李迎秋，女，博士，中山大學生命科學學院教授、博士生導師。
基本介紹
- 中文名：李迎秋
- 畢業院校：中山大學
- 學位/學歷：博士
- 專業方向：生化分子生物學
- 任職院校：中山大學
人物經歷,研究方向,講授課程,論文專著,
人物經歷
1995年獲中山大學生命科學學院生化分子生物學專業博士學位。1995年12月起任中山大學生物防治國家重點實驗室講師直至1997年12月出國。1997年12月起，先後在美國Scripps研究所免疫系和美國LIAI免疫研究所進行博士後研究工作，研究方向為天然免疫MAPK p38蛋白激酶信號通路及T淋巴細胞的TCR信號轉導機制。2005年起，受聘為中山大學生命科學學院任教授。2007年入選教育部新世紀優秀人才支持計畫。
研究方向
免疫細胞信號轉導，免疫應答
講授課程
免疫學I，II
論文專著
Wang QL, Liang JQ, Gong BN, Xie JJ, Yi YT, Lan X,Li Y*. T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1. Front Immunol. 2019 Feb 28;10:314.
Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd,Li Y, Lillemeier BF, Altman A*. Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling. Sci Signal. 2019 Apr 16;12(577)
Chen ZL, Gong BN, Wang QL, Xiao ZH, Deng C, Wang WQ,Li Y*. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Fish Shellfish Immunol. 2019 Jan;84:1100-1107
Qu X, Lan X, Deng C, Zhou J, Du J, Huang S,Li Y*.Molecular mechanisms underlying the evolution of the slp76 signalosome. Sci Rep. 2017 May 4;7(1):1509
Yu X, Wang QL, Li YF, Wang XD, Xu A,Li Y*. A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation. Cell Discov. 2016 Jan 26;2:15043.
Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A,Li Y*.TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation. Nat Immunol. 2015 Nov;16(11):1195-203.
Liu X, Xiao W, Wang XD, Li YF, Han J,Li Y*. The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013 Dec 20;288(51):36648-61.
Xie JJ, Liang JQ, Diao LH, Altman A,Li Y*. TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol. 2013 Apr 15;190(8):4027-36.
Wang K, Diao LH, Gong Y, Liu X,Li Y*. NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cell Signal. 2012 Aug;24(8):1556-64.
Zohn IE,Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69.
Li Y,Sedwick CE, Hu J, Altman A. Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation. J Biol Chem. 2005 Jan 14;280(2):1217-23.
Li Y,Hu J, Vita R, Sun B, Tabata H, Altman A. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J. 2004 Mar 10;23(5):1112-22.
Li Y, Jiang B, Ensign WY, Vogt PK, Han J. Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cell Signal. 2000 Dec;12(11-12):751-7.
