李曉萌，教授，博士生導師。教育部新世紀人才獲得者，吉林省遺傳學會常務理事等。在美國和日本從事過博士後等科研工作。 研究領域（1）蛋白質SUMO化修飾與腫瘤（2）神經退行性疾病的藥物研發。
作為項目負責人主持國家和省市各級各類項目 30餘項，包括主持科技部國家重點研發計畫國際合作項目兩項，另外主持國家自然科學基金、教育部、吉林省團隊項目等科研項目多項，近五年主持科研經費 500 萬元以上。在 J BiolChem、Cancer Res、Cancer Prev Res、Mol Endocrinol、Cell Death & Disease、Frontier in Aging Neuroschience 等雜誌發表 SCI 論文 30 余篇；獲授權專利5 項。參與編寫教材和專著 3 部，包括國際專著(INTECH)和《細胞生物學簡明教程》（高等教育出版社）的編寫。獲得"教育部國家科學技術二等獎"、"中華醫學科技獎二等獎"和"吉林省科學技術進步獎二等獎/三等獎"科技獎勵 6 項。獲得吉林省中青年科技創新帶頭人培育人選吉林省拔尖創新人才，和吉林省突出貢獻中青年專家等稱號。
基本介紹
- 中文名：李曉萌
- 職業：教授，博士生導師
- 畢業院校：吉林大學
- 主要成就：教育部新世紀優秀人才獲得者
- 研究方向：腫瘤信號轉導，AD藥物研發
- 性別：女
個人履歷,科研方向,科研成果,論文,論著,學術獎勵,代表科研項目,
個人履歷
2011年12月 東北師範大學生命科學學院 教授
2008年9月 東北師範大學生命科學學院 博士生導師
2006年1月-2008年9月 東北師範大學生命科學學院 副教授
2003年1月-2005年12月 美國史丹福大學醫學院 遺傳學泌尿外科學 博士後
2001年6月-2002年 6月 日本東北大學醫學部 JICA研究員
2001年9月-2003年1月 吉林大學基礎醫學院病理生理學教研室 講師
1999年7月-2001年9月 白求恩醫科大學基礎醫學院 助教
1999年9月-2002年 7月 博士，吉林大學 病理學與病理生理學
1996年9月-1999年7月 碩士，白求恩醫科大學 病理學與病理生理學
1990年9月-1996年7月 學士，白求恩醫科大學 日語醫學系
科研方向
（1）腫瘤信號轉導
（2）甾體類激素受體轉錄調控與腫瘤發生
（3）轉錄因子的SUMO化修飾與腫瘤發生
（4）阿爾茲海默症藥物研發
科研成果
論文
(1)Xiaowan Wang, Runmin Song, Wenliang Lu, Ziyu Liu, Lichun Wang, Xiaojuan Zhu, Yanjun Liu, Zijie Sun, Jiang Li*, Xiaomeng Li*. YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.Front Aging Neurosci.9:157:1-15., 2017
(2) Hui Qin, Azhar Rasual, Xin Li, Muqaddas Masood, Guang Yang, Na Wang, Wei Wei, Xi He, Nobumoto Watanabe, Jiang Li*, Xiaomeng Li*. CD147-induced cell proliferation is associated with Smad4 signal inhibition. Exp Cell Res.358(2):279-289. 2017
(3) Chunwa Jiang, Muqaddas Masood, Azhar Rasul, Wei Wei, Ya Wang, Muhammad Ali, Muhammad Mustaqeem, Jiang Li*, Xiaomeng Li*. Altholactone Inhibits NF-κB and STAT3 Activation and Induces Reactive Oxygen Species-Mediated Apoptosis in Prostate Cancer DU145 Cells.Molecules.22(2):1-13., 2017
(4) Chunwa Jiang, Juanjing Wang, Chen Dong, Wei Wei, Jiang Li*, Xiaomeng Li*. Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis.Oncol Lett.14(3):3096-3102., 2017
(5) Moussa Ide Nasser, Muqaddas Masood, Wei Wei, Xiaochun Li, Yifa Zhou, Bao Liu, Jiang Li*, Xiaomeng Li*. Cordycepin induces apoptosis in SGC 7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. Int J Oncol.50(3):911-919., 2017
(6) Faya M. Millimouno, Jia Dong, Liu Yang, Jiang Li*, Xiaomeng Li*. Targeting apoptosis pathways in cancer and perspectives with natural compounds from Mother Nature. Cancer Prev Res.7(11):1081-1107., 2014
(7) N Yang, B Zhao, A Rasul, H Qin, J Li*, X Li*. PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis. Cell Death Dis. 4:e811:1-16., 2013
(8) Bing Zhao, Xiaomeng Li*. Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncol Rep. 31(6):2769-2775., 2014
(9) Liu He, Tingting Wang, Jiping A, Xiaomeng Li*, Lingyu Zhang, Lu Li, Guangzhe Li, Xiaotong Wu, Zhongmin Su*, Chungang Wan*. Carbon nanodots@zeolitic imidazolate framework-8 nanoparticles for simultaneous pH-responsive drug delivery and fluorescence imaging. Cryst Eng Comm. 16:3259-3263.,2014
(10) Azhar Rasul, Bin-Ji Zhao, Jun Liu, Bao Liu, Jia-Xin Sun, Jiang Li*, Xiao-Meng Li*. Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions. Asian Pac J Cancer Prev. 15(21):9049-9058., 2014
(11) Azhar Rasul, Jun D, Faya Martin Millimouno, Mahadev Malhi, Ichiro Tsuji, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Reactive oxygen species mediate Isoalantolactone-induced apoptosis in human prostate cancer cells.Molecules. 18:9382-9396., 2013
(12) Azhar Rasul, Rui Bao, Mahadev Malhi, Bing Zhao, Ichiro Tsuji, Jiang Li*, Xiaomeng Li*. Induction of apoptosis by Costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 18:1418-1433., 2013
(13) WU Jing, LIU Shu, SHEN Xiao-yan, YANG Nan-yang, LIU Ying, TSUJI Ichiro, YAMAMURA Takaki, LI Jiang*, LI Xiao-meng*. Phytoestrogens Inhibiting Androgen Receptor Signal and Prostate Cancer Cell Proliferation. Chem Res Chin Uni. 29(5): 911-916., 2013
(14) WU Jing, WEI Wei, YANG Nan-yang, SHEN Xiao-yan, TSUJI Ichiro, YAMAMURA Takaki, LI Jiang*, LI Xiao-meng*. Xeno-oestrogens Bisphenol A and Diethylstilbestrol Selectively Activating Androgen Receptor Mediated AREs-TATA Reporter System. Chem Res Chin Uni.29(3):512-518.,2013
(15) Zhenyu Chen, Azhar Rasul, Chaoyue Zhao, Faya Martin Millimouno, Ichiro Tsuji, Takaki Yamamura, Rehana Iqbal, Mahadev Malhi, Jiang Li*, Xiaomeng Li*. Dracorhodin perchlorate induces apoptosis in bladder cancer cells through Bcl-2, Bcl-XL, survivin down-regulation and caspase-3 activation. B J Pharmacol.8:276-282., 2013
(16) Wei Wei, Jun Di, Azhar Rasul, Chaoyue Zhao, Faya Martin Millimouno, Ichiro Tsuji, Furhan Iqal, Mahadev Malhi, Xiaomeng Li*, Jiang Li*. Antipro-liferative and apoptotic effects of pinocembrin in humanprostate cancer cells. BJ Pharmacol.8:255-262., 2013
(17) Azhar Rasul, Jinmei Liu, Ying Liu, Faya Martin Millimouno, Xiaowan Wang, Ichiro Tsuji, Takaki Yamamura, Jiang Li*, Xiaomeng Li*. Eriocalyxin B inhibits proliferation and induces apoptosis throughdownregulation of Bcl-2 and activation of caspase-3 in humanbladder cancer cells. B J Pharmacol. 8:116-123., 2013
(18) Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone. Scientifi World J, 248532:1-9.,2013
(19) Azhar Rasul, Faya Martin Millimouno, Wafa Ali Eltayb, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. BioMed Research International.2013:379850:1-9.,2013
(20) Hao Wang, Jiang Li*, Yang Gao, Ying Xu, Ying Pan, Ichiro Tsuji, Zi-Jie Sun, Xiaomeng Li*. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. Asian J Androl.12(4): 535-547., 2013
(21) AzharRasul, ChuanDing, XiaomengLi, MuhammadKhan, FeiYi, MuhammadAli, TonghuiMa*. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis.Apoptosis. 17(10):1104-19.,2012
(22) Xiaomeng Li*, Chunfang Zhu, William H. Tu, Nanyang Yang, Hui Qin, Zijie Sun*. ZMIZ1 preferably enhances the transcriptional activity of androgen receptor with short polyglutamine tract. PLoS One,6(9): e25040.1-12., 2011
(23) ZHANG Ai-li, LI Jiang, WANG Yan-qing, ZAKNROU Zohra, MA Tong-hui , LI Xiao-meng*. Aquaporin 1 Facilitated Hepatocellular Carcinoma SMMC7221 Cell Migration Associated with Water Permeability.Chem Res Chin Uni.27(1):99-103., 2011
(24) Tingting Wang,Xuli Zhang,Ying Pan,Xiumin Miao,Zhongmin Su,Chungang Wang*, Xiaomeng Li*. Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery. Dalton Trans, 40 (38): 9789-9794., 2011
(25) LI Jiang, ZHANG Ai-li, TONG Qian, ZHANG Jun-fang, LI Hai-jing, ZHAO Bing, MA Tong-hui, LI Xiao-meng1*. Expression and Emmprin Regulated Function of Aquaporin1 in SMMC7221 Cells. Chem Res Chin Uni. 26(4):578-582.,2010
(26) LI Jiang*, YANG Nan-yang, GUAN Xin-gang, ZHANG Shu-zhi, ZHANG Yan, QIN Mei-ling, MA Tong-hui, LI Xiao-meng*. GST Fusion Protein Based Specific Polyclonal Antibody Preparation of Mouse Aquaporin 1.Chem Res Chin Uni.25(4):500-505., 2009
(27) Xiao-Meng Li*, Jiang Li, Ichiro Tsuji, Naoki Nakaya, Yoshikazu Nishino, Xue-Jian Zhao*. Mass screening-based case-control study of diet and prostate cancer in Changchun, China. Asian J Androl. 10(4):551-60., 2008
(28) Xiaomeng Li, Gregory Thyssen, Jason Beliakoff and Zijie Sun*.The novel PIAS-like protein HZIMP10 enhances Smad transcriptional activity. J Biol Chem, 281(33):23748-23756., 2006
(29) Xiao-Meng Li, Ling Zhang, Jiang Li, Yang Li, Hong-Liang Wang, Guo-Yi Ji, Masaaki Kuwahara and Xue-Jian Zhao*. Measurement of serum zinc improves prostate cancer detection efficiency in patients with PSA levels between 4 ng/mL and 10 ng/mL. Asian J Androl.7(3): 323-328., 2005
(30) Chun-Yin Huang,Jason Beliakoff , Xiaoyu Li,Jane Lee,Xiaomeng Li,Manju Sharma,Bing Lim,Zijie Sun*. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol Endocrinol.19(12):2915-2929.,2005
(31) XiaomengLi*, ItiroTsuji, MasaakiKuwahara, HaifengZhang, HongliangWang, LingZhang, GuoyiJi, XuejianZhao. Mass screening of prostate cancer in Changchun City of China. Int Urol Nephrol. 36(4): 541-548., 2004
(32) Meletios Verras, Jeffrey Brown, Xiaomeng Li, Roel Nusse and Zijie Sun*. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.Cancer Res. 64(24):8860-8866.,2004
(33)Masaaki Kuwahara*, Tatsuo Tochigi, Sadafumi Kawamura, Yukihiko Ogata, Ning Xu, Hongliang Wang, Haifeng Zhang, Shengwen Li, Xiaomeng Li, Xuejian Zhao. Mass screening for prostate cancer: a comparative study in Natori, Japan and Changchun,China. Urology. 61(1): 137-141., 2003
論著
參編國際專著：“Soybean and Prostate Cancer”in Soybean - Bio-Active Compounds, ISBN 978-953-51-0977-8, Croatia，2013
參編教材：細胞生物學簡明教程，高等教育出版社，2010年4月
學術獎勵
2012年 吉林省科學技術進步獎二等獎： hZimp10在前列腺癌相關信號通路中的作用機制研究
2011年 吉林省科技進步二等獎：前列腺癌篩查中日比較及相關研究
2009年 吉林省科技進步三等獎：恢復前列腺癌TGFβ-Smad信號通路的新型分子靶向研究
代表科研項目
國家重點研發計畫（政府間國際科技創新合作專項）：
SUMO 化修飾與前列腺癌關係的機制研究（2016YFE0128500）（2017-2019），項目負責人。
科技部國際合作項目：
環境雌激素與前列腺癌的關係及植物雌激素的抑癌機制研究（2010DFA31430）（2010-2013），項目負責人。
