楊鈞棠

楊鈞棠，男，博士，河南師範大學生命科學學院講師。

基本介紹

• 中文名：楊鈞棠
• 學位/學歷：博士
• 職業：教師
• 專業方向：肺纖維化發病機制研究
• 職稱：講師
• 任職院校：河南師範大學

個人經歷

博士畢業於第三軍醫大學，

研究領域

肺纖維化發病機制研究。

學術成果

2018年7月進入河南師範大學生命科學學院工作，從事肺纖維化發病機理的研究。目前總計發表SCI論文7篇，其中5分以上5篇，第一作者3篇（＞5分1篇），共同第一作者1篇（＞5分）。博士期間主要從事肺癌和乳腺癌發病機制研究工作，發現了Wnt/β-catenin通路在肺癌中的新的調控機制，該通路在胚胎髮育，腫瘤發生以及肺纖維化中發揮關鍵功能。 博士畢業後於美國希望城國家醫學中心從事DNA損傷修復與肺癌發生關係的研究。

科研項目

1.河南省高等學校重點科研項目（20A310006）2019-2021

2.河南師範大學博士科研啟動基金（5101049170182）2019-2022

發表論文

1.Tang CZ#,YangJT#（共同第一）, Liu QH, Wang YR, Wang WS: Up-regulated miR-192-5pexpression rescues cognitive impairment and restores neural function in micewith depression via the Fbln2-mediated TGF-beta1 signaling pathway. FASEBjournal(IF=5.595) : officialpublication of the Federation of American Societies for Experimental Biology 2019, 33(1):606-618.

2. Tang CZ, Zhang DF, Yang JT,Liu QH, Wang YR, Wang WS. Overexpression of microRNA-301b accelerateshippocampal microglia activation and cognitive impairment in mice withdepressive-like behavior through the NF-κB signaling pathway. Cell Death Dis (IF=5.638). 2019 Apr 8;10(4):316. doi: 10.1038/s41419-019-1522-4.

3.Han F,Liu WB, Li JJ, Zhang MQ, Yang JT, Zhang X, Hao XL, YinL, Mao CY, Jiang X et al: SOX30 is a prognostic biomarker and chemotherapeuticindicator for advanced-stage ovarian cancer. Endocrine-related cancer(IF=5.331) 2019.

4.Han F,Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CSet al: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling viaTranscriptional and Posttranslational Regulation of beta-Catenin in LungCancer. EBioMedicine (IF=6.138) 2018,31:253-266.

5.YangJ, Han F, Liu W, Chen H, Hao X, Jiang X, Yin L, Huang Y, Cao J,Zhang H et al: ALX4, an epigenetically down regulated tumor suppressor,inhibits breast cancer progression by interfering Wnt/beta-catenin pathway.Journal of experimental & clinical cancer research : CR(IF=6.217) 2017, 36(1):170.

6.YangJ, Han F, Liu W, Zhang M, Huang Y, Hao X, Jiang X, Yin L, Chen H,Cao J et al: LHX6, An Independent Prognostic Factor, Inhibits LungAdenocarcinoma Progression through Transcriptional Silencing of beta-catenin.Journal of Cancer 2017(IF=3.2), 8(13):2561-2574.

7.YangJ, Wang R, Liu B, Xue Q, Zhong M, Zeng H, Zhang H: Kinetic analysisof bypass of abasic site by the catalytic core of yeast DNA polymerase eta.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (IF=2.5) 2015, 779:134-143.

8.Yu GY, Yang JT, Zhao WM, Guo XS. Role of HMSG2 MediatedFAO Deficiency in IPF Pathogenesis. AJRCCM-conference. 2019.199.A5232

9. Yu GY, YangJT, Zhao WM, Iberra G, Chen X, Guo XS, Kaminski.N. Role of Terra on Telomericand Mitochondrial Functions in IPF Pathogenesis. AJRCCM-conference. 2019.199. A1045