基本介紹
- 中文名稱：李長紅
- 英文名稱：Changhong Li
- 民族：漢
- 畢業院校：北京醫科大學
- 教學職稱：費城兒童醫院內分泌科科研副教授
- 學位：博士
社會任職,主要成就,發表文章,
社會任職
現任濰坊盛德內乃凳府鴉科醫院（有限公司）院長
兼任南京先進生物技術和生命科學研究院副院長
2017年-2018年: 費城兒童醫院內分泌科，科研副教授
曾任美國賓夕法尼亞大學醫學院兒科系 ，科研助理教授
曾在賓夕法尼亞大學醫學院糖尿病中心,費城兒童醫院內分泌科，博士後, 導師： Charles Stanley, Franz Matschinsky），美國探祖雄
曾在Lipids and Growth, INSERM (U921), 圖爾大學醫學院，博士後,導師： Jacque Delarue, 法國
主要成就
李長紅博士在胰島功能與代謝領域從事基礎及轉化醫學研究20年，洪拔辣店闡述了幾種主要類型先天性高胰島素低血糖症（CHI）的致病機制，構建了主要類型CHI的疾病模型。還主導了針對CHI的新藥研發工作。通過他和北京兒童醫院內分泌科的多年合作，中國兒科界對CHI的認識得到顯著的提高，該病已經列入捆榜采首批中國罕見病名錄。李長紅還把CHI研究中的方法和技術套用到糖尿病人胰島的捆遷墊研究中，闡述了2型糖尿病胰島功能障礙的機制，並參與了作為治療2型糖尿病新藥的葡萄糖激酶刺激劑的研發工作。他還開發了針對糖尿病人的特殊醫用食品，臨床試驗證明這些食品能改善糖尿病人的血糖控制。其研究團隊的多個研究課題獲美國國立衛生研究院(NIH)、強生公司、默克等公司資助,作為領導悼芝去獲得科研經費資助總金額超過500萬兵承美元。至今在國際知名學術刊物如JBC、Diabetes、JCI、Cell Metabolism等發表SCI文章60餘篇,圖書章節4篇,還在中國核心期刊上發表中文文章10餘篇。
發表文章
1. Andrea Kelly,Changhong Li, Zhiyong Gao, Charles A. Stanley, Franz M. Matschinsky. Glutaminolysis and Insulin Secretion: From Bedside to Bench and Back.Diabetes,Vol.51, (Supp 3): S421-S426, 2002
2.Changhong Li, Habiba Najafi, Yevgeny Daikhin, Ilana Nissim, Heather Collins, Marc Yudkoff, Franz M. Matschinsky, Charles A. Stanley: Regulation of Leucine-stimulated Insulin Secretion and Glutamine Metabolism in Isolated Rat Islets.J. Biol. Chem.Vol. 278: 2853-2858, 2003
3.Changhong Li, Carol Buettger, Jae Kwagh, Andrea Matter, Yevgeny Daikhin, Ilana B. Nissim, Heather W. Collins, Marc Yudkoff, Charles A. Stanley, and Franz M. Matschinsky. Asignaling role of glutamine in insulin secretion.J. Biol. Chem.Vol. 279: 13393-13401,2004
4.Nicolai M. Doliba, Wei Qin, Marko Z. Vatamaniuk,Changhong Li, Dorothy Zelent, Habiba Najafi, Carol W. Buettger, Heather W. Collins, Richard D. Carr, Mark A. Magnuson, and Franz M. Matschinsky. Restitution of Defective Glucose-Stimulated insulin Release of Sulfonylurea Type 1 Receptor Knockout Mice by Acetylcholine.Am J Physiol Endocrinol MetabVol. 286(5):E834-43. Epub 2004 Jan 21, 2004
5.D. Zelent, H. Najafi, S. Odili, C. Buettger, H. W. Collins,C, Li, N. Doliba, J. Grimsby and F.M. Matschinsky. Glucokinase and Glucose Homeostasis: Proven Concepts and New Ideas.Biochem Soc Trans.2005 Feb; 33(Pt 1):306-10.
6.Jacques Delarue,Changhong Li, Richard Cohen, Charlotte Corporeau, Brigitte Simon. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects.Br J Nutr.2006. 95(2): 267-272
7.Changhong Li, Aron Allen, Jae Kwagh, Nicolai Doliba, Wei Qin, Habiba Najafi, Heather W. Collins, Franz M. Matschinsky, Charles A. Stanley, and Thomas J. Smith. Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.J. Biol. Chem.Vol. 281: 10214-10221.2006.
8.Changhong Li, Andrea Matter, Andrea Kelly, Thomas J. Petty, Habiba Najafi, Courtney MacMullen,Yevgeny Daikhin, Ilana Nissim, Adam Lazarow, Jae Kwagh, Heather W. Collins, Betty Y.L. Hsu, Itzhak Nissim, Marc Yudkoff, Franz M. Matschinsky and Charles A. Stanley. Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.J. Biol. Chem.Vol. 281: 15064-15072, 2006. (Paper of the week, also illustrated on the cover of June 2issue.)
9.Maria F. Pino, Kyoung-Ah Kim, Kathy D. Shelton, Jill Lindner, Stella Odili,Changhong Li, Heather W. Collins, Masakazu Shiota, Franz M. Matschinsky, and Mark A. Magnuson. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.J. Biol. Chem.282: 13906-13916, 2007
10.Changhong Li, Itzhak Nissim, Pan Chen,Carol Buettger, Habiba Najafi,Yevgeny Daikhin, Ilana Nissim, Heather W. Collins, Marc Yudkoff, Charles A. Stanley and Franz M. Matschinsky. Elimination of KATP channelsin mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis and pyruvate cycling but a decreased GABA shunt.J. Biol. Chem.283: 17238-17249, 2008. PMCID: PMC2427330.
11.Diva D. Deleon,Changhong Li, Madeleine Delson, Charles A. Stanley, Franz M. Matschinsky, Doris A. Stoffers. Exendin (9-39) corrects fasting hypoglycemia in sur-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.J. Biol. Chem.283:25786-25793, 2008. PMCID: PMC3258866.
12.Changhong Li,Pan Chen, Andrew Palladino, Srinivas Narayan, Laurie K. Russell, Samir Sayed, Guoxiang Xiong, Jie Chen, David Stokes, Yasmeen M. Butt, Patricia M. Jones, Heather W. Collins, Noam A. Cohen, Akiva S. Cohen, Itzhak Nissim,Thomas J. Smith, Arnold W. Strauss, Franz M. Matschinsky, Michael J. Bennett, Charles A. Stanley. Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.J. Biol. Chem.285: 31806-31818. 2010.PMCID: PMC2951252.
13.Ming Li,Changhong Li, Aron Allen, Charles A. Stanley and Thomas J. Smith.The structure and allosteric regulation of glutamate dehydrogenase.Neurochem Int. 2011, 59: 445-455 PMCID: PMC3135769.
14.Matschinsky FM,Zelent B,Doliba N,Li C,Vanderkooi JM,Naji A,Sarabu R,Grimsby J. Glucokinase Activators for Diabetes Therapy: May 2010 status report.Diabetes Care.2011 May; 34 Suppl 2:S236-43. PMCID: PMC3632186.
15.Changhong Li, Ming Li, Pan Chen, Srinivas Narayan, Franz M. Matschinsky, Michael J. Bennett, Charles Stanley, and Thomas J. Smith. Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.J. Biol. Chem.2011 Sep 30; 286(39):34164-74. PMCID: PMC3190766.
16.Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, Weik-Collins H,Li C, Stanley CA, Wilson DF, Grimsby J, Sarabu R, Naji A, MatschinskyFM.Glucokinase activation repairs defective bioenergetics of islets of langerhans isolated from type 2 diabetics.Am J Physiol Endocrinol Metab,302(1):E87-E102. 2012. PMCID: PMC3328091.
17. 楊大木，高妍，李長紅，劉玉珍，夏鐵安. 促甲狀腺激素受體基因在自身免疫甲狀腺病中的表達，中華醫學雜誌，1996年10月第76卷第10期，753-755頁
18. 楊大木，袁振芳，李長紅，高妍. 促甲狀腺激素受體、甲狀腺過氧化物酶及甲狀腺球蛋白基因表達與自身免疫甲狀腺疾病，中華內科雜誌，1997年10月第 36卷第10期，685-688頁
19. 邵建華，袁振芳，李長紅，王淑鳳，高妍. 游離脂肪酸促進基礎狀態胰島細胞生長和分泌胰島素，中華內科雜誌,1997年12月第36卷第12期，831-832頁
20. 楊建梅，高妍，李長紅，劉靜霞. 游離脂肪酸、胰島素對脂肪前體細胞分化的影響，北京醫科大學學報，1998, 30: 276-278頁
21. 李長紅. 脂肪組織生長的調節，《國外醫學》內分泌學分冊1998年9月第18卷第3期，123-126頁
22. 邵建華，高妍，袁振芳，李長紅，王淑鳳. 游離脂肪酸對基礎狀態β細胞胰島素分泌和前胰島素原mRNA表達的影響，北京醫科大學學報，1998, 30 : 127-130頁
23. 高妍，馮晉光，李長紅，馮琦，鄭家璣，高燕明，施曼珠，陳瀾，惠岩. 拜糖平和美迪康對 2型糖尿病降糖作用的臨床療效比較。中華內分泌代謝雜誌，1998年2月第14卷第1期，8-10頁
24. 袁振芳，高妍，李長紅，邵建華. γ干擾素對甲狀腺刺激抗體作用下FRTL5細胞TG 、TPO 基因表達的影響，中華內分泌代謝雜誌，2001年4月第17卷第2期，111-114頁
25. 袁振芳，高妍，王薇，董愛梅，李長紅，邵建華. γ干擾素對培養的人甲狀腺細胞HLA-DR 抗原基因表達的影響，中華內科雜誌，2002年4月第41卷第4期，262-263頁
26. 李長紅. 糖尿病藥物研發需緊盯胰島，科技創業，2011, 8: 98-99頁
27. 桑艷梅，胡姝雯，劉敏，李長紅，苞山. ABCC8基因突變致ATP敏感性鉀通道型先天性高胰島素血症一例家系分析，中華內分泌代謝雜誌，2012年28卷01期, 51-53頁
4.Nicolai M. Doliba, Wei Qin, Marko Z. Vatamaniuk,Changhong Li, Dorothy Zelent, Habiba Najafi, Carol W. Buettger, Heather W. Collins, Richard D. Carr, Mark A. Magnuson, and Franz M. Matschinsky. Restitution of Defective Glucose-Stimulated insulin Release of Sulfonylurea Type 1 Receptor Knockout Mice by Acetylcholine.Am J Physiol Endocrinol MetabVol. 286(5):E834-43. Epub 2004 Jan 21, 2004
5.D. Zelent, H. Najafi, S. Odili, C. Buettger, H. W. Collins,C, Li, N. Doliba, J. Grimsby and F.M. Matschinsky. Glucokinase and Glucose Homeostasis: Proven Concepts and New Ideas.Biochem Soc Trans.2005 Feb; 33(Pt 1):306-10.
6.Jacques Delarue,Changhong Li, Richard Cohen, Charlotte Corporeau, Brigitte Simon. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects.Br J Nutr.2006. 95(2): 267-272
7.Changhong Li, Aron Allen, Jae Kwagh, Nicolai Doliba, Wei Qin, Habiba Najafi, Heather W. Collins, Franz M. Matschinsky, Charles A. Stanley, and Thomas J. Smith. Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.J. Biol. Chem.Vol. 281: 10214-10221.2006.
8.Changhong Li, Andrea Matter, Andrea Kelly, Thomas J. Petty, Habiba Najafi, Courtney MacMullen,Yevgeny Daikhin, Ilana Nissim, Adam Lazarow, Jae Kwagh, Heather W. Collins, Betty Y.L. Hsu, Itzhak Nissim, Marc Yudkoff, Franz M. Matschinsky and Charles A. Stanley. Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.J. Biol. Chem.Vol. 281: 15064-15072, 2006. (Paper of the week, also illustrated on the cover of June 2issue.)
9.Maria F. Pino, Kyoung-Ah Kim, Kathy D. Shelton, Jill Lindner, Stella Odili,Changhong Li, Heather W. Collins, Masakazu Shiota, Franz M. Matschinsky, and Mark A. Magnuson. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.J. Biol. Chem.282: 13906-13916, 2007
10.Changhong Li, Itzhak Nissim, Pan Chen,Carol Buettger, Habiba Najafi,Yevgeny Daikhin, Ilana Nissim, Heather W. Collins, Marc Yudkoff, Charles A. Stanley and Franz M. Matschinsky. Elimination of KATP channelsin mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis and pyruvate cycling but a decreased GABA shunt.J. Biol. Chem.283: 17238-17249, 2008. PMCID: PMC2427330.
11.Diva D. Deleon,Changhong Li, Madeleine Delson, Charles A. Stanley, Franz M. Matschinsky, Doris A. Stoffers. Exendin (9-39) corrects fasting hypoglycemia in sur-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.J. Biol. Chem.283:25786-25793, 2008. PMCID: PMC3258866.
12.Changhong Li,Pan Chen, Andrew Palladino, Srinivas Narayan, Laurie K. Russell, Samir Sayed, Guoxiang Xiong, Jie Chen, David Stokes, Yasmeen M. Butt, Patricia M. Jones, Heather W. Collins, Noam A. Cohen, Akiva S. Cohen, Itzhak Nissim,Thomas J. Smith, Arnold W. Strauss, Franz M. Matschinsky, Michael J. Bennett, Charles A. Stanley. Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.J. Biol. Chem.285: 31806-31818. 2010.PMCID: PMC2951252.
13.Ming Li,Changhong Li, Aron Allen, Charles A. Stanley and Thomas J. Smith.The structure and allosteric regulation of glutamate dehydrogenase.Neurochem Int. 2011, 59: 445-455 PMCID: PMC3135769.
14.Matschinsky FM,Zelent B,Doliba N,Li C,Vanderkooi JM,Naji A,Sarabu R,Grimsby J. Glucokinase Activators for Diabetes Therapy: May 2010 status report.Diabetes Care.2011 May; 34 Suppl 2:S236-43. PMCID: PMC3632186.
15.Changhong Li, Ming Li, Pan Chen, Srinivas Narayan, Franz M. Matschinsky, Michael J. Bennett, Charles Stanley, and Thomas J. Smith. Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.J. Biol. Chem.2011 Sep 30; 286(39):34164-74. PMCID: PMC3190766.
16.Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, Weik-Collins H,Li C, Stanley CA, Wilson DF, Grimsby J, Sarabu R, Naji A, MatschinskyFM.Glucokinase activation repairs defective bioenergetics of islets of langerhans isolated from type 2 diabetics.Am J Physiol Endocrinol Metab,302(1):E87-E102. 2012. PMCID: PMC3328091.
17. 楊大木，高妍，李長紅，劉玉珍，夏鐵安. 促甲狀腺激素受體基因在自身免疫甲狀腺病中的表達，中華醫學雜誌，1996年10月第76卷第10期，753-755頁
18. 楊大木，袁振芳，李長紅，高妍. 促甲狀腺激素受體、甲狀腺過氧化物酶及甲狀腺球蛋白基因表達與自身免疫甲狀腺疾病，中華內科雜誌，1997年10月第 36卷第10期，685-688頁
19. 邵建華，袁振芳，李長紅，王淑鳳，高妍. 游離脂肪酸促進基礎狀態胰島細胞生長和分泌胰島素，中華內科雜誌,1997年12月第36卷第12期，831-832頁
20. 楊建梅，高妍，李長紅，劉靜霞. 游離脂肪酸、胰島素對脂肪前體細胞分化的影響，北京醫科大學學報，1998, 30: 276-278頁
21. 李長紅. 脂肪組織生長的調節，《國外醫學》內分泌學分冊1998年9月第18卷第3期，123-126頁
22. 邵建華，高妍，袁振芳，李長紅，王淑鳳. 游離脂肪酸對基礎狀態β細胞胰島素分泌和前胰島素原mRNA表達的影響，北京醫科大學學報，1998, 30 : 127-130頁
23. 高妍，馮晉光，李長紅，馮琦，鄭家璣，高燕明，施曼珠，陳瀾，惠岩. 拜糖平和美迪康對 2型糖尿病降糖作用的臨床療效比較。中華內分泌代謝雜誌，1998年2月第14卷第1期，8-10頁
24. 袁振芳，高妍，李長紅，邵建華. γ干擾素對甲狀腺刺激抗體作用下FRTL5細胞TG 、TPO 基因表達的影響，中華內分泌代謝雜誌，2001年4月第17卷第2期，111-114頁
25. 袁振芳，高妍，王薇，董愛梅，李長紅，邵建華. γ干擾素對培養的人甲狀腺細胞HLA-DR 抗原基因表達的影響，中華內科雜誌，2002年4月第41卷第4期，262-263頁
26. 李長紅. 糖尿病藥物研發需緊盯胰島，科技創業，2011, 8: 98-99頁
27. 桑艷梅，胡姝雯，劉敏，李長紅，苞山. ABCC8基因突變致ATP敏感性鉀通道型先天性高胰島素血症一例家系分析，中華內分泌代謝雜誌，2012年28卷01期, 51-53頁
