李文鑫, 男,漢族,湖北竹溪人,1949年11月出生,研究生學歷,法國第三階段博士,1986年5月加入中國共產黨,1976年12月參加工作。現任武漢大學黨委常委、副校長,教授、博士生導師。
基本介紹
- 中文名:李文鑫
- 國籍:中國
- 民族:漢族
- 出生地:湖北竹溪
- 出生日期:1949年11月
- 主要成就:現任武漢大學黨委常委、副校長,教授、博士生導師。
個人履歷
成就及榮譽
個人其它信息
社會兼職
主要研究領域和興趣
多年來一直從事腫瘤細胞及分子生物學研究,其“無血清細胞培養研究”成果在國內外具有較大影響,提出了細胞表面受體的多功能性,證實了轉化細胞自分泌生長因子的內源性刺激作用。目前主要從事與抗病毒和抗腫瘤密切相關蠍毒素分子生物學和人早期胚胎新基因功能的科學研究。
代表性論文
1. Yibao Ma, Ruiming Zhao, Yawen He, Songryong Li, Jun Liu, Yingliang Wu, Zhijian Cao* and Wenxin Li*. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. BMC Genomics-2009, in press
2. Shijin Yin, Ling Jiang, Hong Yi, Song Han, Daiwen Yang, Maili Liu, Hui Liu, Zhijian Cao, Yingliang Wu*, Wenxin Li*. Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. Journal of Proteome Research, 2008, 7(11): 4890-4897
3. Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z*, Li W*. Mucroporin, the first cationic host defence peptide from the venom of Lychas mucronatus. Antimicrob Agents Chemother, 2008, 52(11): 3967-3972
4. Di Wang , Ming-Xiong Guo, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li*. Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. Journal of Biological Chemistry, 2008, 283(24): 16299-308.
5. Song Han, Hong Yi, Shi-Jin Yin, Zong-Yun Chen, Hui Liu, Zhi-Jian Cao, Ying-Liang Wu*, and Wen-Xin Li*. Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. Journal of Biological Chemistry, 2008, 283: 19058-19065
6. Liu WH, Liu ZC, Cao XB, Cao ZJ, Xue L,Zhu F,He XH*,and Li WX*. Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Molecular Therapy, 2007, 15(10):1834-1841
7. Hong Yi, Zhijian Cao, Shijin Yin, Chao Dai, Yingliang Wu*, Wenxin Li*. Interaction Simulation of hERG K+ Channel with its specific Bekm-1 peptide: Insights into the Selectivity of Molecular Recognition. Journal of Proteome Research, 2007, 6: 611-620
8. Ming-Xiong Guo, Di Wang, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li *. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. Journal of Biological Chemistry, 2006, 281(34): 24623-36
9. Luo Feng, Zeng Xianchun, Li Wenxin*. Genomic organization of four novel nondisulfide-bridge peptides from Mesobuthus martensii Karsch: insight into the evolutionary mechanism. Peptides, 2005, 26: 2427-2433
10. Wu, YL; Cao, ZJ; Yi, H; Jiang, DH; Mao, X; Liu, H; Li, WX*. Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA. Biophysical Journal, 2004, 87 (1): 105-112
11. D.M. Gou, L.M.C. Chow, N.Q. Chen, D.H. Jiang, W.X. Li*. Construction and characterization of a cDNA library from 4-week-old human embryo. Gene, 2001, 278: 141-147.
12. Cao, ZJ; Xiao, F; Peng, F; Jiang, DH; Mao, X; Liu, H; Li, WX*; Hu, D; Wang, T. Expression, purification and functional characterization of a recombinant scorpion venom peptide BmTXK beta. Peptides, 2003, 24 (2): 187-192
13. Peng, F; Zeng, XC; He, XH; Pu, J; Li, WX*; Zhu, ZH; Liu, H. Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin. European Journal of Biochemistry, 2002, 269 (18): 4468-4475
14. Zhu, SY; Li, WX*; Cao, ZJ. A naturally occurring non-coding fusion transcript derived from scorpion venom gland: implication for the regulation of scorpion toxin gene expression. FEBS Letters, 2001, 508 (2): 241-244
15. Zhu, SY; Li, WX*; Zeng, XC; Jiang, DH; Mao, X; Liu, H. Molecular cloning and sequencing of two ’short chain’ and two ’long chain’ K+ channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. FEBS Letters, 1999, 457: 509-514