR angiography and atherosclerotic plaque imaging．
Advanced Materials, 2014, DOI: 10.1002/adma.201305222．
2. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Huaiyong Xing, Fang Han, Qingfeng Xiao, Zhengwei Yao, Feng Chen, Qianjun He, Jianan Liu, Shengjian Zhang, Wenpei Fan, Liangping Zhou, Weijun Peng, Jianlin Shi*.
Dual-Targeting Upconversion Nanoprobes across the Blood-Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma.
ACS Nano, 2014, DOI: 10.1021/nn406197c.
3. Huaiyong Xing, Xiangpeng Zheng, Qingguo Ren, Wenbo Bu*, Weiqiang Ge, Qingfeng Xiao, Shengjian Zhang, Chenyang Wei, Haiyun Qu, Zheng Wang, Yanqing Hua, Liangping Zhou, Weijun Peng, Kuaile Zhao, and Jianlin Shi*.
Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements.
Scientific Reports, 2013, 3: 1751 (DOI: 10.1038/srep01751).
4. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, and Jianlin Shi*.
A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy.
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048
5. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic /Luminescent Dual-modal Imaging.
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
6. Jianan Liu, Wenbo Bu*, Limin Pan, and Jianlin Shi*.
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles Integrated with Azo-Modified Mesoporous Silica.
Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
7. Feng Chen, Wenbo Bu*, Shengjian Zhang, Jianan Liu, Wenpei Fan, Liangping Zhou, WeijunPeng, Jianlin Shi*.
Gd3+ Ions Doped UpconversionNanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization.
Advanced Functional Materials, 2013, 23, 298-307
8. Feng Chen, Wenbo Bu*, Shengjian Zhang, Huaiyong Xing, Jianan Liu, Qingfeng Xiao, Xiaohang Liu, Liangping Zhou, Weijun Peng, Lianzhou Wang and Jianlin Shi*.
Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes.
Advanced Functional Materials 2011, 21, 4285-4294. (Cover Paper)
9. Qingfeng Xiao, Wenbo Bu*, Qingguo Ren, Shengjian Zhang, Huaiyong Xing, Feng Chen, Ming Li, Xiangpeng Zheng, Yanqing Hua, Liangping Zhou, Weijun Peng, Haiyun Qu, Zheng Wang, Kuaile Zhao, Jianlin Shi*.
Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging.
Biomaterials, 2012, 33: 7530-7539.
10. Jianan Liu, Wenbo Bu*, Limin Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuaile Zhao, Weijun Peng, and Jianlin Shi*.
Simultaneous Nuclear Imaging and Intranuclear Drug Delivery by Nuclear-Targeted Multifunctional Upconversion Nanoprobes.
Biomaterials, 2012, 33: 7282-7290.
11. Huaiyong Xing, Wenbo Bu*, Qingguo Ren, Xiangpeng Zheng, Ming Li, Shengjian Zhang, Haiyun Qu, Zheng Wang, Yanqing Hua, Kuaile Zhao, Liangping Zhou, Jianlin Shi*.
A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal-imaging.
Biomaterials, 2012, 33, 5384-5393.
12. Huaiyong Xing, Wenbo Bu*, Shengjian Zhang, Xiangpeng Zheng, Ming Li, Feng Chen, Qianjun He, Liangping Zhou, Weijun Peng, Yanqing Hua, and Jianlin Shi*.
Multifunctional Nanoprobes for Upconversion Fluorescence, MR and CT Trimodal Imaging.
Biomaterials, 2012, 33, 1079-1089.
13. Feng Chen, Wenbo Bu*, Shengjian Zhang, Yu Chen, Qingfeng Xiao, Jianan Liu, Huaiyong Xing, Liangping Zhou, Weijun Peng, and Jianlin Shi*.
Uniform Sub-50 nm sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet oxygen Using 980 nm laser.
Chemistry – A European Journal, 2012, 18, 7082-7090.
14. Jianan Liu, Wenbo Bu*, Shengjian Zhang, Feng Chen, Huaiyong Xing, Limin Pan, Liangping Zhou, Weijun Peng, and Jianlin Shi*.
Controlled Synthesis of Uniform and Monodisperse Upconversion Core/Mesoporous Silica Shell Nanocomposites for Bimodal Imaging.
Chemistry – A European Journal, 2012, 18, 2335-2341.
15. Feng Chen, Wenbo Bu*, Lingxia Zhang, Yuchi Fan and Jianlin Shi*.
Is Black Iron Oxide Nanoparticle Always a Light Absorber.
Journal of Materials Chemistry, 2011, 21, 7990–7995.
16. Feng Chen, Shengjian Zhang,Wenbo Bu*, Xiaohang Liu, Yu Chen, Qianjun He, Min Zhu, Lingxia Zhang, Liangping Zhou, Weijun Peng, and Jianlin Shi*.
A "Neck-Formation" Strategy for an Antiquenching Magnetic/Upconversion Fluorescent Bimodal Cancer Probe.
Chemistry – A European Journal, 2010, 16, 11254-11260.
17. Wenbo Bu, Zhenxing Chen, Feng Chen and Jianlin Shi*.
Oleic Acid/Oleylamine Cooperative-Controlled Crystallization Mechanism for Monodisperse Tetragonal Bipyramid NaLa(MoO4)2 Nanocrystals.
Journal of Physical Chemistry C, 2009, 113: 12176–12185.
18. Feng Chen, Wenbo Bu*, Yu Chen, Yuchi Fan, Qianjun He, Min Zhu, Xiaohang Liu, Liangping Zhou, Shengjian Zhang, Weijun Peng and Jianlin Shi*.
A Sub-50-nm Monosized Superparamagnetic Fe3O4@SiO2 T2-Weighted MRI Contrast Agent: Highly Reproducible Synthesis of Uniform Single-Loaded Core-Shell Nanostructures.
Chemistry - An Asian Journal, 2009, 4, (12), 1809-1816. (Cover Paper)
19. Zhenxing Chen, Wenbo Bu*, Na Zhang, and Jianlin Shi*.
Controlled Construction of Monodisperse La2(MoO4)3:Yb,Tm Micro-Architectures with Upconversion Luminescent Property.
Journal of Physical Chemistry C, 2008, 112: 4378-4383.
20. Wenbo Bu, Lingxia Zhang, Zile Hua, Hangrong Chen, and Jianlin Shi*.
Uniform Spindle-Shaped Nanoarchitectures Self-Assembled from Single-Crystalline Lanthanide Phosphates Nanowires.
Crystal Growth and Design, 2007, 7(11): 2305-2309.
21. Wenbo Bu, Yunpeng Xu, Na Zhang, Hangrong Chen, and Jianlin Shi*.
Controlled Construction of Uniform Pompon-Shaped Micro-Architectures Self-Assembled from Single-Crystalline Lanthanum Molybdate Nanoflakes.
Langmuir, 2007, 23, 9002-9007.
22. Wenbo Bu, Zile Hua, Hangrong Chen, and Jianlin Shi*.
Epitaxial Synthesis of Uniform Cerium Phosphates One-Dimensional Nanocable Heterostructures with Improved Luminescence.
Journal of Physical Chemistry B, 2005, 109(30): 14461-14464.
23. Wenbo Bu, Hangrong Chen, Zile Hua, and Jianlin Shi*.
Surfactant-assisted synthesis of Tb (Ⅲ)-doped cerium phosphate single-crystalline nanorods with enhanced green emission.
Applied Physics Letters, 2004, 85(19): 4307-4309.
