桑慶，博士，復旦大學生命科學學院研究員，博士生導師。主要研究女性生殖疾病的遺傳學基礎：多囊卵巢綜合症（PCOS）的遺傳機制研究；卵子成熟障礙及受精障礙相關致病基因鑑定並利用細胞及動物模型對相關基因功能展開深入研究。
基本介紹
人物經歷,研究方向,主要成就,科研成果,學術成果,所獲榮譽,
人物經歷
2007-2010年獲中山大學碩士學位。
2010-2013獲復旦大學博士學位，主修遺傳學。
2013-2015於復旦大學生物醫學研究院從事博士後研究。
2015年12月任職於復旦大學生命科學學院，從事出生缺陷的遺傳學研究。
2013.7-2015.11 復旦大學生命科學學院博士後
2015.12-2017.12 復旦大學生命科學學院青年副研究員
2018.1-2020.4 復旦大學生命科學學院副研究員
2020.5-2022.12 復旦大學生物醫學研究院副研究員
2022.12- 復旦大學生命科學學院研究員
研究方向
聚焦女性生殖疾病的遺傳學。重點圍繞人類卵子受精異常及早期胚胎停滯的遺傳機制展開研究。
主要成就
科研成果
自2013年以來，以第一作者或通訊作者 (含並列) 在N Engl J Med, Science, J Clin Invest, Sci Transl Med, Genom Biol, Am J Hum Genet等期刊發表SCI論文40餘篇。發現啟動人類卵母細胞紡錘體組裝關鍵結構huoMTOC；闡明人類合子分裂失敗的首個致病基因BTG4及機制；揭示新發突變在人卵母細胞成熟和早期胚胎髮育中的關鍵作用；發現核轉運蛋白缺陷導致人類早期胚胎停滯的新機制。相關分子指標已被廣泛套用於臨床不孕患者檢測中。
學術成果
1. Qing Sang#*, Bin Lin*, Xueqian Wang*, Zhihua Zhang*, Biaobang Chen*, Ling Wu，Qingfeng Lyu Zheng Yan, Xiaoyan Mao, Yao Xu, Jian Mu, Qiaoli Li, Li Jin, Lin He, Lei Wang#. Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.Am J Hum Genet,2018 Apr 5;102(4):649-657
2.Biaobang Chen*, Zhihua Zhang*, Xiaoxi Sun*, Yanping Kuang*, Xiaoyan Mao*, Xueqian Wang, Zheng Yan, Bin Li, Yao Xu, Min Yu, Jing Fu, Jian Mu, Zhou Zhou, Qiaoli Li, Li Jin, Lin He,Qing Sang#and Lei Wang#. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest.Am J Hum Genet,2017，Oct 5;101(4):609-615
3.Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y,Sang Q*, Wang L*. Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development.Hum Reprod. 2017 Feb;32(2):457-464
4.Ruizhi Feng*,Qing Sang*, Yanping Kuang*, Xiaoxi Sun*，Zheng Yan*, Shaozhen Zhang*, Juanzi Shi, Guoling Tian, Anna Luchniak, Yusuke Fukuda, Bin Li, Min Yu, Junling Chen,Yao Xu, Luo Guo, Ronggui Qu, Xueqian Wang, Zhaogui Sun, Miao Liu, Huijuan Shi, Hongyan Wang, Yi Feng, Ruijin Shao, Renjie Chai, Qiaoli Li, Qinghe Xing, Rui Zhang, Eva Nogales, Li Jin, Lin He, Mohan L. Gupta, Jr., Nicholas J. Cowan# and Lei Wang#. Mutations in TUBB8 and Human oocyte meiotic arrest.N Engl J Med.2016; 374:223-32.
5. Sang Q, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R, Liu D, Jin L, He L, Li H*, Wang L*. Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.Hum Mol Genet.2014 Dec 1;23(23):6201-11.
6. Sang Q*, Yao Z*, Wang H*, Feng R, Wang H, Zhao X, Xing Q, Jin L, He L, Wu L, Wang L*.Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.J Clin Endocrinol Metab. 2013 Jul;98 (7):3068-3079.
7. Qing Sang*, Shaozhen Zhang*, Sien Zhou, Ruizhi Feng, Lei Wang*. Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome.Reprod Biomed Online.2013 Feb;26(2):157-63.
8. Sang Q*, Li W*, Xu Y, Qu R, Xu Z, Feng R, Jin L, He L, Li H, Wang L*.ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42.Biol Open. 2015 Mar 27;4(4):411-8
9. Sang Q*, Mei H*, Kuermanhan A, Feng R, Guo L, Qu R, Xu Y, Li H, Jin L, He L, Wang L*. Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment.Mol Genet Genomics. 2015 Jun;290(3):1135-9.
10.Zou S*,Sang Q*, Wang H, Feng R, Li Q, Zhao X, Xing Q, Jin L, He L, Wang L*. Common genetic variation inCYP1B1is associated with concentrations of T4, FT3 and FT4 in the sera of polycystic ovary syndrome patients.Mol Biol Rep. 2013 Apr;40 (4):3315-20.
所獲榮譽
國家優秀青年基金（2018）
復星獎教金一等獎（2017）
全國婦幼健康科技獎自然科學一等獎(2017)
中國動物學會生殖生物學分會第二屆青年科技獎（2017）
全國婦幼健康科技獎自然科學二等獎(2015)
