人物經歷
2016 ~至今四川大學,華西藥學院,副教授
2011College of Health and Science, University of Western Sydney博士後
研究方向
醫藥檢測新方法研究
藥物監管科學
學術任職
中國商品學會中藥專業委員會 副秘書長
四川省分析測試學會色譜專業委員會 委員
承擔課題
1. 四川大學引進人才科研啟動經費資助項目,20822041A4160,2017-2019,已結題,主持
2. 北京市自然科學基金面上基金,2172056,基於螢光分子開關的靶向多肽篩選及納米載藥示蹤研究,2017-01至2019-12,20萬元,已結題,主研
3. 國家自然科學基金青年基金,31400702,免疫蛋白質組SPRi晶片篩選阿爾茨海默症分子探針,2015-01至2017-12,24萬元,已結題,主持
4. 國家自然科學基金青年基金,21305023,腫瘤標記物親和肽庫的微流控-質譜聯用篩選及原位鑑定分析,2014-01至2016-12,25萬元,已結題,主研
5. 國家自然科學基金面上基金,31270875,利用高通量SPR微陣列晶片對類肽-蛋白親和作用的研究,2013-01至2016-12,70萬元,已結題,主研
6. 國家自然科學基金青年基金,61204118,利用柔性襯底微針尖電極陣列實現活體組織基因治療基礎研究,2013-01至2015-12,25萬元,已結題,主研
7. 中國科學院科研裝備研製項目,YZ201217,基於微流控結構的高通量多肽合成技術平台,2012-11至2014-10,278萬元,已結題,主研
8. 國家自然科學基金面上基金,81072576,以G-四鏈體為靶點的新型抗癌藥物-異喹啉生物鹼類衍生物的結構最佳化及機理研究,2011-01至2013-12,34萬元,已結題,主研
獲獎情況
1. 科技獎
2019年度北京市科學技術獎(科學進步獎)二等獎
2. 四川大學本科優秀畢業論文(設計)指導教師
2019屆 二等獎
論文題目:用於優勢菌基因靶標檢測的CHA放大體系(莊睿)
2018屆 二等獎
論文題目:專一性檢測人肺癌細胞中
半胱氨酸的新方法研究(宋凌波)
2017屆 二等獎
論文題目:DNA邏輯門的構建並用於重金屬並行檢測(鄒丹)
“大學生創新創業訓練計畫”項目指導
2018年度“大學生創新創業訓練計畫”項目(國家級)指導教師,C2018101206
2018年度“大學生創新創業訓練計畫”項目(校級)指導教師,C2018101654
代表性論著
1. Chen D., Yang S.*, Wu Z., Xu X., (2020) A supramolecular counter circuit based on cyanine dye assembly, Chem.-Eur. J.202001240. IF 5.16
2. Zhang Y., Wu J., Liu X., Sun H., Chen C., Fu C., Xu X., Yang S.*, Tang Y., (2020) A novel approach for anticancer compounds screening analysis from traditional Chinese medicine by G-quadruplex functionalized magnetic system, Anal. Methods, 12(4), 528-534. IF 2.078
3. Huang D., Guo C., Miao J., Zhang Y., Lin X., Chen D., Yang S.*, Yang Q.*, Tang Y., (2019) The construction of a novel DNA-based comparator and its application in intelligent analysis, Nanoscale, 11(35), 16241-4. IF 6.97
4. Yang C., Yang S., Song L.,Yao Y., Lin X., Cai K., Yang Q.*, Tang Y., (2019) A resettable supramolecular platform for constructing scalable encoders, Chem. Commun., 55(55), 8005-8. IF 6.834
5. Chen J.#, Yang S.#, Yang C., Li J., Huang D., Lin X., Guo C., Zhou Q., Yang Q.*, Tang Y., (2019) A Visibly Observable, Programmable Supramolecular Logic Platform and Its Application in Smart Thiols Sensing, Chem.-Eur. J., 25(22), 5691-7. (Inside cover) IF 5.16
6. Yang, S., Yang C., Huang, D., Song L., Chen, J., Yang, Q. *, (2019) Recent Progress in Fluorescence Signal Design for DNA-based Logic Circuits, Chem.-Eur. J., 25(21), 5389-405. (Invited review, Frontispice) IF 5.16
7. Yang, C.#, Yang, S.#, Li, J., Du, Y., Song, L., Huang, D., Chen, J., Zhou, Q., Yang, Q. *, Tang, Y. (2018) The intelligent sensors of lead based on a reconfigurable DNA-supramolecule logic platform. Anal. Chem., 90 (17), 10585-90. (Supplementary cover) IF 5.636
8. Yang C., Song L., Chen J., Huang D., Deng J., Du Y., Yang D., Yang S.*, Yang Q.*, Tang Y. (2018) A versatile DNA-supramolecule logic platform for multifunctional information processing. NPG Asia Mater., 10,497-508. IF 7.208
9. Yang C., Zhou D., Chen J., Zhang L., Miao J., Huang D., Du Y., Yang S.*, Yang Q.*, Tang Y.,(2018) A novel reconfigurable logic unit based on the DNA-templated potassium-concentration-dependent supramolecular assembly. (2018) Chem.-Eur. J., 24(16),4019-25. (Hot Paper, Frontispice) IF 5.16
10. Yang S., Gao H.*(2017) Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy. Pharmacol. Res., 126:97-108.(Invited review, 高被引) IF 4.897
11. Han Q., Jia X., Qian Y., Wang Z., Yang S., Jia Y.*, Wang W.* and Hu Z.* (2016) Peptide Functionalized Targeting Liposomes: for Nanoscale Drug Delivery towards Angiogenesis. J. Mater. Chem. B, 4 (44): 7087-7091. IF 4.543
12. Zhao, Z., Zhu, L., Bu, X., Ma, H., Yang, S., Yang, Y., Hu, Z.*(2014) Label-free detection of Alzheimer’s disease through the ADP peptoid recognizing the serum amyloid-beta42 peptide. Chem. Commun., 51(4), 718-21. IF 6.834
13. Codling, D., Zheng, G., Stait-Gardner, T., Yang, S., Nilsson, M., Price, W.* (2013) Diffusion studies of dihydroxybenzene isomers in water-alcohol systems. J. Phys. Chem. B, 117(9), 2734-41. IF 3.302
14. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y.*, Xu, G. (2011) An important functional group: Benzo[1,3]dioxole, of Alkaloids to induce the formation of human telomeric DNA G-quadruplex. Chin. Sci. Bull., 56, 613-7. IF 1.579
15. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y.*, Xu, G. (2010) Distinct G-quadruplex structures of human telomeric DNA formed by the induction of Sanguinarine and Nitidine under salt-deficient condition. Fitoterapia, 81, 1026-32. IF 2.345
16. Yang, S., Xiang, J., Yang, Q., Li, Q., Zhou, Q., Zhang, X., Tang, Y.*, Xu, G.. (2010) Formation of Human Telomeric G-quadruplex Structures Induced by the Quaternary Benzophenanthridine Alkaloids: Sanguinarine, Nitidine, and Chelerythrine. Chin. J. Chem., 28, 771-80. IF 1.578
17. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Zhang, X., Zhang, H., Tang, Y.* and Xu, G. (2010) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism. Nucleic Acids Res., 38, 1022-33. IF 9.112
18. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Lin, L., Zhang, X., Zhang, H., Tang, Y.* and Xu, G. (2010) Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in Solution and on Au Film. Anal. Chem., 82 (22), 9135–7. IF 5.636
19. Yang, Q., Xiang, J., Yang, S., Zhou, Q., Li, Q., Tang, Y.* and Xu, G. (2009) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres. Chem. Commun., 1103-5. IF 6.834
20. 楊舒, 劉岩, 楊千帆, 向俊鋒, 唐亞林, 徐廣智,(2011)中藥博落回抗腫瘤分子機理研究:誘導人體端粒DNA形成G-四鏈體, 中草藥,42 (4), 738-42.
參編教材
1. 常用中藥安全性檢測(中藥科學鑑定方法與技術叢書),
化學工業出版社,2008年7月第一版,ISBN 9787122021137
2. 中藥鑑定研究方法學,
人民衛生出版社,2010年8月第一版,ISBN 9787117125208
3. 中國新材料熱點領域產業發展戰略,
科學技術文獻出版社,2015年5月第1版,ISBN 9787518902262