梁德生，男，醫學遺傳學博士，二級教授，博士生導師，享受國務院政府特殊津貼專家。現任中南大學醫學遺傳學國家重點實驗室副主任、國家生命科學與技術人才培養基地主任、中南大學湘雅醫院產前診斷中心副主任。2005年3月至2008年3月任職日本國立長崎大學醫學院邀請教授，2008年3月起受聘為日本北海道醫療大學客座教授。兼任東亞人類遺傳學會聯盟常務理事，中華預防醫學會出生缺陷預防與控制專業委員會副主任委員兼遺傳病學組組長、中國醫藥生物技術協會基因治療分會常務委員、中華醫學會醫學遺傳學分會委員、湖南省遺傳學會副會長。主要負責基因治療、臨床遺傳學、人類遺傳資源的收集、保藏和共享以及主持“基地”學研產工作。
基本介紹
- 中文名：梁德生
- 職業：博士生導師
- 主要成就：醫學遺傳學博士，二級教授，博士生導師
- 性別：男
個人簡介,論文/著作,
個人簡介
2004年至今，主持國家“973”、“863”、支撐計畫、科技基礎性工作專項等計畫課題和國家自然科學基金項目10項，主持或參加國際、國家和省部級重大科研計畫課題9項；獲國家科學技術進步獎二等獎1項，省部級科學技術進步獎4項；在Am J Med Genet, Nat Genet, PLoS One等雜誌發表論文100餘篇，其中SCI收錄論文30餘篇。
論文/著作
主要論文
Peer review publications (since 2004):
1. Li Z, Liu J, Li H, Peng Y,Lv W, Long Z, Liang D, Wu L. Phenotypic expansion of the interstitial16p13.3 duplication: A case report and review of the literature. Gene.2013 Sep 12. [Epub ahead of print] (Correspondence)
2. Wu L, Liu J, Lv W, Wen J, XiaY, Liang D. An Xp21.3p11.4 duplication observed in a boy withintellectual deficiency and speech delay and his asymptomatic mother. Birth Defects Res A Clin Mol Teratol. 2013 Jul;97(7):467-70. (Correspondence)
3. Hu Y, Liu X, Long P, Xiao D,Cun J, Li Z, Xue J, Wu Y, Luo S, Wu L, Liang D. Nonviral gene targetingat rDNA locus of human mesenchymal stem cells. Biomed Res Int.2013;2013:135189. Epub 2013 May 14. (Correspondence)
4. Liang D, Lv W, Wang H, Xu L, Liu J, Li H, Hu L,Peng Y, Wu L. Non-invasive prenatal testing of fetal whole chromosomeaneuploidy by massively parallel sequencing. Prenat Diagn. 2012 Jan 9.[Epub ahead of print]
5. Liu X,Wu Y, Li Z, Yang J, Xue J, Hu Y, Feng M, Niu W, Yang Q, Lei M, Xia J, Wu L, Liang D. Targeting of the HumanCoagulation Factor IX Gene at rDNA Locus of Human Embryonic Stem Cells.PLoS One. 2012;7(5):e37071. (Correspondence)
6. Liang D, Zhou Z, Meng D, Du J, Wen J, Niikawa N,Wu L. Three Patients with Wolf-Hirschhorn Syndrome Carrying a SatellitedChromosome 4p. Birth Defects Res A Clin Mol Teratol.2012 Jul; 94(7):549-52.
7. Xue J, Peng J, Zhou M, Zhong L, Yin F, Liang D, Wu L. Novel compound heterozygous mutation of MLYCD in a Chinese patient withmalonic aciduria. Mol Genet Metabo 2012Jan;105(1):79-83.
8. Hu Y,Liu X, Xiao D, Gao T, Feng M, Li Z, Xue J, Pan Q, Wu L, Liang D. Improved gene targeting at the human rDNA locus stimulatedby Zinc finger nucleases. Mol Ther (2011) 19(S1):S267. (Correspondence)
9. PengJ, Wu L, Liu X, Liang D.Nonviral-mediated Endostatin Delivery Results in Inhibition of FibrosarcomaGrowth. Mol Ther (2011) 19(S1):S267-268. (Correspondence)
10. HannibalMC, Buckingham KJ, Ng SB, Ming JE, Beck AE, McMillin MJ, Gildersleeve HI,Bigham AW, Tabor HK, Mefford HC, Cook J, Yoshiura K, Matsumoto T, Matsumoto N,Miyake N, Tonoki H, Naritomi K, Kaname T, Nagai T, Ohashi H, Kurosawa K, HouJW, Ohta T, Liang D, Sudo A, MorrisCA, Banka S, Black GC, Clayton-Smith J, Nickerson DA, Zackai EH, Shaikh TH,Donnai D, Niikawa N, Shendure J, Bamshad MJ. Spectrum of MLL2 (ALR) mutationsin 110 cases of Kabuki syndrome. Am J Med Genet A. 2011Jul;155(7):1511-6.
11. Wu L, Liao X, Wang H, Zhou Z, Lv W, Liang D. A Patient with Apparently Reciprocal Translocation andCryptic 10p Deletion. Am J Med Genet A (2011) 155(7):1753-5. (Correspondence)
12. Hu J, Liang D, Xue J, Liu J, Wu L. Anovel GPR143 splicing mutation in a Chinese family with X-linked congenitalnystagmus. Mol Vis (2011) 17:715-22. (Co-author).
13. Wu L,Meng D, Zhou Z, Du J, Long Z, Liang D.A Family with Partial Duplication/Deletion 4p Due to a Balanced t (4; 15)(p16.2; p11.2) Translocation. Am J Med Genet A (2011) 155A(3):656-9. (Correspondence)
14. Liao X,Liang D, Li Y, Xi H, Quan Y,Wu L. Mutation analysis of the SRY, NR5A1 and DHH genes in six Chinese 46,XYwomen. J Matern Fetal Neonatal Med (2011) 24(6):863-6. (Co-author).
15. ShenJD, Liang DS, Zhou ZM, Xia Y, LongZG, Wu LQ. Pallister-Killian Syndrome: meiosis II non-disjunction may be thefirst step in the formation of isochromosome 12p. Chin Med J (Engl). 2010December 5; 123(23):3482-3485. (Co-author)
16. GrossmannV, Höckner M, Karmous-Benailly H, LiangD, Puttinger R, Quadrelli R, Röthlisberger B, Huber A, Wu L, Spreiz A,Fauth C, Erdel M, Zschocke J, Utermann G, Kotzot D. Parental Origin ofApparently Balanced De Novo Complex Chromosomal Rearrangements Investigated byMicrodissection, Whole Genome Amplification, and Microsatellite MediatedHaplotype Analysis. Clin Genet 2010 Dec; 78(6): 548-553.
17. YangJ, Liu X, Yu J, Sheng L, Shi Y, Li Z, Hu Y, Xue J, Wu L, Liang Y, Xia J, and Liang D*. A non-viral vector forpotential DMD gene therapy study by targeting a minidystrophin-GFP fusion geneinto the hrDNA locus. Acta Biochim Biophys Sin 2009, 41(12):1053–1060. (Correspondence)
18. XueJF, Liu XH, He Q, Xue ZG, Hu YJ, Li Z, Yang JL, Gao T, Pan Q, Long ZG, Wu LQ, XiaK, Liang DS, Xia JH. In vitroEfficacy of mda-7 Gene for Hepatocellular Carcinoma Gene Therapy Mediated byHuman Ribosomal DNA Targeting Vector*. Prog Biochem Biophys 2009, 36(11):1429~1435. (Correspondence)
19. Shi Y,Liu XH, Liang DS, Feng M, Wu LQ, YangJL, Li Z, Zhao K, Pan Q, Long ZG, Xia JH. The Transfection EfficiencyImprovement of hrDNA Targeting Vectors with NLS Peptide. Prog Biochem Biophys2009; 36(10): 1283-1290. (Correspondence)
20. Wu L, Liang D, Niikawa N, Ma F, Sun M, Pan Q,Long Z, Zhou Z, Yoshiura KI, Wang H, Sato D, Nishimura G, Dai H, Zhang X, XiaJ. A ZRS duplication causes syndactyly type IV with tibial hypoplasia. Am JMed Genet A. 2009 Mar 16;149A(4):816-818. (Co-author)
21. Wu L, Long Z, LiangD, Harada N, Pan Q, Yoshiura KI, Xia K, Dai H, Niikawa N, Xia J. Pre- andpostnatal overgrowth in a patient with proximal 4p deletion. Am JMed Genet A. 2008 Mar 15; 146A(6):791-4. (Correspondence)
22. Wen L, Liang de S,Wu LQ, Cai F, Pan Q, Long ZG, Dai HP, Xia K, Xia JH.Efficient proteinexpression from the endogenous RNA polymerase I promoter using a humanribosomal DNA targeting vector. Biochem Biophys Res Commun. 2008 Mar21; 367(4):846-51.
23. Xue ZG, Li J, Yin B, Zhang YK, Liu XH, Pan Q, Long ZG,Dai HP, Xia K, Wu LQ, Liang DS, XiaJH. p53 Anti-tumor Research inBel-7402 by Using Human-derived Vector. Prog Biochem Biophys 2007; 34(5):465-470. (Correspondence)
24. Sato D, Liang D,Wu L, Pan Q, Xia K, Dai H, Wang H, Nishimura G, Yoshiura K, Xia J, Niikawa N.(2007) A syndactyly type IV locus maps to 7q36. J Hum Genet. 52(6):561-4. (Co-author)
25. Hu H，Wu L，Feng Y，Pan Q，Long Z，Li J，Dai H，Xia K，Liang D，Niikawa N，Xia J. (2007)Molecular analysis of hearing loss associated with enlarged vestibular aqueductin the mainland Chinese:a unique SLC26A4 mutation spectrum. J Hum Genet. 52(6):492-7. (Correspondence)
26. Liu X, Liu M, Xue Z, PanQ, Wu L, Long Z, Xia K, Liang D, XiaJ. Non-viral ex vivo transduction of human hepatocyte cells to express factorVIII using a human ribosomal DNA-targeting vector. J Thromb Hoemost. 2007 Feb; 5(2):347-51. (Correspondence)
27. WANG L*, XUE Z*, LI Z, XUE J, LIU X, PAN Q, LONG Z, CAIF, WU L, DAI H, XIA K, LIANG D &XIA J. (2006) Investigation of hrDNA targeting vector-mediated tumor-specificsuicide gene therapy for hepatocellular carcinoma, Chinese Sci Bull,51(19):2342-2350. (Correspondence)
28. Yoshiura K, Kinoshita A, Ishida T, Ninokata A, IshikawaT, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA,Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N,Mapendano CK, Ghadami M, Nomura M, LiangDS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A,Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, MurrayJC, Saito S, Nakamura Y, Niikawa N. A SNP in the ABCC11 gene is the determinantof human earwax type. Nat Genet. 2006 Mar; 38(3):324-30.
29. Liang D, Wu L, Pan Q, HaradaN, Long Z, Xia K, Yoshiura K, Dai H, Niikawa N, Cai F, Xia J. A father and sonwith mental retardation, a characteristic face, inv(12), and insertion trisomy12p12.3-p11.2. Am J Med Genet A. 2006 Feb 1;140(3):238-44.
30. Zhang R, Zhu Z, Zhu H, Nguyen T, Yao F, Xia K, Liang D and Liu C. SNP Cutter: acomprehensive tool for SNP PCR–RFLP assay design, Nucleic Acids Res, 2005, Vol.33,Web Server issue W489–W492.
31. Lyu QF, Wu LQ, Li YP, Pan Q, Liu DE, Xia K, Liang DS, Cai F, Long ZG,Dai HP, XiaJH. An improved mechanical technique for assisted hatching. HumReprod, 2005 Apr 28; 20(6):1619-1623.
32. XUE Z, LIANG D, LONG Z, PAN Q, LIU X,WU L, CAI F, DAI H, XIA K & XIA J. Silica nanoparticle is a possible safecarrier for gene therapy. Chinese Sci Bull, 2005, 50(20): 2323-2327. (Co-author)
33. Xia K, Wu L, Liu X, Xi X, Liang D, Zheng D, Cai F, Pan Q, Long Z, Dai H, Hu Z, Tang B, ZhangZ, Xia J. (2004) Mutation in PITX2 is Associated with Ring Dermoid of theCornea. J Med Genet 41(12):e129.
34. Xia K, Liang D,Tang A, Feng Y, Zhang J, Pan Q, Long Z, Dai H, Cai F, Wu L, Zhao S, Chen Z, XiaJ. (2004) A Novel Fusion Suicide Gene Yeast CDglyTK plays a Role inRadio-genetherapy of Nasopharyngeal Carcinoma. Cancer Gene Ther,11(12):790-6.
著作
1. 《醫學遺傳學》，第6、12章，全國醫藥衛生高等院校研究生規劃教材，2004年，人民衛生出版社
2. 《實用產前診斷學》，參編，全國產前診斷培訓教材，2008年，人民軍醫出版社
3. 《精編人類遺傳學實驗指南》，參編，2009年，科學出版社
