基本介紹
- 中文名：李淑鋒
- 國籍：中國
- 畢業院校：南京大學
- 性別：女
- 辦公地點：東南大學丁家橋校區綜合樓407
- 職稱：副教授
- 職務：碩士生導師
研究方向,代表性論文,
基因轉錄調控的分子機制熱微拘研究
黏著斑激酶（FAK）是一種定位於黏著斑的非受體型酪氨酸激酶，參與細胞信號的傳導、調控細胞的遷移和增殖等生命功能。FAK在腫瘤的發生和發展過程中起重要作用，在多種腫充多訂瘤中均觀察到了嚷埋頌FAK的高表達現象。FAK在腫瘤中的作用雖然很重要，但鞏嫌邀去是關於FAK基因的轉錄與甩乎表達的調控機制卻研究很少。
基因的差異表達不論是對於正常的細胞生長過程，還是對於異常的疾病相關過程都是至關重要的。特別是在人類基因組計畫完成後，對轉錄控制區和調控機制進行嚴密分析的需要更加束笑辣迫切。了解FAK基因的調控區立犁頁碑、調控區包含的DNA元件以及與這些元件結合的DNA結合蛋白是我們感興趣的問題。
1．Li S, Dong W, Zong Y, Yin W, Jin G, Hu Q, Huang X, Jiang W, Hua ZC. Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther. 2007 Mar;15(3):515-23.
2．Li S, Li J, Cheng J, Zhou B, Tong X, Dong X, Wang Z, Hu Q, Chen M, Hua ZC. Non-syndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of EDA (ectodysplasin A). PLoS One. 2008 Jun 11;3(6)
3．Li S, Hua ZC.FAK expression regulation and therapeutic potential. Adv Cancer Res. 2008;101:45-61.
4．Dong W,Li SF, Jin GH, Sun QM , Ma DY, Hua ZC. Efficient gene transfection into mammalian cells mediated by cross-linked polyethylenimine. Int J Mol Sci 2006;7:1-32.
5．Dong X, Li J, Li S, Zhang J, Hua ZC.A novel genotyping strategy based on allele-specific inverse PCR for rapid and reliable identification of conditional FADD knockout mice. Mol Biotechnol. 2008 Feb;38(2):129-35.
6. Dong W, Jin GH, Li SF, Sun QM, Ma DY, Hua ZC.Cross-linked polyethylenimine as potential DNA vector for gene delivery with high efficiency and low cytotoxicity. Acta Biochim Biophys Sin. 2006 Nov;38(11):780-7.
6. Dong W, Jin GH, Li SF, Sun QM, Ma DY, Hua ZC.Cross-linked polyethylenimine as potential DNA vector for gene delivery with high efficiency and low cytotoxicity. Acta Biochim Biophys Sin. 2006 Nov;38(11):780-7.
