李永東，1997年6月畢業於贛南師範學院化學系，2007年6月 獲得中科院福建物構所理學博士學位。現為贛南師範學院，江西省有機藥物化學重點實驗室副教授。
基本介紹
- 中文名：李永東
- 國籍：中國
- 民族：漢族
- 職稱：研究員
研究方向,主要貢獻,
研究方向
主要是從事結構生物學與分子生物學結構蛋白晶體培養及蛋白質表達等方面的研究。
主要貢獻
作為主要成員參與了國家自然科學基金重點項目、福建省科技廳重點項目等課題的研究，研究成果在《Science》，《Journal of Molecular Biology》等國際一流期刊上發表論文7篇，獲專利1項。
【學術論文】
1. Huai, Q., Marzar, A. P., Kuo, A., Parry, G. C., Shaw, D. E., Callahan, J., Li Yongdong., Yuan, C.,Bian, C., Chen, L., Furie, B., Furie, B. C., Cines, D. B. & Huang, M. (2006). Structure of humanurokinase plasminogen activator in complex with its receptor. Science 311, 656-9。
2. Li, Yongdong., Parry, G., Chen, L., Callahan, J. A., Mazar, A. P. & Huang, M. (2007). An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope. Journal of Molecular Biology 365. 1117-1129（IF: 5.23)
3. Li, Yongdong., Shi, X., Parry, G., Chen, L., Callahan, J. A., Mazar, A. P. & Huang, M. (2005). Optimization of crystals of an inhibitory antibody of urokinase plasminogen activator receptor (uPAR) with hydrogen peroxide and low protein concentration Protein Pept Lett 12. 655-8 (IF: 0.84)
4. Rao, Y., Bian, C., Yuan, C., Li, Yongdong., Chen, L., Ye, X., Huang, Z. & Huang, M. (2006). An open conformation of swith I revealed by Sar1-GDP crystal structure at low Mg(2+). Biochem Biophy Res Commun 348 (3). 908-15. (IF: 3.0)
5. Shi, X., Li, Yongdong., Bian, C., Zhao, G. & Huang, M. (2005). Crystallization of an anti-factor IX antibody and its complex. Acta Crystallogr D Biol Crystallogr 61, 701-3 (IF: 1.4)
6. Rao, Y., Yuan, C., Bian, C., Hou, X., Li, Yongdong., Zhao, G., Ye, X., Huang, Z., & Huang, M.(2006). Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP II. Chinese J Struct Chem 25, 854-860 (IF: 0.669)
7. Bian C, Yuan C, Zhao G, LI Yongdong, Huang M. (2005) Progress in the Structural Study of Urokinase Receptor System CHINA BIOTECHNOLOGY 25 (B04) 144-7.
