梁瓊麟，清華大學長聘副教授、博士生導師
以微流控學為基礎，發展微納流體操控的新原理新技術，並將其套用於微納尺度的輸運、組裝和生物製造，模擬組織器官的微結構和微環境，結合原位光譜成像分析和質譜聯用分析等檢測技術，構建生命分析和生物醫學研究的新模型，發展微流控生命分析的原理、方法及裝置，參與生命科學前沿基礎研究，服務於藥物研發、臨床檢測等國家重大需求。研究重點方向包括組織器官晶片、單細胞亞細胞分析晶片及臨床組學分析與生物標誌物檢測的微流控晶片系統研製。主持承擔國家自然科學基金項目，國家重大科技專項課題，國家973計畫和重點研發計畫計畫子課題等多項國家科研任務。發表SCI論文150餘篇，他引3000餘次。以共同作者出版學術著作5部, 獲得授權中國發明專利十餘項。部分研究成果在合作的製藥企業、臨床醫院得到一定套用，曾共同獲得國家科技進步二等獎3項。
基本介紹
- 中文名：梁瓊麟
- 國籍：中國
- 民族：漢
- 出生地：湖南
- 職業：教師
- 畢業院校：清華大學
- 信仰：共產主義
- 主要成就：共同獲得國家科技進步二等獎3項
人物經歷,學習經歷,工作履歷,社會任職,主要成就,科研成就,獎勵榮譽,學術成果,
人物經歷
學習經歷
1996.9 - 2000.7 清華大學化學系化學專業 理學學士
2000.9 - 2005.7 清華大學化學系分析化學 理學博士
2000.9 - 2005.7 清華大學化學系分析化學 理學博士
工作履歷
2005.8 - 至今， 清華大學化學系 歷任講師，副教授
2008 年聘任碩士生導師，2012 年被聘任為博士生導師
2005 年 8 月任研究生工作組組長，
2012 年 11 月任化學系黨委副書記，
2015 年 4 月任化學系黨委書記，
2016 年獲聘教研系列長聘副教授。
社會任職
中國化學會青年化學工作者委員會委員
北京理化分析測試技術學會青委會理事長
中國分析測試協會青委會副主任委員
中國醫藥生物技術協會藥物分析技術分會常務委員兼秘書長
中國中藥協會中藥產品培育與開發專業委員會副主任委員
主要成就
科研成就
科研綜述：
在以微流控學為基礎，發展微納流體操控的新原理新技術，並將其套用於微納尺度的輸運、組裝和生物製造，模擬組織器官的微結構和微環境，結合原位光譜成像分析和質譜聯用分析等檢測技術，構建生命分析和生物醫學研究的新模型，發展微流控生命分析的原理、方法及裝置，參與生命科學前沿基礎研究，服務於藥物研發、臨床檢測等國家重大需求。研究重點方向包括組織器官晶片、單細胞亞細胞分析晶片及臨床組學分析與生物標誌物檢測的微流控晶片系統研製。主持承擔國家自然科學基金項目，國家重大科技專項課題，國家973計畫和重點研發計畫計畫子課題等多項國家科研任務。發表SCI論文150餘篇，他引3000餘次。以共同作者出版學術著作5部, 獲得授權中國發明專利十餘項。部分研究成果在合作的製藥企業、臨床醫院得到一定套用，曾共同獲得國家科技進步二等獎3項。
獎勵榮譽
2018 世界中醫藥學會聯合會中醫藥國際貢獻獎-科技進步二等獎（2/10）
2016 國家科技進步二等獎（3/10）
2015 中華中醫藥學會科學技術進步一等獎(3/15)
2014 國家科技進步二等獎(8/10)
2014 清華大學第十四屆“良師益友”
2013 教育部新世紀優秀人才支持計畫
2012 北京市科技進步二等獎（4/10）
2012 河北省科技進步一等獎（7/10）
2011 上海市科技進步一等獎（12/15）
2011 The PSC (Permanent Scientific Committee of HPLC Symposium) Young Scientist Lecture Award
2010 河北省醫藥科學技術進步一等獎（6/10）
2009 清華大學“先進工作者”稱號
2007 國家科學技術進步二等獎(7/10)
學術成果
近三年代表性論文（Selected Recent Publications）：
1. Xie RX, Xu PD, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. Advanced Materials, 2018, 30: 1705082.
2. Zhang F, Xiong LG, Ai YJ, Liang Z and Liang QL*. Stretchable Multi-responsive Hydrogel with Actuatable, Shape memory and Self-healing Properties. Advanced Science, 2018, 5: 1800450.
3. Li LL, Li YQ, Shao ZX, Luo GA, Ding MY and Liang QL*. Simultaneous Assay of Oxygen-Dependent Cytotoxicity and Genotoxicity of Anticancer Drugs on an Integrated Microchip. Analytical Chemistry, 2018,90（20）：11899-11907. (cover feature)
4. Ma LD, Wang YT, Wang JR, Wu JL, Meng XS, Hu P, Mu X, Liang QL* and Luo GA*. Design and Fabrication of a Liver-on-a-chip Platform for Convenient, Highly Efficient, and Safe in Situ Perfusion Culture of 3D Hepatic Spheroids. Lab on a Chip, 2018, 18: 2547 -2562.
5. Ai YJ, Liu L, Zhang C, Qi L, He MQ, Liang Z, Sun HB*, Luo GA and Liang QL*. Amorphous Flowerlike Goethite FeOOH Hierarchical Supraparticles: Superior Capability for Catalytic Hydrogenation of Nitroaromatics in Water. ACS Applied Materials & Interfaces, 2018, 10: 32180-32191.
6. Yang SH, Zhang FF, Liang QL* and Wang ZH*. A Three-Dimensional Graphene-Based Ratiometric Signal Amplification Apta sensor for MUC1 Detection. Biosensors & Bioelectronics,2018, 120: 85-92.
7. Yang SH, Zhang FF, Wang ZH* and Liang QL*. A Graphene Oxide-based Label-free Electrochemical Aptasensor for the Detection of Alpha-fetoprotein. Biosensors & Bioelectronics, 2018, 112: 186-192.
8. Ai YJ, He MQ, Zhang F, Long Y, Li YZ, Han Q, Ding MY, Sun HB* and Liang QL*. Metallo-supramolecular Polymer Engineered Porous Carbon Framework Encapsulated Stable Ultra-small Nanoparticles: a General Approach to Construct Highly Dispersed Catalysts. Journal of Materials Chemistry A, 2018, 6: 16680-16689.
9. Long Y, Han Q, Yang ZQ, Ai YJ, Sun SA, Wang Y, Liang QL * and Ding MY*. A Novel Solvent-free Strategy for the Synthesis of Bismuth Oxyhalides. Journal of Materials Chemistry A, 2018, 6: 13005-13011. (cover feature)
10. Ai YJ, Hu ZN, Shao ZX, Qi L, Liu L, Zhou JJ, Sun HB* and Liang QL*. Egg-like Magnetically Immobilized Manospheres: A Long-lived Catalyst Model for the Hydrogen Transfer Reaction in a Continuous-flow Reactor. Nano Research, 2018, 11: 287–299.
11. Liang Z, Liu, YP, Zhang F, Ai YJ and Liang QL*, Dehydration-triggered Shape Morphing Based on Asymmetric Bubble Hydrogel Microfibers. Soft Matter, 2018, 14: 6623-6626. (cover feature)
12. Liu L, Liu YH*, Ai, YJ, Li JF, Zhou JJ, Fan ZB, Bao HJ, Jiang RH, Hu ZN, Wang JT, Jing K, Wang Y, Liang QL* and Sun HB*. Pd-CuFe Catalyst for Transfer Hydrogenation of Nitriles: Controllable Selectivity to Primary Amines and Secondary Amines,iScience, 2018, 8: 61-73.
13. Wang JD, Tan SY, Liang QL*, Sun SA, Han Q, Ding MY*. Preparation of magnetic microspheres functionalized by lanthanide oxides for selective isolation of bovine hemoglobin. TALANTA 2018, 190: 210-218
14. Bao HJ, Li YN, Liu L, Ai YJ, Zhou JJ, Qi L, Jiang RH, Hu ZN, Wang JT, Sun HB*, and Liang QL*. Ultrafine FeCu Alloy Nanoparticles Magnetically Immobilized in Amine‐Rich Silica Spheres for Dehalogenation-Proof Hydrogenation of Nitroarenes. Chemistry-A European Journal, 2018, 24: 14418-1442.
15. Hu ZN, Zhou, JJ, Ai YJ, Liu L, Qi L, Jiang RH, Bao HJ, Wang JT, Hu JS, Sun HB* and Liang QL*. Two Dimensional Rh/Fe3O4/g-C3N4-N Enabled Hydrazine Mediated Catalytic Transfer Hydrogenation of Nitroaromatics: A Predictable Catalyst Model with Adjoining Rh. Journal of Catalysis, 2018, 368: 20-30.
16. Han Q, Aydan T, Yang L, Zhang XQ; Liang QL* and Ding MY*. In-syringe Solid-phase Extraction for On-site Sampling of Pyrethroids in Environmental Water Samples. Analytica Chimica Acta,2018, 1009: 48-55.
17. Wang WX, Li LL*, Ding MY, Luo GA and Liang QL*. A Microfluidic Hydrogel Chip with Orthogonal Dual Gradients of Matrix Stiffness and Oxygen for Cytotoxicity Test. BioChip Journal, 2018, 12: 93-101.
18. Wang JT, Chen YX, Zhang ZQ, Ai YJ, Liu L, Qi L, Zhou JJ, Sun HB*, Niu D* and Liang QL*. Microwell Confined Iron Oxide Nanoparticles in Honeycomblike Carbon Spheres for the Adsorption of Sb (III) and Sequential Utilization as a Catalyst. ACS Sustainable Chemistry & Engineering, 2018, 6: 12925-12934.
19. Ai YJ, He MQ, Lv QR, Liu L, Sun HB*, Ding MY and Liang QL*. 3D Porous Carbon Framework Stabilized Ultra-Uniform Nano γ-Fe2O3: A Useful Catalyst System. Chemistry-An Asian Journal, 2018, 13,89–98.
20. Tan SY, Wang JD, Han Q, Liang QL* and Ding MY*. A Porous Graphene Sorbent Coated with Titanium (IV)-Functionalized Polydopamine for Selective Lab-in-syringe Extraction of Phosphoproteins and Phosphopeptides. Microchimica Acta, 2018, 185: 316-326.
21. Li YZ, Xiong JL, Shao ZX, Ai YJ, Hua RM, Luo GA and Liang QL*. An Asymmetrical Cyanine Dye Nanoparticles for Small Vessel Photoacoustic Imaging In Vivo. ChemNanoMat, 2018, 4, 626-630.
22. Liu CG, Zheng WC, Xie RX, Liu YP, Liang Z, Luo GA, Ding MY and Liang QL*. Microfluidic Fabrication of Water-in-water Droplets Encapsulated in Hydrogel Microfibers. Chinese Chemical Letters, 2018, in press, DOI: 10.1016/j.cclet.2018.09.010.
23. Fan XM, Huang, CL, Wang, YM, Li N, Liang QL, and Luo GA*. Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array. Journal of Diabetes Research, 2018, 2018: Article ID 8237590, 10 pages.
24. Liu YP, Xu PD, Liang Z, Xie RX, Ding MY, Liu HX and Liang QL*. Hydrogel Microfibers with Perfusable Folded Channels for Tissue Constructs with Folded Morphology. RSC Advances, 2018, 8: 23475-23480.
25. Wang JD, Tan SY, Liang QL*, Sun SA, Han Q and Ding MY*. Preparation of Magnetic Microspheres Functionalized by Lanthanide Oxides for Selective Isolation of Bovine Hemoglobin. Talanta, 2018, 190: 210-218.
26. Xu PD, Xie RX, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Bioinspired Microfibers with Embedded Perfusable Helical Channels. Advanced Materials, 2017, 29: 1701664. (cover feature)
27. Huang ZQ, Fan XM*, Wang YM, Liang QL, Tong XL, Bai Y, Li YM, Luo GA and Chen C*. A New Method to Evaluate the Dose-effect Relationship of a TCM Formula Gegen Qinlian Decoction: “Focus” Mode of Integrated Biomarkers. Acta Pharmacologica Sinica, 2017, 8: 1141-1149.
28. Zhou JJ, Li YN, Sun HB*, Tang ZK, Qi L, Liu L, Ai YJ, Li S, Shao ZX andLiang QL*. Porous Silica-Encapsulated and Magnetically Recoverable Rh NPs: A Highly Efficient, Stable and Green catalyst for Catalytic Transfer Hydrogenation with “Slow-release” of Stoichiometric Hydrazine in Water. Green Chemistry, 2017, 19: 3400-3407.
29. Ai YJ, Liu L, Jing K, Qi L, Fan ZB, Zhou JJ, Sun HB*, Shao ZX and Liang QL*. Noncovalently Functionalized Carbon Nanotubes Immobilized Fe–Bi Bimetallic Oxides as a Heterogeneous Nanocatalyst for Reduction of Nitroaromatics. Nano-Structures & Nano-Objects, 2017, 10: 116-124.
30. Han Q, Yang L, Liang QL* and Ding MY*. Three-Dimensional Hierarchical Porous Graphene Aerogel for Efficient Adsorption and Preconcentration of Chemical Warfare Agents.Carbon, 2017, 122: 556-563.
31. Liu L, Ai YJ, Li D, Qi L, Zhou JJ, Tang ZK, Shao ZX, Liang QL* and Sun HB*. Recyclable Acid-Base Bifunctional Core-Shell-Shell Nanosphere Catalyzed Synthesis of 5-Aryl-1H-1,2,3-triazoles through the “One-Pot” Cyclization of Aldehydes, Nitromethane, and Sodium Azide. ChemCatChem, 2017, 9: 3131-3137.
32. Qi L, Li YN, Liu L, Zhou JJ, Ai YJ, Tang ZK, Wang JT, Bao HJ, Zhang C, Liang QL, Sun HB* and Niu D*. Immobilizing Multifunctional Fe2O3-SnO2 Nanoparticles to Carbon Nanospheres: An Extremely Active and Selective Catalyst for Hydrogen Transfer Reaction. ChemistrySelect, 2017, 2: 8288-8295.
33. Sun HB*, Ai YJ, Li D, Tang ZK, Shao ZX and Liang QL*. Bismuth Iron Oxide Nanocomposite Supported on Graphene Oxides as the Highly Efficient, Stable and Reusable Catalysts for the Reduction of Nitroarenes Under Continuous Flow Conditions. Chemical Engineering Journal, 2017, 314: 328-335.
34. Xu Y, Tan SY, Liang QL* and Ding MY*. One-Step Facile Synthesis of Aptamer-Modified Graphene Oxide for Highly Specific Enrichment of Human A-Thrombin in Plasma. Sensors, 2017, 17: 1986-1996.
35. Yan M, Liang QL*, Wan W, Han Q, Tan SY and Ding MY*. Amino Acid-modified Graphene Oxide Magnetic Nanocomposite for the Magnetic Separation of Proteins. RSC Advances, 2017, 7: 30109-30117.
36. Zhou BJ, Li YZ, Niu GL, Lan MH, Jia QY, Liang QL*. Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer. ACS Applied Materials & Interfaces, 2016, 8: 29899-29905.
37. Li LL, Wang WX, Ding MY, Luo GA and Liang QL*. Single-Cell-Arrayed Agarose Chip for in Situ Analysis of Cytotoxicity and Genotoxicity of DNA Cross-Linking Agents. Analytical Chemistry, 2016, 88: 6734-6742.
38. Liang Z, Liu CG, Li LL, Xu PD, Lu GA, Ding MY andLiang QL*. Double-Network Hydrogel with Tunable Mechanical Performance and Biocompatibility for the Fabrication of Stem Cells-Encapsulated Fibers and 3D Assemble. Scientific Reports, 2016, 6: 33462.
39. Zhang F, Gao D* and Liang QL*. Advances of Microfluidic Technologies Applied in Bio-analytical Chemistry. Chinese Journal of Analytical Chemistry, 2016, 12: 1942-1949.
40. Xie YY, Wang XM, Wang SH, Wang YM, Tian HF, Yuan YS, Li HY,Liang QL* and Luo GA*. Metabolism and Pharmacokinetics of Major Polyphenol Components in Rat Plasma After Oral Administration of Total Flavonoid Tablet from Anemarrhenae Rhizoma. Journal of Chromatography B, 2016, 1026: 134-144
41. Li YQ, Li LL, Liu ZX, Ding MY, Luo GA and Liang QL*. A Microfluidic Chip of Multiple-channel Array with Various Oxygen Tensions for Drug Screening. Microfluidics and Nanofluidics, 2016, 20, 97-106.
42. Zhu C*, Liang QL, Wang YM, Luo GA, Vreeken RJ and Hankmeimer T. Advance in Analysis and Detection Technologies for Phospholipidomics. Chinese Journal of Analytical Chemistry, 2016, 44: 984-992.
43. Han Q,Liang QL*, Zhang XQ, Yang L and Ding MY*. Graphene Aerogel Based Monolith for Effective Solid-phase Extraction of Trace Environmental Pollutants from Water Samples. Journal of Chromatography A, 2016, 1447: 39-46.
44. Wan W, Liang QL*, Zhang XQ, Yan M and Ding MY*. Magnetic Metal-Organic Frameworks for Selective Enrichment and Exclusion of Proteins for MALDI-TOF MS Analysis. Analyst, 2016, 141: 4568-4572.
45. Wang H, Liang XP, Luo GA, Ding MY and Liang QL*. Protection Effect of Nicotinamide on Cardiomyoblast Hypoxia/re-oxygenation Injury: Study of Cellular Mitochondrial Metabolism. Molecular BioSystems, 2016, 12: 2257-2264.
46. Zhang XQ, Liang QL*, Han Q, Wan W and Ding MY*. Metal-Organic Frameworks @Graphene Hybrid Aerogels for Solid-Phase Extraction of Nonsteroidal Anti-inflammatory Drugs and Selective Enrichment of Proteins. Analyst, 2016, 141: 4219-4226.
