基本介紹
- 中文名：歐建君
- 學歷：博士
- 教學職稱：碩士生導師
- 臨床職稱：主治醫師
- 執業地點：中南大學湘雅二醫院
研究方向,教育經歷,學術任職,發表論文,人物成就,
研究方向
兒童和青少年精神疾病（孤獨症譜系障礙、情感障礙相關自傷自殺行為）；
精神藥理學和生物精神病學。
教育經歷
2008年獲得中南大學精神醫學學士學位，2011年獲得中南大學臨床醫學碩士學位，2014年獲中南大學臨床醫學博士學位。
學術任職
中國婦幼保健協會自閉症防治專業委員會委員
湖南省遺傳學會罕見病專業委員會副主任委員
發表論文
1. Jianjun Ou, YidongShen, Yamin Li, Guanglei Xun, Huaqing Liu, Yiqun He, Hui Guo, Renrong Wu,Claude Hughes, Kun Xia, Jingping Zhao, Zhang F. Prenatal Environment andPerinatal Factors Associated with Autism Spectrum Disorder. Global Clinical andTranslational Research. 2019;1(3):100-8.
2. Jianjun Ou, Kuokuo Li, Hui Guo, KunXia, Zhengmao Hu, Jingping Zhao, Fengyu Zhang. ULK4 Genetic Variants HavePleiotropic Effect on Risk of Autism, Associated with Brain mRNA Expression andAntipsychotic Treatment Response. Journal of Psychiatry and Brain Science. 2019,4: e190010.
3. Jianjun Ou, Ruiting Liu, Yidong Shen, Kun Xia, Zhao J*. AnOverview on Genetic and Environmental Risk of Autism Spectrum Disorder. GlobalClinical and Translational Research. 2019, 1(1):37-44.
4. Ying Wang, Lu Xiao, Runsen Chen, Chen Chen, Guanglei Xun,Xiaozi Lu, Yidong Shen, Renrong Wu, Kun Xia, Jingping Zhao*, Jianjun Ou*. Social impairment ofchildren with autism spectrum disorder affects parental quality of life indifferent ways. Psychiatry Research, 2018, 266:168-174
5. Yidong Shen, Huixi Dong, Xiaozi Lu, Nan Lian, Guanglei Xun,Lijuan Shi, Lu Xiao, Jingping Zhao*, JianjunOu*. Associations among maternal pre-pregnancy body mass index, gestationalweight gain and risk of autism in the Han Chinese population. BMC psychiatry,2018, 18:11
6. Yamin Li, Yidong Shen, Yongjiang Li, Guanglei Xu, Huaqing Liu,Renrong Wu, Kun Xia, Jingping Zhao*, Jianjun Ou*. Maternal dietary patterns, supplements intake and autismspectrum disorders: A preliminary case-control study. Medicine. 2018, 97(52): e13902.
7. Chen Chen, Yidong Shen, Guanglei Xun, Weixiong Cai, LijuanShi, Lu Xiao, Renrong Wu, Jingping Zhao* and Jianjun Ou*. Aggressive behaviors and treatable risk factors ofpreschool children with autism spectrum disorder. Autism Research, 2017,10(6):1155-1162.
8. Yidong Shen#, Jianjun Ou#, Mengmeng Liu, Lijuan Shi, Yamin Li, LuXiao, Huixi Dong, Fengyu Zhang, Kun Xia, Jing-Ping Zhao*. Altered plasma levelsof chemokines in autism and their association with social behaviors. Psychiatryresearch. 2016, 244:300-305.
9. Jianjun Ou, LijuanShi, Guanglei Xun, Chen Chen, Renrong Wu, Xuerong Luo, Fengyu Zhang, JingpingZhao*. Employment and financial burden of families with preschool childrendiagnosed with autism spectrum disorders in urban China: results from adescriptive study, BMC psychiatry, 2015, 15(1): 3
10. Lijuan Shi#, Jianjun Ou#, Jingbo Gong,Suhong Wang, Yuanyue Zhou, Furong Zhu, Xudong Liu, Jingping Zhao, Xuerong Luo*.Broad autism phenotype features of Chinese parents with autistic children andtheir associations with severity of social impairment in probands, BMC psychiatry,2015, 15: 168
11. Jianjun Ou, Yi Xu, Honghui Chen, Xiaoduo Fan, Keming Gao,Juan Wang, Xiaofeng Guo, Renrong Wu, Jingping Zhao*. Comparison of metaboliceffects of ziprasidone versus olanzapine treatment in patients withfirst-episode schizophrenia. Psychopharmacology, 2013, 225(3): 627-635
12. Jianjun Ou#, Guanglei Xun#, Renrong Wu, Lehua Li,Maosheng Fang, Honggeng Zhang, Shiping Xie, Jianguo Shi, Bo Du, Xueqin Yuan,Jingping Zhao*. Efficacy and safety of escitalopram versus citalopram in majordepressive disorder: a 6-week, multicenter, randomized, double-blind,flexible-dose study. Psychopharmacology, 2011, 213(2-3): 639-646
人物成就
歐建君課題組在孤獨症譜系障礙的社會學、病因學和治療學上取得了一些成績，首次以量化的形式報告了中國孤獨症家庭面臨的經濟和照顧負擔；與中南大學生命科學院合作建成了國內最大的孤獨症譜系障礙遺傳-環境樣本庫（>2500個家系），並率先在國內開展遺傳-環境致病機制研究；首次利用中國南北兩個獨立的大樣本數據發現了“母親既往流產史”和“孕期家裝相關毒物暴露”這兩個新的孤獨症譜系障礙風險因素，並驗證了國際上已有報導的多個母孕產期危險因素；2019年完成的蘿蔔硫素治療孤獨症譜系障礙研究是國際領先且樣本量最大的同類臨床試驗，打破了孤獨症無藥可用的困難局面，為孤獨症譜系障礙治療提供了新方法。歐建君主持國家自然科學基金面上和青年項目共2項，以項目骨幹身份參加國家重點研發計畫3項，國家自然科學基金重點項目2項，國際合作項目3項，湖南省重大專項1項。
目前，歐建君正領導團隊開展蘿蔔硫素治療孤獨症譜系障礙的生物學機制研究。將利用覆蓋遺傳組、轉錄組和代謝組的多組學研究新方法，揭示蘿蔔硫素起效的具體生物學機制和個體療效差異原因。另一方面，歐建君領導的團隊正基於對孤獨症譜系障礙遺傳和孕產期環境風險因素的系統研究，制定覆蓋孕前和孕期的綜合干預方案，並通過佇列研究驗證其效果，進而實現孤獨症譜系障礙的產前預防，降低疾病患病率。
