李蘇華

李蘇華，男，1983年5月生，籍貫江蘇姜堰 （江西德安人），中山大學化學學院教授，博士生導師。

人物經歷

教育經歷

2007.09–2012.07 中國科學院上海有機化學研究所，有機化學博士 導師：麻生明 院士

2002.09–2006.06 南京大學 化學學士學位

工作經歷

2017.07–至今     中山大學化學學院，教授，博士生導師

2014.07–2017.06 The Scripps Research Institute 博士後 合作導師：K. Barry Sharpless教授

2012.08–2014.07 The Scripps Research Institute 博士後 合作導師：Jin-Quan Yu教授

2006.08–2007.09 康化（上海）新藥研發有限公司

科研方向

通過研究新型化學試劑來發展經濟高效的合成方法學，並探索其在能源、環境、材料以及生物中的套用。

學術成果

期刊論文

(1) Wan Jung Kim, Keith Korthals, Suhua Li, Christine Le, Jaroslaw Kalisiak, K. Barry Sharpless, Valery V. Fokin, Yukiko Miyamoto, Lars Eckmann*, Click chemistry-facilitated structural diversification of nitrothiazoles, nitrofurans and nitropyrroles enhances antimicrobial activity against Giardia lamblia, Antimicrob. Agents Chemother. 2017, 61, e02397-16.

(2) Bukeyan Miao, Yangguangyan Zheng, Penglin Wu, Suhua Li, Shengming Ma*, Bis(cycloocta- 1,5-diene)nickel-Catalyzed Carbon Dioxide Fixation for Stereoselective Synthesis of 3-Alkylidene-2-indolinones, Adv. Synth. Catal. 2017, 359, 1691.

(3) Suhua Li, Peng Wu, John E. Moses, K. Barry Sharpless*, Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub, Angew. Chem. Int. Ed. 2017, 56, 2903. (VIP文章, highlighted in C&E News, 2017, 95, 10; Chemistry World:

(4) Haiyan Fu, Peng-Xiang Shen, Jian He, Fanglin Zhang, Suhua Li, Peng Wang, Tao Liu, Jin-Quan Yu*, Ligand-Enabled Alkynylation of C(sp3)-H Bonds with Pd(II) Catalysts, Angew. Chem. Int. Ed. 2017, 56, 1873.

(5) Wentao Chen†, Jiajia Dong†, Lars Plate†, David E. Mortenson, Gabriel J. Brighty, Suhua Li, Yu Liu, Andrea Galmozzi, Peter S. Lee, Jonathan J. Hulce, Benjamin F. Cravatt, Enrique Saez, Evan T. Powers, Ian A. Wilson, K. Barry Sharpless*, Jeffery W. Kelly*, Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue, J. Am. Chem. Soc. 2016, 138, 7353.

(6) Bukeyan Miao, Suhua Li, Gen Li and Shengming Ma*, Cyclic Anti-Azacarboxylation of 2‑Alkynylanilines with Carbon Dioxide, Org. Lett. 2016, 18, 2556. (Highlighted in Synfacts, 2016, 12, 890.)

(7) Suhua Li, Ru-Yi Zhu, Kai-Jiong Xiao and Jin-Quan Yu*, Ligand-Enabled Arylation of γ-C-H Bonds, Angew. Chem. Int. Ed. 2016, 55, 4317.

(8) Enxuan Zhang*, Jiaze Tang, Suhua Li, Peng Wu, John E. Moses and K. Barry Sharpless*, Chemoselective Synthesis of Polysubstituted Pyridines From Heteroaryl Fluorosulfates, Chem. Eur. J. 2016, 22, 5692. (Highlighted in Synfacts, 2016, 12, 617.)

(9) Wentao Chen†, Jiajia Dong†, Suhua Li, Yu Liu, Yujia Wang, Leonard Yoon, Peng Wu, K. Barry Sharpless*, Jeffery W. Kelly*, Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy, Angew. Chem. Int. Ed. 2016, 55, 1835.

(10) Ru-Yi Zhu, Keita Tanaka, Gen-Cheng Li, Jian He, Hai-Yan Fu, Suhua Li and Jin-Quan Yu*, Ligand-Enabled Stereoselective β-C(sp3)–H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-amino Acids, J. Am. Chem. Soc. 2015, 137, 7067.

(11) Xiao-Chen Wang, Wei Gong, Li-Zhen Fang, Ru-Yi Zhu, Suhua Li, Keary M. Engle and Jin-Quan Yu*, Ligand-enabled meta-CH activation using a transient mediator, Nature, 2015, 519, 334.

(12) Gang Chen, Toshihiko Shigenari, Pankaj Jain, Zhipeng Zhang, Zhong Jin, Jian He, Suhua Li, Claudio Mapelli, Michael M. Miller, Michael A. Poss, Paul M. Scola, Kap-Sun Yeung and Jin-Quan Yu*, Ligand-Enabled beta-C-H Arylation of alpha-Amino Acids Using a Simple and Practical Auxiliary, J. Am. Chem. Soc. 2015, 137, 3338.

(13) Suhua Li, Gang Chen, Chen-Guo Feng, Wei Gong and Jin-Quan Yu*, Ligand-Enabled γ-C–H Olefination and Carbonylation: Construction of β-Quaternary Carbon Centers, J. Am. Chem. Soc. 2014, 136, 5267. (Highlighted in Organic Chemistry Portal, 2015, Jan 26th:

(14) Jian He†, Suhua Li†, Youqian Deng, Haiyan Fu, Brian N. Laforteza, Jillian E. Spangler, Anna Homs and Jin-Quan Yu*, Ligand-Controlled C(sp3)–H Arylation and Olefination in Synthesis of Unnatural Chiral α–Amino Acids, Science, 2014, 343, 1216. (Highlighted in C&EN News, 2014, 92, 5. †共同第一作者.)

(15) Chen-Guo Feng, Mengchun Ye, Kai-Jiong Xiao, Suhua Li and Jin-Quan Yu*, Pd(II)-Catalyzed Phosphorylation of Aryl C-H Bonds, J. Am. Chem. Soc. 2013, 135, 9322.

(16) Suhua Li, Juntao Ye, Weiming Yuan and Shengming Ma*, Highly Regioselective Three-component Palladium-Catalyzed Synthesis of 5-Vinyloxazolidin-2-one from 2,3-Allenyl Amines, Organic Iodides and Carbon Dioxide, Tetrahedron, 2013, 69, 10450.

(17) Juntao Ye, Suhua Li and Shengming Ma*, Gorlos-phos: Addressing the Stereoselectivity in Palladium-catalyzed Exo-mode Cyclization of Allenes with a Nucleophilic Functionality, Org. Biomol. Chem. 2013, 11, 5370.

(18) Suhua Li, Bukeyan, Miao, Weiming Yuan and Shengming Ma* Carbometalation–Carboxylation of 2,3-Allenols with Carbon Dioxide: A Dramatic Effect of Halide Anion, Org. Lett., 2013, 15, 977. (Highlighted in Organic Chemistry Portal, Abstracts:)

(19) Juntao Ye, Suhua Li and Shengming Ma*, Palladium-Catalyzed Cyclization Reactions of 2,3-Allenyl Amines with Propargylic Carbonates,Org. Lett. 2012, 14, 2312.

(20) Suhua Li and Shengming Ma*, Quadri-Synergetic Effect for Highly Effective Carbon Dioxide Fixation and Its Application to Indoloquinolinone. Adv. Synth. Catal. 2012, 354, 2387.

(21) Juntao Ye, Suhua Li, Bo Chen, Wu Fan, Jingqiang Kuang, Jinxian Liu, Yu Liu, Bukeyan Miao, Bao Wan, Yuli Wang, Xi Xie, Qiong Yu, Weiming Yuan and Shengming, Ma*, Catalytic Asymmetric Synthesis of Optically Active Allenes from Terminal Alkynes,Org. Lett., 2012, 14, 1346.

(22) Suhua Li and Shengming Ma*, CO2-Activation for γ-Butyrolactones and its Application in the Total Synthesis of (±)-Heteroplexisolide E, Chem. Asian J. 2012, 7, 2411.

(23) Suhua Li and Shengming Ma*, Highly Selective Nickel-Catalyzed Methyl-Carboxylation of Homopropargylic Alcohols for α-Alkylidene-γ-butyrolactones. Org. Lett. 2011, 13, 6046. (Highlighted in Synfacts, 2012, 8, 196.)

(24) Suhua Li, Weiming Yuan and Shengming Ma*, Highly Regio- and Stereoselective Three-Component Nickel-Catalyzed syn-Hydrocarboxylation of Alkynes with Diethyl Zinc and Carbon Dioxide, Angew. Chem. Int. Ed. 2011, 50, 2578. (Highlighted in Nature China doi: 10.1038/nchina.2011.13; Angew. Chem. Int. Ed. 2011, 50, 6210.)

(25) Shengming Ma*, Jinxian Liu, Suhua Li, Bo Chen, Jiajia Cheng, Jinqiang Kuan, Yu Liu, Baoqiang Wan, Yuli Wang, Juntao Ye, Qiong Yu, Weiming Yuan and Shichao Yu, Development of a General and Practical Iron Nitrate/TEMPO Catalyzed Aerobic Oxidation of Alcohols to Aldehydes/Ketones: Catalysis with Table Salt, Adv. Synth. Catal. 2011, 353, 1005.

相關成果

首次實現了炔烴與CO­2的氫羧化反應；發展了兩個高效的喹啉類配體,並由Sigma-Aldrich公司將之商品化，命名為Li-Quinoline和Li-Yu t-Butyl Quinoline；將碘基化學發展到一個全新的維度，實現了三維連線。在國際著名刊物上發表學術論文25篇，其中第一作者10篇，包括1篇Science (共同第一作者)，1篇J. Am. Chem. Soc., 3篇Angew. Chem. Int. Ed.，他引數已超過700次。

獲獎情況

· 2011年度麻生明小組“研究貢獻獎”, 2012

· 布勞恩獎學金, 布勞恩惰性氣體系統有限公司, 2011

· 中國科學院院長優秀獎, 2011