李陶(幹細胞科學家)

李陶(幹細胞科學家)

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李陶,男,生於1957年,日本東京大學農業生物學博士,美籍華人。李陶博士在Science、Cell Stem Cell等國際學術刊物上發表30多篇原創論文,其中影響因子5.0以上的文章近20篇,在Science上發表的論文影響因子達到31.9,發明專利9項。

基本介紹

  • 中文名:李陶 
  • 國籍:美籍華人 
  • 出生日期:1957年 
  • 職業:生物學博士 
  • 畢業院校:日本東京大學 
  • 性別:男 
個人簡介,人物影響,科研成果,部分專利,

個人簡介

李陶,日本東京大學農業生物學博士,美籍華人。曾在日本岩手生物工學研究中心、美國史丹福大學醫學院擔任研究員,現任深圳市幹細胞工程技術研究開發中心主任、深圳北科生物科技有限公司研發部總監、IPS首席科學家。
李陶李陶
李陶在Science、Cell Stem Cell等國際學術刊物上發表30多篇原創論文,其中影響因子5.0以上的文章近20篇,在Science上發表的論文影響因子達到31.9,發明專利9項。

人物影響

李陶博士對於幹細胞的研究在國內外均有較高的影響和學術地位。

科研成果

1.Tao Li, Ji-Fan Hu, Jianqun Ling, Thanh H. Vu, Andrew R. Hoffman. AberrantIGF2imprinting in human malignancy is associated with the altered CTCF-PRC2-IGF2 promoter intrachromosomal loop complex. in preparation.
2.Tao Li, Ji-Fan Hu, Xinwen Qiu, Jianqun Ling, Huiling Chen, Shukui Wang, Aiju Hou, Thanh H. Vu, Andrew R. Hoffman. CTCF regulates allelic expression ofIgf2by orchestrating a promoter-polycomb repressive complex-2 intrachromosomal loop.Proc Natl Acad Sci U S A, in press.(Sci, 10.5)
3.Theresa L. Chen,Wen-Jun Shen, Xin-Wen Qiu,Tao Li,Andrew R. Hoffman and Fredric B. Kraemer (2007). Generation of novel adipocyte monolayer cultures from embryonic stem cell. Stem cells and Development, 16:371–380.
4.Hui Ling Chen*,Tao Li* (*並列第一作者),Xin Wen Qiu, JieWu, Jian Qun Ling, Zhi Hong Sun, Weibo Wang, Wei Chen, Aiju Hou, Thanh H Vu, Andrew R Hoffman and Ji-Fan Hu (2006). Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming.The EMBO Journal25, 5329–5338. (Sci, 10.5)
5.Jianqun Ling,Tao Li, Ji Fan Hu,1 Thanh H. Vu, Hui Ling Chen, Xin Wen Qiu, Athena M. Cherry, Andrew R. Hoffman (2006). CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1.ScienceVol. 312: 269-272. (Sci, 31.9)
6.Tao Li, Thanh H.Vu, Gary A.Ulaner, Eva Littman, Jian-Qun Ling, Hui-Ling Chen, Ji-Fan Hu, Barry Behr, Linda Giudice and Andrew R. Hoffman (2005). IVF results inde novoDNA methylation and histone methylation at anIgf2-H19imprinting epigenetic switch.Mol Hum Reprod11(9): 631-640.(Sci, 3.1)
7.Thanh H Vu*,Tao Li*(*並列第一作者)and Andrew R Hoffman (2004). Promoter-specific histone code marks imprinting status of IGF2 receptor in human and mouse.Human Molecular Genetics13(19):2233-2245.(Sci, 7.8)
8.Xiaoming Yao, Ji-Fan Hu,Tao Li,Youwen Yang, Zhihong Sun, Gary Ulaner, Thanh H Vu, and Andrew R. Hoffman (2004). Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.Cancer Genetics and Cytogenetics. 151(1):1-13.(Sci, 1.6)
9.Tao Li, Thanh H. Vu, Gary A. Ulaner, Youwen Yang, Ji-Fan Hu and Andrew R. Hoffman (2004). Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.Human Molecular Genetics13: 741–750.(Sci, 7.8)
10.Youwen Yang, Ji-Fan Hu, Gary A. Ulaner,Tao Li, Xiaoming Yao, Thanh H. Vu, and Andrew R. Hoffman (2003). Epigenetic Regulation of Igf2/H19 Imprinting at CTCF Insulator Binding Sites.Journal of Cellular Biochemistry90:1038–1055. (Sci, 3.0)
11.Youwen Yang*,Tao Li*(*並列第一作者), Thanh H, Gary A. Ulaner, Jifan Hu and Andrew R. Hoffman (2003). The Histone Code Regulating Expression of the Imprinted MouseIgf2rGene.Endocrinology144:5658–5670.(Sci, 5.2)
12.Thanh H. Vu*,Tao Li*(*並列第一作者),Chuyen V. Nguyen and Andrew R. Hoffman (2003). Loss of Imprinting ofIGF2Sense and Antisense Transcripts in Wilms’ Tumor.Cancer Research63: 1900–1905.(Sci, 7.7)
13.Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Huifan Yien, Hongqi Lu, Hadas Sharan, Xiangjun Zhou, Zhilan Zeng,Tao Li, Youwen Yang, and Andrew R. Hoffman (2003). A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.Clinical Cancer Research. 9:2719-2726.(Sci, 5.6)
14.Gary A. Ulaner, Thanh H. Vu,Tao Li, Ji-Fan Hu1, Xiao-Ming Yao, Youwen Yang, Richard Gorlick, Paul Meyers, John Healey, Marc Ladanyi and Andrew R. Hoffman (2003). Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site.Human Molecular Genetics12: 535–549.(Sci, 7.8)
15.Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Xingjun Zhou, Huifan Yien, Hongqi Lu, Zhilan Zeng, Tao Li, and Andrew R. Hoffman (2002). A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.J. Clin. Invest.111: 265–273.(Sci, 14.2)
16.Tao Li, Thanh H. Vu, Kok-Onn. Lee, Chuyen V. Nguyen , Huy Q. Bui, Zhi-Lan Zeng, Binh T. Nguyen, Ji-Fan Hu, Susan K. Murphy, Randy L. Jirtle, and Andrew R. Hoffman (2002). Imprinted PEG1/MEST Antisense Expressed Predominantly in Human Testis and in Mature Spermatozoa.Journal of Biological Chemistry16:13518-13527.(Sci, 6.4)
17.Killian JK, Nolan CM, Wylie AA,Li T, Vu TH, Hoffman AR, Jirtle RL (2001). Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary.Human Molecular Genetics10:1721-1728. (Sci, 7.8)
18.Tao Li,Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Jifan Hu and Andrew Hoffman (2000). Tissue-specific expression of antisense and sense transcript at the imprinted Gnas locus.Genomics69: 295-304.(Sci, 3.8)
19.Ji-fan Hu, Jung Pham, Indiral Dey,Tao Li, Thanh H. Vu and Andrew R. Hoffman (2000). Allele-specific histone Acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene.Endocrinology. 141: 4428-35. (Sci, 5.2)
20.Tao Li, Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Xiaoming Yao, Jifan Hu and Andrew Hoffman (2000). Symmetric and Asymmetric DNA methylation in the Human IGF2-H19 imprinted region.Genomics.64, 132-143.(Sci, 3.8)
21.Okamura K, Hagiwara-Takeuchi Y,Li T,Vu TH, Hirai M, Hattori M, Sakaki Y, Hoffman AR, Ito T. (2000). Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.Genome Research. 10: 1878-1889.(Sci, 10.4)
22.Hu JF, Balaguru KA, Ivaturi RD, Oruganti H,Li T, Nguyen BT, Vu TH and Hoffman AR (1999). Lack of reciprocal genomic imprinting of sense and antisense RNA of mouse insulin-like growth factor II receptor in the central nervous system.Biochem Biophys Res Commun. 257: 604-608.(Sci, 2.9)

部分專利

細胞轉核誘導體細胞成多能二倍體幹細胞的方法
單個核細胞培養液 Mononuclear cell culture medium
通過mRNA誘導體細胞為多能幹細胞的方法
一種高效誘導人類體細胞重編程為多潛能幹細胞的方法
一種可用於肝衰竭治療的經HGF基因修飾的UCMSC製備方法
牙齒來源間充質幹細胞體外分離與培養方法
一種用於免疫治療的EB病毒LMP2A串聯表位肽及其套用

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